Melkersson-Rosenthal综合征1例

患者女,50岁。因唇部反复进行性红肿伴轻微瘙痒半年就诊。皮肤科情况:上唇弥漫性红肿,压之无凹陷,上下唇红斑脱屑。口角略向右侧歪斜,左侧鼻唇沟变浅,吹口哨嘴唇,并向右侧倾斜,伸舌稍向左侧歪斜,舌体肥大,舌面有明显沟纹。上唇皮损病理检查示:真皮浅层可见弥漫性淋巴细胞、少量上皮样细胞和多核巨细胞浸润。诊断:Melkersson-Rosenthal综合征。     

Melkersson-Rosenthal综合征1例

患者男,41岁。口唇进行性肿胀4年,双手麻木2周,皱襞舌。皮损组织病理示:真皮深部可见非坏死性肉芽肿。诊断:Melkersson-Rosenthal综合征。     

Melkersson-Rosenthal综合征和口面部肉芽肿病

Melkersson-Rosenthal综合征的主要特征为反复面部水肿、面部瘫痪和阴囊舌。其病因尚不清楚,典型的组织学为非干酪样坏死性肉芽肿。口面部肉芽肿病则包括一系列病谱。目前无满意疗法,仅为对症处理,局部外用和系统性皮质类固醇比较有效。     

Melkersson-Rosenthal综合征并发反复口腔溃疡1例

患者，男，24岁，因首颜面肿胀8年，反复口腔溃疡6年就诊，患者于8年前无明显诱因出现颜面肿胀，以唇部及颊部明显，自觉口唇麻木，开始可自行消退，以后颜面肿胀反复发作，持续不消，逐渐加重，曾于某医院诊断为“自管性水肿”，给予抗组胺药治疗无好转。6年来反复出现口腔溃疡，常多发，自觉疼痛，     

2例Melkersson-Rosenthal综合征患者免疫状态的检测

目的 :总结分析两例Melkersson Rosenthal(MRS)综合征患者的临床表现、组织病理和治疗转归 ,探讨其可能的免疫学发病机制。方法 :对 2例MRS患者的外周血IL 2、IFN γ、IL 4、IL 1 0水平应用ELISA方法作检测。结果 :2例MRS患者外周血Th1型血细胞因子IL 2、IFN γ水平明显低于正常对照组 ,Th2型细胞因子LI 4、IL 1 0水平和正常对照组相比增高。结论 :Th1 /Th2细胞动态平衡打破 ,可能是MRS的一个重要发病机制     

Melkersson-Rosenthal综合征1例

患者男，32岁，因口唇肿胀7年，反复面瘫5年，加重3个月，于2003年12月就诊于我院，8年前患者左上眼睑经蚊虫叮咬后出现肿胀，逐渐扩展至左面颊部，予口服抗生素和清热解毒中药治疗无效，经静脉滴注地塞米松后好转，7年前曾因“感冒”出现口唇肿胀，经静脉滴注地塞米松后症状不缓解，且口唇肿胀逐渐加重，持续不退。近5年来5次出现左侧或右侧面瘫经针     

2例Melkersson-Rosenthal综合征患的检测者免疫状态

目的：总结分析两例Melkersson-Rosenthal(MRS)综合征患者的临床表现、组织病理和治疗转归，探讨其可能的免疫学发病机制。方法：对2例MRS患者的外周血IL-2、IFN-γ、IL-4、IL-10水平麻用ELISA方法作检测。结果：2例MRS患者外周血Th1型血细胞因子IL-2、IFN-γ水平明显低于正常对照组，Th2型细胞因子LI-4、IL-10水平和正常对照组相比增高。结论：Th1／Th2细胞动态平衡打破，可能是MRS的一个重要发病机制。     

女性完全型Reiter综合征1例

<正>临床资料患者女.25岁,农民。周身红斑鳞屑脓疱疹半年.加重半个月。患者半年前发现阴道较多黄棕色稀薄分泌物,头皮、躯干、四肢及外阴起粟粒至蚕豆大红斑、丘疹及脓疱。曾在当地拟"阴道炎"治疗1周无好转。半个月前皮疹明显增多。3天前双眼红.摩擦性疼痛及视物不清,腰椎及右膝关节疼痛。发病以来自觉发热,体温未测。偶有乏力,无腹痛、腹泻及恶心呕吐,无尿频、尿急及尿痛,无胸闷气短。既     

Melkersson-Rosenthal综合征1例

<正>1临床资料患者男,20岁,学生。褶皱舌15年,上唇肿胀1年。患者15年前,发现舌部出现皱褶、萎缩,无伴不适。1年前无明显诱因上唇出现肿胀、肥厚,无伴瘙痒、疼痛,食用海鲜或饮酒后加重,伴脱屑。日晒后,病情无明显加重。患者曾至外院诊治,行唇部皮损病理活检术,考虑肉芽肿性唇炎,予抗组胺、糖皮质激素等治疗后,病情无明显改善。患者既往3年前     

Melkersson-Rosenthal综合征一例

患者73岁，因下唇反复肿胀4年，持续加重20余天就诊。自诉4年前非婚性接触史后，发现下唇轻微肿胀，伴有右脸麻木及轻微肿胀，可自行缓解。因恐感染性病，4年来先后8次到多家医院反复检查梅毒、淋病、支原体、衣原体，结果均为阴性，自行外用百多邦等药物，无好转。     

Association of Melkersson-Rosenthal Syndrome with Rosacea

A rare case of Melkersson-Rosenthal syndrome with all the cardinal signs of the triad, including facial swelling, facial nerve palsy and glossitis, is described. The additional feature of this case was an association with rosacea.     

Melkersson-Rosenthal Syndrome in India: Experience with Six Cases

Six patients with Melkersson-Rosenthal syndrome (M-R syndrome) were presented. Their ages varied from 20 to 60 years; age at onset was between 15 and 50 years. In all 6 patients, swelling started first over the lower lip. Associated facial palsy, facial edema, and scrotal tongue were found in three, four and one patients, respectively. Lip biopsies from 5 patients failed to show any granuloma. Intralesional corticosteroids produced mild regression of labial swelling in two patients after 6 injections. In one patient, near total reduction of labial swelling and facial edema was achieved after 5 months of clofazimine treatment. However, there was no improvement of facial palsy. To the best of our knowledge, this is the largest series of M-R syndrome reported from India.     

变形综合征1例

患儿男,2岁。右侧躯干、肢体肥大2年。手足脑回状结缔组织痣,腹部表皮痣,右侧肢体不成比例的过度生长,脂肪组织不规则分布,脉管畸形。皮损组织病理示:真皮浅中层见大量的成熟的脂肪组织。符合变形综合征的诊断标准。     

Peutz-Jeghers综合征1例

患者男,32岁。口唇、口腔黏膜、手足出现褐色斑点24年。皮肤科检查示:唇部、颊黏膜、齿龈、双手指规则的黑色色素沉着斑。肠镜示多发息肉。诊断:Peutz-Jeghers综合征。     

Successful treatment of Melkersson-Rosenthal Syndrome with lymecycline

The cause of Melkersson-Rosenthal syndrome, a granulomatous, inflammatory disease is still unknown. Many treatments have been tried with variable and often disappointing results. We report the case of a 31-year-old woman affected by Melkersson-Rosenthal syndrome, who has been successfully treated with lymecycline, after variable results with steroids alone or combined with antihistamines, sulphasalazine and clofazimine.     

Melkersson-Rosenthal Syndrome with Genitalia Involved in a 12-Year-Old Boy

Melkersson–Rosenthal syndrome (MRS) is an uncommon granulomatous disease characterized by the triad of relapsing facial paralysis, orofacial swelling, and fissured tongue. Genital swelling in MRS is rarely reported. We presented the first case of complete MRS with genital swelling in a child. Biopsy examinations of both the child''s lower lip and penis showed noncaseating granuloma and intralymphatic granuloma infiltration. No symptoms or signs of other systemic disease (Crohn''s disease or sarcoidosis) were observed after 2 years of follow-up. Genetic screening for CARD15/NOD2 in this patient showed negative, which further confirmed the diagnosis of MRS. Eleven other cases of suspected complete or incomplete MRS with genitalia involved were reviewed. Our case emphasizes the specific clinical feature of MRS with genitalia involved, which was genetically different from Crohn''s disease and could be an independent entity. Lymphatic obstruction is responsible for localized edema in MRS.     

抗磷脂抗体综合征1例

患者女,71岁。6个月前间断出现双下肢紫癜,7d前双小腿出现红斑和坏死,疼痛剧烈,抗心磷脂抗体IgM明显升高,狼疮抗凝物(LAC)和抗β2-糖蛋白I(β2-GPⅠ)均(+),皮损组织病理示:小血管内血栓形成。诊断:抗磷脂抗体综合征。予抗凝治疗3周后患者皮损明显好转。提示临床医师对此类坏死皮损应考虑到本病的可能性,及时予以抗凝治疗。