功能性消化不良44例危险因素调查分析

目的：探讨不良饮食、生活习惯及精神心理因素与功能性消化不良的关系。方法：采用功能性消化不良危险因素调查表评定病人饮食、生活习惯及心理健康状况。包括采用焦虑自评量表（SAS）和自评抑郁量表（SDS）评定病人情绪状况。结果：功能性消化不良病人与非功能性消化不良人群相比存在明显焦虑、抑郁心理，其发生率差异有明显统计学意义（P〈0．01），而不良的饮食生活习惯的发生率在上述两者之间无明显差异（P〉0．05）。结论：功能性消化不良病人存在较重的焦虑、抑郁心理。     

胃癌患者家属心理健康状况分析

目的探讨胃癌患者家属心理健康状况。方法采用症状自评量表（SCL-90）、抑郁自评量表（SDS）、焦虑自评量表（SAS）及自编一般项目调查表对88例住院胃癌患者家属进行测评。结果住院胃癌患者家属SCL-90评分高于国内常模（P〈0．01）,女性家属SDS、SAS评分高于男性家属（P〈0．05）,无业者SDS、SAS评分高于有业者（P〈0．01,P〈0．05）。结论胃癌患者家属心理健康状况不容乐观,应积极进行心理社会干预。     

癌症患者的心身状况及心理干预

【目的】研究癌症患者的心身状况及心理干预对心身状况的影响。【方法】采用症状自评量表（SCL-90）、焦虑自评量表（SAS）、抑郁自评量表（SDS）评定癌症组（72例）、肝炎对照组（30例）及健康对照组（30例）的心身状况，并随机72例癌症患者分为两组，干预组（40例）接受生物学治疗及心理干预，对照组（30例）只接受生物学治疗，治疗后用上述量表再评定一次。【结果】癌症组的SAS标准分、SDS抑郁指数及各项抑郁特异症状评分、SCL-90总分、阳性均分、躯体化、抑郁、焦虑因子分高于肝炎组和健康组（P〈0．01）；干预组SAS标准分、SDS指数、SCL-90总分、躯体化、抑郁、焦虑及敌对因子分干预后评定显著低于干预前（P〈0．01），SAS标准分、SDS指数、SCL-90抑郁因子的减分值显著高于对照组（P〈0．01）。【结论】癌症患者有明显的焦虑抑郁症状，心身状况较差；心理干预能有效改善癌症患者的焦虑抑郁情绪，减轻心理症状。     

肠易激综合征患者的心理健康状况分析

目的：探讨肠易激综合征（IBS）与心理健康状况之间的关系．方法：采用心理卫生自评量表（SCL-90）、抑郁自评量表（SDS）、焦虑自评量表（SAS）对40例IBS患者进行了调查．结果：IBS组在躯体化、强迫症状、抑郁、焦虑、恐怖、偏执因子分及总分方面均高于对照组和急性胃炎组（P〈0．05）;IBS组SDS,SAS分值均高于对照组（P〈0．05）．结论：IBS患者存在一定程度的心理异常,心理因素可能在IBS发病过程中起重要作用．     

车伤患者心理健康状况的调查和分析

目的：调查并分析车伤患者伤后心理健康状况,为临床护理工作提供理论依据。方法：采用心理症状自评量表（SCL-90）、焦虑自评量表（SAS）和抑郁自评量表（SDS）调查300例车伤患者的心理健康状况,并与国内常模相比较。结果：车伤患者SCL-90总均分及各维度评分、SAS和SDS评分均明显高于国内常模,差异有统计学意义（P〈0．01）。车伤患者的创伤严重度评分（ISS）与人际敏感、抑郁、焦虑和偏执等SCL-90各维度评分呈显著正相关,且与SAS和SDS呈显著正相关（P〈0．01或〈0．05）。结论：车伤患者伤后心理健康状况较差,护理人员应在重视其心理健康状态并及时给予心理干预。     

Ⅱ型糖尿病患者的心理状况调查分析

目的：了解Ⅱ型糖尿病患者的心理状况。方法：采用症状自评量表（SCL-90），抑郁自评量表（SDS）和焦虑自评量表（SAS）对50例Ⅱ型糖尿病患者进行心理状况问券调查，并对50例体检正常者进行对照。结果：Ⅱ型糖尿病患者在SCL-90量表总分，阳性项目分、躯体化、焦虑、抑郁、恐怖以及SAS、SDS量表得分与对照组相比，差异有显著性（P〈O．05～0、01）。结论：Ⅱ型糖尿病患者存在明显的心理障碍，主要表现为躯体化、焦虑、紧张、抑郁、恐惧，因此对Ⅱ型糖尿病患者在药物治疗的同时，还应进行积极的心理干预。     

维持性血液透析患者焦虑抑郁状态的分析及心理干预

【目的】探讨维持性血液透析患者焦虑抑郁状态及心理干预的影响。【方法】将88例行维持性血液透析（MHD）患者随机分为干预组和对照组,对干预组44例血液透析患者进行心理干预20周,干预前后分别采用焦虑自评量表（SAS）、抑郁自评量表（SDS）和症状自评量表（SCL-90）进行评价。【结果】两组患者干预前SAS、SDS评分无统计学意义,干预后干预组SAS、SDS评分显著低于对照组且差异具有统计学意义（P〈0．01）。两组患者干预前症状自评量表（SCL-90）评分,无统计学意义,干预后干预组躯体化、抑郁、焦虑、敌对、恐怖因子分显著低于对照组且差异具有统计学意义（P〈0．05或P〈0．01）。【结论】对MHD患者进行心理干预可改善其焦虑、抑郁情绪,提高血液透析的治疗效果及生活质量。     

生物反馈疗法对乙肝肝硬化患者焦虑抑郁状态的治疗效果分析

目的探讨生物反馈疗法对乙肝肝硬化焦虑抑郁的疗效。方法将82例乙肝肝硬化合并焦虑抑郁患者随机分为对照组44例和治疗组38例,两组均给予常规保肝抗乙肝病毒及心理护理干预,治疗组同时予生物反馈治疗4周,采用焦虑自评量表（SAS）、抑郁自评量表（SDS）、生活满意度评定量表（LSR）、90项症状自评量表（SCL-90）进行心理状况调查并评定两组临床疗效。结果治疗结束时,两组SAS、SDS评分较入组时均显著降低;与对照组比较,治疗组SAS、SDS评分显著降低,LSR评分显著升高（P〈0.05）,SCL-90项目中躯体化、强迫、抑郁、焦虑、恐怖、精神病性等因子分及总分下降更明显（P〈0.05）,治疗组有效率高于对照组（P〈0.05）。结论生物反馈治疗乙肝肝硬化焦虑抑郁的疗效优于常规治疗。     

汶川地震后四川籍大学生的心理健康状况

目的评估汶川地震后一周内四川籍学生的心理健康状况。方法对汶川地震后南昌大学医学院四川籍学生采用症状自评量表（SCL-90）、焦虑自评量表（SAS）、抑郁自评量表（SDS）进行评估。结果完成调查的62名学生中SCL-90各因子与国内青年组常模相比,躯体化、强迫、抑郁、焦虑、敌对、精神病因子分均高于国内常模。差异具有统计学意义（P〈0．05）;焦虑抑郁情绪均显著高于国内常模（P〈0．01）。结论地震灾害造成四川籍学生心理健康问题较为突出。因此,应及时时该人群施予心理干预。     

成都孤独症患儿家长心理现状调查

目的：研究成都孤独症患儿家长的心理现状。方法：采用抑郁自评量表（SDS）、焦虑自评量表（SAS）、症状自评量表（SCL-90）对孤独症患儿家长和健康儿童家长各40例进行评分。结果：孤独症儿童组SDS、SAS和SCL-90的量表总均分和躯体化、强迫、抑郁、焦虑、敌对、恐怖、精神病性、其他（睡眠及饮食）8个因子均高于正常儿童组（P＜0．05）;患儿父亲仅抑郁因子得分高于健康儿童父亲（P＜0．05）;患儿母亲躯体化、强迫、人际关系敏感、抑郁、焦虑、恐怖、精神病性、其他（睡眠及饮食）8个因子得分较正常儿童母亲高（P＜0．05）;在恐怖和其他（睡眠及饮食）2个因子上,患儿母亲得分比父亲高（P＜0．05）。结论：孤独症患儿父母存在显著的心理健康问题,需重视他们的需求给予及时有效的心理辅导。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.