Squamous cell carcinoma arising in Verneuil's disease: two cases and literature review

Verneuil's disease (hidradenitis suppurativa) is a chronic inflammatory, suppurating, fistulizing and scar-producing disease of apocrine gland-bearing skin. Its transformation into epidermoid carcimona has been reported 38 times in literature. We describe two new cases - two males aged 67 and 68-years-old. The first one is still alive with no recurrence after one year and the second patient died 2 months after surgery, showing generalised scattering. This rare complication is interesting for two reasons. It only concerns perianal location and it targets mainly men. Surgical treatment consists of wide excision. However, it is often too late. The outcomes are critical for it has been reported a 50% rate of deaths within 2 years after surgery. It is therefore imperative that both general practitioners and dermatologists follow patients with Verneuil's disease so that they can propose a preventive excision at the right time.     

Squamous cell carcinoma arising in epidermoid cysts: report of four cases and review of the literature

Epidermoid cysts are commonly encountered in clinical practice and while the majority are benign, isolated cases of premalignant and malignant conditions have been identified in their walls. We report four cases of squamous cell carcinoma arising in the walls of epidermoid cysts and review the literature.     

Squamous cell carcinoma arising in a suprasellar epidermoid cyst. Case report

A case is presented in which a squamous cell carcinoma developed in an intracranial epidermoid cyst. The patient was a 54-year-old woman with a 3-year history of depression and amblyopia; no focal findings were noted and she was diagnosed as having psychiatric disorders. On her final admission she showed clinical evidence of a rapidly growing intracranial mass. Computerized tomography (CT) identified a right parasellar and temporal lesion which was then incompletely removed. The literature on primary intracranial squamous cell carcinoma is reviewed, and the role of CT scanning in preoperative diagnosis of this lesion is discussed.     

Squamous cell carcinoma arising in a giant epidermal cyst of the perineum: A case report and literature review

Abstract This case pertains to a 76-year-old woman with a giant cyst in the perineum. Extirpation was performed. The result of a pathological investigation was squamous cell carcinoma arising in an epidermal cyst. An epidermal cyst is necessary to conduct an examination bearing in mind the possibility of a malignant tumour.     

Squamous cell carcinoma arising in a giant epidermal cyst of the perineum: A case report and literature review

Abstract

This case pertains to a 76-year-old woman with a giant cyst in the perineum. Extirpation was performed. The result of a pathological investigation was squamous cell carcinoma arising in an epidermal cyst. An epidermal cyst is necessary to conduct an examination bearing in mind the possibility of a malignant tumour.     

Squamous cell carcinoma arising in a median sternotomy scar—a case report and a brief review of literature

A 71 year old gentleman presented with a nodular growth in the upper end of a median sternotomy scar 17 years after an uneventful cardiac surgery. In the months immediately following the surgery he had itching over the scar and there was an episode of superficial infection in the scar two years hence. He presented this time with a history of itching, ulceration and nodule formation in the upper end of the old surgical scar over the last five months. On examination there was an ulcer at the top end of the sternotomy scar containing a three centimetre diameter nodular growth. He underwent a wide excision biopsy of the lesion which was reported as squamous cell carcinoma. Carcinomas are known to arise from scars of diverse aetiologies, but to our knowledge this is only the second time in the English literature a squamous cell carcinoma has been reported arising from a sternotomy scar.     

Squamous cell carcinoma in chronic ulcerative lesions: a case report and literature review

A case report and literature review are presented involving a fatal case of squamous cell carcinoma of the lower extremity. The unique aspects of this patient include the young age at presentation (35 years old), and the association with both a burn scar (Marjolin's) ulcer and a draining osteomyelitis fistulus tract. Epidemiologic data for Marjolin's ulcers as well as squamous cell carcinoma associated with draining sinus tracts of osteomyelitis are reviewed, in addition to the recommended management of such patients. The case presented is a reminder of the need to maintain a high index of suspicion for malignant transformation within ulcerative lesions.     

A huge renal cell carcinoma: Case report and literature review

In the current era, because of the prevalence of sonography, renal cell carcinoma usually can be detected in the early stages and a huge tumor is rarely encountered. Recently, we found a huge clear cell-type renal cell carcinoma that weighed approximately 2.7 kg, which is very rare.     

Odontogenic keratocyst and uterus bicornis in nevoid basal cell carcinoma syndrome: case report and literature review.

Nevoid basal cell carcinoma syndrome (NBCCS), an autosomal dominant disorder with a high degree of penetrance and variable expressivity, is characterized by basal cell carcinomas, odontogenic keratocysts, palmar and/or plantar pits, and ectopic calcifications of the falx cerebri. More than 100 minor criteria have been described, but 2 major and 1 minor criteria or 1 major and 3 minor criteria are necessary for the diagnosis. In this report we present an 8-year-old girl affected by NBCCS showing a uterus bicornis, a hitherto unreported association. However, further research is needed to confirm the association between NBCCS and mullerian fusion defects and to assess the hypothesis that focuses on chromosome 9 the mutant gene for NBCCS and fusion defects of female genital tract.     

Squamous cell carcinoma arising in an intracranial dermoid cyst--case report

A 47-year-old male presented with headache. Magnetic resonance imaging revealed an enhanced mass lesion in the cerebellar vermis and left cerebellar hemisphere and in the cisterna magna. Gross total removal of the tumor was performed. Histological examination demonstrated squamous cell carcinoma in the dermoid cyst. The patient subsequently received localized radiation therapy of total 55 Gy. He has been without tumor recurrence for 6 years since the surgery. We recommend local radiation therapy over 50 Gy following surgery.     

Merkel cell carcinoma of the hand: Case report and literature review

We are reporting on a 72-year-old male who was diagnosed with Merkel cell carcinoma on the dorsal aspect of his left index finger. This rare highly aggressive malignancy of the skin has only exceptionally been described on the finger or hand. This case report helps review important findings associated with this rare malignancy and reviews the pertinent literature.     

Clear cell variant of calcifying epithelial odontogenic tumor: Case report and review of the literature

The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm which was first described by Pindborg in 1955 and accounts for less than 1% of all odontogenic lesions. Recently, a clear cell variant of CEOT has been identified with only eight well-documented cases in the literature. We present an additional case of clear cell CEOT of the mandible and review the salient clinical, radiologic, and histopathologic features of this entity and CEOTs in general. The differential diagnosis of clear cell tumors in the mandible includes: clear cell odontogenic tumor, clear cell ameloblastoma (odontogenic carcinoma), metastatic clear cell adenocarcinoma, primary intraosseous mucoepidermoid carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, clear cell salivary gland tumors, and clear cell variant of squamous cell carcinoma. Because of the belief that clear cell odontogenic tumors are locally aggressive neoplasms, definitive resection of the entire mass with tumor-free surgical margins and long-term follow-up are recommended. © 1994 John Wiley & Sons, Inc.     

前列腺鳞状细胞癌1例报告并文献复习

目的 提高对前列腺鳞状细胞癌诊断及治疗的认识.方法 报告一例62岁男性,前列腺鳞状细胞癌并膀胱结石患者的诊治结果,并复习文献,探讨本病的病因及诊治、预后.结果 病理检查:前列腺表面呈结节状,切面灰白、质韧.镜下观察:癌组织呈巢团状排列,有角化珠形成,癌细胞胞浆丰富,异型性明显,核分裂相多见.病理诊断:前列腺低分化鳞癌并前列腺结石.患者术后6个月死于多脏器转移.结论 前列腺鳞癌临床罕见,可由多种因素导致,恶性程度高,肿瘤进展快,预后差,对内分泌治疗无效.     

Marjolin's ulcer revisited--basal cell carcinoma arising from grenade fragments? Case report and review of the literature.

BACKGROUND: Marjolin's ulcer is a rare and often aggressive cutaneous malignancy arising in previously traumatized or chronically inflamed skin. METHOD: Case report: A 79-year-old World War II veteran developed basal cell carcinoma (BCC) at the site of a war wound. The tumour developed in relation to several metal grenade fragments. With a disease-free interval of 61 years between injury and onset of complications the patient had one of the longest latency periods of tumour development described so far. RESULTS: Review of the literature reveals only five cases of relation between grenade fragments and malignancy formation. Presence of foreign bodies has been described as possible aetiology for malignancy development. Explosives and additives contain several mutagenic and tumourigenic substances. We hypothesize a causal connection between the grenade fragments and the development of BCC. Considering the long period of latency between injury and tumour development we suggest grenade injury with left fragments in soft tissue to be a new origin of Marjolin's ulcer.     

Small cell carcinoma arising from the bulbar urethra: a case report and literature review

Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carrying a bad prognosis. With squamous cell and transitional cell carcinoma being the most commonly reported urethral malignancies, primary small cell carcinoma (SCC) of the urethra is extremely rare. To date, only 5 cases have been reported in the literature. We present the first case of primary SCC occurring in the bulbar urethra in an 89-year-old male. We discuss the clinical, histological and immunohistochemical features of SCC of the urethra. Furthermore, we summarize the available literature and discuss the possible treatment options for this rare yet aggressive neoplasm.     

An unusual case of squamous cell carcinoma arising at the stomal site: Case report and review of the literature

An unusual case of squamous cell carcinoma arising at the ileocutaneous stomal site is reported. The presenting symptoms were peristomal ulceration and bleeding. The patient was treated with wide local excision of the stoma and the peristomal skin, and relocation of the ileostomy. A search of the literature for other similar cases subsequently identified two additional cases that were reported in the literature in 1987 and 2000.     

前列腺小细胞癌1例报告并文献复习

目的 提高前列腺小细胞癌的诊治水平.方法 报告前列腺小细胞癌1例,结合文献复习,进行回顾和分析.前列腺体积明显增大,质地硬,表面尚光滑,轻度触痛;B超、MRI提示盆腔巨大肿块,分叶状,质地不均匀,大小为9 cm×9 cm×10cm,压迫并突向膀胱和直肠腔,双侧肾盂积水.结果 前列腺穿刺活检,病理为小细胞癌,免疫组化提示PSA(-),CgA(-),Syn( ),CD56( );因无手术适应证,以及患者拒绝化疗,故施以内分泌治疗,其临床症状无缓解,排尿困难及双肾积水进行性加重,并出现不完全性肠梗阻,全身状况进行性恶化,3月后死于多系统器官功能衰竭.结论 前列腺小细胞癌须病理和免疫组化来确诊,其发病率低,恶性度极高,生长迅速,应与前列腺肉瘤鉴别.治疗以化疗为主,但缓解期短;对内分泌治疗不敏感,姑息性手术和局部放疗可以改善患者生存质量.     

Squamous cell carcinoma arising in a giant epidermal cyst: a case report

Epidermal cysts are commonly encountered in surgical practice. Malignant degeneration of epidermal sebaceous cyst is uncommon. The authors report the case of a 38-year Filipino woman presenting with a voluminous sebaceous cyst of the left buttock. Ultrasonography and computer tomography were made preoperatively without any hint of eventual malignant degeneration. Marginal excision was performed with direct closure of the skin. The histological examination revealed epidermal sebaceous cyst with squamous cell carcinoma in situ, which is a quite rare, but well known complication occurring in sebaceous cysts.     

Squamous cell carcinoma of renal pelvis: a case report and review of the Japanese literature

Squamous cell carcinoma of renal pelvis is relatively rare and its prognosis is very poor. A 72-year-old man was introduced to our institute because of macroscopic hematuria. He had no history of urolithiasis or urinary tract infection. Excretory urography showed a nonfunctioning right kidney. Cytologic examination of urine was positive for malignant cell from squamous cell carcinoma. Preoperative diagnosis was made as right renal pelvic tumor, but it appeared to be renal tumor on the roentgenogram. Right radical nephrectomy and transurethral ureterectomy was performed. Radiation therapy was done after operation. Pathological diagnosis was squamous cell carcinoma of renal pelvis extensively infiltrating to the renal parenchyma. The patient is alive with no recurrence or metastasis for eight months after operation. Statistical analysis was made on 136 cases of squamous cell carcinoma of renal pelvis reported in the Japanese literature including our case, and this disease is also briefly reviewed.