肝片形吸虫病1例报告

肝片形吸虫是寄生于牛、羊等哺乳动物胆道中的大型吸虫,人偶尔感染,报告1例胆管结石嵌顿患者,术中发现肝片形吸虫。     

肝片形吸虫病1例报告

肝片形吸虫是寄生于牛、羊等哺乳动物胆道中的大型吸虫,人偶尔感染,报告1例胆管结石嵌顿患者,术中发现肝片形吸虫。     

人肝片形吸虫病1例报告

<正>1临床资料患者,女,41岁,因肝区胀痛2个月余入院。2个月前无诱因出现肝区胀痛,伴发热(体温最高38℃),当地医院予抗感染后疼痛症状缓解,体温下降,但此后症状时有反复发作。入院1 d前当地医院腹部CT平扫提示肝左叶低密度灶。转本院,入院时查体:无肝掌、蜘蛛痣,皮肤巩膜无黄染,心肺听诊无异常,腹平软,无压痛及反跳痛,肝脾肋下未及,肝区叩痛阳性,     

片形吸虫病11例临床分析

目的 总结片形吸虫病的临床资料,为片形吸虫病的防治积累临床经验。方法 回顾性分析11例片形吸虫病病例的流行病学特点、实验室资料、临床特征和治疗方案。结果 11例片形吸虫病患者均来自宾川县州城镇,有家庭聚集现象,以农民为主,青年女性多见。患者均有发热、肝区疼痛、肝大,ALT和AST轻度升高,ALP和GGT明显升高,嗜酸性粒细胞增多,红细胞沉降率增快,CRP和免疫球蛋白升高。10例血象高,9例有不同程度的贫血,骨髓培养和血培养阴性,甲、乙、丙、丁、戊型肝炎病原学阴性,CT/磁共振成像均提示肝实质内散在多发低密度影,肝占位性病变,AFP及癌胚抗原正常。给予三氯苯达唑驱虫治疗,同时保肝、对症支持治疗,疗效显著。结论 要重视片形吸虫病在大理州宾川县的流行,诊断时要关注流行病学史。该病预防的关键是加强健康宣教,提高居民食品卫生意识,加强牲畜的治疗和放牧管理,防止粪便污染,改善椎实螺孳生环境。     

肝片吸虫病一例报告

患者男性 ,40岁 ,云南省牟定县人 ,右上腹不适一年余 ,B超提示“胆囊内胆汁淤积 ,结石可能 ,肝右叶异常回声” ,入院。查体 :腹软 ,无压痛、反跳痛 ,Murphy征 (-)。血检 :谷丙转氨酶(GPT) 5 5U ,嗜酸粒细胞正常。磁共振 (MRI) :肝右后叶下段良性占位性病变 ,范围 3 .5cm× 2 .6cm× 4.0cm。数字减影血管造影 (DSA) ,考虑 :原发性肝癌可能。 1周后拟行肝Ⅳ段切除 ,胆囊切除 ,胆总管探查术。术中见肝纤维化明显 ,肝Ⅳ段 5cm× 4cm× 4cm大小病灶 ,胆囊壁厚 ,慢性充血 ,行胆囊切除术时发现胆总管壁厚 ,上段厚达 3mm ,粘膜粗糙 ,慢性充血 ,…     

人肝片形吸虫感染1例

患者,女,66岁,农民,2022年2月15日因“上腹部胀痛伴恶心不适7天”至当地县医院就诊,行腹部CT,示胆总管扩张,肝左叶肝内胆管结石并左叶胆管扩张,肝左叶萎缩;次日转至中国人民解放军联勤保障部队第九二四医院。患者生活于广西桂林山区,长期直接饮用山泉水及食生鱼腥草。入院后查体,剑突下压痛,无反跳痛;血常规无明显异常。MRI检查提示：肝左叶萎缩,肝左叶肝内胆管扩张,其近端内多发颗粒状T2低信号影,胆总管扩张,其内见条状T2低信号影。排除相关手术禁忌征后行内镜逆行胰胆管造影术,术中用取石网篮取出1条灰褐色活体成虫,予留置鼻胆管引流。虫体转送桂林医学院基础医学院人体寄生虫学教研室,鉴定为肝片形吸虫。术后予每12小时口服阿苯达唑0.6 g、吡喹酮0.6 g,治疗2 d。术后2个月复诊,患者无不适;复查腹部CT提示肝左叶萎缩,肝左叶肝内胆管及胆总管扩张。     

肝片吸虫病2例报告

肝片吸虫(Fasciola laepatica)是寄生于牛、羊等哺乳动物胆道中的大型吸虫,人偶尔感染.笔者于2005年报告肝片吸虫病1例[1],2008年又在相同地点一农户家庭发现2例肝片吸虫病例,现报告如下:     

云南省片形吸虫和片形吸虫病研究进展

片形吸虫病是一种人兽共患寄生虫病,严重危害人类生命健康、阻碍社会经济发展.片形吸虫主要感染牛、羊等反刍动物,但近年来随着诊断水平的提升,人体片形吸虫感染病例报道有所增多.云南省人体片形吸虫病多年来主要以散在病例发生,并出现过暴发流行,已引起高度关注.本文主要就云南省片形吸虫虫种分布和片形吸虫病研究状况进行综述.     

三峡库区首例肝片形吸虫病

本文回顾分析了三峡库区首例肝片形吸虫病病例的诊断过程。对患者进行了感染来源的追溯调查,认为该例患者可能因饮用含有囊蚴的水而感染。     

片形吸虫病诊断抗原的研究进展

片形吸虫病(fascioliasis)是由片形吸虫(Fasciola spp.),包括肝片形吸虫和大片形吸虫感染引起的人畜共患寄生虫病。牛羊等经济动物的感染可引起产奶、产肉量降低,劳作能力下降,造成巨大的经济损失:人体片形吸虫病可导致感染者严重的肝、胆病理损伤。片形吸虫病的临床表现和影像学诊断与其它肝胆疾病类似,极易被误诊。目前粪便虫卵病原学检测是最常用的片形吸虫病诊断方法,但存在漏诊、需要专业的镜检人员操作等问题。免疫学诊断技术因具有较高的特异性、敏感性且操作简单易行,近年来已成为片形吸虫病最常用的辅助诊断手段。该文主要综述了片形吸虫病免疫诊断抗原的研究进展。     

Fascioliasis presenting as colon cancer liver metastasis on 18Ffluorodeoxyglucose positron emission tomography/computed tomography: A case report

BACKGROUND Fascioliasis is caused by watercress and similar freshwater plants or drinking water or beverages contaminated with metacercariae. Fascioliasis can radiologically mimic many primary or metastatic liver tumors. Herein, we aimed to present the treatment process of a patient with fascioliasis mimicking colon cancer liver metastasis.CASE SUMMARY A 35-year-old woman who underwent right hemicolectomy due to cecum cancer was referred to our clinic for management of colon cancer liver metastasis. Both computed tomography and 18 F-fluorodeoxyglucose positron emission tomography revealed several tumoral lesions localized in the right lobe of the liver. After a 6-course FOLFOX(folinic acid, fluorouracil, oxaliplatin) and bevacizumab regimen, the hypermetabolic state on both liver and abdominal lymph nodes continued, and chemotherapy was extended to a 12-course regimen. The patient was referred to our institute when the liver lesions were detected to be larger on dynamic liver magnetic resonance imaging 6 weeks after completion of chemotherapy. Right hepatectomy was performed, andhistopathological examination was compatible with fascioliasis. Fasciola hepatica Ig G enzyme-linked immunosorbent assay was positive. The patient was administered two doses of triclabendazole(10 mg/kg/dose) 24 h apart. During the follow-up period, dilatation was detected in the common bile duct, and Fasciola parasites were extracted from the common bile duct by endoscopic retrograde cholangiopancreatography(ERCP). Triclabendazole was administered to the patient after ERCP.CONCLUSION Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas.     

3种ELISA试剂盒检测片形吸虫病的效果评价

目的 目的 评价3种人体片形吸虫病ELISA试剂盒的检测效果。方法 方法 采用本研究室大片吸虫抗原、 肝片吸虫成虫可溶性抗原包被的人体片形吸虫病ELISA试剂盒 （Fg?ELISA和Fh?ELISA） 及德国DRG公司生产的人体片形吸虫IgG抗体 ELISA试剂盒 （DRG?ELISA）, 分别检测26份大片吸虫患者血清、 180份其他寄生虫病患者血清和26份健康人血清, 评价3 种检测试剂盒的检测效果。 结果 结果 Fg?ELISA、 Fh?ELISA 和DRG?ELISA 3种检测盒的敏感性分别为100.0%、 80.8%（95% CI： 65.7%～95.9%） 和100.0%, 特异性分别为87.9%（95% CI： 83.5%～92.4%）、 85.0% （95% CI： 80.1%～89.9%） 和83.5% （95% CI： 78.4%～88.6%）, 约登指数分别为0.88、 0.66和0.84。其中, Fg ?ELISA检出率（100%）明显高于Fh?ELISA （80.8%） （P < 0.05）; Fg?ELISA 检测26例大片吸虫病患者血清的吸光度 （A） 绝对值 （A/ CO） 为1.70, 明显高于Fh?ELISA的 1.18（P < 0.000 1）。结论 结论 Fg?ELISA试剂盒检测效果较好, 且成本相对较低, 比Fh?ELISA和DRG?ELISA两法更适宜用于我国西南大片吸虫病流行区临床样本检测及大规模筛查。     

贵州省贵阳市蛲虫感染1例

本文报道贵州省贵阳市1例蛲虫感染病例，旨在提高对寄生虫感染的重视。     

The serum antibody response of infected rats, rabbits, lambs and calves to Fasciola hepatica adult antigen fractions separated by preparative flatbed iso-electrofocussing

Electrofocusing of F. hepatica adult antigen in granulated gels separated the material into 22 arbitrary fractions. Polyacrylamide gel analysis demonstrated groups of proteins with similar iso-electric points in 19 of the fractions. A microplate ELISA detected antigens in all 22 fractions and was used to test the serum antibody response in infected rats, rabbits, lambs and calves to these antigen fractions. The results indicated that rat and calf sera gave a much stronger response than rabbit and lamb sera to the antigens which separated above pH 7.0. It is possible that the greater efficiency of the rat and bovine immune systems in combating re-infection with F. hepatica may be related to this response.     

A study of the antigens produced by adult Fasciola hepatica maintained in vitro

Summary Metabolic antigen of adult Fasciola hepatica was prepared by concentrating the culture medium in which 100 adult flukes had been maintained in vitro for 7 days. Serological reactions between this antigen and sera from fluke-infected rabbits, rats and sheep were studied using immunodiffusion in agar and enzyme linked immunosorbent assay. The used medium contained a number of antigenic components and their various reactions with the sera from these different hosts were investigated.     

贵州省遵义地区人体结膜吸吮线虫线粒体DNA分析

目的通过线粒体DNA测序及亲缘关系分析初步确定贵州省遵义地区结膜吸吮线虫的来源。方法采集2016年贵州省遵义地区7例人体结膜吸吮线虫病例患者中取出的虫体,提取DNA,PCR扩增结膜吸吮线虫线粒体DNA COX1序列,与已发表的结膜吸吮线虫线粒体DNA COX1序列进行比对和系统进化分析。结果自结膜吸吮线虫患者所得虫体扩增的COX1基因存在差异,人体感染的虫株之间存在较低的遗传变异。结论遵义地区是新的结膜吸吮线虫病流行区,其结膜吸吮线虫流行株包含了亚洲及欧洲两种来源,至少有4种单倍体型。     

Indirect evidence of ectopic pancreatic fascioliasis in a human

Fascioliasis is not common in humans and, furthermore, its ectopic migration into the pancreas is extremely rare. A definitive diagnosis of ectopic fascioliasis is based on the demonstration of flukes in the affected organ. If the flukes invade the parenchyma, however, imaging studies are limited in the detection of worms and surgical identification is required. We encountered a clinical case of probable ectopic pancreatic fascioliasis diagnosed through indirect evidence. A 46-year-old Korean woman was admitted with left upper quadrant pain. She had taken praziquantel for hepatic fascioliasis, which had been diagnosed at another hospital, and then developed abdominal pain. Peripheral eosinophilia, hyperamylasemia and hyperlipasemia were documented. Abdominal computed tomography (CT) revealed multiple, hypodense foci which had coalesced, forming irregular nodules in the medial and lateral segments of the left lobe of the liver, and similar 2- to 3-cm sized, hypodense lesions in the body and isthmus of the pancreas. IgG antibody against Fasciola hepatica was positive. Bithionol was given orally, and the patient's symptoms and biochemistry then improved, with reversal of eosinophilia. Radiological studies showed normalization of the liver and pancreas at the 10th week, and the serology for Fasciola hepatica was negative at the fifth month.     

两型肝片吸虫同工酶等电点聚焦电泳比较研究

本文以等电点聚焦电泳对两型肝片吸虫过氧化物酶、苹果酸脱氢酶、酯酶同工酶进行了比较研究。结果显示,两型肝片吸虫过氧化物酶同工酶谱有显著性差别,苹果酸脱氢酶及酯酶同工酶谱也出现变异酶带。提示两型肝片吸虫已发生了一定程度的遗传分化。     

云南省砚山县首例并殖吸虫病报道

本文报道了云南省砚山县首例并殖吸虫病病例,该病例曾误诊为慢性血吸虫病,后经流行病学和病原学诊断确诊为并殖吸虫病。本病例报道旨在提高当地医务人员对并殖吸虫病的认知,为临床诊断该类疾病提供指导。