联合应用脾肾分流加贲门周围血管离断术治疗门脉高压症

目的　探讨联合应用脾肾分流加贲门周围血管离断术治疗门脉高压症的效果。方法　29例病人术前均确诊为肝硬化、门脉高压症,全部采用脾肾分流加贲门周围血管离断术治疗。结果　手术成功率达100%,术后自由门静脉压(FPP)降低有显著意义(P<0.01),术后随访6～24个月,患者食管胃底静脉曲张大部分消失,少部分有不同程度的改善,肝功亦有好转,无肝性脑病发生,无再出血。结论　脾肾分流加贲门周围血管离断术,既保留了断流术和分流术的优点,又克服了二者的缺点,是一种较理想的治疗门静脉高压症的手术方式。     

分流断流联合术治疗肝硬化门脉高压症出血

目的:分析分流术、断流术的利与弊,探讨分流断流联合术式优势互补,治疗门静脉高压症出血的临床疗效。方法:对2001年至2005年4例门静脉高压症出血病人进行脾切除、脾肾静脉分流加贲门周围血管离断术,联合手术进行治疗。结果:4例门静脉压术后较术前平均降低0.89kPa,术后血常规及肝功能恢复正常,腹水消失,无肝性脑病和再出血发生,均康复出院。随访期间无再出血、肝性脑病、腹水及门静脉高压性胃病发生。结论:掌握好适应证开展分流加断流联合手术,在一定程度上能使二者优势互补,是一种理想的治疗门静脉高压症出血的术式。     

应用脾腔分流联合断流术提高门脉高压症的疗效观察

目的:探讨应用脾腔分流联合断流术提高门脉高压症的手术治疗效果.方法:对照分析135例施行脾腔分流联合断流术和120例接受单纯断流术的肝硬化门脉高压症患者的临床资料.结果:脾腔分流联合断流术后的再出血率、门静脉血栓形成率及腹水复发率均明显低于单纯断流术后,而断分流联合组术后肝性脑病发生率及原发性肝癌发生率与断流组无显著差异,围手术期死亡率两组无显著差异.结论:改良脾腔分流联合断流术提高了门脉高压症的疗效,为外科治疗门静脉高压症提供一个较好的思路.     

脾肾静脉小口径分流术加贲门周围血管离断术治疗门脉高压症

目的:探讨脾肾静脉小口径分流术加贲门周围血管离断术治疗门脉高压症的效果。方法:对我院近几年采用该手术方法治疗的门脉高压症患者术前术后门静脉压力的变化及术后随访。结果:患者的术后门静脉压力平均下降3cm～4cm水柱。86%的患者(32/38)食管静脉曲张好转胃黏膜糜烂得到改善。35例随访1a～3a无一例再出血。结论:脾肾静脉小口径分流术加贲门周围血管离断术既保留了分流术和断流术的优点。又克服了二者的缺点,是当今治疗门脉高压症的理想术式。     

断流联合部分脾切除及网膜包残脾、肾术治疗门脉高压症的疗效评估

目的：探讨断流联合部分脾切除及网膜包残脾、肾术治疗乙型肝炎后肝硬化门脉高压症的疗效.方法：回顾2003～2007年因乙型肝炎后肝硬化门脉高压症行手术治疗的70例病人,其中40例选择断流联合脾部分切除及网膜包残脾、肾术（A组）,30例选择断流联合全脾切除术（B组）,比较两组术前、术后1d及术后2个月患者门静脉血流量（PVF）.观察术后2个月血中IgM水平、术后出血、肝性脑病、腹腔感染及门脉血栓发生率等情况.随访5年后,再出血率、门脉高压胃病发生率及生存率.结果：两组术后1d、术后2个月PVF均较术前减低（P＜0.05）,但B组较A组低（P＜0.05）.术后2个月,两组PVF比较无明显差异（P＞0.05）,但A组血中IgM水平高于B组（P＜0.05）,门静脉血栓发生率低于B组（P＜0.05）.A组术后随访5年较B组发生再出血、门静脉高压性胃病发生率均明显下降（P＜0.05）,而生存率差异无统计学意义（P＞0.05）.结论：断流联合部分脾切除术及网膜包残脾、肾术治疗门脉高压症,术后复发出血率低,又可维持脾脏的免疫功能,并有部分自发性分流,兼有分流术及断流术的特点,是治疗乙型肝炎后肝硬化门脉高压症的合理术式.     

门静脉高压症手术治疗49例临床分析

目的探讨肝硬化门脉高压症手术治疗术式及临床应用。方法回顾2003年1月至2008年4月期间采用脾肾静脉分流加门奇断流联合手术治疗49例门静脉高压症患者临床资料进行总结分析。结果术中无一例死亡,肝功能ChildC级死亡1例,余无肝性脑病发生。左膈下积液合并染1例,经抗生素及营养支持治疗痊愈,12例出现少至中等量腹水,经治疗短期内消失。2例切口部分裂开,保守治疗而愈,术后经上消化道钡餐检查,食道静脉曲张消失或明显好转40例,好转8例,肝功能分级较术前好转32例,无变化14例,加重2例。结论分流加断流的联合术式扩大了手术范围,增加了手术难度,严格把握手术指征,细致周密的手术方案,良好的围手术期管理,分流加断流的联合手术术式是安全可行的较为理想的治疗门脉高压症的方法。     

脾肾分流加贲门周围血管离断术门静脉系统血流动力学的临床研究

目的　探讨外科手术门脉高压血流动力学影响。方法　应用彩色多普勒观测门静脉系统血流和术中门静脉测压 ,对 2 2例门脉高压症脾肾分流加贲门周围血管离断术前后的血流动力学进行研究。结果　本组术后的门静脉血流量介于断流组与脾肾分流组之间 ,自由门静脉压亦介于断流组与脾肾分流组之间 ;本组门静脉压的下降与门静脉血流量的减少呈正相关 (r =0 70 6 7,P 0 0 0 5 )。结论　该术后门静脉血流肝内灌注良好 ,门静脉瘀血状态缓解。     

选择性断流术与断流加分流术治疗门静脉高压症24例分析

目的观察选择性断流术与断流加分流术治疗门静脉高压症上消化道出血的临床效果。方法回顾性分析10例采用断流术加脾肾分流术（联合组）与14例选择性断流术（断流组）患者的临床资料,比较术前、术后及手术前后下降的自由门静脉压、术前及术后1个月行胃镜检查的食道静脉曲张及门脉高压性胃黏膜病变的变化情况。结果两组均无无手术死亡、再出血及肝性脑病发生。断流组FPP降低（4.25±0.74）cmH2O,联合组降低（7.49±1.23）cmH2O,联合组降压效果明显优于断流组（t=-8.078,P〈0.01）。胃镜检查食道静脉曲张均有明显好转,组间无差异（P〉0.05）,而门脉高压性胃黏膜病变好转情况两组间有统计学差异（P〈0.05）。结论分流加断流联合手术门静脉降压及胃黏膜病变改善均明显好于选择性断流术,故联合手术应作为肝硬化门静脉高压症出血治疗的首选术式。     

断流加脾肾静脉分流联合手术治疗门静脉高压症

目的 评价应用断流加脾肾静脉分流联合手术治疗门静脉高压症的效果.方法 对1998年5月至2005年5月我院采用断流加脾肾静脉分流联合手术治疗门脉高压症10例病例进行回顾性总结.结果 手术前后平均自由门静脉压由(3.586±0.54)kPa降至(3.056±0.41)kPa.手术死亡率为0,术后1年内无死亡,无上消化道再出血,无肝性脑病发生,临床疗效满意.结论 断流加脾肾静脉分流联合术既保留了断流术及分流术的优点,又克服了二者的缺点,是治疗门静脉高压症一种合理、可行、理想的术式.     

门奇断流/近端脾肾分流联合手术治疗门脉高压症疗效观察

目的评价门奇断流/近端脾肾分流联合手术治疗门脉高压症的疗效.方法将58例门脉高压症择期手术病人随机分为3组:(1)门奇断流术组(断流组)23例;(2)近端脾肾分流术组(分流组)19例;(3)门奇断流/近端脾肾分流联合手术组(联合组)16例,观察病人手术前后血流动力学指标、门脉高压性胃病的程度及近、远期疗效.结果关腹前联合组自由门静脉压明显低于断流组(P＜0.05),而与分流组的差别无显著性意义(P＞0.05),术后及随访时联合组门静脉直径、门静脉血流量均显著小于断流组(P＜0.05),术后门静脉血流速度和血流量显著大于分流组(P＜0.05);术后断流组门脉高压性胃病的程度明显重于分流组和联合组(P＜0.05),而分流组和联合组间的差别无显著性意义(P＞0.05).3组无手术死亡,近期未发生消化道出血和肝性脑病;在远期疗效上,联合组再出血率显著低于断流组(P＜0.05),肝功能分级显著好于分流组(P＜0.05).结论联合术应为目前门脉高压症外科治疗的理想术式.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.