共查询到20条相似文献,搜索用时 15 毫秒
1.
W. A. Weber J. Neverve J. Sklarek S. I. Ziegler P. Bartenstein B. King T. Treumann A. Enterrottacher M. Krapf K. E. Häußinger H. Lichte H. W. Präuer O. Thetter M. Schwaiger 《European journal of nuclear medicine and molecular imaging》1999,26(4):388-395
Dual-head gamma cameras operated in coincidence mode are a new approach for tumour imaging using fluorine-18 fluorodeoxyglucose
(FDG). The aim of this study was to assess the diagnostic accuracy of such a camera system in comparison with a full-ring
positron emission tomography (PET) system in patients with lung cancer. Twenty-seven patients (1 female, 26 males, age 62±9
years) with lung cancer or indeterminate pulmonary nodules were studied on the same day with a full-ring PET scanner (Siemens
ECAT EXACT) and a coincidence gamma camera system (ADAC Vertex MCD). Sixty minutes after injection of 185–370 MBq FDG, a scan
of the chest was performed with the full-ring system. Approximately 2 h p.i., the coincidence camera study was performed.
Coincidence gamma camera (CGC) and PET images with (PETac) and without attenuation correction (PETnac) were analysed independently
by two blinded observers. In addition, FDG uptake in primary tumours and involved lymph nodes was quantified relative to normal
contralateral lung (T/L ratios). All primary tumours were histologically proven. The lymph node status was histologically
determined in 23 patients. In four patients, no lymph node sampling was performed because of extensive disease or concurrent
illnesses. In the 27 patients, 25 primary lung cancers and two metastatic lesions were histologically diagnosed. The number
of coincidences per centimetre axial field of view was 3.33±0.93×105 for the CGC and 1.09±0.36×106 for the dedicated PET system. All primary tumours (size: 4.6±2.6 cm) were correctly identified in the CGC and dedicated PET
studies. T/L ratios were 4.7±2.5 for CGC and 6.9±2.8 for PETnac (P <0.001). Histopathological evaluation revealed lymph node metastases in 11 of 88 sampled lymph node stations (size: 2.3±1.0 cm).
All lymph node metastases were identified in the PETac studies, while PETnac detected 10/11 and CGC 8/11. For positive lymph
nodes that were visible in CGC and PETnac studies, T/L ratios were 3.7±2.3 for CGC and 6.6±3.1 for PETnac (P=0.02). The diameters of false-negative lymph nodes in the CGC studies were 0.75, 1.5 and 2 cm. False-positive FDG uptake in
lymph nodes was found in two patients with all three imaging methods. For all lesions combined, T/L ratios in CGC relative
to PETnac studies decreased significantly with decreasing lesion size (r=0.62; P<0.001). In conclusion, compared with a full-ring PET system the sensitivity of CGC imaging for detection of lung cancer is
limited by a lower image contrast which deteriorates with decreasing lesion size. Nevertheless, the ability of CGC imaging
to detect pulmonary lesions with a diameter of at least 2 cm appears to be similar to that of a full-ring system. Both systems
provide a similar specificity for the evaluation of lymph node involvement.
Received 29 August and in revised form 7 December 1998 相似文献
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3.
Nowak B Zimny M Schwarz ER Kaiser HJ Schaefer W Reinartz P vom Dahl J Buell U 《European journal of nuclear medicine》2000,27(10):1501-1508
This study assessed a dual-head coincidence gamma camera (hybrid PET) equipped with single-photon transmission for myocardial fluorine-18 fluorodeoxyglucose (FDG) imaging by comparing this technique with conventional positron emission tomography (PET) using a dedicated ring PET scanner. Twenty-one patients were studied with dedicated FDG ring PET and FDG hybrid PET for evaluation of myocardial glucose metabolism, as well as technetium-99m tetrofosmin single-photon emission tomography (SPET) to estimate myocardial perfusion. All patients underwent transmitted attenuation correction using germanium-68 rod sources for ring PET and caesium-137 point sources for hybrid PET. Ring PET and hybrid PET emission scans were started 61+/-12 and 98+/-15 min, respectively, after administration of 154+/-31 MBq FDG. Attenuation-corrected images were reconstructed iteratively for ring PET and hybrid PET (ac-hybrid PET), and non-attenuation-corrected images for hybrid PET (non-ac-hybrid PET) only. Tracer distribution was analysed semiquantitatively using a volumetric vector sampling method dividing the left ventricular wall into 13 segments. FDG distribution in non-ac-hybrid PET and ring PET correlated with r=0.36 (P<0.0001), and in ac-hybrid PET and ring PET with r=0.79 (P<0.0001). Non-ac-hybrid PET significantly overestimated FDG uptake in the apical and supra-apical segments, and underestimated FDG uptake in the remaining segments, with the exception of one lateral segment. Ac-hybrid PET significantly overestimated FDG uptake in the apical segment, and underestimated FDG uptake in only three posteroseptal segments. A three-grade score was used to classify diagnosis of viability by FDG PET in 136 segments with reduced perfusion as assessed by SPET. Compared with ring PET, non-ac-hybrid PET showed concordant diagnoses in 80 segments (59%) and ac-hybrid PET in 101 segments (74%) (P<0.001). Agreement between ring PET and non-ac-hybrid PET was best in the basal lateral wall and in the apical-septal segment (80%-100%), and lowest in the apical, supra-apical and posteroseptal segments (41%-55%). Ac-hybrid PET showed highest agreement in the lateral wall (89%-100%), and lowest agreement in the apical and the basal septal segments (59%-67%). In conclusion, non-uniform attenuation correction with singles transmission significantly improves the diagnostic accuracy of myocardial dual-head gamma camera coincidence imaging with FDG. However, results equivalent to those obtained with ring PET cannot yet be attained, even if attenuation correction is applied. New rebinning algorithms for three-dimensional data may further improve the performance of ac-hybrid PET and should be evaluated in future studies. 相似文献
4.
Bernd Nowak Michael Zimny Ernst Ruediger Schwarz Hans-Juergen Kaiser Wolfgang Schaefer Patrick Reinartz Juergen vom Dahl Udalrich Buell 《European journal of nuclear medicine and molecular imaging》2000,27(10):1501-1508
This study assessed a dual-head coincidence gamma camera (hybrid PET) equipped with single-photon transmission for myocardial fluorine-18 fluorodeoxyglucose (FDG) imaging by comparing this technique with conventional positron emission tomography (PET) using a dedicated ring PET scanner. Twenty-one patients were studied with dedicated FDG ring PET and FDG hybrid PET for evaluation of myocardial glucose metabolism, as well as technetium-99m tetrofosmin single-photon emission tomography (SPET) to estimate myocardial perfusion. All patients underwent transmitted attenuation correction using germanium-68 rod sources for ring PET and caesium-137 point sources for hybrid PET. Ring PET and hybrid PET emission scans were started 61ᆠ and 98ᆣ min, respectively, after administration of 154ᆳ MBq FDG. Attenuation-corrected images were reconstructed iteratively for ring PET and hybrid PET (ac-hybrid PET), and non-attenuation-corrected images for hybrid PET (non-ac-hybrid PET) only. Tracer distribution was analysed semiquantitatively using a volumetric vector sampling method dividing the left ventricular wall into 13 segments. FDG distribution in non-ac-hybrid PET and ring PET correlated with r=0.36 (P<0.0001), and in ac-hybrid PET and ring PET with r=0.79 (P<0.0001). Non-ac-hybrid PET significantly overestimated FDG uptake in the apical and supra-apical segments, and underestimated FDG uptake in the remaining segments, with the exception of one lateral segment. Ac-hybrid PET significantly overestimated FDG uptake in the apical segment, and underestimated FDG uptake in only three posteroseptal segments. A three-grade score was used to classify diagnosis of viability by FDG PET in 136 segments with reduced perfusion as assessed by SPET. Compared with ring PET, non-ac-hybrid PET showed concordant diagnoses in 80 segments (59%) and ac-hybrid PET in 101 segments (74%) (P<0.001). Agreement between ring PET and non-ac-hybrid PET was best in the basal lateral wall and in the apical-septal segment (80%-100%), and lowest in the apical, supra-apical and posteroseptal segments (41%-55%). Ac-hybrid PET showed highest agreement in the lateral wall (89%-100%), and lowest agreement in the apical and the basal septal segments (59%-67%). In conclusion, non-uniform attenuation correction with singles transmission significantly improves the diagnostic accuracy of myocardial dual-head gamma camera coincidence imaging with FDG. However, results equivalent to those obtained with ring PET cannot yet be attained, even if attenuation correction is applied. New rebinning algorithms for three-dimensional data may further improve the performance of ac-hybrid PET and should be evaluated in future studies. 相似文献
5.
Zimny M Hochstenbag M Lamers R Reinartz P Cremerius U ten Velde G Buell U 《European radiology》2003,13(4):740-747
The aims of the present study were (a) to evaluate mediastinal staging in patients with lung cancer with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose
(FDG) using a coincidence gamma camera (hybrid PET) in comparison with dedicated positron emission tomography (PET) and computed
tomography (CT), and (b) to assess the feasibility to determine standardized uptake values (SUV) with hybrid PET. Forty patients
were included in the study. Hybrid PET was performed without and with attenuation correction. Data were rebinned with single-slice
(SSRB) or Fourier rebinning (FORE). The SUVs of primary tumors were calculated with hybrid PET and compared with SUVs determined
by dedicated PET. Diagnostic accuracy for hybrid with or without attenuation correction was 80 or 74% compared with 82% for
dedicated PET, and 63% for CT. Attenuation-corrected hybrid PET revealed a higher specificity than CT (83 vs 52%; p<0.05). The SUVs of primary tumors were similar to those of hybrid PET and dedicated PET with a mean relative difference of
20.8±16.4%. The FORE improved the agreement of SUVs with a mean relative difference of 13.8±9.9 vs 36.0±17.9% for SSRB (p<0.001). Hybrid PET with attenuation correction is more specific than CT for mediastinal staging in patients with lung cancer
(p<0.05). It reveals similar results in comparison with dedicated PET. Calculation of SUVs with hybrid PET is feasible.
Electronic Publication 相似文献
6.
De Sutter J De Winter F Van de Wiele C De Bondt P D'Asseler Y Dierckx R 《European journal of nuclear medicine》2000,27(6):676-685
Dual-headed gamma cameras with coincidence detection (MCD) are increasingly used for imaging of positron-emitting tracers, such as fluorine-18 fluorodeoxyglucose (FDG). In this study, we examined differences between FDG MCD and FDG positron emission tomography (PET) as the gold standard to determine whether FDG MCD could be used for assessment of myocardial viability in daily practice. Nineteen patients with a previous myocardial infarction (17 men; mean left ventricular ejection fraction 44%+/-13%) underwent FDG MCD, FDG PET, resting echocardiography and technetium-99m tetrofosmin gated single-photon emission tomography (SPET). At the 50% threshold value for FDG PET, the area under the receiver operating characteristic curve for FDG MCD was 0.77+/-0.03. In 107 dyssynergic segments on echocardiography and 151 segments with hypoperfusion on 99mTc-tetrofosmin SPET, the specificity of FDG MCD for the detection of myocardial viability was 72% and 76% respectively, with a sensitivity of 69% and 72% respectively. Regional analysis showed a significantly lower agreement of FDG MCD and FDG PET in the inferior and septal regions (58% for dyssynergic segments and 65% for segments with hypoperfusion), as compared with the other regions (85% for dyssynergic regions, P<0.05, and 86% for segments with hypoperfusion, P<0.05). Five patients (26%), who all had a body mass index > or =25% kg/m2, showed more than 25% disagreement between FDG MCD and FDG PET. Because of the moderate overall agreement with FDG PET, the low sensitivity in akinetic or dyskinetic regions and the low agreement in the inferior and septal regions, further studies and implementations of technical developments are needed before FDG MCD can be introduced into clinical practice for the assessment of myocardial viability. 相似文献
7.
Cardiac fluorine-18 fluorodeoxyglucose imaging using a dual-head gamma camera with coincidence detection: a clinical pilot study 总被引:1,自引:0,他引:1
Johan De Sutter Frederic De Winter Christophe Van de Wiele Pieter De Bondt Yves D’Asseler Rudi Dierckx 《European journal of nuclear medicine and molecular imaging》2000,27(6):676-685
Dual-headed gamma cameras with coincidence detection (MCD) are increasingly used for imaging of positron-emitting tracers,
such as fluorine-18 fluorodeoxyglucose (FDG). In this study, we examined differences between FDG MCD and FDG positron emission
tomography (PET) as the gold standard to determine whether FDG MCD could be used for assessment of myocardial viability in
daily practice. Nineteen patients with a previous myocardial infarction (17 men; mean left ventricular ejection fraction 44%±13%)
underwent FDG MCD, FDG PET, resting echocardiography and technetium-99m tetrofosmin gated single-photon emission tomography
(SPET). At the 50% threshold value for FDG PET, the area under the receiver operating characteristic curve for FDG MCD was
0.77±0.03. In 107 dyssynergic segments on echocardiography and 151 segments with hypoperfusion on 99mTc-tetrofosmin SPET, the specificity of FDG MCD for the detection of myocardial viability was 72% and 76% respectively, with
a sensitivity of 69% and 72% respectively. Regional analysis showed a significantly lower agreement of FDG MCD and FDG PET
in the inferior and septal regions (58% for dyssynergic segments and 65% for segments with hypoperfusion), as compared with
the other regions (85% for dyssynergic regions, P<0.05, and 86% for segments with hypoperfusion, P<0.05). Five patients (26%), who all had a body mass index ≥25% kg/m2, showed more than 25% disagreement between FDG MCD and FDG PET. Because of the moderate overall agreement with FDG PET, the
low sensitivity in akinetic or dyskinetic regions and the low agreement in the inferior and septal regions, further studies
and implementations of technical developments are needed before FDG MCD can be introduced into clinical practice for the assessment
of myocardial viability.
Received 4 December 1999 and in revised form 5 February 2000 相似文献
8.
Yanagawa T Watanabe H Inoue T Ahmed AR Tomiyoshi K Shinozaki T Oriuchi N Endo K Takagishi K 《Journal of computer assisted tomography》2003,27(2):175-182
PURPOSE: Recently, a new positron emission tomography (PET) tracer, carbon-11 choline, has been introduced in oncology investigations, but the role of choline PET in musculoskeletal tumor evaluation has not been previously examined. This is the first trial to investigate the utility of choline PET in evaluating musculoskeletal tumors in comparison with fluorine-18 fluoro-2-deoxy-D-glucose (FDG) PET. METHOD: Thirty-three patients were examined with both choline PET and FDG PET, of which standardized uptake values (SUVs) were used for evaluation of the lesions. To decide the appropriate cutoff value and compare the two PET studies, receiver operating characteristic curve analysis was used. The binomial test was used for comparison of sensitivities between choline PET and FDG PET. RESULTS: A significant correlation (r = 0.537, P = 0.0013) between choline and FDG SUVs was noted for all lesions (n = 33). Mean SUVs for malignant tumors were significantly higher than those for benign lesions in both choline PET and FDG PET. Using a cutoff value of 2.7 for choline SUVs, the sensitivity for correctly diagnosing malignancy was 92.3% (12/13) with a specificity of 90.0% (18/20), resulting in an accuracy rate of 90.9%. With use of a cutoff value of 3.3 for SUVs in FDG PET, the sensitivity was 84.6% (11/13) with a specificity of 80.0% (16/20), resulting in an accuracy rate of 81.8%. The receiver operating characteristic curves of two analyses showed that the mean area under the curve value of choline PET (0.9577 +/- 0.041) was significantly greater (P = 0.0488) than that of FDG PET (0.8192 +/- 0.0806). There was no significant difference in sensitivity and specificity between choline PET and FDG PET analysis using either the binomial test (P = 0.4531) or McNemar test (P = 0.371). CONCLUSION: Choline PET analysis may not be inferior to FDG PET analysis for differentiating malignant from benign musculoskeletal tumors. The advantages of choline PET were shorter examination time and little retention in the bladder; therefore, this modality may be useful for preoperative planning for musculoskeletal tumors, especially for lesions around the hip joints. 相似文献
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The detection of local recurrent head and neck cancer with fluorine-18 fluorodeoxyglucose dual-head positron emission tomography. 总被引:2,自引:0,他引:2
M P Stokkel C H Terhaard G J Hordijk P P van Rijk 《European journal of nuclear medicine》1999,26(7):767-773
Primary tumors of the larynx and hypopharynx are preferably treated with high-dose radiation therapy. In these patients, it may be difficult to distinguish recurrent disease from post-treatment reactions. The aim of the present study was to assess the value of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in the detection of local relapses of laryngeal or hypopharyngeal carcinoma after radiotherapy using a dual-head PET camera. Forty-eight patients (43 male, 5 female; mean age +/-SD, 61+/-9.5 years) with suspected recurrent laryngeal or hypopharyngeal cancer were prospectively studied. The mean interval between initial treatment and suspicion of recurrent disease was 14.6 months (range: 3-100 months). FDG dual-head PET was followed by endoscopy with or without biopsy under general anaesthesia within a period of 2 months in all patients. The mean period of follow-up after FDG dual-head PET was 13.7 months. In 19 out of 31 patients with focally increased uptake, tumour recurrence (mean diameter: 2.4 cm; range 0.4-6.5 cm) was found at initial endoscopy. In five patients recurrence was found during follow-up with a mean interval of 6.6 months. Seven patients had a false-positive study due to benign lesions or swallowing artefacts. In none of the patients with a normal PET study was tumour recurrence found during follow-up. The sensitivity and specificity of FDG dual-head PET were 100% and 71%, respectively. It is concluded that FDG dual-head PET is highly sensitive for the detection of local recurrence of laryngeal and hypopharyngeal carcinoma after radiotherapy. Some lesions were detected with a mean interval of 6.6 months before histological confirmation. In patients suspected of having recurrent laryngeal or hypopharyngeal cancer in whom FDG-PET is negative, endoscopy may be omitted for at least 6 months and possibly for up to 1 year. 相似文献
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Detection of lung cancer with positron coincidence gamma camera using fluorodeoxyglucose in comparison with dedicated PET 总被引:2,自引:0,他引:2
Zhang H Tian M Oriuchi N Higuchi T Tanada S Endo K 《European journal of radiology》2003,47(3):199-205
OBJECTIVE: Dual-head gamma cameras with sodium iodide (NaI) detectors operated in coincidence mode provide a new approach for imaging with positron-labeled tracers. The purpose of this study was to evaluate the feasibility of FDG imaging with positron coincidence detection gamma camera (PCD) in detecting lung tumor in comparison with FDG imaging with the dedicated positron emission tomography (PET). METHODS AND MATERIAL: Twenty-six lesions of 13 patients with suspected lung cancer were studied with both FDG PET and FDG PCD on the same day. Pulmonary lesions were analyzed visually and semi-quantitatively using the ratio of target-to-background counts (T/B ratio). RESULTS AND CONCLUSIONS: FDG PCD and FDG PET could detect visually 21 lesions (80.8%) and 23 lesions (88.0%), respectively. The mean T/B ratio and standard deviation (S.D.) of FDG PCD was 4.6 +/- 3.9, significantly lower than that of FDG PET (11.4 +/- 6.6, P<0.001). When pulmonary lesions were no more than 2.0 cm in diameter, the sensitivity of FDG PCD was 37.5%, significantly inferior to that of FDG PET (62.5%, P<0.001). There was no statistically significant difference of the sensitivity between the FDG PCD and FDG PET in lesions of more than 2.0 cm in diameter. FDG PCD with uniform attenuation correction was clinically available in detecting lung cancer. However, the sensitivity for small lesions less than 2.0 cm was limited. The application of measured attenuation correction and scatter correction may to be needed to improve the detectability of FDG PCD, especially for detecting small lung cancer. 相似文献
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Detection of occult bone metastases of lung cancer with fluorine-18 fluorodeoxyglucose positron emission tomography 总被引:1,自引:0,他引:1
Accurate staging of cancer has a critical role in optimal patient management. Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) is superior to CT in the detection of local and distant metastases in patients with non-small cell lung cancer. Although Tc-99 m methylene diphosphonate (MDP) bone scanning is well established in the evaluation of bone metastases, there are conflicting reports on the use of FDG PET in the evaluation of skeletal metastases. We report on a patient with locally advanced lung carcinoma in whom FDG PET accurately identified previously unsuspected widespread asymptomatic bone metastases (bone scan and X-rays negative, confirmed on MRI). Assessment of glucose metabolism with FDG PET might represent a more powerful tool to detect bone metastases in lung cancer compared with conventional bone scans. 相似文献
13.
Feasibility of fluorodeoxyglucose dual-head gamma camera coincidence imaging in the evaluation of lung cancer: comparison with FDG PET. 总被引:14,自引:0,他引:14
M Tatsumi K Yutani Y Watanabe S Miyoshi N Tomiyama T Johkoh H Kusuoka H Nakamura T Nishimura 《Journal of nuclear medicine》1999,40(4):566-573
The purpose of this study was to elucidate the feasibility of fluorodeoxyglucose gamma camera coincidence imaging (FDG GCI) in the evaluation of lung cancer in comparison with FDG PET. METHODS: Twenty-three patients with recently diagnosed lung cancer were examined with both FDG PET and FDG GCI on the same day. Pulmonary lesions were analyzed visually and semiquantitatively using the ratio of lesion-to-background counts (L/B ratio). The L/B ratio of FDG PET without attenuation correction (AC) was also calculated and compared. Nodal stations were only visually analyzed. RESULTS: FDG GCI and FDG PET could detect 22 and 23, respectively, of 23 pulmonary lesions by visual analysis (95.7% versus 100%). The L/B ratio of FDG GCI was 4.26 +/- 2.55, and significantly lower than that of FDG PET (9.29 +/- 4.95; P < 0.01). The L/B ratio of FDG PET was significantly higher with AC than that without AC (9.29 +/- 4.95 vs. 6.66 +/- 4.65; P < 0.01). When the L/B ratio threshold was set at 5.0 for FDG PET and 2.7 for FDG GCI, their sensitivity was 87.0% and 73.9%, respectively. Of the 3 and 6 patients with false-negative results on semiquantitative analysis, the lesions in 3 patients on FDG PET and 4 patients on FDG GCI were less than or equal to 2.0 cm in greatest diameter, respectively. In the assessment of mediastinal involvement, FDG PET was 77.8% sensitive, 78.6% specific and 78.3% accurate, whereas FDG GCI was 77.8% sensitive, 92.9% specific and 87.0% accurate. In the hilar regions, FDG PET was 100% sensitive, 84.2% specific and 87.0% accurate, whereas FDG GCI was 75.0% sensitive, 89.5% specific and 87.0% accurate. CONCLUSION: In this study, FDG GCI yielded results comparable to FDG PET on visual analysis to detect pulmonary lesions and lymph node metastases. However, the lesion-to-background contrasts of pulmonary lesions and nodal involvement were lower in FDG GCI than in FDG PET. Comparison between the L/B ratio of FDG PET with and without AC indicated that, with AC, FDG GCI would be closer to FDG PET in the evaluation of lung cancer. 相似文献
14.
Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose 总被引:11,自引:3,他引:11
P. Rigo P. Paulus B. J. Kaschten R. Hustinx T. Bury G. Jerusalem T. Benoit J. Foidart-Willems 《European journal of nuclear medicine and molecular imaging》1996,23(12):1641-1674
Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and follow-up. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved. 相似文献
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Imran MB Kubota K Yoshioka S Yamada S Sato T Fukuda H Yoshioka T Kanamaru R Fujiwara T Itoh M 《Clinical nuclear medicine》1999,24(5):305-308
Whole-body serial positron emission tomography scanning was done using fluorine-18 fluorodeoxyglucose (F-18 FDG) in a patient with a mediastinal mass. Uptake correlated well with the clinical symptoms and aggressiveness of the disease. Based on the F-18 FDG findings, a biopsy specimen was taken from the active region of the mass, which confirmed the diagnosis of sclerosing mediastinitis. 相似文献
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Optimal scan time for fluorine-18 fluorodeoxyglucose positron emission tomography in breast cancer 总被引:4,自引:0,他引:4
A. R. Boerner M. Weckesser H. Herzog T. Schmitz W. Audretsch U. Nitz H. G. Bender H.-W. Mueller-Gaertner 《European journal of nuclear medicine and molecular imaging》1999,26(3):226-230
Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) has proven useful in the differentiation of various
tumour entities, including breast cancer. In patients with primary breast cancer we performed a 3-h imaging protocol to examine
possible improvements in tumour detectability and image contrast. Twenty-nine patients with primary breast cancer with a diameter
of ≥2 cm that was demonstrated to be malignant by biopsy or surgery were injected with 370–740 MBq 18F-FDG and scanned in the prone position. Data were acquired 0–40 min, 1.5 h and 3.0 h after injection. After correction for
measured attenuation, decay and scatter and iterative reconstruction, standardised uptake values (SUVs) and tumour-to-non-tumour
and tumour-to-organ ratios were calculated. Visual analysis was performed using transverse, sagittal and coronal slices as
well as 3D reprojection images. Tumour-to-non-tumour and tumour-to-organ ratios were significantly higher for the 3-h images
than for the 1.5-h images. SUVs did not increase to the same extent. Lesion detectability was 83% in 1.5-h images compared
to 93% in 3-h images. We conclude that tumour contrast in breast cancer is improved by starting the PET acquisition at 3 h
p.i. rather than at 1.5 h p.i.
Received 17 October and in revised form 8 December 1998 相似文献