共查询到20条相似文献，搜索用时 82 毫秒
1.
2.
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis 
下载免费PDF全文
下载免费PDF全文 Russell R. Nofsinger Pingping Li Suk-Hyun Hong Johan W. Jonker Grant D. Barish Hao Ying Sheue-yann Cheng Mathias LeBlanc Wei Xu Liming Pei Yeon-Joo Kang Michael Nelson Michael Downes Ruth T. Yu Jerrold M. Olefsky Chih-Hao Lee Ronald M. Evans 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(50):20021-20026
3.
SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor 下载免费PDF全文
下载免费PDF全文 Park EJ Schroen DJ Yang M Li H Li L Chen JD 《Proceedings of the National Academy of Sciences of the United States of America》1999,96(7):3519-3524
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Fernández-Majada V Aguilera C Villanueva A Vilardell F Robert-Moreno A Aytés A Real FX Capella G Mayo MW Espinosa L Bigas A 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(1):276-281
Nuclear functions for IkappaB kinase (IKK), including phosphorylation of histone H3 and nuclear corepressors, have been recently described. Here, we show that IKK is activated in colorectal tumors concomitant with the presence of phosphorylated SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor that is aberrantly localized in the cytoplasm. In these tumors, IKKalpha associates to the chromatin of specific Notch targets, leading to the release of SMRT. Abrogation of IKK activity by BAY11-7082 or by expressing dominant negative IKKalpha restores the association of SMRT with Notch target genes, resulting in specific gene repression. Finally, BAY11-7082 significantly reduces tumor size in colorectal cancer xenografts (CRC-Xs) implanted in nude mice. 相似文献
16.
17.
18.
19.