针灸治疗中风偏瘫的疗效观察

目的观察针灸治疗中风偏瘫促进神经功能恢复的疗效。方法将82例偏瘫患者随机分成针灸组41例、康复组41例。针灸组采用针灸治疗,取穴：百会、四神聪、臂臑、曲池、手三里、外关、合谷、梁丘、阴陵泉、阳陵泉、足三里、丘墟、太冲等;康复组采用理疗、肢体功能训练等其他康复治疗。5周后观察比较两组治疗前后神经功能缺损的减少程度。结果两组患者治疗后,针灸组与康复组治疗总有效率分别为：90.4%、83.3%;显著有效率分别为：33.3%、23.8%,两组比较差异有统计学意义（P〈0.05）,针灸组的疗效明显高于康复组。结论针灸疗法治疗,可促进中风偏瘫患者神经功能恢复,减少致残率,疗效较显著,且不良反应小,值得临床推广。     

针刺对严重脑损害昏迷患者疗效的量化研究

目的 应用SPECT观察针刺治疗改善严重脑损害昏迷患者脑血流灌注和脑功能活动的可行性和价值，为针刺促醒及功能的康复治疗提供依据。方法 严重脑损害继发脑梗死（DCI）昏迷患者39例。随机分为观察组（针刺组，17例）和对照组（22例）。以韩氏穴位神经刺激仪电针患肢合谷、曲池穴、足三里和三阴交穴。使用Siemens ECAM/ICON SPECT系统，同一患者同体位下，40min之内连续接受针刺前和电针状态下2次SPECT脑灌注显像。用BFCR％数学模型定量分析，并在同样针刺1周后比较对照组临床指标。结果 17例严重脑损害昏迷患者针刺治疗前SPECT皆显示脑内大片放射性分布稀疏区或缺损区。电针治疗时，诸患者脑血流灌注和脑功能活动增高，所有病灶都有不同程度的缩小。BFCR％增高差异有非常显著性（P＜0．01），较对照组有明显的促醒和防治DCI作用。结论 针刺治疗确实可以改善病灶区的脑血流灌注和脑细胞的功能，激发脑细胞活性，可以作为严重脑损害患者综合治疗的方法之一。     

Observations on Curative Effect of High-frequency Electric Sparkle and Point-injection Therapy on Knee Osteoarthritis

Objective: To observe the curative effect of high-frequency electric sparkle and point-injection therapy (HESPT) on knee osteoarthritis (KOA). Methods: Two hundred and five patients were randomly divided into a warming needle moxibustion group (68 cases), a HESPT group (68 cases) and a point-injection group (69 cases). In the warming needle moxibustion group, the main points of Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5), Dubi (ST 35), Zusanli (ST 36) and Yanglingquan (GB 34), and the adjunct points of Yinlingquan (SP 9) and Sanyinjiao (SP 6), on the affected side, were chosen for stimulation. In the HESPT group, tenderness points, the main points of Liangqiu (ST 34), Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5) and Zusanli (ST 36), and the adjunct points of Yinlingquan (SP 9), Weizhong (BL 40) and Chengshan (BL 57), were chosen. After proper manipulation, Corydalis decumbens Pers. liquid was injected into the points and a high-frequency electric sparkle was applied to stimulate the needles for 30 seconds. In the point-injection group, point injection was performed with the same method, but the patients did not receive electric stimulation. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC), the Lysholm Knee Score Scale (LKSS) and the ROM (Range of Motion) scale were used to evaluate the severity of KOA and the function of knee joints before treatment and 4 weeks after treatment. Finally, the Nimodipine method was used to assess the total curative effect. Results: After HESPT treatment, the scores for pain, morning stiffness and swelling were significantly lower (P<0.01) and LKSS index and ROM were much higher (P<0.01 and P<0.05 respectively) compared to the two other groups. The obviously effective rate and total effective rate were also significantly higher in the HESPT group than in the two other groups (P<0.01 or P<0.05). Conclusion: HESPT can improve joint function in KOA patients, and the curative effect is better than for warming needle moxibustion or point-injection only.     

针刺干预化疗副反应作用的临床研究

目的观察针刺对化疗药物不良反应的改善作用,为针刺疗法对肿瘤化疗不良反应的防治作用提供临床依据。方法选择癌证患者共40例,随机分为治疗组和对照组,两组同时应用化疗药物。治疗组自化疗开始针刺,取穴：双侧曲池、内关、合谷、足三里、三阴交、阳陵泉,每周5次,连续两周;对照组不予针刺。分别在化疗前、化疗第5天、第10天观察相关指标的变化并进行组间对比。结果治疗组消化道不良反应积分低于对照组（P〈0.05）;治疗组中医证候积分低于对照组（P〈0.01）;治疗组平均KPS下降分值与对照组比较,差异有统计学意义（P〈0.05）。结论针刺对化疗后消化道不良反应、脾虚证证候、KPS评分有较为显著的改善作用。     

Auricular-Plaster Therapy Plus Acupuncture at Zusanli for Postoperative Recovery of Intestinal Function

In order to relieve the abdominal distension and other discomforts due to gastrointestinal dysfunctionafter abdominal operations,the patients were treated by auricular-plaster therapy plus acupuncture atZusanli(ST 36).12(92.4%)of the 13 cases in the treatment group showed recovery of normalperistalsis within 72 hours after operations,while that in 13 cases of the control group was 46.1%,indicating that auricular-plaster therapy plus acupuncture at Zusanli(ST 36)may promotepostoperative recovery of the intestinal function.     

Clinical observation on Wang Juyi's applied channel theory in treating stroke-sequel patients

OBJECTIVE

To explore the advantages of acupuncture treatment guided by channel palpation on stroke-sequel patients.

针灸刺激对健康人及中风患者功能磁共振显像脑活动的影响

Objective

To investigate brain activity patterns during acupuncture in stroke patients, and to compare the result with normal subjects using functional magnetic resonance imaging (fMRI).

Methods

A total of 11 stroke patients with motor weakness and 10 healthy subjects were studied. fMRI was performed during acupuncture on the left side at points Quchi (LI11) and Zusanli (ST36). Data were analyzed using statistical parametric maps of brain activation induced by acupuncture stimulation.

Results

The results showed that stimulation of both LI11 and ST36 produced significantly different brain activation patterns between the two groups. The normal group showed a greater overall activation than the stroke group. In the normal group, parts of the frontal lobe, parietal lobe, sub-lobar, cerebellum and midbrain regions were activated by acupuncture at the left LI11. On the other hand, only the right side of the inferior parietal lobule region was activated in the stroke patients. When the left ST36 was stimulated in the normal group, both sides of the frontal lobe, parietal lobe, temporal lobe, and sub-lobar, and the left side of occipital lobe, and the right side of cerebellum and midbrain regions were activated. For the same stimulation in the stroke group, only both sides of the inferior parietal lobule and cerebellum regions were activated (P<0.05, cluster level). Deactivation pattern was not noted during any acupuncture stimulation in both groups.

Conclusion

Brain signal activations during the same acupuncture were different between the healthy and the stroke patients, and the effects showed a correlation of different acupuncture points.     

电针曲池、足三里穴对脑缺血再灌注损伤大鼠神经功能缺损的影响

目的：研究电针曲池、足三里穴对脑缺血再灌注损伤大鼠神经功能缺损的影响。方法：Wistar大鼠随机分为5组：正常组、假手术组、模型组、电针非经穴组和电针经穴组,各组再随机分成1d．3d、7d三个时间点。采用改良线栓法制备大鼠大脑中动脉闭塞（MCAO）再灌注模型,应用Zea—Longa的4分制评分法观察各组大鼠在各时间点神经功能缺损评分的变化。结果：随着缺血再灌注时间的延长,模型组大鼠神经功能缺损有不同程度的自愈趋势;电针经穴组可明显降低脑缺血再灌注损伤大鼠神经功能缺损评分,与电针非经穴组和模型组在3d、7d时间点比较均有显著性差异（P〈0．05）。结论：电针曲池、足三里穴对脑缺血再灌注损伤大鼠神经功能缺损具有相对特异性的调节作用。     

针灸配合放血疗法治疗痛风性关节炎临床观察

目的观察针灸配合放血疗法治疗痛风性关节炎临床疗效.方法将60例患者随机分为2组,对照组20例以别嘌呤醇和痛舒胶囊口服治疗,治疗组40例,在此基础上予针灸加放血,取穴隐白、昆仑、太溪、阿是穴等,疗程均为2周.比较两组临床疗效、急性期患者主要关节症状疗效,血尿酸变化、不良反应和复发情况.结果治疗组临床治愈率明显高于对照组（P〈0.05）;在降低血尿酸、改善急性期患者主要关节疼痛、肿胀症状及疗效稳定性方面均优于对照组;不良反应少.结论针药配合放血疗法治疗痛风有良好的协同效应,并能提高临床疗效.     

针刺足三里、太冲、合谷穴配合三阶梯止痛治疗胃癌痛临床观察

【目的】观察针刺足三里、太冲、合谷穴配合世界卫生组织(WHO)三阶梯止痛法治疗胃癌癌性疼痛(简称胃癌痛)的疗效及安全性,为临床上治疗胃癌痛提供一种安全有效的治疗方案。【方法】将60例中重度胃癌痛患者随机分为治疗组和对照组各30例。治疗组采用针刺足三里、太冲、合谷穴配合WHO三阶梯止痛法治疗,对照组仅釆用WHO三阶梯止痛法治疗,2组均以7 d为1个疗程。1个疗程后釆用癌痛数字分级法(NRS)、生活质量量表[QOL-BREF(WHO)]、抑郁自评量表(SDS)来评价2组患者疗效,并比较2组患者的不良反应发生率。【结果】(1)治疗后,治疗组的止痛显效率明显高于对照组,差异有统计学意义(P0.05)。(2)治疗后,2组患者的生活质量均较治疗前明显改善(P0.05),且治疗组的改善作用优于对照组,差异有统计学意义(P0.05)。(3)治疗后,2组患者的抑郁评分均较治疗前明显改善(P0.05);但治疗后2组比较,差异无统计学意义(P0.05)。(4)治疗组的药物不良反应发生率较对照组低,差异有统计学意义(P0.05)。【结论】针刺足三里、太冲、合谷穴配合三阶梯止痛法治疗胃癌痛的效果明显优于单用三阶梯止痛法。     

Altered Brain Regional Homogeneity Following Contralateral Acupuncture at Quchi (LI 11) and Zusanli (ST 36) in Ischemic Stroke Patients with Left Hemiplegia: An fMRI Study

Objective: To study the effect of contralateral acupuncture (CAT) at acupoints of Quchi (LI 11) and Zusanli (ST 36) on the unaffected limbs of ischemic stroke patients with left hemiplegia based on regional homogeneity (ReHo) indices. Methods: Ten ischemic stroke patients with left hemiplegia received CAT on right side at LI 11 and ST 36. Functional magnetic resonance imaging (fMRI) was performed before and after acupuncture. A ReHo analytical method was used to compare brain responses of patients before and after CAT operated by REST software. Results: The stimulation at both LI 11 and ST 36 on the unaffected limbs produced significantly different neural activities. CAT elicited increased ReHo values at the right precentral gyrus and superior frontal gyrus, decreased ReHo value at right superior parietal lobule, left fusiform gyrus and left supplementary motor area. Conclusions: Acupuncture at one side could stimulate bilateral regions. CAT could evoke the gyrus which was possibly related to motor recovery from stroke. A promising indicator of neurobiological deficiencies could be represented by ReHo values in post-stroke patients.     

中西医结合治疗60例代谢综合征疗效观察

目的:观察中西医结合治疗代谢综合征的疗效。方法:采用自愿原则,将120例MS患者按照自愿原则分为观察组和对照组各60例,观察组采用药物综合治疗+调理脾胃针法(取中腕、水分、天枢、大横、中极、气海、足三里、丰隆、曲池、阴陵泉、三阴交、血海、太冲、太溪等。)。对照组只采用药物综合治疗,两组治疗2个疗程后,观察2组治疗前、后各项指标的变化及终止治疗2个月后比较2组体重、腰围、糖化血红蛋白及血压的变化。结果:药物综合治疗+调理脾胃针法对MS患者体重、腰围、血压、血脂、糖化血红蛋白及尿蛋白水平有良性调节作用,与对照组比较差异有统计学意义(Pa(0.05)。结论:药物综合治疗+调理脾胃针法能有效减轻体重、腰围和改善胰岛素抵抗的作用,可改善MS患者糖、脂代谢,降低尿蛋白水平,对停药后防止病情复发及进展有重要意义。     

Clinical Observation on Senile Patients with Impaired Glucose Tolerance Treated by Point Application

In order to observe and evaluate the therapeutic effects of point application on senile impaired glucose tolerance （IGT）, 64 senile IGT patients were randomly divided into two groups with 32 cases in each group. The control group was treated with interference therapy of controlling diet, while the observation group was given point application at Yishu （胰俞 1.5 cun lateral to the Du Channel, at the level of the lower border of the spinous process of the eighth thoracic vertebra）, Pishu （BL 20）, Sanyinjiao （SP 6）, Zusanli （ST 36） and other points in addition to interference therapy of controlling diet. After 2 courses of treatment, the postprandial blood sugar was detected. As a result, the postprandial blood sugar obviously reduced in both groups （P〈0.05, P〈0.01） with a lower level in the observation group than in the control group （P〈0.05）, indicating that point application in combination with interference therapy of controlling diet has a reliable therapeutic effect on senile IGT patients.     

He-Ne Laser Auricular Irradiation Plus Body Acupuncture for Treatment of Acne Vulgaris in 36 Cases

Acne vulgaris is a kind of chronic inflammation of the hair follicle and sebaceous gland commonly seen in young people at the puberty stage. Usually it affects the face, chest and back to form the black-headed comedo, papule, pus-pocket, node or cystis, o…     

Changes in Small Intestinal Motility and Related Hormones by Acupuncture Stimulation at Zusanli (ST 36) in Mice

Objectives

To clarify the effects of acupuncture stimulation at Zusanli (ST 36) on the hormonal changes.

Methods

Eight-week-old male C57BL/6 mice received acupuncture stimulation at acupoint ST 36 or Quchi (LI 11) once a day for 3 or 5 days in the acupuncture-stimulated groups, but not received in the normal group (n=6 in each group). On day 3 or 5, animals were given 0.1 mL of charcoal orally with a bulbed steel needle, 30 min after the last acupuncture stimulation. Ten minutes later, mice were anesthetized, and the intestinal transit and the concentrations of vasoactive intestinal peptide (VIP), motilin, ghrelin and gastrin in the serum were measured.

Results

Compared to no acupuncture stimulation, acupuncture stimulation at ST 36 for 5 days increased the intestinal transit and down-regulated the concentration of VIP and up-regulated the concentrations of motilin, ghrelin and gastrin (P<0.05 or 0.01), whereas acupuncture stimulation at LI 11 did not change them signifificantly (P>0.05).

Conclusion

Acupuncture stimulation at ST 36 for 5 days enhances the small intestinal motility and regulates the secretion of hormones related to small intestinal motility.

     

Comparative study of cerebral infarction treated with acupuncture at 6 acupoints of yang meridian and calan

This article reports the curative effects of acupuncture on 6 acupoints of Yang meridian in treating 32 cases of cerebral infarction in comparison with another 31 cases treated with calan tablets 55 out of 63 patients have been diagnosed as cerebral infarction by computer tomography. Diagnosis of 8 cases relied on history, symptoms, signs together with cerebrospinal fluid examination. Patients were divided randomly into two treatment groups: acupuncture group and calan tablet group. Therapeutic method: (1) For acupuncture group, main acupoints consisted of Jianyu (L.I. 15), Quchi (I. I. 11), Hegu (L. I.4) in the upper extremity and Huantiao (G. B. 30), Yanglingquan (G. B. 34), Guangming (G. B. 37) in the lower extremity. According to the syndrome differentiation, Taichong (Liv. 3), Fengchi (G. B. 20), Tianshu (St. 25), Fenglong (St. 40), Zusanli (St. 36), Sanyinjiao (Sp. 6), Taixi (K. 3) were added. The lifting and thrusting was manipulated. The needles were retained for 30 minutes after the patient felt local sourness, distension and heaviness. Acupuncture was carried out every day for 6 weeks. (2) For calan tablet group, calan tablet 5 mg was administered 3 times a day for the same treatment session as the former group. Result: The total effective rates were 93. 75% and 83.87% respectively. The therapeutic effect in the acupuncture group was much better than that in the calan tablet group (P less than 0.05). The majority of hemorheological indices of patients in two groups were obviously higher than those of the normal in the same age group.(ABSTRACT TRUNCATED AT 250 WORDS)     

电针对2型糖尿病大鼠右心房自主神经损害的调节作用

目的 探讨针刺对2型糖尿病大鼠右心房自主神经损害的调节水平,为针刺临床优化选穴提供参考依据.方法 60只SD雄性大鼠随机分为4组,空白对照组、DM模型组、电针1组、电针2组.除空白对照组外,其余3组给予高脂高糖喂养4周后,用STZ 25 mg/kg连续2 d腹腔注射制作实验性糖尿病大鼠模型.造模2周后,空白对照组和DM模型组不予治疗;电针1组:选内关、曲池、后三里、三阴交;电针2组:选肺俞、心俞、胰俞、脾俞、肾俞,1次/d,6 d为1个疗程,连续治疗4个疗程,疗程间休息1 d.Elisa法检测4组大鼠右心房心肌中酪氨酸羟化酶(TH)、胆碱乙酰转移酶(ChAT)、神经生长因子(NGF)、生长相关蛋白-43(GAP-43)、睫状神经生长因子(CNTF)等含量.结果 与空白对照组比较,DM模型组ChAT显著下降(P<0.05),NGF有明显上升(P<0.05),GAP-43和CNTF有明显下降(P<0.05);与DM模型组相比较,2个电针组的ChAT有明显上升(P<0.05),NGF有明显下降(P<0.05),GAP-43和CNTF均有明显上升(P<0.05),且电针1组优于电针2组.结论 电针肢体腧穴对DM模型大鼠FPG有良好的调整作用,电针能够良性调节右心房TH、ChAT、NGF、GAP-43、CNTF的水平,减轻心脏自主神经纤维损害程度,且肢体腧穴组优于背俞穴组.     

Forty Cases of Gastrointestinal Neurosis Treated by Acupunture

Objective: To compare the therapeutic effect of acupuncture for gastrointestinal neurosis with that of oral remedy. Methods: Eighty cases were randomly divided into the following 2 groups. In the treatment group, acupuncture was given for one month at the main points of Zhongwan (CV 12), Zusanli (ST 36), Taichong (LR 3) and Shenmen (HT 7), with the auxiliary points selected according to TCM differentiation. In the control group, Domperidone was orally administered for one month. Results: The total effective rate was 92.5% in the treatment group and 75.0% in the control group, with a significant difference between the 2 groups (χ2=4.423, P<0.05). Acupuncture was superior to the oral remedy in therapeutic effects. Conclusions: Acupuncture may show better results for gastrointestinal neurosis and with less toxic side effects.     

针刺对慢性萎缩性胃炎大鼠“足三里”穴区 HRH2、SP及炎性因子表达的影响

目的观察针刺对慢性萎缩性胃炎(chronic atrophic gastritis,CAG)大鼠及正常大鼠“足三里”穴区组胺H2受体(histamine H2 receptor,HRH2)、P物质(substance P,SP)及炎性因子(IL-6、IL-1β、TNF-α)的影响,并判断两者间是否存在差异。方法:将32只SD大鼠随机分为正常组、模型组、正常+针刺组和模型+针刺组,每组8只。采用1-甲基-3-硝基-1-亚硝基胍(1-methyl-2-nitro-1-nitrosoguanidine,MNNG)+乙醇灌胃+饥饱失常法建立大鼠CAG模型。针刺组每日治疗1次,每次20 min,连续针刺14 d。干预结束后,运用HE染色法观察胃组织病理学变化,运用免疫组化(immunohistochemistry,IHC)检测“足三里”局部穴区HRH2、SP、IL-6、IL-1β及TNF-α的表达。结果造模后胃组织病理形态改变显著,光镜下可见大量炎症细胞浸润,腺体萎缩且结构紊乱,纤维组织增生充填,并伴有散在出血点,符合CAG病理诊断标准。IHC染色IOD值显示,与正常组相比,模型组、正常+针刺组均能升高局部穴区HRH2表达(P<0.01);与模型组相比,模型+针刺组可以显著上调穴区组织SP表达(P<0.01)。对于炎性因子而言,与正常组相比,模型组均能上调IL-6、IL-1β、TNF-α表达(P<0.05或P<0.01),正常+针刺组可使IL-6表达上调(P<0.01);与模型组相比,模型+针刺组可以降低IL-6、IL-1β表达(P<0.05),而升高TNF-α表达(P<0.01)。结论针刺能对正常和CAG状态下大鼠“足三里”穴区HRH2、SP及炎性因子的表达产生影响,且所产生的生物学效应具有一定趋势,跟是否处于疾病状态有关。     

针刺血清对体外培养神经细胞内钙离子浓度的影响

目的:通过观察针刺大鼠经穴后收集的血清对体外培养的神经细胞内Ca2 浓度的影响,为探讨针灸作用的机制中是否存在着体液因素提供直接的证据.方法:取新生大鼠大脑皮层细胞进行原代培养.7～10 d后应用荧光分子探针Fluo-3AM染色,激光共焦扫描显微镜动态扫描观察加入正常大鼠血清和电针刺激百会、足三里、曲池、三阴交2周后的血清对神经细胞内Ca2 浓度的影响.结果:加入正常血清后,细胞内的Ca2 浓度会有一定的升高,经过一段时间后升高的Ca2 浓度会趋向平稳.而再加入针刺血清后,在一定程度上可以降低神经细胞Ca2 的浓度.结论:针刺腧穴后,除了神经的调节机制外,针刺血清中存在某种活性物质,可以明显地使神经细胞内Ca2 浓度降低,为针灸体液因素的存在提供了直接的证据.