体检人群的体脂率与代谢指标的相关性分析

目的 观察并探讨体检人群的体脂率与代谢指标的相关性.方法 3410例于本院体检中心进行体检的人员为研究对象,通过数据分析探讨人群的体脂率与代谢指标的相关性.结果 男女体检者在年龄、体脂率、舒张压(SBP)、收缩压(DBP)、空腹血糖(Glu)、甘油三酯(TG)、高密度脂蛋白(HDL)、总胆固醇(TC)、糖化血红蛋白(H...     

代谢综合征患者血清脂联素水平与胰岛素抵抗的相关性研究

目的:探讨代谢综合征患者血清脂联素水平与胰岛素抵抗的关系。方法:选取代谢综合征患者35例,另选健康对照组20例,所有实验对象空腹采血离心取血清测定脂联素、胰岛素、血糖、胰岛素敏感性指数、胰岛素抵抗指数。结果:与对照组相比,代谢综合征组血清脂联素水平、胰岛素敏感性指数显著降低(P<0.01),血清胰岛素、血糖显著升高(P<0.01)。在代谢综合征组中,血清脂联素与胰岛素、血糖、胰岛素抵抗指数呈负相关,与胰岛素敏感性指数呈正相关(P<0.05)。结论:低血清脂联素水平与胰岛素抵抗密切相关。     

体检人群超敏C反应蛋白与代谢综合征的相关性研究

目的：探讨体检人群超敏 C 反应蛋白（hs‐CRP）与代谢综合征（MS）的关系。方法选取健康体检者中体检数据完整的975例受检者,其中符合 MS 诊断的277例,采用秩和检验分析 MS组与非 MS 组间的各组分关系,应用 Spearman 秩相关分析 hs‐CRP 与 MS 各组分的相关性。结果 MS组 HDL‐C 水平低于非 MS 组,BMI 、SBP 、DBP 、hs‐CRP 、TC 、TG 、LDL‐C 、FPG 、ALT 、AST 水平均高于非 MS 组,差异有统计学意义（P＜0．05）。不同年龄段人群非 MS 组与 MS 组 hs‐CRP 水平均有差异（P＜0．05）。肥胖组 hs‐CRP 水平与低体质量组、正常体质量组、超重组比较明显升高（P ＜0．05）。hs‐CRP 水平与 BMI 、TC 、TG 、FPG 、ALT 、AST 、SBP 及 DBP 呈正相关;与 HDL‐C 呈负相关。结论hs‐CRP 水平与 MS 的发生、发展密切相关。     

胰岛素和瘦素与代谢综合征相关性研究

代谢综合征是一种常见的异质性疾病,以胰岛素抵抗和/或高胰岛素血症为代谢综合征的共同病因学基础。业已证实,体内存在脂肪—胰岛内分泌轴,而瘦素与胰岛素抵抗、糖代谢异常、脂质代谢紊乱、高血压等密切相关,在代谢综合征和其它肥胖相关疾病的发生发展中演重要角色。胰岛素与瘦     

代谢综合征与感染及其抗菌治疗

随着经济的发展和人群生活方式的改变,肥胖、糖尿病、血脂异常、脂肪肝、高血压、高尿酸血症的发病率明显上升,且发病年龄有年轻化趋势。这类疾病大多表现为胰岛素抵抗和高胰素血症相关的糖代谢、脂代谢紊乱综合征,即代谢综合征。上海市20岁以上的成人中,患病率达17%。代谢综合     

社区老年男性人群代谢综合征与高尿酸血症相关性分析

目的探讨社区老年男性代谢综合征（MS）与高尿酸血症（HUA）之间的相关性。方法随机抽取已规范建立健康档案的老年男性代谢综合征患者160例,对研究对象进行年度体检,按尿酸水平分为高尿酸血症组与正常尿酸组。比较两组人群的体重指数、腰围、血压、血糖、血脂水平及合并相关疾病的情况。结果高尿酸血症组的体重指数（BMI）、腰围、舒张压（DBP）、餐后2小时血糖（2hPG）、甘油三酯（TG）高于正常尿酸组（P〈0．05）,且高尿酸血症组合并冠心病的患病率高于正常尿酸组（P〈0．05）。结论高尿酸血症与老年男性代谢综合征相关,老年男性MS患者合并高尿酸血症患心血管病的风险增加,应积极进行社区干预。     

上海政府公务员血尿酸水平与代谢综合征相关性研究

目的探讨上海政府公务员血尿酸水平与肥胖、血压、血脂、血糖等代谢综合征各组分的关系。方法选取2007年至2009年在我院进行健康体检的上海政府公务员共3563例,测定和统计分析腰围、收缩压、舒张压、血尿酸、空腹血糖、空腹胰岛素、TC、TG、LDL-C、HDL-C等指标。结果男性和女性公务员组的高尿酸血症患病率分别为26.7%和14.8%（P〈0.001）;男性公务员组的腰围、收缩压、舒张压、TC、TG、LDL-C、GLU和HOMA-IR均随血尿酸水平的升高而显著升高（P〈0.05）,HDL-C则显著降低（P=0.034）;女性公务员组的腰围、收缩压、舒张压、TG、LDL-C、GLU和HOMA-IR均随血尿酸水平的升高而升高（P〈0.05）,而TC、HDL-C差异无统计学意义（P值分别为0.218和0.146）。结论血尿酸水平与肥胖、血脂异常、血压、血糖及胰岛素抵抗等MS组分之间关系密切,控制血尿酸水平是代谢综合征治疗中的重要环节之一。     

高尿酸血症与代谢综合征的相关性研究

目的探讨高尿酸血症与代谢综合征(MS)的相关性。方法选取在我院体检的354例健康体检者,根据尿酸水平分别高尿酸血症组合正常尿酸组,对比两组病例的血脂、血压、血糖指标;统计分析MS的发病率及其与高尿酸血症的相关性。结果高尿酸血症组高血压病发生率、空腹血糖、血脂水平均高于正常尿酸组,差异有统计学意义(P<0.05);高尿酸血症组MS发病率高于正常尿酸组,差异有统计学意义(P<0.01)。MS组血尿酸显著高于非MS组,差异有统计学意义(P<0.01)。结论高尿酸血症患者存在显著的血压、血糖、血脂异常;高尿酸血症与MS密切相关,可能为MS的危险因素之一。     

贵州地区体检人群高尿酸血症流行病学研究

目的探讨贵州地区20岁以上人群的高尿酸血症的发病情况。方法对我院2009年到2011年期间到我院进行体检的健康人群2 616例,于空腹静脉抽血查血糖、血脂、血尿酸、肾功能等,并作身高、体重、血压等测定。结果2 616例体检人群,男性1 929例,女性686例。高尿酸血症共551例,占总抽样人群21.06%,其中女性74例,占10.79%,男性477例,占24.73%。男女两组组间比较差异具有显著性(χ2=59.38,P<0.05)。男性血尿酸均值显著高于女性(t=30.23,P<0.05),女性在50岁以后血尿酸水平逐渐升高接近男性。男性高尿酸血症组年龄显著高于女性组(t=3.773,P<0.05)。高尿酸人群中患高血糖、高血压、超重、高脂血症的患病率显著高于总体人群(P<0.05)。结论贵州地区体检人群高尿酸血症较高。男性的高尿酸血症发病率高于女性,女性于更年期后血尿酸发病率逐渐接近男性。体重指数超标、高血压、高血糖、高脂血症是高尿酸血症的重要相关因素。     

2型糖尿病与代谢综合征

糖尿病是代谢综合征(MS)或胰岛素抵抗综合征(IR)的重要组成部分，80％以上的2型糖尿病合并MS。代谢综合征(MS)，又称胰岛素抵抗综合征(IR)，最早提出于1779年，Fronzo等应用正常血糖高胰岛素钳夹技术(Euglyeenic Hyperinsulinemic Clamp Technique)测定患者的胰岛素敏感性，结果发现：肥胖、2型糖尿病、高血压、高甘油三酯血症／低高密度脂蛋白血症和动脉粥样硬化等疾病患者多存在胰岛素抵抗和高胰岛素血症。随后各国学者在此领域进行了深入而广泛的研究。     

人血清中骨形态发生蛋白质4表达水平与体质量指数的相关性研究

目的研究人群血清中骨形态发生蛋白质4(BMP4)水平与体质量指数(BMI)的相关性,推断血清BMP4水平是否成为肥胖人群发生心血管疾病的危险因素。方法入选180名受试者,根据BMI分为正常体质量组和超重组,采用酶联免疫吸附试验(ELISA)分别测量2组人群血清BMP4的水平。并对BMP4水平与BMI、高敏C反应蛋白(hs-CRP)的相关性进行分析,同时分析BMP4水平与传统心血管危险因素的相关性。结果超重组血清BMP4水平显著高于正常体质量组(P<0.05),与BMI及hs-CRP之间呈正相关(P<0.01);血清BMP4水平与传统的心血管危险因素,包括高密度脂蛋白胆固醇(HDL-C)、空腹血糖,血压无相关性,而与年龄呈正相关。结论超重组BMP4水平与BMI以及hs-CRP呈正相关,是肥胖人群心血管疾病的危险因素。     

糖尿病患者体脂分布与骨质疏松的关系研究

目的探讨分析糖尿病患者体脂分布与骨质疏松的相关性,为该疾病预防治疗提供参考价值。方法 80例2型糖尿病患者,根据是否合并骨质疏松分为A组(合并骨质疏松)与B组(未合并骨质疏松),每组40例。检测两组患者生化指标、双股骨密度及L1~4骨密度。比较两组患者骨密度情况,分析骨密度与各体脂分布指标的相关性。结果 A组双股骨密度(0.96±0.02)g/cm^2、L1~4骨密度(0.83±0.04)g/cm^2均低于B组的(1.16±0.31)、(1.09±0.17)g/cm^2,差异具有统计学意义(P<0.05)。患者全身脂肪、躯干脂肪、四肢脂肪含量与双股骨密度、L1~4骨密度均呈正相关(r=0.488、0.569、0.425、0.453、0.571、0.043;P<0.05),其中,与躯干脂肪含量相关性最大。患者瘦肉组织含量与双股骨密度、L1~4骨密度无相关性(P>0.05)。结论糖尿病患者的体脂分布与骨质疏松有较大相关性,特别是躯干脂肪组织含量。     

Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjects

1. Obesity appears to influence vascular stiffness, an important cardiovascular risk factor. An accurate picture of arterial stiffness may be obtained when a combination of various techniques is used. 2. The purpose of the present study was to assess whether the body mass index (BMI) and body fat content obtained by bioimpedance were of equal value in estimating the influence of body fatness on various indices of vascular stiffness and wave reflection. 3. A total of 175 healthy subjects was studied. Anthropometric measurements and total body bio-impedance analysis were performed to assess fat mass as a proportion of total body composition. Arterial stiffness and wave reflection were assessed using digital volume pulse analysis and tonometric measurement of the wave reflection indices and central haemodynamics. 4. Significant differences in the stiffness index (SI(DVP); P < 0.0001), peripheral augmentation index (pAI(x); P < 0.0001), central augmentation index (cAI(x); P < 0.0001), peripheral pulse pressure (pPP; P = 0.026) and central pulse pressure (cPP; P < 0.0001) were found when the population examined was divided accordingly to tertile of body fat content. However, subdividing various indices of arterial stiffness according to the tertile of BMI did not reveal any significant differences between groups, except for pPP and cPP. 5. Body fat content was significantly correlated with SI(DVP), pAI(x), cAI(x), pPP and cPP. The BMI correlated weakly with SI(DVP), pPP and cPP. 6. In conclusion, the BMI is not very useful in predicting changes in arterial stiffness and wave reflection due to obesity. However, stiffness and wave reflection indices derived from digital volume pulse analysis, the characteristics of radial and aortic pressure waveforms and peripheral and aortic pulse pressure are all related to body fat content, as estimated by bioimpedance.     

昼夜规律和性别对健康人窦性心率震荡的影响

目的探讨健康人窦性心率震荡的昼夜规律及其与性别的关系。方法43例非器质性心脏病的正常人,其中男22例,年龄40～70岁,平均年龄54岁;女21例,年龄42～68岁,平均年龄52岁。男女2组分别按不同的时间段分为3组：第1组（22∶00～5∶59）,第2组（6∶00～13∶59）和第3组（14∶00～21∶59）。然后分别计算震荡初始（TO）和震荡斜率（TS）。观察不同时间、不同性别间心率震荡的差异。结果女性的TO阳性率在夜间和上午高于男性（P＆lt;0.05）;而男性的TS阳性率在下午高于女性（P＆lt;0.05）。结论TO和TS均存在近日节律。     

低血糖指数膳食对代谢综合征患者体重指数、腰臀比值及内脏脂肪的影响

目的研究低血糖指数（GI）膳食对代谢综合征（MS）患者体重指数（BMI）、腰臀围比值（W/H）和内脏脂肪的影响。方法选取BMI≥25 kg/m2的MS患者296例,进行为期8周的低GI膳食的标准化的营养干预,观察干预前后BMI、W/H、VFA及非酒精性脂肪肝（NAFLD）的变化情况,采用SPSS 15.0软件包进行统计分析。结果干预后BMI、W/H下降,VFA减少,NAFLD的严重程度改善,与干预前对比,P均〈0.01,有统计学意义。结论在控制总能量的基础上,采用低GI膳食的标准化营养干预能有效改善MS患者的BMI、W/H、内脏脂肪积聚及NAFLD。     

良性前列腺增生症与血糖和血脂等代谢性指标的相关性

目的:探讨老年良性前列腺增生症(BPH)患者与血糖、血脂等代谢性指标的临床相关性。方法:收集92例BPH患者的临床资料,采用国际前列腺症状评分表(IPSS)对患者进行评价,所有患者均详细询问病史,并检测空腹血糖(FBG)、血脂系列、前列腺特异性抗原(PSA)水平,采用腹部超声测量前列腺体积(PV)。结果:老年BPH患者PV和PSA随年龄增加而增高;PV与FPG、血清PSA水平呈正相关;与高密度脂蛋白胆固醇(HDL-C)呈负相关;与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)无相关性。结论:FBG,HDL-C为BPH患者病情进展的独立危险因素,TC、三酰甘油(TG)、LDL-C为前列腺增生的相关危险因素,与BPH之间存在密切关系。     

Abnormal correlation between serum leptin levels and body mass index may predict metabolic dysfunction irrespective of the psychopharmacological treatment

In an earlier study, we found a similar frequency of individuals with an abnormal correlation between serum leptin levels and body mass index (BMI) (outliers above or below the 95% confidence interval in the regression line) during treatment with antipsychotic drugs (n=301), other psychotropic drugs (n=65), and drug-free individuals (n=229). In this secondary analysis, we compare the frequency of the metabolic syndrome (International Diabetes Federation), its constituting variables, obesity, (BMI>30 kg/m), leptin and insulin serum levels, and an insulin-resistance index (homeostatic model assessment-insulin resistance) in outliers, nonoutliers distributed in their original treatment groups, and all the nonoutliers controlled by age, sex, and BMI. We identified 28 outliers, 24 above and four below the 95% confidence interval limits. Nine individuals were under antipsychotic treatment, four under other drug treatment, and 15 were drug-free. The outliers had a significantly higher frequency of metabolic syndrome and obesity, and higher values of waist circumference, triglycerides, insulin, and blood diastolic pressure. The outliers in the correlation between leptin and BMI may represent a population at high risk of metabolic dysfunction, irrespective of the specific psychotropic drug treatment administered.     

Total body water as an index for predicting body fat in rats

The determinations of total body water, body density, surface area and Lee index were carried out on 15 live Sprague-Dawley rats. The rats were subsequently sacrificed and subjected to carcass analysis by desiccation, gravimetry and ether extraction of body fat. The results of multiple regression using the maximum R2 improvement technique indicated that a strong correlation existed only between body fat and total body water which was statistically significant (P = 0.0001). The regression equation representing such a relationship was % of body fat = 83.167-1.067 X (% total body water). The % body fat computed from density, multiple regression models, and the actual fat content of carcass were not significantly different by the Newman-Keuls range test. The validation of the predicting equation was done using lean and obese Zucker rats. It was found that the predicting equation overestimated body fat by 0.67% for lean rats and underestimate 1 body fat of obese Zucker rats by 3.57%.     

Comparison study on the daily performance capability and body fat percentage for a healthy life among elderly people using a senior welfare center

The prevalence of chronic diseases in Korea has been rising with obesity as the result of increasing elderly population. Secondary problems such as hypertension, diabetes, and degenerative arthritis caused by obesity affect activities of daily living (ADLs) and instrumental activities of daily living (IADLs) among elderly people. However, the performance level of ADLs/IADLs and obesity rates according to age have scarcely been investigated. Therefore, we focused on the performance level of ADLs and IADLs among the elderly for investigating disabilities, obesity, and their correlation to age. The subjects were divided into three groups on 80 elderly men and 143 women registered at a senior welfare center (SWC) in I-Cheon according to their age (in their 60s, 70s, and 80s). Their disabilities and body fat percentages were measured and then compared to data from young adults who were in their 20s to discover changes according to age. In this results, 90% of the elderly possessed chronic diseases when their performance levels of ADLs and IADLs were lowered. Those in their 70s, the group that used the senior welfare facilities the most, showed the lowest levels of decline in ADLs and IADLs among participants aged 60–80. In terms of obesity, the elderly possessed a higher degree of overall body fat and a higher ratio of body fat to lean body mass. There were no significant differences in skinfold thickness according to age group. Our results suggest that social education for exercise programs and the use of physical therapy facilities should be encouraged to promote a healthy lifestyle among the elderly people.     

Basal metabolic rate and body composition in elderly Indian males

Aging is associated with a decline in basal metabolic rate (BMR) and total energy expenditure. The extent to which changes in fat free mass (FFM) alone, explains the reduction in BMR is still unresolved. In this study, we documented changes in body composition and evaluated its contribution to measured BMR in young and elderly Indian subjects. We compared 16 healthy elderly male subjects in the age group of 60-75 years with 16 Body Mass Index (kg/m2) matched controls in the age group of 18-25 years. Body composition measurements were determined by using multiple skinfolds and bio-impedence method. BMR measured by indirect calorimetry. The % fat and fat free mass was significantly different between two groups. There were significant difference in BMR between elderly and control group (elderly, 5.91 +/- 0.54 vs control; 7.08 +/- 0.65 MJ/day, P < 0.001), which disappeared when corrected for FFM. This suggests that the age related decrease in the BMR is related to the absolute decrease in the FFM in the elderly without any change in the metabolic activity per kg FFM.