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1.
Inés Oliveira Souto Izaskun Alejo-Cancho Joaquim Gascón Brustenga Aida Peiró Mestres Jose Muñoz Gutiérrez Miguel J. Martínez Yoldi 《Enfermedades infecciosas y microbiología clínica》2018,36(1):21-23
Introduction
Zika virus is mainly transmitted through the bites of infected Aedes mosquitoes, although mother-to-child and sexual transmission have also been described. The presence of Zika virus in semen after infection seems to be not uncommon, but the duration of viral persistence has not been well-determined.Methods
Molecular, serological and cell culture methods were used for the diagnosis and follow up of a case of Zika virus infection imported from Venezuela. Serial samples of serum, urine and semen were analyzed to investigate the persistence of the Zika virus.Results
Zika virus was detected in semen samples up to 93 days after the onset of symptoms.Conclusions
Our results confirm the persistence of Zika virus in semen samples for long periods after infection. 相似文献2.
Irene Fuertes de Vega Carola Baliu-Piqué Jordi Bosch Mestres Andrea Vergara Gómez Xavier Vallés Mercè Alsina Gibert 《Enfermedades infecciosas y microbiología clínica》2018,36(3):165-168
Background
There are very few data available regarding risk factors associated with antibiotic resistant-Neisseria gonorrhoeae.Methods
A study was conducted on 110 samples from 101 patients with gonococcal infection, in order to describe their characteristics and compare them with the antimicrobial susceptibility profile of their samples.Results
An association was observed between resistant infections and heterosexual men, older age, concurrent sexually transmitted infection, and unsafe sexual behaviors.Conclusion
There is a need for improved data on the risk factors associated with antibiotic resistant gonococcal infection in order to identify risk groups, and to propose public health strategies to control this infection. 相似文献3.
4.
Tarek Mohamed Ali Ahmad El Askary 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1045-1050
Background
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).Aim
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.Subjects and methods
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.Results
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.Conclusions
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis. 相似文献5.
Francisco Valverde-López C. Mel Wilcox Eduardo Redondo-Cerezo 《Gastroenterologia y hepatologia》2018,41(10):618-628
Introduction
The aim of this systematic review is to summarize epidemiological data and areas of future acute pancreatitis research in Spain.Methods
We conduct an independent search in PubMed and Web of Science and analyse articles by Spanish researchers from 2008 to 2018.Results
We identified an overall incidence of 72/100,000 person-years, with biliary pancreatitis as the most common etiology. BISAP was useful but suboptimal for predicting severity and some biomarkers such as Oleic acid chlorohydrin have shown promising results. The modified determinant-based classification can help to classify patients admitted to intensive care units. Ringer's lactate solution is currently the fluid of choice and classic surgery has been surpassed by minimally-invasive approaches. Starting a full-caloric diet is safe when bowel sounds are present.Discussion
There are numerous well-defined research fields in Spain. Future multicentre studies should focus on management, predicting severity and cost-effectiveness. 相似文献6.
Mahmoud Abdallah El-Husseiny Ashraf Abdel-Hameed Abdel-Moneim Mohammed Arafat Abdel-Maksoud Kamel Suliman Hammad 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):491-495
Objective
The study was performed to evaluate the technique of laproscopic minigastric bypass for metabolic syndrome patients.Study design
The patients were enrolled in a combined prospective study and had a retrospectively gathered outcome analysis.Patient and methods
The study includes thirty patients; 24 females and 6 males suffering from metabolic syndrome with a mean age of 33.15?±?10.17?years (range, 20–59), who fulfilled the criteria for bariatric surgery with BMI >35 with associated co-morbidities, all patients underwent laparoscopic mini-gastric bypass.Results
BMI and WC were significantly reduced post-operatively; also co-morbidities as DM, hypertension and dyslipidemia were resolved or controlled. The mean operative time was 90?±?12.6?min (range, 80–120). No mortality was reported within 30?days of surgery.Conclusion
Laparoscopic mini gastric bypass is an effective procedure for the treatment of obesity, HTN, type 2 DM and dyslipidemia, technically feasible, safe operation with a low rate of major postoperative complications. 相似文献7.
Ivan Sanz Muñoz Silvia Rojo Rello Raúl Ortiz de Lejarazu 《Enfermedades infecciosas y microbiología clínica》2018,36(9):572-575
Introduction
The aim of this study was to analyze the presence of antibodies against both Yamagata and Victoria influenza B lineages and to check the response after seasonal trivalent vaccination.Materials and methods
Haemagglutination inhibition assays were performed with pre-and post-vaccination serum samples from 174 individuals ≥65 years of age vaccinated with seasonal trivalent influenza vaccines during the 2006–2007, 2008–2009, 2009–2010 and 2010–2011 vaccine campaigns.Results
33.9% of individuals showed pre-vaccine protective antibodies (≥1/40) against B/Yamagata lineage and 41.4% against B/Victoria lineage. The annual trivalent vaccine induced significant homologous seroconversion in 14–35.6% of individuals in each vaccine campaign.Conclusions
The population ≥65 years has low-moderate seroprotection against B influenza lineages. Trivalent vaccination induced a slight increase of seroprotection. The trivalent vaccine should be administered to all individuals ≥65 years in all vaccine campaigns. 相似文献8.
T.D. Filippatos V. Tsimihodimos G. Liamis M.S. Elisaf 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(1):59-63
Aims
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of antidiabetic drugs that affect serum electrolytes levels. The aim of this review is the detailed presentation of the associated mechanisms of the SGLT2 inhibitors-induced electrolyte abnormalities.Materials and methods
Eligible trials and relevant articles published in PubMed (last search in July 2017) are included in the review.Results
SGLT2 inhibitors induce small increases in serum concentrations of magnesium, potassium and phosphate. The small increase in serum phosphate concentration may result in reduced bone density and increased risk of bone fractures, mainly seen with canagliflozin, but recent meta-analyses did not show increased risk of bone fractures with SGLT2 inhibitors.Conclusion
The increases in serum electrolytes levels may play a role in the cardiovascular protection that has been recently reported with empagliflozin and canagliflozin. 相似文献9.
S. Tsabouri A. Gkoutsias C.J. Lolis A. Makis N. Chaliasos A. Bartzokas 《Allergologia et immunopathologia》2018,46(1):24-30
Objective
To evaluate the relationship between meteorological factors in North-western Greece and the incidence of bronchiolitis.Methods
Meteorological data (air temperature and rainfall) for Ioannina city in North-western Greece and medical data from hospitalised patients at University Hospital of Ioannina were collected between January 2002 and December 2013. The association between meteorological factors and rate of hospitalisation due to bronchiolitis was investigated. The data processing was done using the Pearson product-moment correlation coefficient and applying the chi-square test at contingency tables of the parameters.Results
Of the 792 hospitalised cases, 670 related to infants (<1 year) and 122 concerned patients aged 1–2 years old. The disease is more common among boys (59.5%) than girls (40.5%). The disease course through the year has a double variation with a main maximum in March and a main minimum in August. The statistical study showed statistically significant correlation of bronchiolitis with: (a) the temperature parameters on an annual basis; (b) precipitation in autumn and dryness in spring; and (c) with sudden changes in diurnal temperature range on an annual basis.Conclusion
A peak incidence of bronchiolitis was noticed in cold and wet seasons during the five days preceding hospitalisation. 相似文献10.
Gustavo Rodrigues António Tralhão Carlos Aguiar Pedro Freitas António Ventosa Miguel Mendes 《Revista portuguesa de cardiologia》2018,37(6):491-496
Introduction
A new drug with prognostic impact on heart failure, sacubitril/valsartan, has been introduced in current guidelines. However, randomized trial results can be compromised by lack of representativeness. We aimed to assess the representativeness of the PARADIGM-HF trial in a real-world population of patients with heart failure.Methods
We reviewed the records of 196 outpatients followed in a heart failure clinic between January 2013 and December 2014. After exclusion of 44 patients with preserved ejection fraction, the inclusion and exclusion criteria of the trial were applied.Results
Of the 152 patients with systolic heart failure, 106 lacked one or more inclusion criteria and 45 had at least one exclusion criterion. Considering only patients with ejection fraction ≤35% (HFrEF) (n=88), 43 patients lacked at least one inclusion criterion and 25 patients had at least one exclusion criterion. Combining the inclusion and exclusion criteria, 24.3% of patients with systolic HF (ejection fraction ≤50%) and 42% of patients with HFrEF would be eligible for the PARADIGM-HF trial.Conclusion
One in four patients with systolic HF followed in a heart failure outpatient clinic would fulfill the reference study criteria for treatment with the new drug, sacubitril/valsartan. 相似文献11.
Maryam Abbasian Mehri Delvarianzadeh Hossein Ebrahimi Farideh Khosravi Pirasteh Nourozi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):497-500
Aims
This study aimed to investigate the relationship between the total antioxidant capacity (TAC) and Malondialdehyde (MDA) with number of metabolic syndrome (Mets) components on the personnel working in Shahroud University of Medical Sciences.Methods
This cross-sectional study was conducted on 167 personnel aged 30–60 years old. ATP III criteria were used to diagnose patients with MetS. Oxidative stress indicators were measured. The data was analyzed via one-way ANOVA, and Pearson and Spearman correlation coefficients.Results
The result showed that TAC had a significant positive correlation with HDL and a significant negative correlation with abdominal obesity. In addition, there was a significant positive association between the level of MDA and age, BMI, abdominal obesity, diastolic blood pressure, triglycerides, and LDL; however, it had a negative significant correlation with HDL.Conclusions
The measurement of TAC and MDA biomarkers can increase the early diagnosis of patients at risk of developing Mets. 相似文献12.
Ana Márcia Tomé Camargos Ana Carolina Oliveira Gonçalves Maurílio de Souza Cazarim Cristina Sanches Leonardo Régis Leira Pereira André Oliveira Baldoni 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):279-283
Introduction
DM spending in the world is high, and Brazilian studies of public spending caused by DM are scarce.Objective
To estimate the annual direct cost for the municipal health sphere, related to DM2 treatment, in patients with and without glycemic control.Method
A cross-sectional study carried out in a city in the interior of Minas Gerais state, with patients with DM2, being municipal PHS users. Data were collected from the computerized system of the municipality and patient records, and analyzed using the IBM SPSS v.19 statistical package. The response variable was categorized into controlled A1c (≤7%) and uncontrolled A1c (>7%).Results
Glycemic control in 56.6% of the patients was unsatisfactory; the mean cost of pharmacotherapy for DM2 was US$ 3.14 per year for patients in the control group and US$ 45.54 per year for uncontrolled patients.Conclusion
Patients with unsatisfactory glycemic control are more expensive for the municipal health system. 相似文献13.
Deldar Morad Abdulah Alan Bapeer Hassan Farsat Saeed Saadi Ary Habeeb Mohammed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):969-975
Objectives
Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study.Study design
A Double-arm post-test intervention study.Methods
In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017. The level of physical activity was measured through International Physical Activity Questionnaire (IPAQ), dietary habits through UK Diabetes and Diet Questionnaire (UKDDQ), and biochemical indicators including HbA1c were measured after three months of program completion.Results
The study showed that walking, taking vegetable, fruit, and bread were higher and taking full-fat cheese and full-fat spread was lower among experimental group significantly compared to control arm. In addition, the experimental group had a substantial higher albumin and lower urea, ALP-Phosphatase, and glucose levels in comparison with control patients. No substantial change was seen in HbA1C and no change in milk and fish products.Conclusions
The substantial positive changes in physical activity, dietary habits, and some biochemical indicators were seen following intervention completion in the experimental arm. 相似文献14.
Marta Gómara Ana Isabel López-Calleja Berta María Pilar Vela Iglesia Isabel Ferrer Cerón Antonio Rezusta López María José Revillo Pinilla 《Enfermedades infecciosas y microbiología clínica》2018,36(5):296-301
Introduction
Our objective was to characterize the enzymatic β-lactam resistance in clinical Enterobacteriaceae isolates with diminished susceptibility to carbapenems from 2013 to 2014 at Hospital Universitario Miguel Servet.Material/methods
A total of 63 clinical isolates were analyzed for the presence of carbapenemases (KPC, OXA-48 and MBL), ESBLs and AmpC enzymes by combined disk methods and PCR detection of carbapenemase-encoding and beta-lactamase-encoding genes.Results
Fifteen isolates had a phenotypic test compatible with carbapenemase production; two of these were confirmed by PCR as OXA-48 producers. ESBL detection was positive in 27 isolates (43%); plasmid-mediated AmpC was detected in nine isolates (14.2%) and derepressed AmpC β-lactamase was present in 18 isolates (28%).Conclusion
During the study period, the decreased susceptibility to carbapenems in Enterobacteriaceae in our area was not due to true carbapenemases but rather to β-lactamase activity (82.5% were ESBL or AmpC producers), probably in combination with decreased permeability of the outer membrane. 相似文献15.
Renata N. Pires Cassia F.B. Caurio Gabriele Z. Saldanha Andreza F. Martins Alessandro C. Pasqualotto 《The Brazilian journal of infectious diseases》2018,22(4):345-346
Introduction
Clostridium difficile is an important cause of diarrhoea, particularly in patients receiving antibiotic therapy. Recent studies have shown that a substantial proportion of C. difficile infections are acquired in the community, as a zoonotic disease. Brazil is a large exporter of meat and so far no study has evaluated meat contamination with C. difficile spores.Methods
Here we analysed 80 retail meat products purchased from local supermarkets in a Brazilian metropolis (Porto Alegre, Southern Brazil). Samples from these products were grown in anaerobic conditions, and tested with a real time polymerase chain reaction test.Results
Contamination with C. difficile spores was not found in the study. Bacteria isolated from meat included Streptococcus gallolyticus, Lactobacillus plantarum, Enterococcus gallinarum and Pediococcus acidilactici.Discussion
Close vigilance is required in order to guarantee the quality of Brazilian retail meat in the long term. 相似文献16.
Claudio M. Bentes Monique Resende Humberto Miranda Claudia C. Netto Lizanka P.F. Marinheiro 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(1):65-68
Background
During the climacteric period, occur an aging process of the skin, and promote several decreases in the ability of vitamin D synthesis in an organism and lower levels of Vitamin D may contribute to the appearance of conditions such as osteomalacia, osteoporosis, falls and fractures.Aim
The present brief review focuses on the influence of Vitamin D supplementation alone on physical fitness (strength, endurance, and balance) in postmenopausal with diseases or not.Methods
Search in Medline and PubMed relevant articles with Vitamin D supplementation alone on physical fitness (strength, endurance, and balance) in postmenopausal with diseases or not, were included only 5 clinical.Conclusions
In conclusion, the effectiveness depends on the amount was prescribed for supplementation and the patient's characteristics. Doses less than 1000 IU/d did not show significant changes in physical fitness on post-menopausal women with metabolic diseases or not. 相似文献17.
João Carmo Rui Campante Teles Sérgio Madeira António Ferreira João Brito Tiago Nolasco Pedro de Araújo Gonçalves Henrique Mesquita Gabriel Luís Raposo Nelson Vale Regina Ribeiras Miguel Abecasis Manuel de Sousa Almeida José Pedro Neves Miguel Mendes 《Revista portuguesa de cardiologia》2018,37(7):585-590
Introduction
Surgical risk scores are widely used to identify patients at high surgical risk who may benefit from transcatheter aortic valve implantation (TAVI). A multiparametric TAVI mortality risk score based on a French registry (FRANCE-2) has recently been developed. The aim of our study was to compare the 30-day mortality prediction performance of the FRANCE-2, EuroSCORE II and STS scores.Methods
We retrospectively studied 240 patients from a single-center prospective registry who underwent TAVI between January 2008 and December 2015. All scores were assessed for calibration and discrimination using calibration-in-the-large and ROC curve analysis, respectively.Results
The observed mortality was 5.8% (n=14). The median EuroSCORE II, STS and FRANCE-2 scores were 5.0 (IQR 3.2-8.3), 5.1 (IQR 3.6-7.1) and 2.0 (IQR 1.0-3.0), respectively. Discriminative power was greater for EuroSCORE II (C-statistic 0.67) and STS (C-statistic 0.67) than for FRANCE-2 (C-statistic 0.53), but this was not statistically significant (p=0.26). All scores showed adequate calibration.Conclusions
All scores showed modest performance in early mortality prediction after TAVI. Despite being derived from a TAVI population, FRANCE-2 was no better than surgical risk scores in our population. 相似文献18.
S. Zoghi V. Ziaee T. Hirschmugl R. Jimenez-Heredia A. Krolo K. Boztug N. Rezaei 《Allergologia et immunopathologia》2018,46(6):594-598
Introduction and objectives
Pediatric Systemic Lupus Erythematosus (pSLE) is an autoimmune disorder of children. Early disease onset raises the probability of genetic etiology and it is more severe than adult SLE.Patients and methods
Herein an eight-year-old girl with pSLE from consanguineous parents is reported.Results
Although she was diagnosed as pSLE since the age of two years, Whole Exome Sequencing (WES) revealed a rare stop-gained C>T mutation in C1QA gene. The variant was validated and segregated in patient and the family. Furthermore, serum levels of the C1q protein were measured and found to be much lower than normal ranges.Conclusions
This study indicated that C1Q deficiency should be considered as a differential diagnosis of pSLE. Therefore, measurement of C1q should be recommended in all cases with pSLE. 相似文献19.
Reem M. Al Haj Ahmad Hayder A. Al-Domi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1091-1094
Introduction
Dementia and type 2 diabetes mellitus (T2DM) are two of the epidemics of our time; in which insulin resistance (IR) is playing the central role. Epidemiological studies found that different types of dementia development may be promoted by the presence of T2DM.Objectives
We aimed in this review to highlight the role of insulin and the IR in the brain as a pathophysiological factor of dementia development and also to expand our understanding of T2DM as a mediator of IR in the brain and to review the possible mechanisms of action that may explain the association.Methodology
A critical review of the relevant published English articles up to 2018, using PubMed, Google Scholar, Science Direct, ADI, and WHO database was carried out. Keywords were included insulin resistance, T3DM, T2DM, dementia, brain insulin resistance were used.Conclusion
The rapidly increased prevalence of dementia concurrently with T2DM and obesity need urgent action to illustrate guidelines for prevention, modifying, and treatment based on mechanistic studies. 相似文献20.
V. Tsimihodimos T.D. Filippatos M.S. Elisaf 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1117-1123