中国部分地区中老年人群骨质蔬松症流行病学研究

Theresearchisthelargesteffortonosteoporosisthathasbeenundertaken，andoneofthefewcountry－wideglobalefforts．TheresearchisespeciallyimportantwiththesuggestionthatChinesehavelowbonedensityingeneral，andtherapidagingoftheChinesepopulation犤１－２犦．１Materialsandmethods１．１SubjectsSubjectswereobtainedwithinformedconsentfrom５５９３HannationalityandregisteredinfiveareasofChinaincludingNorth，South－middle，East，South－westandNorth－eastbythestrati－fied－multi－steps－clustersamplingmethod…     

曲美他嗪对陈旧性心肌梗死康复期运动耐量的影响

Persistentinsufficientflowofcoronaryarterywillleadtohi－bernationofpartialmyocardiumfollowingmyocardialinfarctionduetocoronaryheartdisease，andthusdecreasingheartfunction，ex－ercisetolerance，andqualityoflifeduringrehabilitationphase．TMZ，theinhibitorof３－KAT，playsthecardinalroleinen－ergymetabolismofmyocardium．Inpresentstudy，weobservedim－pactofTMZonexercisetoleranceofpatientswitholdmyocardialinfarction．１Subjectsandmethod１．１Subjects５８patientssufferedfromcoronaryscopyorclini－…     

奇曼丁治疗晚期癌症疼痛的疗效

Itisestimatedthat７０％patientssufferedfromadvancedtumorsdevelopedpainofdifferentextent．Painaffectsqualityoflifedirect－ly，mind，psychology，socialandpersonalrelationandleadtodis－comfort犤１犦．WiththespreadingofWHOthree－stepmanagement，ad－ministrationwaysaretransformedfromdemanddependanttotimedepend犤１犦．Tramcontin（slowreleasedtramadol），theweakthebaicdrug，cancontrolmoderatepain．１Subjectandmethod１．１Subject１１６caseswithpathologicallyandradiologicallyprovedadvancedtumors（６…     

神经根性疼痛与肿瘤坏死因子相关性研究

Itisgenerallythoughtthatnerveroot，whichiscompressedbydiscprotrusionorbonehyerplasia，doesn＇tresultinpain．PGE－２，PLA－２，NOandsoonareallinflammationagents．TNFisalsoakindofinflammationagent．TNFhaswidebiologyrole．Itsimpor－tancewasemphasizedandithasbeenreportedthatTNFhasex－pressionindisc犤１犦．ThesubjectofthisarticleaimstostudythecorrelationbetweenTNFandnerverootpain．１Subjectsandmethod１．１SubjectsInthearticle４５caseswerereported，male２４cases，female２１cases；cervicalsy…     

采用四股半腱肌肌腱和缝线钢板重建前十字韧带后的康复训练

FromMay１９９７toApril２００１，wereconstructedoldanteriorcruciateligament（ACL）injuryusingquadrupled－strandedsemi－tendinosustendonandsutureplateand１－yearrehabilitationexer－cise，andtherapeuticeffectwasfavorable．Hereisthereport．１Subjectandmethod１．１Subjects５１patients（２７malesand２４femalesaged１３～５７years，meanage：２４．７）enteredourstudy．Patientswithseverecompoundinjuriesofposteriorinnerandouterligamentswereex－cludedfromourstudy．AccordingtoLysholmkneescorescale犤１犦…     

He-Ne激光重复照射抑制培养增生性瘢痕成纤维细胞胶原合成的实验研究

Hypertrophicscar（HS），atypeoffibrosisdiseaseofskinwhichischaracterizedbyhyperproductionanddepositionofcolla－genmatrix．So，inhibitionofcollagensynthesisanddepositionofcollageninfibroblastsareimportantforpreventionofHS犤１犦．Inthecurrentstudy，He－NelaserofvariouspowerdensitywasusedtoirradiateculturedfibroblastsderivedfromHStostudythepre－ventingeffectsofHe－NelaseronHS．１Materialsandmethod１．１Cellcultureandgrouping５casesofHSwereincludedinthisstudyaged１２～３１yearsold（２males，…     

腹膜后转移瘤介入治疗后生存质量随访

Nowadays，interventionaltherapyacquiredmoresignificanceinthetreatmentofmalignanttumors．Weappliedintra－tumorinjectionofanti－carcinomadrugs，inducedbyB－ultrasound，totreatpost－peritoneummetastatictumor．Hereisthereport．１Materialsandmethods１．１Materials１１caseswithpost－peritoneummetastatictumorswerechosenduringJanuary１９９８andJanuary２００１．Theoriginaltumors：２casesoflungcancer，２casesofgastriccarcinomaand６casesofcoliccarcinoma．７malesand４femaleswithaverageageof４９years．１…     

腰椎间盘突出症术后早期主动训练效果的临床观察

FromJanuary１９９３toJanuary１９９９，wehaveobserved７９casesaftertheoperationformonosegmentallumberintervertebraldischer－niationcontinuously，andthepatientsweredividedintoearlyactivetraininggroupandroutinecontrolgrouprandomly，aswellasacceptedtrainingandfollow－upof１～６yearsrespectively．Theresultsshowedthattheearlyactivetraininggrouphadbetterrecentanddistantob－jectiveeffectandmorepatientsweresatisfiedwiththeoperationalef－fects．Sowewillreportitasfollowing．１ObjectsandMethod１．１Obje…     

P27基因对人喉癌细胞抑制作用的研究

１Materialsandmethods１．１CelllinesandvectorHumanlaryngealcarcinomacelllineHep－２weregrowninDulbeccomodifiedEaglemedium．Thep２７eu－karyoticexpressionvectorpCMV－p２７wasagiftfromDrLijinge．１．２DNAtransfectionDNAtransfectionbyLipofectamineac－cordingtothemanufacturer｀sinstructions（Gibco）．１．３AnalysisofcellcyclebyflowcytometryCellstransfectedwithpCMV－p２７werecollectedbytrypsinization，fixedwith７０％ethanol．After４８hours，cellswerecollected，resuspendedin１mloflysisbuffe…     

非稳态噪声作业对油田压裂工人听力损伤的调查研究

１Subjectandmethod１．１Subject１４５６fracturingworkersofoilfieldwererandomlyselectedassubjects．Workerssufferingfromhearinglossduetononindustrialdamagewereexcludedfromthestudy．３５１workerswhodidnotworkedinfracturingplantwereselectedascontrolgroup．１．２MethodUsingfinesound－levelmeterND－２correctedbyChinaAcademic，weassessfieldnoiseofenvironmentwherefrac－turingworkersworkedaccordingtoEvaluationStandardsfornoiseofIndustryandEnterprise．Self－madequestionnairewasusedforas－sessmentofp…     

老年脑卒中后继发性癫痫的相关因素分析

背景老年卒中后继发癫痫是老年人癫痫的主要原因,对卒中的康复和预后有一定的影响.目的探讨卒中后癫痫发作与卒中类型、部位以及卒中面积的关系.设计病例分析.单位山东省千佛山医院神经内科.对象选择1999-01/2004-12山东省千佛山医院神经内科住院的脑卒中后继发癫痫患者68例,男42例,女26例;年龄60～83岁,平均(68±7)岁.患者均知情同意.方法[1]根据入组患者卒中后癫痫首发时间分为早发型癫痫(卒中后2周内发作);迟发性癫痫(卒中后2周后发作),分析癫痫发生时间与卒中类型的关系.[2]根据影像学结果将缺血性卒中(包括脑血栓形成和脑栓塞)按梗死面积分为＜一侧半球的1/4,1/4～1/2和＞1/2;按脑出血量分为小于20 mL,20～40 mL和大于40mL.分析癫痫发作与卒中部位和面积的关系.[3]对患者进行对症治疗,并采用复诊形式进行随访6个月～4年,平均21个月.[4]计数资料差异比较采用χ2检验.结果脑卒中后癫痫发作患者68例均进入结果分析.[1]癫痫发生时间与卒中类型的关系早发性癫痫患者脑出血、蛛网膜下腔出血患者数明显多于迟发性癫痫患者(10,2例;4,0例,P＜0.05),而脑血栓形成患者数明显少于迟发性癫痫患者(3,36例,P＜0.05).[2]癫痫发作与卒中部位和面积的关系脑梗死面积占一侧半球的1/4～1/2和＞1/2患者明显多于＜一侧半球的1/4(26,17,9例,P＜0.05);脑出血20～40和＞40 mL患者明显多于＜20 mL者(4,9,1例,P＜0.05).[3]癫痫发作的预后21例早发性癫痫患者中,6例以癫痫为首发症状,15例患者2周内未再发作.47例迟发性癫痫患者中,18例1年后完全控制;23例癫痫控制良好;6例发作较频繁.结论[1]早发性癫痫以脑出血、蛛网膜下腔出血和脑栓塞为主,迟发性癫痫以脑血栓形成为主.[2]脑梗死面积超过一侧半球面积的1/4,脑出血＞40mL者发生癫痫的危险性明显增高.[3]早发性癫痫的预后较好.     

脑卒中后癫痫的临床、影像学特点与预后分析

目的 探讨脑卒中后继发癫痫的临床表现、影像学特点与预后的关系。方法 对840例脑卒中后出现癫痫发作的患者78例进行临床资料回顾性分析。结果 脑卒中后癫痫的发生率为9.29%,其中早期发作癫痫(2周内)占61.54%,发作类型以部分发作及强直-阵挛发作为主,脑出血及病灶累及皮层者发病率高,对症治疗控制良好,但病死率比无癫痫发作者高(P<0.05)。结论 脑卒中后癫痫多并发于皮层病灶,脑出血比脑梗死多见,控制良好,但预后欠佳。     

脑卒中后症状性癫痫398例临床分析

[目的]探讨脑卒中后症状性癫痫的临床特点,为临床诊治提供指导依据.[方法]对5168例脑卒中患者中的398例症状性癫痫患者的临床资料进行回顾性分析.[结果]脑卒中后症状性癫痫的发生率为7.7%,其中早发型癫痫占59.3%,迟发型癫痫占40.7%;早发型癫痫以脑出血为多,占63.1%,发作类型以全面性发作为多;迟发型癫痫...     

Gender and family composition related to discharge destination and length of hospital stay after acute stroke

Informal care by family members still plays an important role in home care after acute stroke. This study determined the clinical and demographic factors, such as family structure, that predict discharge to home and length of hospital stay (LOS) after acute stroke hospitalization. We reviewed the sex, age, family structure before stroke, type of stroke, size of the lesion, activities of daily living (ADL) function at discharge, discharge destination, and LOS of stroke patients (114 cerebral infarctions and 44 intracerebral hemorrhages) admitted to a neurosurgical hospital. Patients with cerebral infarction were older than those with intracerebral hemorrhage (median 75 vs 66 years). Ninety-eight were discharged to home (62%). In the logistic regression analysis, low ADL function, medium or large infarction, and intracerebral hemorrhage (vs lacunar infarction) were significantly associated with discharge to a destination other than home. Of the patients discharged home, low ADL function was strongly associated with LOS in the multiple regression analysis. In addition, living with a spouse only had the opposite effect on LOS in men and women (p=0.050 and 0.071, respectively). LOS tended to be shorter for men with a wife, but longer for women with a husband. The structure and gender roles in a stroke patient's household may need further attention for the efficient use of hospital resources.     

急性脑卒中患者伴发谵妄的相关因素分析

目的探讨急性脑卒中患者发生谵妄的相关危险因素。方法收集375例脑卒中患者的临床资料,包括年龄、肺部感染、高血压、发热、出血量大小、梗死面积、肝肾功能损伤等指标,评估患者有无谵妄发生。收集到的数据进行描述性分析和二分类回归分析以找出脑卒患者澹妄发生情况和影响因素。结果全部急性脑卒中患者发生谵妄共77名(20.5%)。脑出血患者多因素回归分析示低龄、肺部感染、发热、大量出血均为谵妄发生的高危因素。急性脑梗死多因素回归分析示高龄、发热、大面积梗死均为谵妄发生的高危因素。结论急性脑卒中患者较易发生谵妄。肺部感染、发热、年龄、出血量或梗死面积是谵妄发生的高危因素。     

脑卒中后继发性癫痫的临床研究

【目的】探讨脑卒中后继发性癫痫患者的临床特征。【方法】回顾性分析本院脑卒中后癫痫患者70例的临床资料,分析癫痫发作与脑卒中发作时间、病灶部位的相关性以及癫痫发作类型的发生率。【结果】70例病例中,早发型癫痫45例（64．2％）,迟发型癫痫25例（35．8％）;脑卒中病灶位于皮质的55例,占78．6％,其中颞叶癫痫17例;癫痫发作类型中全身强直阵挛性发作35例,占50％。【结论】脑卒中后癫痫以早发型癫痫为主,病灶部位多位于皮质,而癫痫发作类型多见于全身强直阵挛性。     

急性缺血性脑卒中患者机械取栓后出血转化的影响因素

机械取栓是治疗急性缺血性脑卒中(AIS)极具前景的方法,已成为AIS脑血管闭塞患者的首选治疗方案,可通过缩小梗死区获得更好的临床结果,但仍有50%的患者出现不良结局,以出血转化(HT)最为常见,尤其是实质出血,与神经症状的恶化密切相关。本文就AIS患者经机械取栓治疗后发生HT的影响因素进行综述。     

急性脑梗死静脉溶栓后脑出血的危险因素分析

目的 :探讨与急性脑梗死静脉溶栓治疗后继发脑出血 (ICH)有关的危险因素。方法 :82例急性脑梗死患者在发病 12 h内接受了尿激酶静脉溶栓治疗 ,选取溶栓前的临床和实验室资料作为 ICH的可能危险因素 ,分析与 ICH的关系。结果 :15例患者继发 ICH(18.3% ) ,其中 6例为出血性梗死 (7.3% ) ,9例为脑实质血肿(11.0 % )。发生症状性脑出血 (SICH) 7例 ,死亡 4例。统计学分析表明继发 ICH者有较低的神经功能缺损评分 (ESS) ,ESS评分 <6 0分、溶栓前头颅 CT可见早期缺血改变 (EIC)及存在心房纤颤的患者有更高的出血率。结论 :溶栓前的神经功能缺损程度、CT早期缺血改变和心房纤颤是 ICH的危险因素。     

脑卒中后继发癫痫相关性临床分析

目的 探讨脑卒中与卒中后继发癫痫的关系.方法 回顾性分析脑卒中后继发癫痫42例病例的发作时间、分类及治疗.结果 脑卒中后继发癫痫占同期住院卒中患者的 9.63%(42/436),以早发型、大脑皮质受损常见,迟发型易复发.结论 脑卒中后继发癫痫与卒中类型、病变部位关系密切,应进行正规治疗.     

脑静脉/静脉窦血栓形成合并脑出血的症状特点及危险因素分析

目的 探讨脑静脉/静脉窦血栓形成(cerebral venous sinus thrombosis,CVST)合并脑出血的症状特点,并应用logistic回归分析法分析其危险因素.方法 回顾性分析2016年8月至2019年8月河南省人民医院收治的120例CVST患者的临床资料,根据是否合并脑出血将其分为出血组和未出血组...