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黑果枸杞抗衰老作用研究 总被引:1,自引:0,他引:1
《实用药物与临床》2015,(10)
目的观察黑果枸杞对D-半乳糖诱导的小鼠衰老模型的学习记忆力及抗氧化能力的影响。方法注射5%D-半乳糖制备小鼠衰老模型,灌胃给予黑果枸杞6周后,水迷宫法测定模型小鼠的空间学习记忆能力,试剂盒法测定脑中丙二醛(MDA)、过氧化脂质(LPO)含量及超氧化物歧化酶(SOD)活力,以及血清中谷胱甘肽过氧化物酶(GSH-Px)、MDA含量及SOD活力。结果黑果枸杞能缩短衰老模型小鼠在水迷宫的逃避潜伏期、游泳总路程、近台区停留时间、远台区停留时间、远台区游泳路程,增加衰老小鼠平均游泳速度及近台区的游泳路程;降低模型小鼠血清中MDA含量,升高血清中GSH-Px含量和SOD活力;降低模型小鼠脑中MDA、LPO含量,升高脑中SOD活力。结论黑果枸杞能改善衰老小鼠学习记忆能力,提高机体的抗氧化能力,具有一定的延缓衰老的作用。 相似文献
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目的:研究延寿口服液抗衰老作用。方法:采用D-半乳糖(D-gal)制备衰老模型,测定延寿口服液对衰老小鼠血、肝超氧化物歧化酶(SOD)的活性;脑、肝测定过氧化脂质(MDA)含量;脑、心脂褐质(LF)的含量和小鼠应激能力:抗疲劳和耐缺氧实验及小鼠腹腔巨噬细胞吞噬功能测定。结果:延寿口服液能明显使衰老小鼠血、肝中SOD活性升高,脑、肝中MDA的生成减少,脑、心中LF的含量降低,能显著延长小鼠游泳时间的耐缺氧生存时间及增强小鼠腹腔巨噬细胞吞噬能力,促进血清溶血素的形成。结论:延寿口服液具有一定的抗衰老作用。 相似文献
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目的:考察复方乌贼墨胶囊对延缓衰老的影响。方法:果蝇生存试验;小鼠血和组织中丙二醛、SOD和谷胱甘肽过氧化物酶测定。结果:复方乌贼墨胶囊对果蝇的平均寿命天数有明显延长作用;对消除小鼠体内脂质过氧化降解产物效果显著并能增强SOD活性。结论:复方乌贼墨胶囊具有延缓衰老作用。 相似文献
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851牌劲源片改善性功能等作用的研究 总被引:1,自引:0,他引:1
目的 研究851牌劲源片的延缓衰老、改善性功能和抗疲劳等作用。方法 采用小鼠肝匀浆脂质过氧化物(LPO)水平测定试验、小鼠慢性悬吊应激性功能紊乱交配试验和血清睾酮水平测定试验、小鼠负重游泳试验等分别评价851牌劲源片对小鼠的延缓衰老、改善性功能和抗疲劳等作用。结果 本品能显著降低小鼠肝匀浆LPO水平、显著缩短交配潜伏期和增加20分钟的交配次数并提高血清睾酮水平、显著延长小鼠负重游泳时间。结论 本品 相似文献
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祁州漏芦乙醇提取物对D-半乳糖所致衰老小鼠学习记忆的影响 总被引:6,自引:0,他引:6
目的研究漏芦乙醇提取物对D 半乳糖所致衰老小鼠学习记忆的影响以及对脑组织中过氧化脂质及脂褐质含量的影响。方法采用一次性被动回避式条件反射的方法 (跳台法及避暗法 )测定动物的学习记忆能力 ,用生化学方法测定脑组织过氧化脂质及脂褐质含量。结果漏芦乙醇提取物剂量依赖性地减少D 半乳糖致衰老小鼠跳台及避暗错误反应次数并延长错误反应潜伏期 ;显著减少衰老小鼠脑组织中过氧化脂质及脂褐质的含量。结论实验结果提示漏芦乙醇提取物具有抗衰益智作用。其改善记忆障碍作用可能与抗自由基过氧化 ,减少脑组织中过氧化脂质及脂褐质生成有关 相似文献
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摘 要 目的: 观察巴马神酒对小鼠免疫功能、肝脏脂质过氧化损伤及游泳耐力的药理作用。方法: 采用碳粒廓清实验法及环磷酰胺致小鼠免疫低下模型评价巴马神酒对免疫功能的作用;建立四氯化碳致小鼠急性肝损伤模型,以血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸转移酶(AST)、超氧化物歧化酶(SOD)以及丙二醛(MDA)的水平,评价巴马神酒抗肝脏脂质过氧化损伤作用;以小鼠负重游泳的持续时间,评价巴马神酒提高游泳耐力的功能。结果: 巴马神酒能提高小鼠吞噬指数K及吞噬系数α(与空白组比较,P<0.01或P<0.05);对环磷酰胺诱发的胸腺、脾脏脏器指数的下降有一定的提高(与模型组比较,P<0.05);能够降低四氯化碳致小鼠急性肝损伤血清中AST、ALT含量,降低血清MDA的含量,增强SOD的活性(与模型组比较,P<0.01或P<0.05);可以延长小鼠负重游泳时间(与空白组比较,P<0.01或P<0.05)。结论: 巴马神酒具有提升小鼠巨噬细胞吞噬能力、保护免疫低下小鼠的胸腺和脾脏指数的作用,并具有抗肝脏脂质过氧化损伤和提高游泳耐力的作用。 相似文献
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目的研究定志小丸对D-半乳糖所致亚急性衰老小鼠学习记忆能力和脂质过氧化的影响.方法小鼠背部皮下注射D-半乳糖造成早衰模型,采用跳台法测小鼠学习记忆能力,血清和脑组织SOD、MDA.结果定志小丸使致D-半乳糖衰老小鼠跳台错误潜伏期显著延长,错误次数显著减少,血清和脑组织SOD 活力提高,MDA含量降低.结论定志小丸能改善D-半乳糖致衰小鼠的学习记忆功能,其机制可能与降低脑组织中脂质过氧化物的含量有关. 相似文献
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目的观察美保口服液的抗氧化和抗疲劳作用。方法选用ICR小鼠,用黄嘌吟氧化酶法测定血清SOD;硫代巴比妥酸比色法测定肝、脑组织中MDA含量;以及小鼠爬杆和游泳时间。结果美保口服液能使小鼠血清SOD活性明显上升;肝脑组织中LPO含量明显降低;延长小鼠爬杆和游泳时间。结论美保口服液具有明显的抗氧化及抗疲劳作用,从而发挥具保健美容作用。 相似文献
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An association between lipid peroxidation and alpha-naphthylisothiocyanate (ANIT)-induced liver injury was examined in rats injected once with the toxicant (75 mg/kg body weight). The severity of liver injury was estimated 12, 24, 48, and 72 h after ANIT injection. Liver injury appeared 24 h after ANIT injection, progressed at 48 h, and recovered at 72 h, judging from the serum levels of marker enzymes and components. Serum lipid peroxide (LPO) concentration increased 24 h after ANIT injection and further increased at 48 h, but this increase was attenuated at 72 h. In contrast, liver LPO content increased 12 h after ANIT injection and further increased 24 and 48 h, but this increase was attenuated at 72 h. Similarly, myeloperoxidase (MPO) activity, an index of neutrophil infiltration, in the liver tissue increased 12 h after ANIT injection and further increased at 24 and 48 h, but this increase was attenuated at 72 h. Either serum LPO concentration or liver LPO content was significantly correlated with liver MPO activity (r = 0.661 for serum LPO concentration; r = 0.585 for liver LPO content). These results suggest that lipid peroxidation might be associated with ANIT-induced liver injury in rats and that this lipid peroxidation might occur via oxygen radicals derived from neutrophils infiltrated into the liver tissue of ANIT-intoxicated rats. 相似文献
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日本海马温肾壮阳相关活性的实验研究 总被引:10,自引:4,他引:6
对日本海马进行了温肾壮阳相关活性的实验研究,实验证实,口服日本海马能明显提高氢化可的松所致“阳虚”小鼠的抗疲劳能力,提高小鼠碳粒廓清速率,促进小鼠外周血液溶血素的生成,增加幼鼠前列腺,精囊,睾丸的重量,并且能提高小鼠血清睾酮的含量及睾丸组织中cAMP水平,为其临床应用提供了实验依据。 相似文献
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目的:观察复方丹参注射液对急性汞中毒家兔血浆、肾组织脂质过氧化物(LPO)的清除作用。方法:家兔30只,分3组,汞中毒组和治疗组皮下注射HgCl21.7mL/kg(每mL含HgCl210mg)。治疗组在注汞后30min及10h分别给予复方丹参注射液2mL/kg,iv。正常对照组及汞中毒组给予等剂量生理盐水。各组在中毒前、中毒后分别测定血浆、肾组织LPO及血尿素氮(BUN)。结果:急性汞中毒组血浆、肾组织LPO及BUN明显升高(P<0.01)。治疗组均明显下降(P<0.01)。结论:复方丹参注射液对汞中毒家兔血浆及肾组织LPO有清除作用。 相似文献
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Abidova SS 《Eksperimental'naia i klinicheskaia farmakologiia》2002,65(6):46-48
Ketamine (50 mg/kg, i.p.) increases the intensity of lipolysis in Wistar male rats, as manifested by increasing content of nonetherified fatty acids and cholesterol in the blood serum. This drug also enhances the lipid peroxidation (LPO) process, as manifested by the content of LPO products in the blood serum and in the liver and heart tissues. Propofol in the same dose also influences the lipid metabolism and LPO intensity, but to a lower extent. 相似文献
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Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice 总被引:1,自引:0,他引:1
The protective role of leaves of Mentha piperita Linn (Mint) was studied in adult Swiss albino mice against arsenic-induced hepatopathy. The animals were divided into four groups. Group I: only vehicle (0.9% NaCl) was administered. Group II: the animals received Mentha leaf extract (1 g/kg body weight per day) orally for 30 days. Group III: animals were treated with sodium arsenite (4 mg/kg body weight) intraperitoneally in 0.9% NaCl. Group IV: animals were given Mentha extract for 10 consecutive days prior to sodium arsenite treatment and continuously for 30 days after sodium arsenite treatment. The animals from the above groups were killed at various time-points, and body weight and liver weight were measured. The biochemical estimation of lipid peroxidation (LPO), reduced glutathione (GSH), lactate dehydrogenase (LDH), acid phosphatase (ACP), and alkaline phosphatase (ALP) in liver and serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) in serum were done. In the arsenic-treated group there was a significant increase in ACP, ALP, SGOT, SGPT and LPO content, whereas a significant decrease was recorded in body weight, liver weight, GSH and LDH activity in liver. Pre- and post-treatment of Mentha with arsenic significantly alters the biochemical parameters in liver. A significant decline in ACP, ALP, SGOT, SGPT and LPO content was observed. However, a significant increase in body weight, liver weight, GSH content and LDH activity in liver was estimated. The results indicate that the Mentha extract may be useful in reducing the side effects of arsenic-induced hepatopathy. 相似文献
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目的观察合用N-乙酰半胱氨酸和牛磺酸对四氧嘧啶诱发糖尿病大鼠的作用。方法实验组灌胃给予N-乙酰半胱氨酸和牛磺酸各125mg/(d·kg),连续28d,然后测定空腹血糖浓度、血浆超氧物歧化酶(SOD)活性和全血脂质过氧化物(LPO)含量。结果合用N-乙酰半胱氨酸和牛磺酸具有明显的降血糖作用(P<0.01),并可使糖尿病大鼠全血IPO含量显著下降(P<0.01)、血浆SOD的活性明显增加(P<0.05)。结论N-乙酰半胱氨酸和牛磺酸可显著改善四氧嘧啶诱发糖尿病大鼠的糖代谢,二者合用可显示出较强的抗氧化作用。 相似文献