银屑病合并症的研究进展

既往认为银屑病是一类慢性炎症性疾病,发病仅表现于皮肤.目前许多的研究证明,在银屑病患者群体中,某些其他疾病的发生率或风险率均较普通人群高,其中包括代谢综合征、肥胖、心血管疾病、关节炎、自身免疫性疾病、恶性肿瘤、精神疾病、肝脏疾病、慢性阻塞性肺部疾病、睡眠呼吸暂停综合征等.通过对这些合并症发病机制的研究,免疫介导的机制似乎是其诸多合并症的共同原因,但要确切了解其发病机制及有效治疗方法,须依靠多学科的有效联合和交叉研究.概述近年来银屑病合并症的流行病学研究及发病机制和治疗方法.     

银屑病合并症的研究进展

既往认为银屑病是一类慢性炎症性疾病,发病仅表现于皮肤.目前许多的研究证明,在银屑病患者群体中,某些其他疾病的发生率或风险率均较普通人群高,其中包括代谢综合征、肥胖、心血管疾病、关节炎、自身免疫性疾病、恶性肿瘤、精神疾病、肝脏疾病、慢性阻塞性肺部疾病、睡眠呼吸暂停综合征等.通过对这些合并症发病机制的研究,免疫介导的机制似...     

白细胞介素17A介导银屑病及心血管合并症的研究进展

白细胞介素（IL）-23/IL-17轴是寻常型斑块状银屑病发病的主要通路,IL-17A是相关免疫通路中的关键节点,介导了动脉粥样硬化和银屑病的重叠炎症通路,促进炎症、凝血和血栓形成,在银屑病心血管合并症的发生发展中起重要作用。抑制IL-17A的炎症作用能减少重度银屑病患者心血管合并症的发生率及病死率。本文综述近年来IL...     

生物制剂治疗银屑病共病研究进展

银屑病是一种常见的免疫介导的慢性炎症性疾病,与之相关的共病包括银屑病关节炎、心血管疾病、代谢综合征、炎症性肠病和心理疾病等。由于银屑病及其共病之间可能存在共同的致病途径,抑制相应免疫反应靶点的生物制剂可以通过改变全身炎症状态而对其共病产生影响。本文就生物制剂对银屑病共病治疗的应用进展进行综述。     

银屑病流行病学研究进展

本文综述了近年来银屑病流行病学的研究进展,结果表明:银屑病在不同人群患病率有很大差异(0%～11.8%);男性和女性银屑病患病率基本相同;银屑病可发生于任何年龄,发病高峰在15～30岁之间;遗传因素在银屑病发病中起重要作用。     

银屑病共病的研究进展

【摘要】 银屑病是一种免疫介导的慢性炎症性皮肤病,其发病与基因、免疫、环境等因素密切相关。传统的与银屑病相关的共病主要包括心血管疾病、肥胖和炎症性肠病等,越来越多的研究发现其他一些疾病与银屑病之间的密切关联,包括代谢综合征、慢性肾脏疾病、肿瘤、感染等。本文总结现有研究报道的银屑病相关共病,分析这些疾病与银屑病可能的共同发病机制。     

银屑病的流行病学研究进展

银屑病的患病率欧洲较高约为0.75％ ～ 2.9％,亚洲较低为＜1％；中国银屑病患病率＜0.5％,大陆部分地区的最新数据为0.47％；银屑病的发病率、患病率均有逐年升高的趋势.银屑病最常见的并发症包括高血压、糖尿病、脂代谢异常、代谢综合征、心脏病,年轻患者及病情严重者更易产生并发症、死亡率较高,但并发代谢综合征的风险则与病情严重性无关.与普通高血压患者相比,银屑病高血压者更容易患难治性高血压,男性患者并发代谢综合征的风险明显高于女性患者,女性患者并发糖尿病的风险则明显高于男性患者.     

老年银屑病患者的临床特征分析

目的 探讨老年银屑病患者的临床特征及其共病情况.方法 回顾性分析186例年龄≥60岁的老年银屑病患者和166例年龄＜60岁的非老年银屑病患者在临床特征上的差异.结果 与非老年银屑病患者相比,老年银屑病患者发病较晚,关节病性银屑病的比例、银屑病累及头皮和关节及甲的比例明显增高.老年银屑病患者常并发高血压、糖尿病、高尿酸血...     

银屑病合并代谢综合征的研究进展

银屑病合并代谢综合征日益增多.相同的炎症过程,遗传和环境因素可能是导致两种疾病并存的原因,银屑病增加代谢综合征的发病风险,治疗同时可降低代谢综合征的发病危险,针对代谢综合征的综合治疗有助于银屑病皮损的改善.为有效治疗和管理银屑病,需认清其与代谢综合征之间的关联,探讨更新的治疗标准,并采取多学科合作的综合治疗方式.     

银屑病的流行病学

银屑病有遗传背景，但其遗传方式尚不清楚，有证据表明该病力多基因遗传。除遗传因素外，环境暴露因素可促进疾病的发生，其中包括感染，吸烟、应激、药笺和外伤等。银屑病并发关节较多，如无有关药物治疗。避免了医源性损害，疾病本身并无增加 发生肿瘤的危险，而且和心血管疾病也无实质上的联系。     

Psoriasis in Taiwan: From epidemiology to new treatments

Psoriasis is a common, chronic immune-mediated disorder that occurs worldwide. The prevalence of psoriasis in Taiwan is lower than that in Caucasian countries. Nevertheless, an increasing trend in the prevalence of psoriasis and psoriatic arthritis has been observed in Taiwan over the past decade. Accumulating studies have also suggested that psoriasis is not a disease limited to the skin and joints but has far-reaching systemic effects, associated with a higher prevalence of comorbid diseases, such as cardiovascular diseases, diabetes mellitus, metabolic syndrome, depression, and chronic kidney disease, than in the normal population. To date, our understanding of the mechanisms linking psoriasis and comorbidities remains far from complete. Psoriasis and its comorbid diseases confer substantial disease and health care burdens and have a significant negative impact on the quality of life of affected patients. The discovery of new, promising drugs has revolutionized psoriasis treatment, but patients still have unmet needs that require further investigation. Studies specifically on the Taiwanese population with psoriasis remain scarce. Herein, we review the medical literature, with a focus on studies examining the Taiwanese population, with regard to epidemiology, comorbidities, and effects of antipsoriatic agents on comorbidities, as well as the efficacy and safety of novel antipsoriatic treatments for patients with psoriasis.     

Prevalence of comorbidities in atopic dermatitis and psoriasis in the French population

BackgroundAtopic dermatitis (AD) and psoriasis (Pso) are highly prevalent chronic inflammatory skin diseases. They share similarities regarding severity and impact on quality of life but display differences regarding risk factors, comorbidities, and pathogenesis.ObjectiveThis study sought to assess the prevalence of AD and Pso among the French population, along with associated comorbidities, and to compare these data with those of the age- and gender-adjusted French population with neither AD nor Pso.MethodsThe survey was conducted by a polling institute between September 1 and November 30, 2016, with proportional quota sampling being applied to render the study population representative of the French population. In all, 20 012 individuals were selected from among 900,000 internet users aged ≥ 15 years.ResultsOverall, 20,012 adults (48.8% men; 51.2% women) completed a digital questionnaire. The prevalence of AD was 4.65% [95% confidence interval (CI) 4.36%–4.94%] and that of Pso was 4.42% [95% CI: 4.14%–4.71%]. More AD patients presented ≥ 1 comorbidity compared to subjects without AD (57.04% vs. 49.2%, P < 0.0001) and more Pso patients presented ≥ 1 comorbidity compared to subjects without Pso (60.68% vs. 49.05%, P < 0.0001). After adjustment for gender and age, hypertension and dyslipidemia, a greater prevalence of osteoarticular, respiratory and psychiatric diseases was noted in both AD and Pso patients, whereas increased prevalence of obesity was seen only in Pso patients. The prevalence of components of metabolic syndrome was higher among Pso than AD patients.ConclusionFurther studies are required to consolidate these findings, to better characterize the entire spectrum of AD and Pso comorbidities, and to better identify determinants and risk factors, along with targeted therapies.     

银屑病与系统性疾病

银屑病是一种常见的慢性、免疫介导的炎症性疾病,重度银屑病患者常伴发一系列的内科疾患,如:代谢综合征、动脉粥样硬化、心肌梗死、恶性肿瘤等.因此,认为银屑病是一种系统性疾病而非单纯的皮肤病.Th1型细胞因子是银屑病与其伴发症的共同免疫基础.为了更有效的治疗银屑病及其伴发症,应提倡综合治疗,需考虑到银屑病与其伴发症在治疗方面的相互影响,另外以潜在炎症基础为治疗靶点的药物可同时治疗银屑病及其伴发症.     

Psoriasis: classical and emerging comorbidities

Psoriasis is a chronic inflammatory systemic disease. Evidence shows an association of psoriasis with arthritis, depression, inflammatory bowel disease and cardiovascular diseases. Recently, several other comorbid conditions have been proposed as related to the chronic inflammatory status of psoriasis. The understanding of these conditions and their treatments will certainly lead to better management of the disease. The present article aims to synthesize the knowledge in the literature about the classical and emerging comorbidities related to psoriasis.     

初诊银屑病患者364例临床资料分析

目的了解湖北地区银屑病患者流行病学基本特征。方法采用问卷调查及详细体格检查,对初诊银屑病患者进行现况调查。结果①多数银屑病患者发病年龄<40岁(61%),且男性平均发病年龄(26.35±13.24岁)高于女性(21.56±12.34岁),二者差异有显著性(P<0.01);②银屑病首发、加重及复发以秋冬季为主,病情的减轻、缓解则以夏季明显;③在银屑病的诱发因素中,位于前四位的分别是感染、精神因素、饮食和染发剂,其中染发剂为本次调查首次提出的诱发因素;④皮损的初发及分布部位以头皮和四肢伸侧为主。结论目前银屑病患者流行病学特征与此前调查结果基本一致,但呈现出新的发展趋势。     

银屑病伴发疾病的研究进展

银屑病是一种慢性炎症性皮肤病,除皮肤表现外,银屑病患者还可能存在其他多系统疾病,其中包括心血管疾病、肥胖症、糖尿病、高血压、血脂异常、代谢综合征、肝脏疾病、炎症性肠病、哮喘、精神疾病、多囊卵巢综合征及牙周病等.这些疾病在银屑病患者中的患病率明显高于健康人群.因其涉及多系统疾病,临床中对银屑病患者尚需更全面的筛查及评估,多学科交叉探讨,以制定有效的治疗方案.     

银屑病的瘙痒特征及相关因素分析

目的调查银屑病患者中瘙痒发生率、瘙痒程度等临床特征及其影响瘙痒的相关因素。方法采用问卷调查的形式调查了112例银屑病患者,评价其瘙痒特征及影响瘙痒的相关因素。结果 112例银屑病患者中83%存在不同程度瘙痒,相关分析显示:患者瘙痒与否与年龄、疾病活动度呈显著相关(P0.05),而与患者性别、病程、家族史、吸烟、饮酒及身体质量指数(BMI)无相关性,瘙痒程度与银屑病皮损面积及严重程度指数(PASI)评分、浸润程度呈显著相关(P0.05),而与红斑、鳞屑无相关性。结论大多数银屑病患者存在不同程度的瘙痒症状,年纪越大、皮损越广泛、浸润程度越高以及处在进展期的银屑病患者瘙痒越剧烈。