盆炎消止痛Ⅰ号方与坤复康片联合治疗慢性盆腔炎的临床对比研究

目的:观察盆炎消止痛Ⅰ号方联合坤复康片治疗慢性盆腔炎的临床疗效。方法:选取本院2015年11月-2016年8月收治的慢性盆腔炎患者86例,按数字奇偶法将其分为观察组和对照组,每组43例。对照组使用坤复康片治疗,观察组在坤复康片的基础上联合盆炎消止痛Ⅰ号方进行治疗。治疗期间观察两组临床症状,记录盆腔炎性包块面积和血液流变学指标变化;观察两组治疗过程中不良反应发生情况;比较两组治疗总有效率。结果:治疗前,两组盆腔炎性包块面积和血液流变学指标比较,差异均无统计学意义(P0.05);治疗后,两组盆腔炎性包块面积和血液流变学指标均有所降低,观察组盆腔炎性包块面积[(4.30±2.23)cm~2]和血液流变学指标[(5.66±1.37)mm/h]比对照组[(8.66±2.32)cm~2、(11.27±2.39)mm/h]降低幅度更大(P0.05)。观察组总有效率为88.37%(38/43),对照组为69.77%(30/43),观察组高于对照组(P0.05)。观察组不良反应发生率为2.33%(1/43),对照组为13.95%(4/86),观察组不良反应率明显比对照组低(P0.05)。结论:与单纯应用坤复康片治疗相比,联合盆炎消止痛Ⅰ号方治疗慢性盆腔炎更有显著疗效,可有效降低患者的盆腔炎性包块面积和血液流变学指标,缓解病状,减少不良反应的发生,提高治疗总有效率,该方法安全可靠,具有较高的临床推广价值。     

坤复康胶囊联合氧氟沙星治疗盆腔炎性包块的临床疗效

目的观察坤复康胶囊联合氧氟沙星治疗盆腔炎性包块的临床疗效。方法选择符合诊断标准的145例盆腔炎性包块患者,随机分为两组,对照组72例采用左氧氟沙星注射液0.2×100 ml,静脉滴注,每日2次;治疗组73例在对照组基础上口服坤复康胶囊,4粒/次,3次/d。两组均以10天为一疗程,共3个疗程,观察各组症状改变及临床疗效。结果治疗组总有效率为93.15%,对照组总有效率为75.00%,两组比较,差异有统计学意义(P<0.01),治疗组的疗效显著优于对照组。结论坤复康胶囊联合抗生素治疗盆腔炎性包块可取得良好的临床疗效。     

坤复康片联合抗生素治疗慢性盆腔炎的临床疗效分析

目的 探讨坤复片联合抗生素治疗慢性盆腔炎的临床疗效.方法 选择本院2011～2012年确诊符合诊断标准的慢性盆腔炎患者160例,随机分为两组,对照组80例患者采用静脉滴注头孢曲松钠和奥硝唑;治疗组80例在对照组基础上加服坤复康片,7天为1个疗程,共3个疗程,分别统计两组的临床疗效.结果 治疗组总有效率为93.75％,对照组总有效率为66.25％,两组总有效率比较,差异有显著性(P＜0.05).结论 坤复康片联合抗生素治疗慢性盆腔炎疗效显著,优于单独应用抗生素.     

少腹康颗粒治疗慢性盆腔炎的临床疗效观察

目的 评价少腹康颗粒治疗慢性盆腔炎的临床疗效.方法 将符合慢性盆腔炎诊断标准的60例随机分为2组:治疗组34例,口服少腹康颗粒,每日3次,20g/次;对照组26例,口服妇科千金片,每日3次,每次2片.服药4周为1个疗程.结果 治疗组总有效率88.20%,对照组总有效率61.50%,比较2组疗效差异有显著性(P<0.05).结论 少腹康颗粒治疗慢性盆腔炎疗效显著,未见不良反应.     

妇康口服液治疗慢性盆腔炎的临床疗效观察附:120例病例报告

目的探讨妇康口服液对盆腔炎的有效性及安全性.方法随机对照分组.试验组124例(急性盆腔炎34例,慢性盆腔炎90例),予妇康口服液10ml tid,疗程分别为2周和4周;对照组64例(急性34例,慢性30例),分别予青霉素、庆大霉素、甲硝唑 iv,每日1次,金鸡冲剂 1包 tid ,疗程同治疗组.观察指标包括疗效性指标及安全性指标.结果妇康口服液治疗急性盆腔炎显效率88.24%,与对照组比较疗效相似(P＞0.05);治疗慢性盆腔炎显效率73.33%,对照组46.67%,两组比较差异有统计学意义(P＜0.01).结论妇康口服液治疗盆腔炎疗效确切,对慢性盆腔炎的疗效优于对照组.治疗期间,该药未发现不良反应,说明该药使用安全.     

黄藤素序贯联合运动疗法治疗反复发作盆腔炎效果分析

目的:观察黄藤素序贯联合运动疗法治疗反复发作盆腔炎的临床效果及安全性.方法:选取我院2012年1月～2013年1月间收治的反复发作盆腔炎患者60例,随机分为治疗组与对照组,治疗组患者采用黄藤素序贯联合运动疗法治疗,对照组采用替硝唑联合盐酸环丙沙星静滴及肌内注射胎盘组织液治疗;对比两组患者治疗前及治疗后6个月时中医证候积分、血液流变学改善情况,并在彩超下测定盆腔炎性包块面积变化及临床疗效.结果:治疗组治疗后中医证候积分、盆腔炎性包块面积缩小显著优于对照组(P＜0.05);两组患者治疗后血液流变学各项指标较治疗前显著下降(P＜0.05),但组间比较无统计学差异(P＞0.05);治疗组治疗后总有效率显著高于对照组(P＜0.05).结论:黄藤素序贯联合运动疗法可有效改善反复发作盆腔炎患者临床症状,降低血液流变学指标,控制炎症发展,且无明显不良反应,疗效显著.     

中西药联合治疗慢性盆腔炎的疗效及药物作用机制

目的 研究中西药联合治疗慢性盆腔炎的疗效及药物作用机制.方法 选取2018年1月至2019年5月本院收治的慢性盆腔炎患者122例作为研究对象,根据随机数字表法分为西药组和联合组,各61例.西药组采用西药治疗,联合组在西药组的基础上根据患者中医症状分型加服中药.比较两组患者治疗前后盆腔炎性包块直径、盆腔积液深度、炎症因子水平、不良反应发生率、临床疗效及中医症状分级量化积分.结果 联合组总有效率为96.72％,显著高于西药组的85.25％(P<0.05);治疗后,两组盆腔炎性包块直径和盆腔积液深度均显著降低,且联合组显著低于西药组(P<0.05);治疗后,两组IL-6、TNF-α和CRP水平均显著降低,且联合组显著低于西药组(P<0.05);治疗后,两组患者中医症状分级量化积分均显著降低,且联合组显著低于西药组(P<0.05);两组患者治疗期间均无不良反应发生.结论 中西药联合治疗慢性盆腔炎能显著提升临床疗效,降低炎症因子、盆腔炎性包块直径及盆腔积液深度,且安全性较高,值得临床推广应用.     

丹芪蒲藤汤治疗慢性盆腔炎临床研究

目的:观察丹芪蒲藤汤治疗慢性盆腔炎的临床疗效.方法:将156例慢性盆腔炎的患者随机分为治疗组和对照组,治疗组78例,口服中药治疗；对照组78例,用西药治疗,7d为1疗程.2疗程后评定疗效.结果:2组比较差异有显著性(P＜0.05)；中药治疗可明显改善下腹及腰骶疼痛、痛经、白带量多等主要临床症状(P＜0.05).结论:中...     

抗生素及中药保留灌肠续贯治疗盆腔炎性包块疗效观察

目的 观察中药保留灌肠治疗盆腔炎性包块的疗效.方法 将盆腔炎性包块165例随机分为治疗组及时照组,两组均使用青霉素钠、甲硝唑、庆大霉素.对照组抗生素治疗2周,口服妇科千金片1周;治疗组使用抗生素1周后给予中药保留灌肠并药渣热敷下腹部2周.结果 治疗组显效率明显优于对照组(P<0.0005),总有效率治疗组优于对照组(P<0.05).结论 抗生素及中药保留灌肠续贯治疗盆腔炎性包块较单用抗生素治疗方法效果明显.     

妇科千金片联合西药治疗慢性盆腔炎的疗效与安全性分析

目的 探讨妇科千金片联合西药治疗慢性盆腔炎的临床疗效及安全性.方法 在我院2014年1月-6月收治的慢性盆腔炎患者中随机抽取60例,并分为观察组和对照组.对照组进行常规的抗生素克林霉素磷酸酯片治疗,观察组则在对照组的基础上加用妇科千金片,1个疗程后观察2组的疗效及不良反应情况.结果 观察组显效15例,有效13例,无效2例,总有效率93.3％;对照组显效9例,有效10例,无效11例,总有效率63.3％,观察组总有效率显著高于对照组,差异具有统计学意义(P＜0.05).不良反应方面,观察组出现2例,对照组出现3例,差异不具有统计学意义(P＞0.05).结论 妇科千金片与克林霉素磷酸酯片合用,对慢性盆腔炎效果显著,且无明显不良反应,可进一步推广.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.