半夏泻心汤联合胃复安足三里穴位注射防治化疗后呕吐的临床研究

目的评价半夏泻心汤联合胃复安足三里穴位注射在防治化疗后呕吐中的作用。方法观察在化疗后用半夏泻心汤联合胃复安足三里穴位注射和单纯静脉滴注胃复安注射液两组恶性呕吐发生率差异,将化疗患者64例,随机分成两组,各32例。除在化疗时常规应用昂丹司琼止呕,治疗组在化疗前1天至化疗后3 d,加用胃复安10 mg足三里穴位注射,化疗后3 d内配合半夏泻心汤口服;对照组在化疗前1 d到化疗后3 d内静脉滴注胃复安注射液10 mg+生理盐水100 m L。记录两组患者恶性呕吐次数及临床症状情况。结果化疗后第4天统计结果示,治疗组有效率为93.75%,对照组为90.63%,两者相比无显著差异;恶性呕吐0级发生率治疗组为62.50%,对照组为43.75%,治疗组明显优于对照组。结论半夏泻心汤联合胃复安足三里穴位注射能够有效控制恶性呕吐次数,且能明显改善患者生活质量。     

足三里注射甲氧氯普胺联合格拉斯琼预防化疗所致恶心、呕吐的疗效观察

目的:观察足三里注射甲氧氯普胺联合静脉滴注格拉斯琼预防化疗所致恶心、呕吐的临床效果。方法:将98例恶性肿瘤化疗患者随机分成2组,治疗组49例采用足三里注射甲氧氯普胺联合静脉滴注格拉斯琼,对照组49例仅用格拉斯琼静脉滴注;观察2组预防恶心、呕吐的临床效果。结果:治疗组预防恶心、呕吐的有效率为91.84%,明显高于对照组的65.31%(P<0.01)。结论:足三里穴位注射甲氧氯普胺联合静脉滴注格拉斯琼预防恶性肿瘤化疗所致的恶心、呕吐,效果优于单独静脉滴注格拉斯琼。     

足三里穴位注射胃复安预防化疗所致恶心呕吐30例

目的观察足三里穴位注射胃复安预防肿瘤化疗所致恶心、呕吐的临床疗效。方法将60例肿瘤化疗患者随机分为2组。治疗组30例,化疗前30 min胃复安10 mg足三里穴位注射;对照组30例,化疗前30 min胃复安10 mg肌肉注射。2组化疗前30 min均予以格拉司琼3 mg静滴。结果治疗组有效率为90%,明显高于对照组的66.6%（P<0.05）。结论胃复安穴位注射可有效提高化疗所致恶心呕吐的控制率。     

针灸联合穴位注射预防化疗呕吐临床研究

目的:观察胃复安足三里穴位注射配合针刺内关穴防治化疗呕吐的临床疗效。方法:将56例化疗患者随机分为对照组和观察组,对照组肌肉注射胃复安治疗,观察组采用胃复安双侧足三里穴位注射配合针刺内关穴治疗。结果:对照组显效15例,有效8例,无效4例,有效率为85.19%;观察组显效18例,有效9例,无效2例,有效率为93.09%。观察组有效率高于对照组(P<0.05)。结论:胃复安足三里穴位注射配合针刺内关能显著的预防癌症化疗患者呕吐的作用。     

掀针联合胃复安穴位注射治疗化疗相关恶心、呕吐

目的:观察掀针联合胃复安穴位注射治疗食管癌患者顺铂联合5-氟尿嘧啶(PF)方案化疗引起的恶心、呕吐的疗效.方法:64例接受PF方案化疗期间出现恶心呕吐的食管癌患者依据随机数字表法随机平均分为研究组和对照组.对照组给予胃复安穴位注射,研究组在对照组治疗基础上给予掀针.两组均连续治疗3d.治疗后,比较两组患者治疗前后恶心、...     

胃复安穴位注射足三里治疗慢性肾衰竭恶心呕吐的效果观察

目的观察胃复安注射液穴位注射足三里治疗慢性肾衰竭患者恶心呕吐的疗效。方法采用随机对照的方法将住院的115例慢性肾衰竭伴恶心呕吐患者分为对照组(55例)和观察组(60例)。观察组应用胃复安注射液10mg注射足三里穴。对照组常规臀部肌内注射胃复安。应用R-INVR国际量表评估两组患者治疗后1～5天恶心呕吐的发生情况。结果治疗后,两组患者1～2天治疗恶心呕吐效果无统计学意义(P0.05)观察组3～6天治疗恶心呕吐效果优于对照组(P0.05)。结论胃复安穴位注射足三里,能更好的改善慢性肾衰竭患者恶心呕吐的症状。     

足三里穴药物注射治疗围化疗期恶心、呕吐的疗效观察及护理

目的:化疗是肿瘤患者常用的治疗方法,治疗中产生的恶心、呕吐不良反应常引起脱水、代谢紊乱等不良后果,严重者可影响化疗的正常进行。因此,为减轻患者化疗所致的胃肠道反应,采用胃复安加VitB6足三里穴位注射。方法:按随机对照原则,建立相应的治疗组和对照组,治疗组采用胃复安加VitB6足三里穴位注射,对照组采用胃复安肌内注射。结果:治疗组发生恶心反应42例,占87.5%,呕吐反应23例,占47.9%,6例无明显恶心呕吐;对照组发生恶心反应47例,占100%,呕吐反应38例,占80.8%,两组比较差异有统计学意义(P<0.05)。结论:足三里穴位药物注射治疗围化疗期恶心、呕吐的疗效显著。     

穴位注射防治全麻术后恶心呕吐的临床疗效观察

目的:观察穴位注射足三里防治全麻术后恶心呕吐的疗效。方法:对300例全麻手术患者进行术后临床观察,对照组150例,术前半小时给予胃复安、维生素B6静脉注射。治疗组150例,采用穴位注射足三里。结果:治疗组术后恶心、呕吐总发生率为9%,对照组术后恶心、呕吐总发生率为30%,两组发生率经统计学处理P<0.01,有明显差异。结论:穴位注射明显降低术后恶心、呕吐的发生率。     

止呕散穴位贴敷防治顺铂所致消化道反应的临床观察

目的 探讨止呕散外敷穴位加昂丹司琼与单用昂丹司琼在预防肺癌顺铂化疗后恶心呕吐的效果.方法 选取"GP"或"NP"方化疗的非小细胞肺癌共80例,随机分为对照组与治疗组,每组各40例.对照组常规化疗,止吐药选择昂丹司琼;治疗组在对照组基础上,加用由半夏、吴茱萸、生姜等组成的止呕散贴敷患者双侧内关穴、梁门穴和足三里穴,每日更换,21 d为一个观察周期.结果 治疗组控制恶心症状有效率为90.0%,完全控制率为57.5%;控制呕吐症状有效率为92.5%,完全控制率为72.5%;对照组控制恶心症状有效率为72.5%,完全控制率为30.0%;控制呕吐症状有效率为77.5%,完全控制率为40.0%;两者差异有统计学意义(P＜0.05).结论 穴位贴敷治疗可有效防治顺铂所致消化道反应.     

胃复安穴位注射防治化疗后恶心呕吐的Meta分析

目的评价足三里穴位注射甲氧氯普胺（胃复安）防治恶性肿瘤化疗所致恶心呕吐的效果。方法检索万方数据库、重庆维普数据库、CNKI、PubMed、CBM中关于胃复安穴位注射防治恶性肿瘤化疗所致恶心呕吐的临床文献,纳入胃复安穴位注射联合5-HT3受体拮抗剂（治疗组）与单用5-HT3受体拮抗剂（对照组）防治化疗所致恶心呕吐比较的随机对照试验（RCT）和临床对照试验（CCT）,评价质量并提取有效数据,采用RevMan5.2软件进行Meta分析。结果共纳入5篇文献,共计254例患者。Meta分析显示胃复安穴位注射联合5-HT3受体拮抗剂与单用5-HT3受体拮抗剂防治化疗所致恶心呕吐的总有效率相比较,差异具有统计学意义[合并RR（固定效应模型）=6.59,95%可信区间（3.53,12.28）,Z=5.93,P<0.01]。结论胃复安穴位注射联合5-HT3受体拮抗剂防治化疗所致恶心呕吐的总有效率优于单用5-HT3受体拮抗剂,故可初步认为,胃复安穴位注射联合5-HT3受体拮抗剂防治化疗所致恶心呕吐是有效的。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.