裸花紫珠片联合阿达帕林凝胶治疗寻常痤疮的临床研究

目的观察裸花紫珠片联合阿达帕林凝胶治疗寻常痤疮的临床疗效。方法126例寻常痤疮患者,随机分为阿达帕林凝胶组(A组)62例和裸花紫珠片联合阿达帕林凝胶组(B组)64例,A组外用阿达帕林凝胶治疗;B组在A组的基础上加用裸花紫珠片;两组分别于治疗前、治疗后2 w、4w记录不良反应并判断疗效。结果治疗2 w时A组总有效率为54.84%,B组为70.31%,B组疗效优于A组(P0.05);治疗4 w时A组总有效率为74.19%,B组为85.94%,B组疗效优于A组(P0.05);A组的不良反应发生率为35.48%,B组为10.94%,B组明显低于A组(P0.01)。结论裸花紫珠片联合阿达帕林凝胶治疗寻常痤疮比单用阿达帕林凝胶有更好的疗效和安全性。     

红蓝光照射联合复方多粘菌素B治疗寻常型痤疮

目的:探讨红蓝光照射与复方多粘菌素B软膏治疗中、重度寻常型痤疮的临床疗效.方法:将65例中、重度寻常型痤疮患者随机分为2组,治疗组采用复方多粘菌素B软膏联合红蓝光照射治疗,对照组仅用红蓝光照射治疗,连续治疗4周,治疗后对疗效进行评分,比较两组治疗有效率.结果:治疗组的临床疗效明显高于对照组,其有效率为85.7％,对照组的有效率为63.3％,差异有统计学意义(P＜0.05).结论:红蓝光照射联合复方多粘菌素B软膏治疗寻常型痤疮起效快、疗效好、安全性好.     

复方多黏菌素B软膏治疗脓疱病的临床疗效观察

目的:通过观察复方多黏菌素B软膏和2%莫匹罗星软膏治疗脓疱病的临床疗效及不良反应,为复方多黏菌素B软膏的临床应用提供依据。方法:将146例脓疱疮患者分为两组:复方多黏菌素B软膏(孚诺)组和莫匹罗星软膏(百多邦)组。两组患者均将药物直接涂抹在皮损表面,2次/d。分别在第3天和第7天进行随访,并对疗效进行判定,同时记录不良反应。结果:复方多黏菌素B软膏在治疗脓疱疮临床有效率为96%,与莫匹罗星软膏相比,差异有统计学意义(P<0.05)。结论:复方多黏菌素B软膏治疗脓疱疮方面临床疗效显著,且无明显不良反应。     

裸花紫珠片治疗慢性湿疹疗效观察

目的观察裸花紫珠片联合外用地塞米松软膏治疗慢性湿疹的疗效。方法将82例慢性湿疹患者随机分为2组,治疗组口服裸花紫珠片,同时外用地塞米松软膏;对照组单纯外用地塞米松软膏,疗程20d。结果治疗组有效率为74%,对照组为53%,2者之间差异有显著性（P〈0.05）。结论裸花紫珠片联合外用地塞米松软膏治疗慢性湿疹疗效显著,可供临床选用。     

复方多黏菌素B软膏治疗脓疱疮的效果观察

目的探讨复方多黏菌素B软膏治疗脓疱疮的临床效果。方法选择滑县人民医院2015年6月至2016年6月收治的脓疱疮患儿45例,随机分为对照组和观察组。对照组23例接受红霉素软膏外涂治疗,观察组22例接受复方多黏菌素B软膏治疗。比较两组患儿的治疗效果。结果治疗后观察组皮损厚度、皮损硬度、皮损面积和瘙痒程度等症状评分均低于对照组,差异有统计学意义(P<0.05)。对照组和观察组治疗总有效率分别为73.9%和95.5%,差异有统计学意义(P<0.05)。两组患儿治疗期间均未发生明显不良反应。结论复方多黏菌素B软膏治疗脓疱疮效果显著,值得临床推广应用。     

裸花紫珠治疗痤疮50例临床观察

目的 探讨内服裸花紫珠片对痤疮治疗效果的影响。方法 痤疮患者100例，随机分为裸花紫珠片内服，配合痤康王擦剂外用(治疗组)50例，口服维生素B6，配合痤康王擦剂外用(对照组)50例。结果 两组最后的疗效评估经统计学处理有显著的差异性。治疗组在消除炎症，改善症状，缩短病程等方面均优于对照组。结论 裸花紫珠片对痤疮的治疗效果显著。     

中药辨证论治联合裸花紫珠片治疗寻常痤疮的疗效观察

目的:评价中药辨证论治联合裸花紫珠片治疗寻常痤疮的临床疗效。方法:将84例寻常痤疮患者,按中医辨证分为三型:肺胃郁热型、肠胃湿热型、痰瘀互结型,按证型口服相应汤药,同时配合裸花紫珠片,均用药4周后评价疗效。结果:肺胃郁热型有效率为82.3%,肠胃湿热型有效率79.3%,痰瘀互结型有效率61.9%。结论:中药辨证论治联合裸花紫珠片治疗寻常痤疮疗效显著。     

复方珍珠暗疮胶囊联合胶原贴治疗寻常痤疮疗效观察

目的:探讨复方珍珠暗疮胶囊联合胶原贴治疗面部寻常痤疮的疗效。方法:选择面部寻常痤疮患者168例,随机分为两组,每组84例,分别用复方珍珠暗疮胶囊联合胶原贴治疗(治疗组)和复方珍珠暗疮胶囊联合0.1%阿达帕林凝胶治疗(对照组),对比两组的治疗效果。结果:治疗结果显示治疗组总有效率为78.57%,优于对照组的有效率(57.14%),其差异有统计学意义(P<0.01)。结论:复方珍珠暗疮胶囊联合胶原贴治疗寻常痤疮效果明显,值得临床推广。     

盐酸美他环素治疗寻常性痤疮临床疗效观察

目的观察盐酸美他环素治疗寻常性痤疮的疗效。方法将67例寻常性痤疮患者分为两组，治疗组37例，口服盐酸美他环素胶囊0．2g，2次／d；对照组30例，口服罗红霉素片0．15g，2次／d。两组均外用自制的2％复方氯酊2次／d。疗程均为4周。结果治疗组有效率为89．19％，对照组有效率为73．33％，两组比较差异有显著性（P〈0．05）。结论盐酸美他环素治疗寻常性痤疮疗效较好。     

中西医结合治疗寻常型痤疮的临床观察

目的:观察青鹏软膏联合米诺环素、阿达帕林凝胶治疗寻常型痤疮的疗效。方法:将64例轻、中度寻常型痤疮患者随机分成两组,实验组采用青鹏软膏联合米诺环素、阿达帕林凝胶治疗,对照组采用米诺环素与阿达帕林凝胶治疗。两组均治疗9周后统计分析治疗疗效。结果:治疗组、对照组有效率分别为87.5%、50.0%(P<0.05),不良反应比较无统计学差异(P>0.05)。结论:青鹏软膏联合米诺环素、阿达帕林凝胶治疗寻常型痤疮疗效满意。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.