单纤维肌电图信号处理系统的技术研究

本文介绍了在ＡＳＴ４８６微机上利用高速Ａ／Ｄ转换电路ＨＡＳ－１２０４对单纤维肌电信号进行信号采集，并利用Ｃ语言和汇编语言混合编程进行显示分析和处理的有关技术。     

仿生光学人工鼻及其呼吸气体检测的实验研究

针对呼吸气体诊断的需要，介绍了一种新型的具有仿生特点的光学人工鼻实验系统，用于探索通过呼吸气味诊断疾病的可行性。该系统由气敏光纤传感器阵列和信号处理系统组成，利用光纤传感器易与多种聚合物敏感材料相结合和其对气味的响应快、精度高以及易获得嗅觉动态信息的特点，通过计算化学方法，实现了多种聚合物敏感材料与荧光试剂的定量配制，研究了具有不同选择性的气味光纤传感器阵列。此外，将生物嗅觉机理模型用于人工鼻系统的设计过程，采用模拟生物嗅觉的感受器-嗅球-线性延迟神经网络算法，实现了从光纤传感器阵列的响应数据中同时分离出混合气味的成分和浓度信息。实现结果表明，该光学人工鼻传感器实验系统具有一定的仿生特性和应用前景。     

基于Y形光纤的便携式免疫荧光定量检测系统

为了满足POCT仪器体积小、操作简单、携带方便、结果报告及时化的检验模式新要求,设计并开发一款基于Y形光纤的便携式免疫荧光定量检测仪。该设备以恒流源驱动激光二极管作为激发光源,Y形光纤作为光信号传输介质,光电二极管作为荧光信号接收传感器,替代复杂庞大的传统共聚焦光学系统,使光路设计及信号采集模块小型化;设计Sallen-Key拓扑结构的二阶有源低通滤波器对信号进行放大滤波处理,以减少杂波干扰,提高系统灵敏度;采用STM32F103微处理器为主控芯片,控制步进电机驱动机械扫描模块、光电信息采集模块、数据处理及显示模块完成免疫层析试纸条的荧光值定量检测。AD采集精度实验显示,该系统的AD采样偏差为10μV,标准差为1.91E-06;实测荧光微球实验表明,荧光微球稀释倍数和荧光强度信号之间的乘幂关系良好,相关系数为0.99,该系统检测灵敏度高,重复性好。     

一种医学辅助诊疗系统的构造方法

一种医学辅助诊疗系统的构造方法范逢曦，李祥生（山西医学院计算机中心，太原）李茹香，刘卓敏，李运乾（山西医学院第一附属医院心血管科，太原）关键词：医学辅助诊疗，心肌梗塞，预后ＡＳＴＲＵＣＴＵＲＥＤＭＥＴＨＯＤＯＦＭＥＤＩＣＡＬＡＩＤＥＤＤＩＡＧＮＯＳＩ...     

Thioredoxin—GAM融合蛋白的表达及其与GST—gp130融合蛋白的结合

ＧＡＭ是以ｇｐ１３０胞浆区为探针筛选而得到的一个新的ｇｐ１３０结合分子，探讨其在ｇｐ１３０信号传导中可能具有的重要作用的基础是证实ｇｐ１３０胞浆区与ＧＡＭ的结合。我们采用ｔｈｉｏｒｅｄｏｘｉｎ融合蛋白表达系统表达了ＧＡＭ分子的融合蛋白。在此基础上，发现ＧＳＴ－ｇｐ１３０融合蛋白与ｔｈｉｏｒｅｄｏｘｉｎ－ＧＡＭ融合蛋白共沉淀，而单独ＧＳＴ不与ｔｈｉｏｒｅｄｏｘｉｎ－ＧＡＭ融合蛋白共沉淀，证实了ＧＡＭ与ｇｐ１３０的特异性结合，此结果为探讨ＧＡＭ分子的功能打下了重要的基础。     

MPA-2000M多道生物信号分析系统

随着科学技术的发展和医学教学改革的深入，生理学实验方法和实验仪器越来越现代化。记录仪器已从传统的记纹鼓时代发展到记录仪时代，直至当今的计算机时代。自92年起我们在国内率先把计算机运用到生理学教学中，经过几年的改进和提高，目前已形成MPA多道生物信号分析系统系列     

基于笔记本计算机的心音分析仪

基于笔记本计算机的心音分析仪由心音传感器、心音信号预处理盒,笔记本计算机、打印,音箱和心音信号处理软件组成。它的开发目的是充分利用笔记本计算机的便携特点和强大功能。该系统在Ｗｉｎｄｏｗｓ９５操作系统下用ＶＩＳＵＡＬＢＡＳＩＣ编程。     

白鼠活动自动测试系统

本文介绍一种由红外光电传感器阵列和二级计算机网组成的白鼠活动自动测试系统。该系统设计新颖，灵敏度高，响应快，能实时测试几十只白鼠一周的活动规律，并根据对生命节律现象研究要求和中医药特点进行数据处理，输出相应的曲线、表格。本系统还充分考虑了白鼠活动的特点以及喂养方面的要求，采用模块化结构，使拆卸、安装、清洗都非常方便。本系统已应用于北京中医药大学的生命节律研究。     

基于计算机的尿滴自动计数检测与分析系统设计

采用计算机和电子技术,自动检测和分析生理实验中动物的尿液变化。设计光电受滴器检测尿滴,信号放大后送计算机进行自动的检测处理。采用Visual Basic及Borland C 语言编程,设计软件界面和输入输出控制程序,根据实验要求提供参数设置、采样、保存和回放数据等多种功能。实验表明该系统能准确采集和记录数据。该系统操作简便、自动化程度高,能很好地满足生理实验的需要。     

计算机生物信号处理系统在医学机能学实验中的应用

随着计算机技术的飞速发展 ,计算机辅助教学已成为教育改革的重要方向和发展趋势。近年来 ,我校引进 MS30 2多媒体化计算生物信号处理系统 (简称 MS30 2系统 ) ,在原来生理学、病理生理学、药理学 (通称“三理”)各自独立实验的基础上 ,借监经验 ,去粗取精 ,有机综合 ,开设“三理”内容的医学机能学实验教学。本文就这一教学改革的实践及体会 ,从以下几方面谈计算机生物信号处理系统在医学机能学实验中的应用。1　计算机生物信号处理系统对生物医学信号的处理医学机能学科的实验多以生物体作为实验对象 ,利用技术手段提取和采集生命活动过…     

核磁射频系统平板线圈连续烧毁的原因

医用磁共振系统是由磁体构造、波谱分析和计算机成像等多种技术融为一体的医疗成像设备。该文通过对磁共振射频系统与其体部线圈的相互作用进行分析,进一步探讨造成同一平板线圈连续烧毁的原因,并给出相应的维护措施,以此保证设备的正常工作。     

In Vitro and In Vivo characterization of wireless and passive micro system enabling gastrointestinal pressure monitoring

This paper presents a wireless and passive micro pressure system based on the LC mutual inductance detection mechanism for gastrointestinal (GI) pressure monitoring. The micro pressure system is composed of a sensor capsule (a pressure sensitive micro capacitive sensor in series with an induction coil to form an LC tank) and a detection unit (a detection coil connected with a network analyzer). The pressure variations under measurement lead to changes in the capacitance of the pressure sensor and therefore a shift in the LC tank resonant frequency, quantified by the impedance measurement of the detection coil. The pressure sensor was fabricated using microfabrication processes with key parameters optimized. The in vitro characterization of the micro pressure system recorded a sensitivity of 0.2491 kHz/kPa (?10 kPa to 30 kPa). One-month rabbit stomach pressure monitoring was conducted based on the developed micro pressure system as a confirmation of device long term in vivo stability. Furthermore, rabbit stomach pressure variations before and after food feeding was recorded and compared where three distinctive contraction patterns (random contraction with low amplitude, irregular strong contractions and regular contraction in a cyclic manner) following food feeding were located. Compared to previous reported GI pressure sensors, this LC tank is featured with simple device structure without batteries and electrical components for energy transfer. Both in vitro and in vivo characterization confirm the functionality of the system, which may enable the gastrointestinal motility study in the near future.     

An Apparatus for Recording Defensive Responses to Tactile Stimulation in the Ground Snail

We describe here an original working experimental apparatus for non-invasive objective recording of the magnitudes of defensive responses to tactile stimulation in the ground snail. The apparatus includes a tracking device that ensures that the snail's position relative to a light and photodiode remains constant as it ascends a cylinder rotating about a horizontal axis. The device providing tactile stimulation is based on a loudspeaker circuit and provides blows of dosed energy. The snail responds to the tactile stimulation by retracting the antennae, head, and foot, which decreases the area of its shadow; this is recorded by a photodiode.     

Feasibility of a remote monitoring system for patients with an implantable left ventricular assist device using Personal Handy-Phone System telecommunication technology

We have been developing a remote monitoring system for patients with implanted artificial hearts. The remote monitoring system consists of two digital data links: an electromagnetic transcutaneous digital-data transmission (TDT) system between an artificial heart controller inside the body and a mobile computer outside the body, and a public high-speed data transmission service using PHS (Personal Handy-Phone System) between the mobile computer and a host computer in a hospital. The TDT system mainly consists of an ASK (Amplitude Shift Keying) circuit with carrier electromagnetic wave frequencies of 4MHz and 10 MHz and corresponding demodulation circuit, thin loop coil antennas for transmission and receiving, and a one-chip microcomputer for the alarm system for indicating misalignment of antennas outside the transmittable range to ensure error-free data transmission. In our remote monitoring system, motor current and motor rotational angle data from the implanted controller are framed together by a control code for data error checking and correcting at the receiving site, and the data are sent through the PHS connected to the mobile computer. GPS (Global Positioning System) positioning data are also sent to the host computer with control codes. The host computer calculates pump outflow and arterial pressure and displays the data in real-time waveforms. The host computer also displays the patient's position on the map and the condition of the batteries. The results of this study showed that the driving condition of the artificial heart and the subject's position could be remotely monitored on the host computer. It could be concluded that this monitoring system is useful for remote monitoring of patients with an implanted artificial heart.     

基于关节机器人的人体脊柱生物力学试验装置设计

目的建立机器人生物力学试验装置,进行人体脊柱标本生物力学实验研究。方法利用solidwork软件进行夹具设计,通过VisualC++6.0平台进行以太网套接字Socket编程实现PC机与机器人控制器之间的网络通信,读取机器人末端执行器的位置和旋转角度。PC机里面插入数据采集板读取力(力矩)传感器在三维空间中的力和力矩。位姿与力矩数据作为控制程序的输入数据,通过控制程序的处理,绘制出力-位移的二维曲线图,协助分析得出实验结果。结果开发并建立一套基于机器人的用于生物力学特性研究的实验装置,开发了相应的控制软件(力控制、位移控制、混合力/位移控制)及各类监控程序。结论设计出一套基于计算机控制的6自由度机器人全新实验装置,采用混合力/位移控制方法对实验对象进行加载,可以很好地测试脊柱功能单元各组织结构的功能和受力状态,很容易地确定脊柱退变和各类手术对脊柱功能单元各组织结构所承担负载的影响。     

Reference marker stability in computer aided orthopedic surgery: a biomechanical study in artificial bone and cadavers.

INTRODUCTION: In computer assisted orthopaedic surgery, rigid fixation of the Reference Marker (RM) system is essential for reliable computer guidance. A minimum shift of the RM can lead to substantial registration errors and inaccuracies in the navigation process. Various types of RM systems are available but there is little information regarding the relative stabilities of these systems. The aim of this study was to test the rotational stability of three commonly used RM systems. MATERIALS AND METHODS: One hundred and thirty Synbones and 15 cadavers were used to test the rotational stability of three different RM systems (Schanz' screw, RM B and RM C adjustment systems). Using a specially developed testing device, the peak torque sustained by each RM system was assessed in various anatomical sites. RESULTS: Comparison of means for Synbone showed that the RM C was the most stable (mean peak torque 5.60 +/- 1.21 Nm) followed by the RM B system (2.53 +/- 0.53 Nm) and the RM A (0.77 +/- 0.39 Nm) (p<0.01). The order of stability in relation to anatomical site was femoral shaft, distal femur, tibial shaft, proximal tibia, anterior superior iliac spine, iliac crest and talus. Results from the cadaver experiments showed similar results. Bi-cortical fixation was superior to mono-cortical fixation in the femur (p<0.01) but not the tibia (p=0.22). CONCLUSION: The RM system is the vital link between bone and computer and as such the stability of the RM is paramount to the accuracy of the navigation process. In choosing RM systems for computer navigated surgery surgeons should be aware of their relative stability. Anatomical site of RM placement also affect the stability. Mono-cortical fixation is generally less stable than bi-cortical.     

Magnetic propulsion of a magnetic device using three square-Helmholtz coils and a square-Maxwell coil

We introduce a square coil system for remote magnetic navigation of a magnetic device without any physical movements of the coils. We used three square-Helmholtz coils and a square-Maxwell coil for magnetic propulsion of a small magnet along the desired path. All the square coils are mountable on a cubic frame that has an opening to accommodate a living subject. The square-Helmholtz coils control the magnetic propulsion direction by generating uniform magnetic field along the desired direction while the square-Maxwell coil controls the propulsion force by generating magnetic gradient field. We performed magnetic propulsion experiments with a downscaled coil set and a three-channel coil driver. Experimental results demonstrate that we can use the square coil set for magnetic navigation of a magnetic device without any physical movements of the coils.     

凝血仪的研制

凝血是人体重要的生理机能，我们利用旋转粘度法研制了一台凝血仪。包括双圆筒系统、8098单片机数据采集器和486微机，能自动测量四个换血参数（tr、d/dt、TamxS）并打印凝血曲线。     

Gradient waveform synthesis for magnetic propulsion using MRI gradient coils

Navigating an untethered micro device in a living subject is of great interest for both diagnostic and therapeutic applications. Magnetic propulsion of an untethered device carrying a magnetic core in it is one of the promising methods to navigate the device. MRI gradients coils are thought to be suitable for navigating the device since they are capable of magnetic propulsion in any direction while providing magnetic resonance images. For precise navigation of the device, especially in the peripheral region of the gradient coils, the concomitant gradient fields, as well as the linear gradient fields in the main magnetic field direction, should be considered in driving the gradient coils. For simple gradient coil configurations, the Maxwell coil in the z-direction and the Golay coil in the x- and y-directions, we have calculated the magnetic force fields, which are not necessarily the same as the conventional linear gradient fields of MRI. Using the calculated magnetic force fields, we have synthesized gradient waveforms to navigate the device along a desired path.