骨质疏松与脊柱骨关节的关系

骨质疏松与脊柱骨关节炎均属于与人体衰老密切联系的退行性疾患 ,其发生率伴随增龄而逐渐上升 ,但又是两种性质完全不同的疾病 ,骨质疏松与骨关节病之间可能存在负相关性 ,骨关节病反而会使骨密度增高。骨质疏松所导致的椎体塌陷会诱发骨关节病的发生     

骨质疏松的治疗

骨质疏松是许多健康成年人均可 患的一种常见疾病,预防骨折的对策包括最佳的峰值骨密度及预防因绝经和随着年龄增长而引起的骨质丢失。遗传基因营养和生活方式是影响峰值骨密度的因素,也是预防的重点,一旦达到峰值骨密度,骨的吸收增加可能是主要的发病因素。目前,治疗骨质疏松的主要药物有:钙加维生素D、雌激素替代治疗、降钙素及etidronate,它们可以抑制骨的吸收。骨的生成少于骨的吸收也可造成骨质丢失,氟化物及间歇的甲状旁腺激素治疗可以增加骨的生成,然而其确切疗效还有待于进一步论证,胰岛     

旋转恒定磁场对骨质疏松大鼠血清铁和铁调素的影响

目的：研究旋转恒定磁场对骨质疏松大鼠铁代谢的影响,进而探讨磁场治疗骨质疏松的可能机制。方法：雌性SD大鼠灌胃维甲酸建立骨质疏松模型,经Micro．CT分析大鼠T4胸椎骨密度并确定造模成功后,将骨质疏松模型随机分为磁场治疗组（曝磁组）和非治疗组（骨质疏松组）,并设立正常对照。曝磁组每天曝磁2小时,磁场强度0．4T。连续曝磁30天后检测各组大鼠血清铁和血清铁调素浓度,采用Real—timeRT—PCR方法检测肝脏中铁调素mRNA的表达。结果：经磁场治疗后．曝磁组大鼠T4胸椎骨密度较骨质疏松组显著升高（P〈0．01）。磁场能够下调骨质疏松大鼠血清铁浓度,并且能够上调血清中铁调素的表达。结论：上调骨质疏松大鼠血清铁调素的表达从而引起血清铁含量的降低是旋转恒定磁场治疗骨质疏松的可能机制。     

低频脉冲电磁场治疗骨质疏松的机制及临床应用

BACKGROUND: The most commonly used physiotherapies for osteoporosis include low-frequency pulsed electromagnetic field, ultrashort wave therapy, and extracorporeal shock wave therapy. Because of the uncertain intensity of extracorporeal shock wave and uncertain efficacy of ultrasound therapy, low-frequency pulsed electromagnetic fields have become the most widely used treatment for osteoporosis in clinic. OBJECTIVE: To review the mechanism and clinical application of low-frequency pulsed electromagnetic fields in the treatment of osteoporosis. METHODS: A computer search by the first author of PubMed and CNKI databases was performed for relevant articles using the keywords of “pulsed electromagnetic fields and osteoporosis” or “osteoblast or osteoclast” in English and “osteoporosis; pulsed pulsed electromagnetic fields; osteoblasts; osteoclasts” in Chinese, respectively. After initial search, there were 169 articles, and according to the inclusion criteria, 29 highly relevant articles that are authentic and have clear views were analyzed. RESULTS AND CONCLUSION: The pulsed electromagnetic field as a non-drug therapy is characterized by no trauma, no infection, simple operation, low cost, long-term use, and good safety. Its efficacy has been increasingly affirmed by researchers and clinicians. Pulsed electromagnetic fields can promote the synthesis of DNA, influence the proliferation and differentiation of osteoblasts, increase the apoptosis of osteoclasts, and have a certain window effect. Pulsed electromagnetic fields can effectively relieve pain and increase bone density level in patients with osteoporosis, which can increase its efficacy in combination with other drugs and have a wide range of clinical applications.        

骨质疏松治疗仪联合经皮椎体成形术治疗老年骨质疏松性椎体压缩性骨折的效果

目的 探讨骨质疏松治疗仪联合经皮椎体成形术（PVP）治疗老年骨质疏松性椎体压缩性骨折（OVCF）的效果及对血清BGP、CTX-Ⅰ、TRACP-5b水平的影响。方法 选取2019年1月~2021年1月我院收治的82例老年OVCF患者作为研究对象,采用随机数字表法分为对照组和观察组,各41例。对照组给予PVP治疗,观察组在对照组基础上加用骨质疏松治疗仪治疗,比较两组疗效、疼痛程度、功能障碍程度、椎体高度、Cobb角、骨密度及骨代谢生化指标。结果 观察组总有效率为87.80%,高于对照组的68.29%（P＜0.05）;观察组治疗后1个月VAS评分、ODI评分、Cobb、椎体高度、骨密度均优于对照组（P＜0.05）;观察组血清BGP水平高于对照组,CTX-Ⅰ、TRACP-5b水平低于对照组（P＜0.05）。结论 骨质疏松治疗仪联合PVP治疗老年OVCF的效果确切,可减轻患者疼痛与功能障碍程度,改善其骨代谢水平。     

PVP、PKP治疗骨质疏松腰椎压缩性骨折的临床对比研究

目的:探讨经皮椎体成形术(Percutaneous vertebroplasty,PVP)、经皮椎体后凸成形术(Percutaneous kyphoplasty,PKP)治疗骨质疏松腰椎压缩性骨折的临床效果.方法:2018年6月～2020年2月本院收治的62例骨质疏松腰椎压缩性骨折患者,根据手术方式分为PVP组、PKP...     

个性化心理护理干预应用于骨质疏松的临床效果观察

目的探讨个性化心理护理干预和常规护理干预对提高骨质疏松患者的生活质量的影响,评价其改善患者骨密度的作 用遥方法选取我院2013 年7 月~2015 年7 月进行护理的124 例骨质疏松患者,根据护理方法不同分为两组各62 例,对照组采 用常规护理,试验组在对照组的基础上进行个性化康复护理,随访3 y,观察两组患者的骨密度尧生活质量评分及满意度遥结果 两组患者护理后的骨密度明显优于护理前,且试验组骨密度明显优于对照组,差异具有统计学意义（约0.05）曰试验组的生活质 量评分明显优于对照组,差异具有统计学意义（约0.05）曰试验组的满意度明显高于对照组,差异具有统计学意义（约0.05）遥结论 对骨质疏松患者进行个性化心理护理可以有效的改善患者的骨密度,提高患者的生活质量,满意度比较高遥     

骨代谢生化指标在评价绝经后女性骨质疏松治疗中的应用

目的:探讨骨代谢生化指标在绝经后妇女并发骨质疏松的早期诊断和治疗后监测中的应用.方法:临床收集绝经后的女性糖尿病患者56例,合并有骨质疏松,随机分为药物干预组和未治疗组各28例,药物干预组服用二磷酸盐类药物(阿仑膦酸钠)10mg,1片/d;对照组;给予安慰剂,连续观察6个月,分别测定药物干预前后的腰椎、股骨颈骨密度(B...     

体重指数与男性骨质疏松关系的研究

对2003年8月至2005年12月因骨和/或关节疼痛麻木在四川大学华西医院门诊及住院1 207例男性经X线检查判断无骨质增生482人,采用法国DMS公司生产的Challenger双能X线骨密度仪测定L2～4正位骨密度,记录其身高、体重(计算体重指数)、症状、并发症、运动、吸烟等基线状况;测定L2～4骨密度,明确是否骨质疏松;用t检验或2检验比较骨质疏松组和无骨质疏松组基线状况,用逻辑回归分析实验对象中各种可能影响骨质疏松的因素与骨质疏松的相关性。结果显示:骨质疏松和无骨质疏松两组比较:体重指数、运动情况和吸烟比例有显著差异;高血压和糖尿病患病比例、年龄无明显差异;根据多因素分析,体重指数和吸烟是骨质疏松的危险因素,运动是骨质疏松的保护因素。BMI每增加一个单位,男性发生骨质疏松的风险增加0.654倍(P=0.004)。因此,我们认为体重指数是男性骨质疏松的危险因素,可能与体脂分布不同有关。     

正弦波磁场发生器的研制及其对钾通道电流的影响

目的:研制一种低频的正弦波磁场发生装置,使产生的磁场频率和场强等参数均可调节,并且能在生物学实验研究中方便的使用。方法:首先设计一个直流稳压电源为电路各部分提供直流电压,然后用单片机控制正弦信号生成,分离元件组成功放电路,功放实际可提供的电流为0mA～136mA。根据实验的需要自行设计线圈,线圈的几何尺寸和匝数不同,所得到的场强值也不同。结果:该仪器产生的磁场输出频率在0kHz～25kHz,强度在0mT～10mT范围内连续可调,电源功率在30W内时可连续长时间工作。该磁场发生装置运行稳定,使用方便,所得到的场强值与理论推导出来的基本相符,能应用于生物效应的研究。结论:用该仪器生成的不同频率、不同场强的磁场对大鼠的海马神经元进行照射,发现正弦波磁场对海马神经元钾离子通道的电流特性有一定的影响,可能存在频率和场强的"窗口"效应。     

腰椎磁共振影像组学对女性骨质疏松症的诊断价值

背景:磁共振成像(MRI)在骨质疏松症诊断中发挥着越来越重要的作用。影像组学作为一种新的图像分析方法在骨质疏松症诊断中有潜在的临床意义。目的:探讨基于腰椎磁共振影像组学模型对骨质疏松症的诊断价值。方法:纳入2017年2月至2018年10月河北医科大学第一医院门诊女性患者50例,年龄40-84岁,同期进行腰椎MRI及双能X射线骨密度测量。双能X射线骨密度测量结果显示骨质疏松症28例及骨质正常22例,分别在腰椎MRI矢状位T1WI及T2WI序列图像选取L2-4椎体中间连续5个层面进行图像分割,提取影像组学特征,建立诊断模型,并与临床特征结合建立影像临床特征模型,使用曲线下面积(AUC)评估模型效能。试验获河北医科大学第一医院伦理委员会批准。结果与结论:①在50例受试者T1WI、T2WI序列及联合序列分别提取出396×3个特征,通过特征降维后分别筛选出最相关的T1WI序列4个特征、T2WI序列6个特征,T1WI及T2WI联合序列图像筛选出4特征,建立诊断模型,T1WI、T2WI单序列诊断模型AUC值分别为0.810,0.820,T1WI+T2WI联合序列诊断模型AUC值为0.937,高于单个序列;②将T1WI+T2WI组学特征与临床资料结合构建了适用于女性的联合临床资料的影像组学诊断模型,其AUC值为0.960;③结果表明,基于常规腰椎MRI的影像组学特征可以区分骨质疏松及骨量正常,结合临床特征建立的联合诊断模型能够提高诊断效能,对诊断骨质疏松症有较高的临床价值。     

Comparison of effect of treatment with etidronate and alendronate on lumbar bone mineral density in elderly women with osteoporosis

The purpose of this open-labeled prospective study was to compare the treatment effects of cyclical etidronate and alendronate on the lumbar bone mineral density (BMD), bone resorption, and back pain in elderly women with osteoporosis. Fifty postmenopausal women with osteoporosis, age ranging from 55 to 86 years (mean: 70.7 years), were randomly divided into two groups with 25 patients in each group: the cyclical etidronate group (etidronate 200 mg daily for 2 weeks every 3 months) and the alendronate group (5 mg daily). The BMD of the lumbar spine (L1-L4) measured by DXA, the urinary cross-linked N-terminal telopeptides of type I collagen (NTX) level measured by the enzyme-linked immunosorbent assay, and back pain evaluated by the face scale score were assessed at baseline, 6 months, and 12 months. There were no significant differences in baseline characteristics including age, body mass index, years since menopause, lumbar BMD, urinary NTX level, and face scale score between the two treatment groups. Etidronate treatment sustained the lumbar BMD following a reduction in the urinary NTX level and improved back pain, while alendronate treatment reduced the urinary NTX level more significantly, resulting in an increase in the lumbar BMD, and similarly improved back pain. No serious adverse events were observed in either group. This study confirmed that alendronate treatment had a greater efficacy than etidronate treatment in increasing the lumbar BMD through the reduction of bone resorption in elderly women with osteoporosis.     

抗阻训练干预绝经后骨质疏松患者骨密度的系统综述和Meta分析

背景:抗阻训练已经被证实对于改善绝经后妇女骨质疏松患者的骨密度有所帮助,但抗阻运动的运动方式、训练强度、训练时间、训练频率,以及与不同运动(有氧运动等)方式的结合是否效果更好还有待研究。目的:评价抗阻训练对绝经后妇女骨质疏松患者骨密度的干预效果。方法:搜集抗阻训练干预绝经后妇女骨质疏松患者骨密度的相关随机对照试验,研究对象分为抗阻训练组及空白对照组,检索Pub Med、EMBASE、Web of Science、中国知网和万方医学数据库,检索的时间范围从建库到2019年12月,并且对纳入文献的相关参考文献进行检索。由2名研究者按纳入和排除标准筛选文献并提取有效数据,进行质量评价。采用Rev Man 5.3软件对最终纳入的文献数据进行Meta分析。结果与结论:①最终纳入23篇随机对照试验,对纳入的文献进行风险偏倚评价,结果显示整体文献质量为中等偏上;②Meta分析结果显示,与空白对照组相比,抗阻训练组可显著改善绝经后妇女骨质疏松患者的腰椎骨密度[SMD=0.02,95%CI(0.01,0.03),P<0.0001]、全髋骨密度[SMD=0.25,95%CI(0.06,0.44),P=0.03]、股骨颈骨密度[SMD=0.28,95%CI(0.12,0.04),P=0.0005]及大转子骨密度[SMD=0.02,95%CI(0.00,0.03),P=0.02];③提示抗阻训练有利于维持绝经后妇女骨质疏松患者的骨密度水平,可以作为绝经后妇女骨质疏松运动治疗的重要组成部分。     

补肾壮骨方干预去卵巢骨质疏松模型大鼠骨代谢及骨密度的变化

背景：中医药以其良好的治疗效果及安全性越来越多的应用于骨质疏松症的治疗中,补肾壮骨方目前作为山东中医药大学附属医院协定方被广泛应用于临床中,获得了极好的治疗效果。目的：评价补肾壮骨方对去卵巢骨质疏松大鼠骨代谢及骨密度的影响。方法：60只SD大鼠随机分为6组,分别为假手术组、模型组、阿仑膦酸钠组、补肾壮骨方高、中、低剂量组,每组10只,后5组制备去卵巢骨质疏松症模型,假手术组只切除卵巢周围脂肪组织。造模8周后,补肾壮骨方高、中、低剂量组分别予以2.34,1.17,0.58 g/(kg·d)补肾壮骨方,阿仑膦酸钠组予阿仑膦酸钠1 mg/(kg·d),假手术组及模型组给予等体积的生理盐水,1次/d灌胃。连续灌胃12周后检测各组大鼠血清碱性磷酸酶、Runt相关转录因子2及核因子κB受体活化因子配体水平;取右侧股骨观察骨密度及骨微结构;苏木精-伊红染色观察组织病理改变;免疫组化法检测骨组织Wnt1、骨形态发生蛋白2蛋白表达。结果与结论：(1)造模8周后,与假手术组对比,模型组大鼠骨密度、骨小梁数明显降低(P <0.05),提示造模成功;(2)与模型组大鼠对比,补肾壮骨方低、中、高剂量组及阿...     

骨代谢指标与骨关节炎及绝经后骨质疏松症的关系

背景：研究显示,在绝经后骨质疏松症及骨关节炎状态下,原本正常的骨转换平衡状态被破坏,血清、尿液中一些特异性指标可以较敏感地反映出骨转换的具体变化过程。 目的：测量绝经后原发性膝骨关节炎及绝经后骨质疏松症患者的骨密度及骨代谢指标,分析两疾病骨密度及骨代谢指标的变化特点。 方法：选取248例绝经女性受试者,行骨密度、膝关节X射线片检查,最终选出180例进入试验,分为骨关节炎组、骨质疏松组及对照组。对比分析各组观察对象的骨代谢指标：骨碱性磷酸酶、骨钙素、Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b。通过二元Logistic回归分析判断两疾病发病与各项指标间的相关性。 结果与结论：与对照组比较,骨关节炎组腰椎骨密度升高,Ⅰ型胶原交联C末端肽值降低;骨质疏松组腰椎及全髋部骨密度降低,骨钙素、Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b升高。血清Ⅰ型胶原交联C末端肽水平的降低与骨关节炎发病具有显著相关性;血清骨钙素、Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b水平的升高与骨质疏松发病具有显著相关性。提示绝经女性骨关节炎患者骨吸收速率减低,骨质疏松患者骨转换率加快,骨代谢水平的差异导致两疾病患者骨密度呈现出负相关趋势。监测Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b、骨钙素,特别是Ⅰ型胶原交联C末端肽血清水平对骨关节炎及骨质疏松的早期诊断及治疗有一定的参考价值。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接：     

Prevention and treatment of corticosteroid-induced osteoporosis

Osteoporosis is one of the most serious complications of corticosteroid treatment. Loss of bone mineral density (BMD) and fractures occur early in the course of corticosteroid treatment, and thus early recognition of fracture risk and effective intervention based on evidence-based-medicine (EBM) are needed. A study of meta-analysis representing the highest level in a hierarchy of evidence showed that when the outcome measure of interest was limited to changes in lumbar spine BMD, bisphosphonates were the most effective of the agents studied in comparison with no therapy or treatment with calcium, and were also more efficacious than either vitamin D or calcitonin; the efficacy of bisphosphonates was enhanced when used in combination with vitamin D. Randomized controlled trials (RCTs) representing the second level in a hierarchy of evidence showed that bisphosphonates stabilized BMD not only in the lumbar spine, but also in the hip, and that parathyroid hormone (PTH) markedly increased lumbar spine BMD. According to the EBM, bisphosphonates and possibly PTH are suggested to be the most efficacious for preserving BMD. The efficacy of these agents in reducing the incidence of vertebral fractures in patients exposed to corticosteroids remains to be established in meta-analysis studies, although some RCTs have demonstrated the anti-fracture effects of etidronate, alendronate, and risedronate in the spine. Further RCTs of fracture prevention conducted on a large number of patients and their meta-analysis are needed to confirm the efficacy of bisphosphonates, PTH, or other agents in preventing vertebral and nonvertebral fractures.     

磁场对去卵巢大鼠骨密度、骨强度和骨代谢的影响

本文研究了旋转恒定磁场对去卵巢大鼠骨密度,骨强度和骨代谢的影响。结果表明磁场处理30分钟且加钙组的骨密度,能量吸收,弹性能量吸收,最大载荷,最大桡度和弹性桡度等指标均显著高于去卵巢组,分别增加3.5%,15.4%,12.4%,7.6%,5.8%,11.9%t 5.2%。其碱性磷酸酶,血磷,血钙等指标也比去卵巢组分别高71％,108％,156％。实验还检测了暴磁1个月及停止暴磁后1到2个月,大鼠骨密度和骨矿含量的变化,结果表明磁场处理存在着窗口效应和滞后效应。     

Effects of alendronate and hormone replacement therapy, alone or in combination, on bone mass in postmenopausal women with osteoporosis: a prospective, randomized study

The effectiveness of hormone replacement therapy (HRT) and alendronate, alone and in combination, was evaluated in 120 postmenopausal patients with osteoporosis with bone mineral density (BMD) measurements at least 2 SD below the mean value for young premenopausal subjects. They had no contra-indications to HRT or alendronate use and were randomized to three different treatment groups. Group I was treated with micronized 17 beta-oestradiol 2 mg and norethisterone acetate 1 mg/day per os, group II received alendronate 10 mg/day per os and group III received micronized 17 beta-oestradiol 2 mg, norethisterone acetate 1 mg/day per os and alendronate 10 mg/day per os for 1 year. Elementary calcium 1500 mg/day was supplied to patients in all three groups. Spinal and femoral neck BMD and markers of bone mineral metabolism were measured on each patient before treatment and 6 and 12 months after treatment in 95 patients. At the end of the 12th month, significant increases in spinal and femoral neck BMD were found in all groups. Increases in spinal BMD were significantly higher in patients treated with alendronate and alendronate with HRT when compared with patients treated with HRT only. No significant difference was found in femoral neck BMD changes between the groups. Significant decreases in bone resorption and markers of bone formation were observed in all groups. Alendronate was found to be more effective than HRT and could have a very beneficial effect when added to the HRT regimen in patients with postmenopausal osteoporosis. Alendronate might also be used in postmenopausal patients with osteoporosis when HRT is contra-indicated or when there is reluctance to use hormonal treatment.     

Influence of polymorphisms in insulin-like growth factor-1 on the risk of osteoporosis in a Chinese postmenopausal female population

We conducted a case-control study in a Chinese postmenopausal population, and explore the potential role of the promoter region variation of the IGF-1 gene in bone mineral density and osteoporosis risk. 485 postmenopausal women with a primary diagnosis of osteoporosis and 485 age-matched controls were selected between 2012 and 2014. The Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used for rs35767, rs2288377 and rs5742612 of IGF-1 genotyping. By conditional regression analysis, individuals carrying TT genotype and CT+TT genotype of rs35767 were found to be correlated with an elevated risk of osteoporosis, with adjusted ORs (95% CI) of 1.90 (1.23-2.93) and 1.35 (1.04-1.76), respectively. Our study found that CT+TT genotype of rs35767 was significantly associated with moderate increased risk of osteoporosis in smokers and drinkers, and the ORs (95% CI) were 2.11 (1.06-4.20) and 2.36 (1.29-4.32), respectively. We found that those carrying CT+TT genotype of rs35767 had a significant lower BMD levels at L1-L4 vertebrae, femoral neck, total hip and trochanter compared to those with CC genotype. Our study suggests that TT genotype and CT+TT genotype of IGF-I rs35767 were associated with risk of osteoporosis and BMD levels.     

不同形式运动对原发性骨质疏松患者骨代谢指标影响的Meta分析

文题释义：原发性骨质疏松：骨质疏松症是最常见的骨骼疾病,是一种以骨量低,骨组织微结构损坏,导致骨脆性增加,易发生骨折为特征的全身性骨病。骨质疏松症分为原发性和继发性两大类。原发性骨质疏松症包括绝经后骨质疏松症(Ⅰ型)、老年骨质疏松症(Ⅱ型)和特发性骨质疏松症(包括青少年型)。 体育锻炼：是指参加者通过重要性的身体运动,以增强体质、增进健康为目的的体力活动。诸多研究证实,体育锻炼对原发性骨质疏松有一定效果,但其作用方式、具体作用效果并不明确。 背景：体育锻炼对骨质疏松症患者骨量丢失、疼痛及骨代谢指标均有明显改善作用,但尚缺乏循证依据。 目的：系统评价不同体育运动对原发性骨质疏松患者治疗效果的干预作用。 方法：筛选体育运动与原发性骨质疏松患者治疗效果的临床随机对照试验,干预组以体育锻炼为主,对照组试验期间无规律运动,主要结局指标为腰椎L₂-L₄骨密度、疼痛目测类比评分、骨代谢指标(骨钙素、总Ⅰ型胶原氨基端延长肽、尿吡啶啉/肌酐、血钙、血磷)。采用Review Manager 5.3软件对纳入的结局指标进行Meta分析。 结果与结论：①总计纳入25篇随机对照试验研究;②Meta分析结果显示,体育锻炼可以有效提高原发性骨质疏松患者L₂-L₄骨密度(MD=0.06,95%CI：0.04-0.08,P < 0.000 01,I²=89%),亚组分析结果为：五禽戏-易筋经、健身操组、复合训练组、递增负荷训练组与对照组比较差异均有显著性意义(P < 0.05),其他运动组与对照组比较差异无显著性意义(P > 0.05);③体育锻炼可显著降低骨质疏松症患者疼痛程度(MD=-0.93,95% CI：-1.08至-0.79,P < 0.000 01,I²=83%);④运动干预可提高骨质疏松症患者血清骨钙素、总Ⅰ型胶原氨基端延长肽及血磷水平,并降低骨质疏松症患者尿吡啶啉及血钙水平,但各运动组与对照组比较差异均无显著性意义(P > 0.05);⑤Egger’s及Begg’s检验结果表明,纳入研究发表偏倚处于低水平;结果提示,体育运动对中老年原发性骨质疏松症患者的骨密度、疼痛具有显著干预作用。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程