卵巢囊性成熟性畸胎瘤伴腹膜神经胶质瘤病一例

患者女,35岁.因腹部逐渐膨隆半年于2008年5月18日入院.既往体健,无不良嗜好,妊3产1,月经不规律.体检:腹部膨隆,右下腹可扪及一巨大包块.B超检查:肿瘤位于盆腔,体积约26 cm×24 cm×16 cm,囊性,囊内呈混合性非均质性回声.后行手术探查术,术中见肿物来自右侧卵巢,呈囊性,表面光滑,部分区域粗糙,与周围组织无明显粘连,术中考虑为卵巢囊性畸胎瘤.腹腔脏器及大网膜表面见大量粟粒状灰白色质硬结节.行右侧卵巢及输卵管切除、部分大网膜切除.     

卵巢成熟型畸胎瘤伴腹膜神经胶质瘤病

卵巢成熟型畸胎瘤是临床常见的一种肿瘤,但伴发腹膜神经胶质瘤病比较少见,如对这一病变缺乏认识,在临床实际工作中可能会作出错误诊断。现将我们在外检中遇到的1例报道如下。     

卵巢成熟性囊性畸胎瘤伴局部甲状腺肿癌变1例

患者女性 ,72岁 ,绝经后阴道不规则流血 1月余 ,伴腹胀、嗳气。门诊以“子宫体癌”收入院。入院后行子宫诊刮术 ,病理诊断为子宫内膜腺癌。体检 :神志清 ,腹部叩诊无移动性浊音 ,无压痛及反跳痛。妇查 :宫体正常大小 ,较硬 ,活动度差 ,附件未触及肿块 ,宫旁两侧软 ,弹性较好。Ｂ超示 :(1)宫体内实性占位 (内膜病变 ?)。 (2 )右附件混合性占位(囊性为主 )。术中见 :子宫正常大小 ,表面光滑 ,右侧卵巢与肝表面相连并与右侧腹膜轻度粘连 ,左附件无异常 ,大网膜未触及肿大淋巴结。术中冲洗盆腔 ,冲洗液送检 ,细胞学检查发现腺癌细胞。病理检查　…     

眼睑成熟性囊性畸胎瘤一例

一、临床资料:患者女,15岁,汉族。左上眼睑发现包块三年,逐渐增大来院就诊。行手术切除,术中见包块源于左上眼睑外侧,与骨膜紧密相连。病理检查:暗红淡黄色囊肿一个呈类圆形,大小约1.5cm×1cm×1cm,囊壁薄,内壁光滑,囊内为皮脂和毛发。镜检:囊壁为薄层纤维组织,间质有中等量淋巴细胞浸润,囊内可见大量毛发及毛囊结构,有吞噬脂质及异物的单核或多核组织细胞,所有组织均分化成熟。 病理诊断:(左上眼睑)成熟性囊性畸胎瘤并感染。     

卵巢成熟性囊性畸胎瘤恶变为黑色素瘤1例

正患者76岁,因间断性下腹部疼痛2年,加重2个月于2018年5月18日入住我院。入院后CT检查示:盆腔巨大囊实性占位,其内见脂肪、钙化成分考虑卵巢畸胎瘤可能。右侧耻骨下支骨质破坏,考虑恶性畸胎瘤并右侧耻骨下支转移。随后完善相关检查于5月29日行手术治疗。术中见子宫形态大小正常,右侧卵巢增大,大小15 cm×14 cm×14cm,形态不规则,与周围组织粘连紧密,右侧输卵管及左侧     

腹膜后成熟性囊性畸胎瘤合并类癌1例

患者女性,57岁,因左上腹部饱胀不适半年入院.20年前曾因胰腺尾部囊肿,行胰尾部假性囊肿空肠内引流术.本次入院腹部MRI示胰腺尾部囊性瘤;腹部增强CT示左侧中上腹腔实性巨大占位性病变.术中见肿块位于腹膜后,胰尾、脾脏、肾脏之间,大小为26 cm×16 cm×8 cm,囊实性,并与空肠吻合.胃肠道、肺及卵巢等器官均未见异常.     

卵巢未成熟畸胎瘤伴腹膜胶质瘤病4例并临床病理分析

目的探讨卵巢未成熟畸胎瘤(ovarian immature teratoma,OIT)伴腹膜胶质瘤病(gliomatosis peritonei,GP)的临床病理特征及预后。方法回顾性分析4例OIT伴GP的临床资料、病理学及免疫表型,并复习相关文献。结果患者年龄17~27岁,OIT肿瘤最大径4~36 cm,镜下由3个胚层来源的各种成熟和未成熟组织组成,并见未成熟原始神经外胚层组织,组织学分级Ⅰ级3例、Ⅲ级1例。4例GP镜下见多个成熟性神经胶质结节播散性种植于大网膜。免疫组化标记GFAP、SOX2均阳性。术后3例采取辅助化疗,分别随访3~114个月,均健康生存,1例失访。结论 OIT伴GP临床罕见,其预后与OIT的组织学分级相关,GP存在复发或恶变风险,需长期密切随访。     

卵巢囊性成熟性畸胎瘤恶变成印戒细胞癌一例

患者女,44岁。因自觉下腹胀2个月,下腹部包块10余天就诊。B超示:右卵巢囊实性肿物15.5cm×14.4cm×10.2cm,内有多房隔,房隔密集区范围6.0cm,实性结节状突起5.0cm×4.6cm×4.0cm,内实性中强等回声区8.7cm×7.7cm×6.9cm,提示:右卵巢未成熟畸胎瘤于2004年8月25日收入院。妇科检查:外阴有血性分泌物,宫颈肥大,Ⅲ°糜烂,活动欠佳,子宫上方偏右可触及一肿物,边界清楚,活动欠佳。手术中将右卵巢肿物送冷冻检查:报告为卵巢成熟性畸胎瘤恶性变,恶变成分为印戒细胞癌。遂行全子宫+双附件+大网膜切除+阑尾切除+盆腹腔淋巴结清扫术,腹腔化疗(顺铂)。病…     

Ovarian mature cystic teratoma containing homunculus: a case report

We report a partial fetus-like structure (homunculus) in benign ovarian mature cystic teratoma removed from a 23-yr-old female. The cyst displayed various tissues derived from the three germ layers. The homunculus had a distinguished fetal cranial structure with one upper extremity. A partially developed osteocartilagenous skeleton was identified in the cranial structure of the homunculus. Intracranial structures such as cerebral cortex, retinal pigment, and leptomeninges were extruded from the partially disrupted calvarium.     

Pseudomyxoma peritonei: unusual origin from an ovarian mature cystic teratoma

Pseudomyxoma peritonei (PMP) is classified into pathologically and prognostically distinct categories, such as disseminated peritoneal adenomucinosis (DPAM) and peritoneal mucinous carcinomatosis. There is overwhelming evidence that DPAM arises from a mucinous adenoma of the appendix. The one exception to this is the presentation of a mature ovarian cystic teratoma as PMP where the appendix is normal. This report describes such a case and discusses the presentation, histopathology, and treatment options.     

Chordoma arising in a mature cystic teratoma of the ovary: a case report

Mature cystic teratoma of the ovary (MCTO) is the most common type of ovarian teratoma and also the most frequent tumor originating from germ cells. It is usually diagnosed in early adulthood and, by definition, is composed of well-differentiated tissues, which originate from all three germ cell layers. Unusual types of tissues can be found in MCTO, such as kidney, adrenal, and prostatic tissues. Malignant transformation is reported in less than 2% of teratomas. Squamous cell carcinoma is the most common malignancy arising in these otherwise benign tumors. We present the first case of MCTO containing a chordoma. The chordoma differentiation was supported by immunohistochemical staining and interphase fluorescence in situ hybridization (IP-FISH) technique showing 19% of the nuclei of the MCTO displaying polysomy for the chromosome X, while 28% of the chordoma nuclei showed chromosome 7 mosaicism. These results are concordant with previous studies, showing chromosomal anomalies in chromosomes X and 7 in MCTO and chordomas, respectively.     

Intestinal adenocarcinoma arising in a mature cystic teratoma of the ovary: a case report

Gastrointestinal adenocarcinoma arising in mature cystic teratomas of the ovary is extremely rare. We report a case of well-differentiated intestinal adenocarcinoma arising in a mature cystic teratoma of the ovary in a 77-year-old woman, presenting as acute abdomen with ovarian torsion. An immunohistochemical study revealed expression of CK20 and CK7, and the tumor was also positive for MUC2. The patient had no evidence of disease after 12 months of follow-up.     

Intrarenal mature cystic teratoma associated with renal dysplasia: case report and literature review

We report a case of intrarenal teratoma in a 6-year-old boy. Two years before his operation, multicystic masses had been found in the left side of his abdomen. In the operation, three main cystic masses were located in the upper and lower poles of the left kidney, which were removed in pieces. Histologically, the cyst wall was lined mainly with keratinizing squamous epithelium with hair follicles, shafts and sebaceous glands. The adjacent renal parenchyma showed atrophy, with partially dysplastic and angiomyolipoma-like lesions. Based on these findings, the lesion was diagnosed as mature cystic teratoma of dermoid cyst type. Extragonadal teratoma occurs predominantly along the median line of the body. Intrarenal teratoma is extremely rare; however, it should be distinguished from teratoid Wilms' tumor and other renal cystic lesions.     

Squamous cell carcinoma arising in a mature cystic ovarian teratoma with bladder invasion: a case report

Background

Malignant transformation in a mature cystic ovarian teratoma is rare. Except in cases with high index of suspicion or overt metastasis, oophorectomy is the mainstay of treatment for ovarian teratoma.

Method

A 46-year-old perimenopausal woman who had salpingo-oophorectomy following a clinical diagnosis of benign ovarian tumour that was subsequently reported histologically as mature cystic ovarian teratoma with malignant transformation is presented.

Results

She was referred to our facility based on the histopathology report and haematuria two weeks after surgery. Cystoscopic biopsy done was reported as metastatic squamous cell carcinoma most probably from the ovary. Patient was thereafter referred for radiotherapy but was lost to follow-up after the first course.

Conclusion

Adequate evaluation prior to surgery in suspected ovarian teratoma with malignant transformation is critical to determine extent of surgery and adjuvant therapy. Prognosis in advanced disease condition such as the case presented is generally poor although radical pelvic surgery with resection of the adjacent involved bladder before radiotherapy would probably have improved her prognosis.     

Ovarian mature cystic teratoma with florid vascular proliferation and Wagner-Meissner--like corpuscles

An ovarian mature cystic teratoma featuring florid vascular proliferation and Wagner-Meissner-like corpuscles is presented. The vascular proliferation is analogous to that seen in other tumors having a prominent neural component. The Wagner-Meissner-like corpuscles are viewed as evidence of a specialized type of differentiation of this neural component. To the best of our knowledge, they had not been previously reported in this setting.     

Ovarian mucinous tumour arising in mature cystic teratoma and associated with pseudomyxoma peritonei: report of two cases and comparison with ovarian involvement by low-grade appendiceal mucinous tumour

AIMS: It is currently accepted that primary ovarian tumours rarely, if ever, give rise to mucinous ascites/pseudomyxoma peritonei (PMP) which most commonly results from the intra-abdominal spread of an appendiceal mucinous neoplasm. However, primary ovarian mucinous tumours of appendiceal type arising within mature cystic teratomas appear to represent an exception to this rule. In this report two further examples of this rare tumour are described, and the immunohistological phenotype including expression of MUC proteins is compared with secondary ovarian involvement by low-grade appendiceal mucinous neoplasm. METHODS: Two cases of ovarian mucinous tumour associated with mature cystic teratoma and PMP are described. The tumours were examined immunohistochemically for expression of cytokeratin (CK)7, CK20, carcinoembryonic antigen (CEA), CDX-2, MUC2, MUC5AC and MUC6. The results were compared with four cases of ovarian neoplasia secondary to primary appendiceal low-grade mucinous tumour. RESULTS: The ovarian mucinous tumours associated with mature cystic teratomas were morphologically similar to those secondary to appendiceal neoplasia. They comprised irregularly distributed glands and cysts lined by tall, mucin-rich epithelial cells exhibiting focal villoglandular architecture and low grade cytological atypia. The immunophenotype of the teratoma-associated tumours and those secondary to appendiceal neoplasia was identical: there was strong and diffuse expression of CK20, CEA, CDX-2, MUC2 and MUC5AC with no reactivity for the other antisera tested. CONCLUSIONS: PMP associated with primary ovarian neoplasia is rare, and probably restricted to mucinous tumours arising in mature cystic teratomas. The immunohistological findings in this study further support the view that such tumours exhibit a lower gastrointestinal and, more specifically, appendiceal phenotype. Careful examination and sampling of the ovaries may be required to demonstrate the teratomatous component of these tumours.