Attempted suicide: Efficacy of treatment programs

Abstract Persons with a history of attempted suicide have an increased risk of eventually committing suicide. Eleven controlled perspective studies are reviewed on treatment programs aimed at reducing the rates of suicide and of repeated suicidal attempt in these considered at risk. None of these aftercare programs had a demonstrable impact on the suicide rate, and only in one investigation was a significant reduction of repeated attempts observed. Lack of statistical power and inadequate treatment strategies are discussed as major contributors to this failure. Recent evidence of a reduction of suicide rates and mortality by consequent and long-term treatment of patients with affective disorders, as well as reports of undertreatment of depression prior to completed suicide, might provide a new stimulus for the development and evaluation of aftercare programs for those who attempt suicide. The available evidence advocates a shift of emphasis from crisis management to the identification and treatment of psychiatric illness in this risk group.     

Attempted suicide in hospitalised schizophrenics

A group of 25 hospitalised schizophrenics who had attempted suicide within the past year was compared with another group of 30 hospitalised schizophrenics who had not attempted suicide, using the PSE symptoms. The former had a significantly higher number of symptoms indicative of a depressive disorder. It is concluded that suicidal risk in schizophrenia is significantly raised when there are concomitant depressive symptoms.     

Attempted suicide and depression in schizophrenia

The relationships between symptoms and both prior suicide attempts and current suicidal thinking were examined in a sample of schizophrenics at 2 points in time. Fifty subjects meeting DSM-III criteria for schizophrenia were assessed within 1 week of admission, and 41 were reassessed at a 6-month follow-up. On admission, prior suicide attempts were significantly associated with current depression, female sex, lower education and more frequent hospitalization. The association with depression remained significant at follow-up. In addition, current suicidal thinking was associated with depression at both times but also with negative symptoms at time 1 and delusions and hallucinations at time 2. These findings confirm and strengthen prior reports of an association between depression and attempted suicide.     

Attempted suicide by elderly Chinese in Singapore

Background: There is a paucity of data on attempted suicide by elderly people in Asian countries. The present paper compares suicide attempts of elderly and young Chinese living in Singapore. Methods: The present study was conducted in a general hospital from 1991 to 2000. All patients were interviewed by a psychiatrist and diagnoses were based on the 3rd edn (revised) of the Diagnostic and Statistical Manual (of Mental Health disorders) (DSM III R) or 4th edn of the Diagnostic and Statistical Manual (of Mental Health disorders) (DSM IV) classification. As well as demographic data, reasons for the suicide attempt and methods used were noted. Results: In the 10 years of the study there were 1568 young (64 years and younger) and 61 elderly (65 years and older) Chinese patients. The male to female ratio was the same in each group. Multiple logistic regression analyses showed that the elderly were more likely to have ingested benzodiazepines (OR: 3.19, CI: 1.34–7.57, P = 0.009), to have a diagnosis of depression (OR: 464, CI: 1.94–11.10, P = 0.001) and to suffer from a physical illness than were the young (OR: 4.39, CI: 1.92–10.04, P = 0.000). Conclusion: The majority of Chinese elderly who attempted suicide had depression and were more likely to have been prescribed benzodiazepines than antidepressants. Prevention strategies in the future should include training programs for doctors to enable them to identify depression and treat depression effectively.     

A 2-Year Psychological Autopsy Study of Completed Suicides in the Athens Greater Area,Greece

ObjectiveTo study the characteristics of a sample of suicide victims from the Athens Greater Area using the psychological autopsy method for the first time in Greece.MethodsWe studied all recorded cases of completed suicide for the 2-year time period November 2007-October 2009 collecting data from the victims'' forensic records as well as from the completion of a psychological autopsy questionnaire.Results335 persons were recorded as suicide victims. We contacted relatives of 256 victims interviewing those of 248 of them (96.9%). The differences regarding sex, marital and employment status between our sample and the general population were statistically significant (p<0.001). The male/female ratio was 3:1. Comparatively more victims were divorced, separated or single and a greater proportion were pensioners or unemployed. 26.0% of the victims had history of prior attempts (64.4% once, 20.3% twice and 15.3% more times). 42.6% were taking psychiatric medication-significantly more women than men according to blood tests; 14.2% had been hospitalized in a psychiatric clinic the year prior to their death. 84.8% have deceased at the place of suicide and 15.2% died in the hospital; 80.3% died indoors and 19.7% outdoors. Men died primarily by hanging or shooting by a firearm while women preferred jumping from height instead (p<0.001). As many as 48.8% had expressed their intention to die to their relatives; 26.6% left a suicide note.ConclusionOur study has shown that the psychological autopsy method is applicable and widely accepted yielding results comparable to the international literature. Specific parameters associated with suicide have been studied for the first time in Greece.     

Attempted suicide in Denmark. IV. A five-year follow-up

From October 1, 1980 to April 20, 1981, 207 patients were admitted to the Department of Psychiatry, Odense University Hospital, after attempting suicide. Information on physical, mental and social conditions was collected. The patients were then followed for 5 years, to register subsequent suicidal behaviour and to try to identify relevant factors for evaluation of future suicide risk. During the follow-up period 11.6% of the attempters committed suicide, the majority within the first year after the index attempt. Seventy-five percent of the suicides were committed less than 6 months after the last contact with the psychiatric ward. Predictors for future suicide were chronic somatic disease, depression, abuse of medicine, and chronic alcohol abuse. The authors emphasize the need for a thorough medical evaluation of patients attempting suicide, to be able to identify and eventually treat these conditions.     

Attempted suicide in Hong Kong

In 1986, psychiatrists saw a total of 307 attempted suicide cases presented to a regional general hospital in Hong Kong, whether admitted or not. Compared with suicide attempts in Hong Kong in 1954 and those in Western countries, suicide attempts in Hong Kong in 1986 were significantly more likely to be precipitated by interpersonal conflicts, and significantly less likely to be precipitated by economic stress. Compared with the methods of attempted suicide in Hong Kong in 1986, those in Hong Kong in 1954 were significantly more likely to be fatal, while those in Western countries are significantly more likely to be ingestion of hyponotics and sedatives. Suicide attempters in Hong Kong are significantly more likely to be diagnosed as schizophrenics or paranoid psychotics than those in Western countries.     

Attempted suicide by jumping: clinical and social features

A group of 46 persons who had attempted suicide by jumping was compared on clinical and social-demographic parameters with another group of 214 persons who had attempted suicide by drug overdose. The differential characteristics of persons attempting suicide by jumping are the following: more often men, of a more advanced age, married or widowed, more often suffering from major psychopathology (that is affective psychosis-depressive type or schizophrenia), and quite frequently having a serious somatic illness.     

Is Religiosity a Protective Factor Against Attempted Suicide: A Cross-Cultural Case-Control Study

This cross-cultural study investigates whether religiosity assessed in three dimensions has a protective effect against attempted suicide. Community controls (n = 5484) were more likely than suicide attempters (n = 2819) to report religious denomination in Estonia (OR = 0.5) and subjective religiosity in four countries: Brazil (OR = 0.2), Estonia (OR = 0.5), Islamic Republic of Iran (OR = 0.6), and Sri Lanka (OR = 0.4). In South Africa, the effect was exceptional both for religious denomination (OR = 5.9) and subjective religiosity (OR = 2.7). No effects were found in India and Vietnam. Organizational religiosity gave controversial results. In particular, subjective religiosity (considering him/herself as religious person) may serve as a protective factor against non-fatal suicidal behavior in some cultures.     

Depression,Anxiety, and Psychological Defense in Attempted Suicide: A Pilot Study using PORT

Depressive affect, anxiety, and psychological defenses were studied in the presented research with PORT, a projective test that exploits subliminal perception of object-relation images. Protocols of 20 hospitalized suicide attempters were compared to those of 20 matched controls, 34 previously studied nonsuicidal depressed patients, 18 patients with panic attack, and 32 patients with borderline and psychotic disorders. The suicide attempters were anxious; their defenses resembled those seen in borderline pathology; depressive reactions were limited in symbolic content; reality testing was poor. The closeness between depression and anxiety in suicidality is further discussed throughout this article. A constellation of signs using the PORT test was hypothesized to be a marker for suicidality. The test is deemed useful for future research on suicide.     

Attempted suicide predicts suicide risk in mood disorders

Suicide risk was studied in a sample of 346 mood disorder inpatients, 92 of whom were admitted after a current suicide attempt. The overall suicide mortality after a mean observation period of 6 years was 8%. The potential of attempted suicide to predict suicide risk in hospitalized patients with mood disorders was studied by survival analysis after subgrouping on the basis of whether a current suicide attempt had occurred or not. The suicide risk the first year after attempting suicide was 12% (11/92), compared with 2% (4/254) in the mood disorder subgroup with no current suicide attempt. The long-range suicide risk after a current suicide attempt in depression was 15% (14/92) as compared with 5% (13/254) among those without a current suicide attempt. It is concluded that a current suicide attempt in mood disorder inpatients predicts suicide risk particularly within the first year and should be taken very seriously.     

Social dysfunction in depressives and attempted suicides

In this study, a group of depressed patients who did not attempt suicide was compared with a group of depressed patients who attemptd suicide. All were English females. The two groups were comparable with regards to social class, and marital status. The suicidal group was younger. The results show no significant difference between the two groups in the degree of severity of depression, which was assessed using the Hamilton Depression Rating Scale. However, there was a significant difference in the degree of social dysfunction between the two groups. This was assessed using the Social Dysfunction Rating Scale described by Linn and co-authors.     

Sociodemographic and Psychopathological Risk Factors for Repetition of Attempted Suicide: A 5-Year Follow-Up Study

The present study examines the association between repetition of suicide attempts and sociodemographic and psychopathological characteristics of patients during a 5-year follow-up period. Participants were 874 suicide attempters referred to the University Hospital of Ghent, among whom 361 (41.3%) patients were available for follow-up analysis. Within 5 years, 29.2% of those admitted for an index suicide attempt repeated non-fatal suicidal behavior. Repetition of suicidal behavior was associated with high scores on measures of psychopathology. In addition, the risk of repetition was increased if the patient was female, aged between 20 and 49, and had a lower education. Multivariate analysis showed significant results for age, the Buglass & Horton Risk of Repetition Scale and for anxiety. Repetition of suicidal behavior is associated with high anxiety, severe depression, more psychiatric symptoms and is increased in young patients.     

Attempted suicide and suicide in functional psychoses.

A total of 2,243 first admissions to Gaustad Hospital between 1938 and 1961 diagnosed as functional psychotics were either followed up to the time of their death within 5 years, or observed over a period of 5 years, and then reexamined. Of these patients, 325 had attempted suicide prior to their admission. The frequency of attempted suicide was equal in both sexes. Men appeared to use more dangerous methods, and to have more serious intentions. The psychosis appears to have been of importance when considering whether, but not how the suicide should be attempted. The greatest risk of attempted suicide was to be found amongst patients with psychoses of a depressive nature. Twenty-eight of the 2,243 patients in this study committed suicide within 5 years following their discharge, and a further 20 took their own lives prior to the reexamination. A certain connection can be seen between attempted suicide and psychotic symptoms.     

Attempted suicide: repetition and survival--findings of a follow-up study.

OBJECTIVE: This was a prospective follow-up study of suicidal patients to assess the influence over time of different risk factors, whether on completed suicides or reattempts. Survival analysis makes it possible to weigh the influence of variables that increase or decrease a patient's life span or that make reattempts less likely. METHOD: A cohort of 150 patients admitted to a psychiatric department after a suicide attempt was followed up over 10 years. The study protocol used standardized criteria, and periodic controls were carried out in all patients. RESULTS: In total, 12% of patients completed suicide, 10% died from natural causes, 75% were still alive and 25% reattempted. In the survival analysis the risk for completed suicide or reattempting was highest during the first 2 years after the index attempt admission. Global Assessment of Functioning (GAF) was the factor that most increased survival time. The number of previous attempts decreased survival time and increased the risk of reattempts. CONCLUSION: Since suicidal risk varied over time, intensifying contact with patients during periods of psychopathological change or life events could prolong their survival.     

Diagnoses, Psychosocial Stressors and Adaptive Functioning in Attempted Suicide

A systematic sample of 78 suicide attempters (37 men and 41 women), of whom 83% were hospitalized, were interviewed according to SCID I and II and Axes III-V according to DSM-III-R. Mood disorders were most common (56%). Forty-four suicide attempters (56%) suffered from comorbid diagnoses on Axis I-II. Borderline personality disorder was more common among women then men (56% vs. 24%, respectively, p = 0.01). Axis III disorders were confirmed for 45%. Sixty-two percent of the suicide attempters had severe psychosocial stressors (Axis IV). When comparing subjects with only Axis I disorders to those with Axis I and II disorders, no difference with respect to psychosocial stressor grade was observed. Moreover, those with only Axis I disorders were not impaired in their adaptive functioning (Axis V) even if severe psychosocial stressors were present. In contrast, an association (p = 0.02) was found between high stress and low functioning in patients with both Axis I and Axis II disorders. The data suggest that in clinical practice, beside evaluation of Axis I and Axis II disorders, also stressors and global functioning should be included in the assessment of suicide risk after attempted suicide.     

Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12.

BACKGROUND: We are interested in identifying susceptibility genes that predispose subjects to attempted suicide. METHODS: We conducted a secondary analysis of genome-wide linkage data from 162 bipolar pedigrees that incorporated attempted suicide as a clinical covariate. RESULTS: The strongest covariate-based linkage signal was seen on 2p12 at marker D2S1777. The logarithm of odds (LOD) score at marker D2S1777 rose from 1.56 to 3.82 after inclusion of the suicide covariate, resulting in significant chromosome-wide empirically derived p-values for the overall linkage finding (p = .01) and for the change in LOD score after the inclusion of the covariate (p = .02). CONCLUSIONS: The finding on chromosome 2 replicates results from two previous studies of attempted suicide in pedigrees with alcohol dependence and in pedigrees with recurrent early-onset depression. Combined, these three studies provide compelling evidence for a locus influencing attempted suicide on 2p12.     

A Dose-Response Relationship Between Imitational Suicides and Newspaper Distribution

Although the Werther effect is well known, up to now a correlation between the differential distribution of particular media reports and subsequent imitational suicides could not be found. This study investigates a celebrity suicide by gun in Austria, which led to extensive reports in the largest Austrian newspaper, whose distribution shows substantial regional differences. The numbers of suicides by firearm in the 3 weeks after the reporting showed an increase over the 3 weeks prior. Regional analysis revealed a strong correlation of suicides by firearm and distribution of the newspaper (log odds ratios; r(9) = .62; p = .04, one-tailed). This dose-response effect explains 40% of the variability of changes. These results underline the influence of media reports on suicidal behavior.     

Attempted and completed suicide in older subjects: results from the WHO/EURO Multicentre Study of Suicidal Behaviour

OBJECTIVE: The authors present an analysis of findings for the 65 years and over age group from the WHO/EURO Multicentre Study of Suicidal Behaviour (1989-93). METHODS: Multinational data on non-fatal suicidal behaviour is derived from 1518 subjects in 16 European centres. Local district data on suicide were available from 10 of the collaborating centres. RESULTS: Stockholm (Sweden), Pontoise (France) and Oxford (UK) had the highest suicide attempts rates. In most centres, the majority of elderly who attempted suicide were widow(er)s, often living alone, who used predominantly voluntary drug ingestion. Non-fatal suicidal behaviour decreased with increasing age, whereas suicide rates rose. The ratio between fatal and non-fatal behaviours was 1:2, that for males/females almost 1:1. In the years considered, substantial stability in suicide and attempted suicide rates was observed. As their age increased, suicidal subjects displayed only a limited tendency to repeat self-destructive acts. Moreover, there was little correlation between attempted suicide and suicide rates, which carries different clinical implications for non-fatal suicidal behaviour in the elderly compared with younger subjects in the same WHO/EURO study.