共查询到20条相似文献,搜索用时 31 毫秒
1.
Articular cartilage is a complex tissue with unique properties that are essential for normal joint function. Many processes can result in cartilage injury, ranging from acute trauma to degenerative processes. Articular cartilage lacks vascularity, and therefore most chondral defects do not heal spontaneously and may require surgical repair. A variety of cartilage repair techniques have been developed and include bone marrow stimulation (microfracture), osteochondral autograft transfer system (OATS) or osteochondral allograft transplantation, autologous chondrocyte implantation (ACI), matrix-assisted chondrocyte implantation (MACI), and other newer processed allograft cartilage techniques. Although arthroscopy has long been considered as the gold standard for evaluation of cartilage after cartilage repair, magnetic resonance (MR) imaging is a non-invasive method to assess the repair site and can be scored using Magnetic resonance Observation of Cartilage Repair Tissue (MOCART). MR also provides additional evaluation of the subchondral bone and for other potential causes of knee pain or internal derangement. Conventional MR can be used to evaluate the status of cartilage repair and potential complications. Compositional MR sequences can provide supplementary information about the biochemical contents of the reparative tissue. This article reviews the various types of cartilage repair surgeries and their postoperative MR imaging appearances. 相似文献
2.
Articular cartilage is a complex tissue with unique properties that are essential for normal joint function. Many processes can result in cartilage injury, ranging from acute trauma to degenerative processes. Articular cartilage lacks vascularity, and therefore most chondral defects do not heal spontaneously and may require surgical repair. A variety of cartilage repair techniques have been developed and include bone marrow stimulation (microfracture), osteochondral autograft transfer system (OATS) or osteochondral allograft transplantation, autologous chondrocyte implantation (ACI), matrix-assisted chondrocyte implantation (MACI), and other newer processed allograft cartilage techniques. Although arthroscopy has long been considered as the gold standard for evaluation of cartilage after cartilage repair, magnetic resonance (MR) imaging is a non-invasive method to assess the repair site and can be scored using Magnetic resonance Observation of Cartilage Repair Tissue (MOCART). MR also provides additional evaluation of the subchondral bone and for other potential causes of knee pain or internal derangement. Conventional MR can be used to evaluate the status of cartilage repair and potential complications. Compositional MR sequences can provide supplementary information about the biochemical contents of the reparative tissue. This article reviews the various types of cartilage repair surgeries and their postoperative MR imaging appearances. 相似文献
3.
Van Breuseghem I 《European radiology》2004,14(2):184-192
The high incidence of cartilage lesions together with new surgical treatment techniques have necessitated the development of noninvasive cartilage evaluation techniques. Although arthroscopy has been the standard for cartilage evaluation, MR imaging has emerged as the imaging method of choice, allowing morphological evaluation of cartilage and cartilage repair tissue, as well as evaluation of its biochemical content. This article deals with current ultrastructural MR imaging techniques for cartilage evaluation, indicating the advantages as well as the drawbacks for routine clinical application. 相似文献
4.
5.
Welsch GH Mamisch TC Hughes T Domayer S Marlovits S Trattnig S 《Seminars in musculoskeletal radiology》2008,12(3):196-211
Morphological and biochemical magnetic resonance imaging (MRI) is due to high field MR systems, advanced coil technology, and sophisticated sequence protocols capable of visualizing articular cartilage in vivo with high resolution in clinical applicable scan time. Several conventional two-dimensional (2D) and three-dimensional (3D) approaches show changes in cartilage structure. Furthermore newer isotropic 3D sequences show great promise in improving cartilage imaging and additionally in diagnosing surrounding pathologies within the knee joint. Functional MR approaches are additionally able to provide a specific measure of the composition of cartilage. Cartilage physiology and ultra-structure can be determined, changes in cartilage macromolecules can be detected, and cartilage repair tissue can thus be assessed and potentially differentiated. In cartilage defects and following nonsurgical and surgical cartilage repair, morphological MRI provides the basis for diagnosis and follow-up evaluation, whereas biochemical MRI provides a deeper insight into the composition of cartilage and cartilage repair tissue. A combination of both, together with clinical evaluation, may represent a desirable multimodal approach in the future, also available in routine clinical use. 相似文献
6.
Magnetic resonance (MR) is a versatile imaging modality that can be tailored to address many of the clinical andresearch questions encountered in musculoskeletal diseases. Developments in MR techniques for cartilage imaging have paralleled the advances in clinical approaches to cartilage injury assessment and repair. This article reviews the current state-of-the-art clinical MR imaging methods designed for noninvasive evaluation of cartilage. Basic technical considerations are discussed, including selection of an imaging site for patient referral, interpretation of MR images, and the limitations of each acquisition technique. Clinical examples are used to illustrate the appearance of chondral lesions. Finally, the unique issues arising from cartilage assessment after surgical repair are examined. 相似文献
7.
Magnetic resonance imaging of cartilage and cartilage repair 总被引:3,自引:0,他引:3
Verstraete KL Almqvist F Verdonk P Vanderschueren G Huysse W Verdonk R Verbrugge G 《Clinical radiology》2004,59(8):674-689
Magnetic resonance (MR) imaging of articular cartilage has assumed increased importance because of the prevalence of cartilage injury and degeneration, as well as the development of new surgical and pharmacological techniques to treat damaged cartilage. This article will review relevant aspects of the structure and biochemistry of cartilage that are important for understanding MR imaging of cartilage, describe optimal MR pulse sequences for its evaluation, and review the role of experimental quantitative MR techniques. These MR aspects are applied to clinical scenarios, including traumatic chondral injury, osteoarthritis, inflammatory arthritis, and cartilage repair procedures. 相似文献
8.
Cartilage repair techniques and pharmacological therapies are currently areas of major clinical interest and research, in
particular to prevent and treat osteoarthritis. MR imaging-based techniques to visualize cartilage are prerequisites to guide
and monitor these therapies. In this review article, standard MR imaging sequences are described, including proton density-weighted
fast spin echo, spoiled gradient echo and dual echo steady state sequences. In addition, new sequences that have been developed
and are currently being investigated are presented, including driven equilibrium Fourier transform and steady-state free precession-based
imaging. Using high-field MR imaging at 3.0-T, visualization of cartilage and the related pathology has been improved. Volumetric
quantitative cartilage MR imaging was developed as a tool to monitor the progression of osteoarthritis and to evaluate new
pharmacological cartilage protective therapies. The most exciting developments, however, are in the field of cartilage matrix
assessment with quantitative dGEMRIC, T2 and T1rho mapping techniques. These techniques aim at detecting cartilage damage
at a stage when changes are potentially still reversible, before cartilage tissue is lost. There is currently substantial
interest in these techniques from rheumatologists and orthopedists; radiologists therefore need to keep up with these developments. 相似文献
9.
MR软骨生理成像技术是一组用于评价关节软骨早期损伤的新技术,其通过反映软骨基质生化成分含量的变化及软骨生理结构异常来评价软骨损伤。与传统影像检查技术相比,MR软骨生理成像技术可对软骨形态轮廓尚未改变之前的损伤进行早期诊断,对疾病的早期干预、治疗和评估具有重要意义。MR生理成像技术多从膝关节开始研究和应用,就各种膝MR软骨生理成像技术的原理、基础研究及临床应用进展予以综述。 相似文献
10.
MR imaging of cartilage repair procedures 总被引:7,自引:0,他引:7
It is becoming increasingly important for the radiologist to evaluate the appearance and outcome of cartilage repair procedures. MR imaging is currently the best method for such evaluation but it is necessary to use cartilage-specific sequences and to modify those sequences when necessary to minimize artifacts from retained metal within the joint. This article reviews the surgical technique of the more commonly performed cartilage repair procedures, currently recommended techniques for the MR imaging evaluation of articular cartilage and cartilage repair procedures, and the MR imaging appearance of cartilage repair procedures and of the most frequently encountered complications following such procedures. 相似文献
11.
The sensitivity of magnetic resonance imaging to biochemical and biophysical changes in the extracellular matrix of articular cartilage give it the potential to noninvasively detect the earliest changes of cartilage damage. The transverse relaxation time (T2) of cartilage has been shown to be a sensitive parameter for evaluation of early degeneration in articular cartilage, particularly changes in water and collagen content and tissue anisotropy. Although initial application has been in microimaging of small cartilage explants, in vivo techniques have been developed for cartilage T2 mapping of human joints. In addition to potential application in development of new pharmaceuticals and surgical techniques for preserving cartilage, in vivo cartilage T2 mapping can improve understanding of arthritis, cartilage aging, and response of cartilage to exercise. 相似文献
12.
Surgical articular cartilage repair therapies for cartilage defects such as osteochondral autograft transfer, autologous chondrocyte
implantation (ACI) or matrix associated autologous chondrocyte transplantation (MACT) are becoming more common. MRI has become
the method of choice for non-invasive follow-up of patients after cartilage repair surgery. It should be performed with cartilage
sensitive sequences, including fat-suppressed proton density-weighted T2 fast spin-echo (PD/T2-FSE) and three-dimensional
gradient-echo (3D GRE) sequences, which provide good signal-to-noise and contrast-to-noise ratios. A thorough magnetic resonance
(MR)-based assessment of cartilage repair tissue includes evaluations of defect filling, the surface and structure of repair
tissue, the signal intensity of repair tissue and the subchondral bone status. Furthermore, in osteochondral autografts surface
congruity, osseous incorporation and the donor site should be assessed. High spatial resolution is mandatory and can be achieved
either by using a surface coil with a 1.5-T scanner or with a knee coil at 3 T; it is particularly important for assessing
graft morphology and integration. Moreover, MR imaging facilitates assessment of complications including periosteal hypertrophy,
delamination, adhesions, surface incongruence and reactive changes such as effusions and synovitis. Ongoing developments include
isotropic 3D sequences, for improved morphological analysis, and in vivo biochemical imaging such as dGEMRIC, T2 mapping and
diffusion-weighted imaging, which make functional analysis of cartilage possible. 相似文献
13.
Gnannt R Chhabra A Theodoropoulos JS Hodler J Andreisek G 《Journal of magnetic resonance imaging : JMRI》2011,34(5):1007-1021
Advances in orthopedic and arthroscopic surgical procedures of the knee such as, knee replacement, ligamentous reconstruction as well as articular cartilage and meniscus repair techniques have resulted in a significant increase in the number of patients undergoing knee arthroscopy or open surgery. As a consequence postoperative MR imaging examinations increase. Comprehensive knowledge of the normal postoperative MR imaging appearances and abnormal findings in the knee associated with failure or complications of common orthopedic and arthroscopic surgical procedures currently undertaken is crucial. This article reviews the various normal and pathological postoperative MR imaging findings following anterior and posterior cruciate ligament, medial collateral ligament and posterolateral corner reconstruction, meniscus and articular cartilage surgery as well as total knee arthroplasty with emphasis on those surgical procedures which general radiologists will likely be faced in their daily clinical routine. 相似文献
14.
Gold GE Hargreaves BA Reeder SB Vasanawala SS Beaulieu CF 《Seminars in musculoskeletal radiology》2005,9(2):161-172
Magnetic resonance (MR) imaging, with its unique ability to noninvasively image and characterize soft tissue, has shown promise in assessment of cartilage. The development of new, fast imaging methods with high contrast will improve the MR evaluation of cartilage morphology. In addition to morphological MR imaging methods, MR imaging contrast mechanisms under development may reveal detailed information regarding the physiology of cartilage. However, many of these methods remain to be tested in the clinical setting. Protocol selection for cartilage imaging requires understanding of the patient population and the advantages and limitations of these techniques. 相似文献
15.
CT arthrography (CTa) and MR arthrography (MRa) are useful tools for the investigation of intra-articular hip disease. They are minimally invasive techniques with a very low rate of complications and can be performed safely. CTa or MRa can be performed after an intra-articular injection of diluted contrast, but both techniques can also be performed after a single injection. As radiologists we should be able to address the surgeon's questions and work together to standardize terminology and classifications systems for accurate reporting. This update emphasizes radiological findings with a clinical perspective. CTa and MRa allow the precise diagnosis of labral tears, loose bodies, and intra-articular ligaments (capsular and ligamentum teres). The use of careful technique and a tailored protocol has improved our ability to detect and describe cartilage lesions. This is essential because knowledge of the status of the cartilage may dictate a specific surgical approach, and when cartilage lesions are extensive, they are a negative prognostic indicator for arthroscopic treatment. 相似文献
16.
Articular cartilage abnormalities of the knee are a cause of significant patient morbidity. Several surgical techniques have been developed to treat these lesions to improve patient symptoms and to delay or prevent the development of osteoarthritis. MRI has been shown to be an accurate non-invasive test for the evaluation of articular cartilage injuries and for evaluating the postoperative knee following chondral repair. As these surgical repair techniques become more commonly performed, is important for radiologists to be familiar with the surgical techniques and the MRI appearance of the postoperative knee including both normal and abnormal findings. In this article, these chondral repair techniques will be reviewed as well those normal and abnormal MRI findings following these surgeries. 相似文献
17.
Articular cartilage is critical to the normal function of diarthrodial joints. Despite the importance of the tissue and the prevalence of cartilage degeneration (e.g., osteoarthritis), the technology required to noninvasively describe nonuniform deformations throughout the volume of the tissue has not been available until recently. The objectives of the work reported in this paper were to 1) describe a noninvasive technique (termed the cartilage deformation by tag registration (CDTR) technique) to determine nonuniform deformations in articular cartilage explants with the use of specialized MRI tagging and image processing methods, 2) evaluate the strain error of the CDTR technique using a custom MRI-compatible phantom material, and 3) demonstrate the applicability of the CDTR technique to articular cartilage by determining 3D strain fields throughout the volume of a bovine articular cartilage explant. A custom MRI pulse sequence was designed to tag and image articular cartilage explants at 7 Tesla in undeformed and deformed states during the application of multiple load cycles. The custom pulse sequence incorporated the "delays alternating with nutations for tailored excitation" (DANTE) pulse sequence to apply tags. This was followed by a "fast spin echo" (FSE) pulse sequence to create images of the tags. The error analysis using the phantom material indicated that deformations can be determined with an error, defined as the strain precision, better than 0.83% strain. When this technique was applied to a single articular cartilage explant loaded in unconfined compression, hetereogeneous deformations throughout the volume of the tissue were evident. This technique potentially can be applied to determine normal cartilage deformations, analyze degenerated cartilage, and evaluate cartilage surgical repair and treatment methodologies. In addition, this technique may be applied to other soft tissues that can be appropriately imaged by MR. 相似文献
18.
19.
Strauss EJ Goodrich LR Chen CT Hidaka C Nixon AJ 《The American journal of sports medicine》2005,33(11):1647-1653
BACKGROUND: Chondral defects may lead to degradative changes in the surrounding cartilage, predisposing patients to developing osteoarthritis. PURPOSE: To quantify changes in the biomechanical and biochemical properties of the articular cartilage adjacent to chondral defects after experimental defect repair. STUDY DESIGN: Controlled laboratory study. METHODS: Specimens were harvested from tissue within (lesion), immediately adjacent to, and at a distance from (remote area) a full-thickness cartilage defect 8 months after cartilage repair with genetically modified chondrocytes expressing insulin-like growth factor-I or unmodified, control chondrocytes. Biomechanical properties, including instantaneous Young's and equilibrium aggregate moduli, were determined by confined compression testing. Biochemical properties, such as water and proteoglycan content, were also measured. RESULTS: The instantaneous Young's modulus, equilibrium modulus, and proteoglycan content increased, whereas water content decreased with increasing distance from the repaired lesion. The instantaneous Young's and equilibrium moduli of the adjacent articular cartilage were 80% and 50% that of remote area samples, respectively, whereas water content increased 0.9% and proteoglycan content was decreased by 35%. No significant changes in biomechanical and biochemical properties were found either in the lesion tissue or in adjacent cartilage with genetic modification of the chondrocytes. CONCLUSION: Articular cartilage adjacent to repaired chondral defects showed significant remodeling 8 months after chondral defect repair, regardless of whether genetically modified or unmodified cells were implanted. CLINICAL RELEVANCE: Changes in the biochemical and biomechanical properties of articular cartilage adjacent to repaired chondral defects may represent remodeling as part of an adaptive process or degeneration secondary to an altered distribution of joint forces. Quantification of these changes could provide important parameters for assessing progress after operative chondral defect repair. 相似文献
20.
MR imaging of articular cartilage using driven equilibrium. 总被引:3,自引:0,他引:3
B A Hargreaves G E Gold P K Lang S M Conolly J M Pauly G Bergman J Vandevenne D G Nishimura 《Magnetic resonance in medicine》1999,42(4):695-703
The high incidence of osteoarthritis and the recent advent of several new surgical and non-surgical treatment approaches have motivated the development of quantitative techniques to assess cartilage loss. Although magnetic resonance (MR) imaging is the most accurate non-invasive diagnostic modality for evaluating articular cartilage, improvements in spatial resolution, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) would be valuable. Cartilage presents an imaging challenge due to its short T(2) relaxation time and its low water content compared with surrounding materials. Current methods sacrifice cartilage signal brightness for contrast between cartilage and surrounding tissue such as bone, bone marrow, and joint fluid. A new technique for imaging articular cartilage uses driven equilibrium Fourier transform (DEFT), a method of enhancing signal strength without waiting for full T(1) recovery. Compared with other methods, DEFT imaging provides a good combination of bright cartilage and high contrast between cartilage and surrounding tissue. Both theoretical predictions and images show that DEFT is a valuable method for imaging articular cartilage when compared with spoiled gradient-recalled acquisition in the steady state (SPGR) or fast spin echo (FSE). The cartilage SNR for DEFT is as high as that of either FSE or SPGR, while the cartilage-synovial fluid CNR of DEFT is as much as four times greater than that of FSE or SPGR. Implemented as a three-dimensional sequence, DEFT can achieve coverage comparable to that of other sequences in a similar scan time. Magn Reson Med 42:695-703, 1999. 相似文献