含5.53%柠檬酸钾牙膏抗牙本质敏感的临床研究

目的：评价含5.53%柠檬酸钾牙膏减轻牙本质敏感症状的效果。方法：试验遵照随机、双盲、对照试验原则,将65名受试者随机分成试验组（含5.53%柠檬酸钾牙膏）和对照组（普通含氟牙膏）,两组受试者每天刷牙2次共4周。采用视觉模拟评分法（VAS）记,牙敏感症状。数据采用非参数检验进行统计分析。结果：与基线相比,使用牙膏4周后,试验组牙本质敏感VAS记分显著降低（P〈0.05）。与对照组相比,试验组4周后的牙本质敏感VAS记分明显低于对照组（P〈0.01）。83.9%的受试者认为使用该牙膏能缓解牙本质敏感症状;77.4%的受试者愿意继续使用该牙膏脱敏。结论：含5.53%柠檬酸钾牙膏具有显著的抗牙本质敏感效果。     

舒适达牙膏的脱敏作用观察

目的 研究比较舒适达牙膏和安慰剂牙膏对缓解牙本质过敏的疗效。方法 这项两组、随机、双盲、平行设计的临床研究选用了63名受试者进行试验,试验周期为8周。通过触觉刺激、冷空气刺激反应对受累牙齿的敏感度进行了评估。结果 舒适达牙膏组空气敏感性VAS值(3.32±1.65)和触觉敏感性VAS值(2.67±2.37)均小于安慰剂牙膏组空气敏感性VAS值(5.72±2.23)和触觉敏感性VAS值(3.97±2.07),P<0.05。结论 含氯化钾牙膏(舒适达牙膏)能显著缓解牙本质过敏,改善患者的整体舒适度。     

NovaMin脱敏效果的体内外研究

目的 通过体内外研究,探讨NovaMin脱敏作用的效果以及影响因素.方法 牙本质过敏症的患者随机分为两组.试验组使用含NovaMin成分的含氟牙膏,对照组使用单一含氟牙膏,进行1周的治疗,分别记录治疗前后敏感牙齿的视觉模拟评分法(VAS)值,比较两组间的差异.体外实验将离体牙暴露牙本质,用37%磷酸凝胶酸蚀处理后分为4组,A组:放置于人工唾液中保存7天;B组:用电动牙刷蘸取包含NovaMin的含氟牙膏刷牙本质表面;C组:用包含NovaMin的含氟牙膏涂布于牙本质表面;D组:用电动牙刷蘸取单一含氟牙膏刷牙本质表面.B、C、D组标本的处理均为每天2次,每次5分钟,持续7天.扫描电镜观察牙本质表面,计算牙本质小管封闭数目比.采用单因素方差分析比较各组小管口封闭率.结果 两组患者的VAS值较治疗前均有显著降低(P<0.05),试验组降低更显著(P<0.01).体外试验A组牙本质小管完全开放,B、C、D组牙本质小管封闭数目比分别为(67.02±14.58)%、(82.79±16.61)%、(14.32±7.29)%,三组间两两比较,差异均有统计学意义(P<0.05).结论 含有NovaMin成分的含氟牙膏比单一含氟牙膏能在牙本质表面形产生更好的封闭效果.延长局部涂抹时间及减少敏感区的机械摩擦,可增强其疗效.     

奥威尔牙膏抗牙本质过敏的疗效研究

目的:评价家庭日常使用奥威尔牙膏后牙本质过敏症状的改善情况。方法:将60名受试者随机分成2组:实验组使用奥威尔牙膏,对照组使用普通牙膏。两组受试者每天刷牙2次共8周,采用VAS记分评价基线0、2、4周和8周受试者的牙本质敏感程度。结果:实验组基线0周时记分为5.92±1.04,4周和8周后为4.39±1.30、3.98±1.19,可显著减少牙本质过敏症状(P<0.05);与对照组4周和8周后记分5.08±1.17、4.65±1.18相比,有显著性差异(P<0.05)。结论:奥威尔牙膏有抗牙本质过敏的效果。     

含5%硝酸钾牙膏抗牙本质敏感的临床研究

目的:评价含5%硝酸钾牙膏减轻牙本质敏感症状的临床效果。方法:根据随机、双盲、平行设计的试验原则,将63名受试者随机分为试验组(含5%硝酸钾牙膏)和对照组(普通牙膏)进行试验,试验周期为4周。采用视觉模拟疼痛评分法(VAS)分别记录基线和4周后受试牙的牙敏感指数。采用SPSS13.0软件包对数据进行非参数检验。结果:使用牙膏4周后,试验组牙本质敏感VAS值显著低于基线(P<0.05)。与对照组相比,试验组使用牙膏前后牙本质敏感VAS记分之差显著高于对照组(P<0.05)。结论:含5%硝酸钾牙膏具有显著的抗牙本质敏感效果,可改善患者的整体舒适度。     

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目的评价含有NovaMin技术的专业修复牙膏治疗牙本质敏感症的临床疗效。方法选择2011年6月至2012年2月在首都医科大学附属北京口腔医院口腔内科就诊的牙本质敏感症患者76例（228颗患牙）,惠牙随机等分为试验组和对照组,分别采用舒适达专业修复牙膏和氟化钠甘油治疗。观察治疗后30min、l周、3个月和6个月的疗效。结果试验组治疗后30min、1周、3个月及6个月有效率均明显高于对照组（P〈0．05）？结论含NovaMin技术的专业修复牙膏治疗牙本质敏感症的临床效果较好。     

NovaMin生物活性玻璃离子牙膏抗牙菌斑和牙龈炎的临床研究

目的：评价NovaMin生物活性玻璃离子牙膏抗牙菌斑和牙龈炎的临床功效。方法：遵照随机、双盲、对照的试验原则,按纳入和排除标准将100名年龄在20～48岁的受试者随机分成试验组（使用NovaMin生物活性玻璃离子牙膏）和空白对照组（使用同一公司生产的普通牙膏）,采用菌斑指数和牙龈出血指数评价受试者的牙龈健康状况。结果：试验组菌斑指数和牙龈出血指数与试验前相比在统计学上有显著性差异,试验6周后牙龈出血指数和菌斑指数分别降低了58．8％和16．4％;而对照组菌斑指数和牙龈出血指数在统计学上无显著性差异（P〉0．05）。结论：本研究提示NovaMin生物活性玻璃离子牙膏能通过减少龈上菌斑和减轻牙龈出血而显著改善牙龈健康状况。     

8％精氨酸牙膏降低牙本质敏感的临床试验

目的 评价含8％精氨酸的抗敏牙膏控制牙本质敏感的效果.方法 采用随机、对照、双盲的研究方法,牙本质敏感的评价采用冷空气喷吹法,在常温下距离牙面1 cm处用气枪吹压缩空气,由受试者确认是否敏感,采用数字化疼痛评判法(visual analogue scale,VAS)记录受试者的敏感程度.按照纳入和排除标准纳入受试者,基线时共纳入受试者88人,按照性别和年龄将受试者分层随机分为试验组和对照组,每组44人.试验组使用含8％精氨酸的抗敏牙膏,对照组使用含5.53％柠檬酸钾的抗敏感牙膏.基线调查后,用棉签将1 cm长的牙膏涂抹于敏感牙表面并按摩1 min,进行敏感检测.受试者使用分派的牙膏和牙刷每天刷牙2次,每次至少1 min,分别在第3天和1周时接受回访.结果 所有受试者均完成了1周的临床试验研究.试验组和对照组受试者基线时的冷空气喷吹敏感VAS值(分别为55.51 ±8.48、56.67±10.22)和自我评价敏感VAS值(分别为43.75±6.65、41.98±8.53)差异均无统计学意义(P＞0.05).局部涂抹牙膏并按摩1 min,刷牙3d和1周后试验组冷空气喷吹敏感VAS值和自我评价敏感VAS值均较基线时显著下降(P＜0.01),对照组虽有下降但差异均无统计学意义(P＞0.05).与基线相比,试验组冷空气喷吹敏感VAS值和自我评价敏感VAS值的减少程度在3个时间点均显著高于对照组(P＜0.05).结论 含8％精氨酸的抗敏牙膏在单次局部涂抹后能即刻缓解牙本质敏感,刷牙1周后可有效缓解牙本质敏感.     

三种脱敏剂防治活髓基牙预备后牙本质敏感的临床研究

目的:评价3种脱敏剂对冠桥活髓基牙预备后牙本质敏感的疗效。方法:局麻下,按照修复体的常规要求行活髓牙的牙体制备。将68例(共153颗)患者随机分为四组:Gluma脱敏剂组,极固宁脱敏剂组,"劲润"牙本质保护膜组,对照组。所有预备后的基牙均佩戴暂时冠,使用RelyX TempNE临时粘固。采用可视分级评价法(VAS)记分评价探针刺激以及空气刺激预备牙的敏感程度。结果:Gluma脱敏剂组:治疗后的触觉敏感性VAS值(2.51±1.13)和空气敏感性VAS值(3.09±0.98)与治疗前触觉敏感性VAS值(4.92±1.35)和空气敏感性VAS值(5.88±1.21)比较差异有统计学意义(P<0.05)。极固宁脱敏剂组:治疗后的触觉敏感性VAS值(3.03±1.58)和空气敏感性VAS值(3.17±1.63)与治疗前触觉敏感性VAS值(4.67±2.36)和空气敏感性VAS值(6.01±1.17)比较差异有统计学意义(P<0.05)。"劲润"脱敏剂组:治疗后的触觉敏感性VAS值(2.56±1.84)和空气敏感性VAS值(2.86±1.19)与治疗前触觉敏感性VAS值(5.21±1.84)和空气敏感性VAS值(5.91±0.95)比较差异有统计学意义(P<0.05)。对照组,VAS记分试验前后差异无显著性(P>0.05)。结论:使用3种脱敏剂可有效缓解备牙后的牙本质敏感症状。     

口腔脱敏糊剂治疗龈下刮治和根面平整术后根面牙本质过敏疗效观察

目的观察口腔脱敏糊剂治疗龈下刮治和根面平整术后根面牙本质过敏的临床疗效。方法将52例接受龈下刮治及根面平整术后出现根面牙本质过敏症的慢性牙周炎患者的368颗患牙随机分为2组,分别采用口腔脱敏糊剂和不含脱敏成分的普通牙膏刷牙,评估使用1周、4周后牙齿敏感情况和安全性。结果脱敏1周后,口腔脱敏糊剂组和普通牙膏组的有效率分别为66.7%、20.0%;脱敏4周后,有效率分别为96.2%、78.9%。两者疗效有显著性差异。试验期间未出现不良反应。结论口腔脱敏糊剂对治疗龈下刮治和根面平整术后产生的根面牙本质过敏有着较为理想疗效,且使用方便。     

Clinical evaluation of a dentifrice containing calcium sodium phosphosilicate (novamin) for the treatment of dentin hypersensitivity

PURPOSE: To evaluate the efficacy of a dentifrice containing calcium sodium phosphosilicate (NovaMin) study versus a placebo and a commercially-available SrCl2 containing dentifrice for the treatment of dentin hypersensitivity. METHODS: This was a 6-week, randomized, parallel-arm, double-blind clinical study. 71 subjects ranging in age from 21 to 56 years old completed the study. Evaporative and thermal stimuli were used to measure pain using a VAS scale. Measurements were obtained at baseline, 2 weeks and 6 weeks. RESULTS: The placebo and the NovaMin groups showed a statistically significant decrease in sensitivity by both measures after 6 weeks (P < 0.05). The SrCl2 group showed a statistically significant decrease from baseline at the 2-week time point, but not at the 6-week time point for the evaporative stimulus. The percent reduction in sensitivity at 6 weeks for the NovaMin test group was 35% for air and 39% for cold water stimulus, versus 11% for air and 22% for cold water for the SrCl2 paste. The reductions for the placebo paste were 21% for the air stimulus and 18% for water. A cross tabulation measure of the reduction in sensitivity at each time point for all three treatments showed that the NovaMin product was more effective than either of the other products. For the air stimulus in the NovaMin group, 58% of subjects improved at each time point compared with 26% for the SrCl2 group and 20% for the placebo group. These results demonstrate that the NovaMin dentifrice was more effective at reducing sensitivity compared with a commercial dentifrice and placebo control.     

Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin) particulate

BACKGROUND: The objective of this pilot clinical trial was to evaluate the anti-gingivitis and anti-plaque effects of a dentifrice containing bioactive glass (NovaMin) compared with a placebo control dentifrice in a 6 weeks clinical study. METHODS: The study design was a randomized, double-blinded, controlled clinical trial. One hundred volunteers took part in the study and were matched for plaque index (PLI), gingival bleeding index (GBI), age and gender. The protocol was reviewed and approved by the Ethical Committee of the University. The subjects received a supragingival prophylaxis to remove all plaque, calculus and extrinsic stain. Following the baseline examination, subjects were instructed to brush with their assigned dentifrice and toothbrush. The PLI and GBI were determined for the baseline and 6 weeks. The data were analysed using a repeated-measures anova conducted on the two dependent measures to compare the effect between the test and control group. RESULTS: Ninety-five subjects finished the study. The results showed that the PLI (baseline=1.54, 6 weeks=1.29) and GBI (baseline=1.14, 6 weeks=0.47) were significantly reduced, respectively, over the 6 weeks period in the test group (p<0.001 for each measure). There was a 58.8% reduction in gingival bleeding and a 16.4% reduction in plaque growth. There was no difference of the PLI (baseline=1.60, 6 weeks=1.57) and GBI (baseline=1.18, 6-week=1.02) over the 6 week period in the control group. CONCLUSION: This study demonstrated that a dentifrice containing NovaMin significantly improves oral health as measured by a reduction in gingival bleeding and reduction in supragingival plaque compared with a negative dentifrice over the 6 weeks study period.     

Effect of a desensitizing dentifrice on dentinal hypersensitivity

Abstract The objective of this study was to assess the effectiveness of a dentifrice with 2% dibasic sodium citrate in poloxamer 407 in decreasing dentinal hypersensitivity. The test toothpaste was compared with a control toothpaste containing 0.76% sodium monofluorophosphate in a 6-week double-blind clinical trial. A total of 75 hypersensitive teeth were examined in the test group, while 100 hypersensitive teeth were in the control group. Changes in hypersensitivity levels were monitored after 6 weeks, using thermal, chemical and mechanical stimuli. At the end of 6 weeks, the test dentifrice was not significantly more effective than the control in decreasing dentinal hypersensitivity. Of the stimuli used, cold was the most effective in eliciting a hypersensitive response, followed by chemical stimulation and air. Heat and toothbrushing caused the least discomfort.     

Effect of a desensitizing dentifrice on dentinal hypersensitivity

The objective of this study was to assess the effectiveness of a dentifrice with 2% dibasic sodium citrate in poloxamer 407 in decreasing dentinal hypersensitivity. The test toothpaste was compared with a control toothpaste containing 0.76% sodium monofluorophosphate in a 6-week double-blind clinical trial. A total of 75 hypersensitive teeth were examined in the test group, while 100 hypersensitive teeth were in the control group. Changes in hypersensitivity levels were monitored after 6 weeks, using thermal, chemical and mechanical stimuli. At the end of 6 weeks, the test dentifrice was not significantly more effective than the control in decreasing dentinal hypersensitivity. Of the stimuli used, cold was the most effective in eliciting a hypersensitive response, followed by chemical stimulation and air. Heat and toothbrushing caused the least discomfort.     

The Effectiveness of a Calcium Sodium Phosphosilicate Desensitizer in Reducing Cervical Dentin Hypersensitivity

BackgroundNovaMin (NovaMin Technology, Alachua, Fla.) was introduced into the dental market as a desensitizer in December 2004. However, to the authors' knowledge, no researchers yet have evaluated the effectiveness of 100 percent NovaMin powder with NovaMin-containing toothpaste in reducing dentin hypersensitivity compared with the effectiveness of NovaMin-containing toothpaste only and a desensitizing toothpaste containing potassium nitrate as a control.MethodsThe authors divided 60 participants randomly into three groups: NovaMin powder with NovaMin-containing toothpaste (group 1), a placebo powder with NovaMin-containing toothpaste (group 2) and a placebo powder with the control toothpaste (group 3). The authors used tactile and cold stimuli and a visual analog scale to evaluate participants' pain at baseline, immediately after powder application and at one week, two weeks and four weeks after powder application. They analyzed data by using Friedman and Wilcoxon signed-rank tests for within-group comparison. They used Kruskal-Wallis and Mann-Whitney U tests for between-group comparison. They considered P < .05 to be statistically significant.ResultsGroups 1 and 2 showed significant hypersensitivity reduction over baseline at all time points. Group 3 showed significant hypersensitivity reduction at one week onward. Group 1 showed significant improvement compared with groups 2 and 3, except for response to tactile stimulus at four weeks with group 2. Between groups 2 and 3, there were significant differences at two and four weeks.Conclusions and Clinical ImplicationsThe use of NovaMin powder and NovaMin-containing toothpaste for hypersensitivity reduction is more effective than the use of a desensitizing toothpaste containing potassium nitrate and fluoride.     

The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity

OBJECTIVES: The purpose of this study was to investigate the effect of a new toothpaste containing an antiplaque and antiinflammatory agent (0.3% triclosan), a desensitizing agent (5% potassium nitrate) and an anticaries agent (0.76% sodium monofluorophosphate (SMFP)) on gingival health, plaque formation and dentine hypersensitivity in a 12-week home study. The efficacy of the test toothpaste was compared with that of a control toothpaste containing 5% potassium nitrate and 0.76% SMFP and a benchmark product containing only 0.76% SMFP. MATERIAL AND METHODS: One hundred and two healthy volunteers, who had a minimum of 20 natural permanent teeth with no probing depth >4 mm and at least one sensitive tooth, participated in this study. Following enrollment, the subjects received a dental prophylaxis and instruction in brushing technique. After a 4-week pre-experimental phase, baseline gingival bleeding index (GBI), plaque index (PI) and visual analogue scales (VASs) indicating dentine hypersensitivity levels responding to tactile and air stimuli were assessed. The subjects were then randomly given one of the three toothpastes; test, control, or benchmark toothpaste, and a soft-filamented toothbrush for home use. The GBI, PI and VASs were re-examined at weeks 4 and 12. RESULTS: Overall, the GBI scores were significantly reduced compared with baseline in all groups (p<0.01). However, there was no significant difference in GBI score among the three comparison groups. The PI score decreased in the test group and benchmark group from baseline to the end of study, whereas there was no significant change in the control group. Post hoc comparison indicated that the PI score was not statistically different between the three groups. There was a significant difference between the three treatment groups for sensitivity. For both the tactile and air stimuli, the reductions in VAS sensitivity scores for the test group and the control group were significantly greater compared with the benchmark group. Although the sensitivity score for air stimulus decreased more rapidly from baseline to week 4 in the test group, there was no overall difference between the test group and the control group. CONCLUSIONS: This study demonstrated that the new toothpaste was effective in reducing dentine hypersensitivity. More studies are needed to further determine the potential interaction between triclosan and potassium nitrate in dentifrices.     

Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity: a randomized clinical trial

Background: Dentinal hypersensitivity has been defined as a short, sharp pain arising from exposed dentine as a result of various stimuli such as heat, cold, chemical, or osmotic, that cannot be ascribed to any other pathology. This study was conducted to assess the efficacy of three commercially available toothpastes in the reduction of dentinal hypersensitivity. Methods: A total of 149 subjects (72 males and 77 females; aged 20 to 60 years) were entered into the study and randomly divided into four groups: Group 1 – toothpaste containing 5% potassium nitrate; Group 2 – toothpaste containing 5% calcium sodium phosphosilicate with fused silica; Group 3 – toothpaste containing 3.85% amine fluoride; and Group 4 – a placebo toothpaste. After sensitivity scores for controlled air stimulus and cold water at baseline were recorded, subjects were given toothpastes and sensitivity scores were measured again at 2 weeks and 6 weeks. Results: All groups showed a reduction in sensitivity scores at 2 weeks and 6 weeks. The calcium sodium phosphosilicate group was found to be significantly better compared to the other groups at the end of 6 weeks. Conclusions: The calcium sodium phosphosilicate group showed a better reduction in the symptoms of dentinal hypersensitivity.