脐针治疗桡骨茎突狭窄性腱鞘炎案

The gen and mao areas, and the responding area of hand were punctured in umbilicus acupuncture, reperfusion activities were also done for a stenosing tenosynovitis of styloid process of radius patient in lactation period, sound effect were obtained.     

林兰治疗糖尿病合并冠心病的辨治思路

在总结林兰教授既往临床和科研经验的基础上,对糖尿病合并冠心病的病因病机作了初步分析,认为糖尿病冠心病以气阴两虚、瘀血痰浊为主要病机特点,提出对糖尿病合并冠心病的中医分型辨证治疗,通过辨证分型进行加减用药治疗,取得明显疗效。     

艾灸三阴交穴对产程的影响：随机对照研究

[摘要]：目的：探讨艾灸三阴交穴对正常分娩产程及母婴安全性影响。方法：将210名正常分娩单胎头位初产妇随机分为实验组、非穴组及空白组,宫口开大2～3cm时实验组艾灸三阴交、非穴组艾灸非穴点各30min,空白组行常规产程护理,比较3组第一产程活跃期、第二产程、第三产程及母婴安全性差异。结果：实验组与非穴组及空白组第一产程活跃期、第二产程3组间比较差异有统计学意义（P＜0.05）。实验组第一产程活跃期（123.05±96.401）min,第二产程（37.407±22.390）min短于非穴组（171.40±94.339）,（49.517±25.373）min及空白组（178.79±97.231）,（53.684±20.087）min,差异有统计学意义（p＜0.05）。第三产程3组及组间比较差异无统计学意义（P＞0.05）。产后出血量：实验组为（187.12±50.653）mL,少于非穴组和空白组的（216.67±54.456）,（214.90±54.787）mL;新生儿Apgar评分：实验组（9.965±0.186）分,高于非穴组和空白组的（9.949±0.289）,（9.707±0.593）分,差异有统计学意义（p＜0.05）。结论：艾灸三阴交穴能缩短产程,减少产后出血,对母婴无不良影响。     

灸治百会穴治疗梅尼埃病44例

直接灸百会穴治疗梅尼埃病44例，有效率占97．7％，在目前尚缺乏特效疗法的情况下，直接灸不失为治疗本病的积极有效方法。     

Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae)

Methanolic extracts prepared from the leaves, twigs and the roots of Vismia laurentii De Wild as well as nine compounds isolated from these crude extracts, were tested for their antimicrobial activity against Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and two Candida species using disc diffusion and well micro-dilution methods. The disc diffusion assay indicated that the crude extract was active against all the pathogens tested, whereas isolated compounds showed selective activities. The degree of sensitivity of the test organisms to purified compounds varied from 25 to 90%. Fridelin (8) was found to be the most active compound, while Bivismiaquinone (3) was the least active. The lowest minimum inhibition concentration (MIC) values as obtained by the micro-dilution assays were 19.53 and 1.22 microg/ml for the crude extracts and purified compounds, respectively. The lowest value for the purified compounds (1.22 microg/ml) was obtained with O(1)-demethyl-3',4'-deoxypsorospermin-3',4'-diol (6) on Candida gabrata and Bacillus subtilis; 1,8-dihydroxy-6-methoxy-3-methylanthraquinone (5) on Bacillus subtilis and 6-deoxyisojacareubin (7) on Bacillus stearothermophilus. These results provide promising baseline information for the potential use of these crude extracts as well as some of the isolated compounds in the treatment of bacterial and fungal infections.     

Effect of Acupuncture at Acupoints Neiguan （PC 6） and Ximen （PC 4） on the Left Cardiac Function in the Patients with Coronary Heart Disease

目的：探讨针刺内关与郄门穴对冠心病患者每博心输出量及左心室排血的峰值流速的影响。方法：60例冠心痛患者分为内关组和郄门组，分别在运针3min后和留针20min后测试每博心输出量，左心室排血的峰值流速。再与针刺前得测试结果相比较。结果：46例患者针刺3min后Q值和VP值较针刺前上升。留针20min后，34例患者Q值和VP值全部上升。结论：针刺内关和郄门可增强左心室壁的收缩能力，使心脏的每博输出量增加，改善冠心病患者的心肌缺血状态。     

Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease

OBJECTIVE: Infl ammation and lung function decline are the main pathophysiological features of chronic obstructive pulmonary disease(COPD). Acupuncture can improve lung function in patients with COPD, but the underlying mechanisms are not well understood. Orexins(OXs), which are found in peripheral plasma, are neuropeptides that regulate respiration and their levels are related to COPD. Therefore, we hypothesized that acupuncture might alter OXs, reduce lung infl ammation and improve lung function in COPD.METHODS: COPD was induced in rats by exposure to cigarette smoke for 8 weeks and injecting with lipopolysaccharide twice. Electroacupuncture(EA) was performed at Feishu(BL13) and Zusanli(ST36) for 30 min/d for 2 weeks. Rat lung function and morphology were assessed after EA. The levels of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in bronchoalveolar lavage fl uid(BALF) and orexin A and B levels in the lung tissue were detected by enzyme-linked immunosorbent assay. OX receptor mRNA levels and immunopositive cells were assessed with real-time polymerase chain reaction and immunohistochemical methods, respectively. The relationships among lung function, cell factors, and OX levels were analyzed by Pearson correlation analyses.RESULTS: Compared with the control group, lung function was signifi cantly decreased in the rats with COPD(P0.05). There were obvious increases in TNF-α and IL-1β levels in BALF(P0.05 and P0.01, respectively), orexin A level in lung tissue(P0.01; but not orexin B) and mRNA expressions of OX 1 type receptor(OXR1) and OX 2 type receptor(OXR2) in lung tissue(P0.05 and P0.01, respectively); the integrative optical densities(IODs) of both receptors were greater in the COPD group(P0.05). For rats with COPD subjected to EA, lung function was improved(P0.05). There were notable decreases in TNF-α and IL-1β levels(P0.05 and 0.01, respectively) in BALF. Orexin A, but not orexin B, levels in lung tissue also decreased(P0.01), as did mRNA expression of OX1 R and OX2 R in lung tissue(P0.05 and P0.01, respectively). Receptor IODs were also reduced after EA treatment(P0.05). Furthermore, orexin A levels and ratio of forced expiratory volume in 0.3 s to forced vital capacity were strongly negatively correlated(P0.01), and orexin A was positively correlated with TNF-α and IL-1β(P0.001 and P0.05, respectively).CONCLUSION: EA at Zusanli and Feishu improved lung function of rats with COPD and had an anti-infl ammatory effect, which may be related to down-regulation of OXA and its receptors.     

Immediate analgesic effect of needling acupoints(bilateral De Qi vs unilateral De Qi) on primary dysmenorrhea: a multi-center,randomized, controlled trail

OBJECTIVE: To analyze the effect of needling acupoints(bilateral vs unilateral) with De Qi using data collected from 501 primary dysmenorrhea(PD) patients participating in multi-center, randomized,controlled trail.METHODS: De Qi was defined as at least one of the feelings in soreness, numbness, fullness or heaviness at the acupoints when stimulated with needles. The 501 patients were grouped in 3 groups in terms of De Qi or not De Qi in one side(unilateral)or both sides(bilateral) of the body: bilateral De Qi group, unilateral De Qi group, and non-De Qi group. The abdominal pains were measured using visual analog scale(VAS).RESULTS: In 501 patients, 472 acquired De Qi at unilateral acupoints, 24 De Qi at bilateral acupoint,and 5 had no De Qi at any acupoint. The data of non-De Qi group was excluded as the sample was less than 5% of that in the bilateral De Qi group.There was significant difference in the VAS before and after treatment between unilateral and bilateral De Qi group(P 0.01). After stratified by acupoints, for the patients needled at Sanyinjiao(SP 6)and Xuanzhong(GB 39), VAS scores in the bilateral De Qi group were larger than those in the unilateral De Qi group(P 0.05).CONCLUSION: Bilateral De Qi was possibly superior to unilateral De Qi in enhancing the immediate analgesic effect of needling the acupoints, but no statistical significance was observed on the pa-tients of needling at non acupoint, which preliminarily suggested this immediate analgesic effect was perhaps along meridians.     

Direct and indirect antimicrobial effects and antioxidant activity of Cordia gilletii De Wild (Boraginaceae)

Cordia gilletii De Wild (Boraginaceae) root bark is traditionally used in Democratic Republic of Congo (DRC) for the treatment of various disorders, including malaria, diarrhea, wounds and skin diseases; part of these activities may rely on antimicrobial and antioxidant properties. Successive extracts of root barks powder with n-hexane, dichloromethane, ethyl acetate, methanol and water were tested for antimicrobial activity, both direct and indirect (antibiotic resistance reversal), against 10 strains of bacteria and 1 strain of fungi by broth microdilution and agar diffusion methods. The eventual synergy between plant extracts and antibiotics was investigated by the determination of the fractional inhibitory concentration index (FIC index). The methanol extract showed direct antimicrobial activity against all tested microorganisms with minimum inhibitory concentrations (MIC) ranging between 125 and 1000 microg/ml, whereas the ethyl acetate and the dichloromethane extracts showed activity on four and three strains, respectively. 200 microg/ml of n-hexane and dichloromethane extracts decreased the MICs of penicillin and streptomycin 4-64-fold for methicillin-resistant Staphylococcus aureus. A synergistic effect was found between the methanol extract and tetracycline, whereas additive effects were observed for the other combinations tested. The methanol and dichloromethane extracts showed the greater antioxidant activity by scavenging the free radical DPPH with IC(50) values of 3.2 and 8.1 microg/ml, respectively. These results support the use of the plant in the treatment of infectious diseases and wounds; they warrant further studies as to the nature of active compounds.     

蒲公英提取工艺优选

目的:优选蒲公英的提取工艺。方法:以总黄酮和槲皮素的含量为指标,通过均匀设计的方法,考察蒲公英提取工艺。结果:溶剂浓度、溶剂用量影响较大。蒲公英的最佳提取工艺为:用13倍药材量的85%乙醇提取2次,每次1h。结论:此工艺提取蒲公英有效成分总黄酮和槲皮素的提取率高。     

在第二次世界中西医结合大会开幕式上的讲话

各位专家、各位来宾、女士们、先生们: 由中国中西医结合学会主办的第二次世界中西医结合大会开幕了,我谨代表中国科学技术协会,向大会的召开表示热烈的祝贺!向来自世界各国和国内的1000多位中西医医务工作者表示热烈的欢迎和崇高的敬意! 在全球跨入21世纪,我国加入世贸组织,中医药走向世界之际,中国中西医结合学会召开第二次世界中西医结合大会,适应时代的发展,事业的要求,必将对推动中西医结合医学及全世界结合医学的创新发展发挥积极作用。     

Long-range (1)H-(15)N heteronuclear shift correlation at natural abundance

Despite the inherently low sensitivity of (15)N NMR because of its low gyromagnetic ratio (gamma(N)) and its relatively low natural abundance (0.37%), this important nuclide still has useful potential as a structural probe even at natural abundance. Inverse-detected NMR methods coupled with major advances in NMR probe designs have made it possible to acquire long-range (1)H-(15)N heteronuclear shift correlation data on samples as small as a micromole overnight. Chemical shift referencing schemes for (15)N and the range of (15)N shifts are discussed, followed by a discussion of the currently available pulse sequences, pulse calibration, parametrization and processing of long-range (1)H-(15)N data, and the implications of probe selection. These topics are followed by a review of the applications contained in the literature that have utilized (1)H-(15)N heteronuclear shift correlation experiments at natural abundance, with emphasis placed on the observed long-range coupling pathways.     

针刺耳门穴治疗牙痛

笔者近年来在临床上应用针刺耳门穴治疗牙痛68例,现报道如下. 1 一般资料 2008年5月-2010年11月来我院针灸科就诊患者68例,其中男38例,女30例;年龄最小12岁,最大75岁,平均33.4岁;病程最短2天,最长1个月.     

太渊穴自发红外辐射的相对特异性

目的探讨太渊穴自发红外辐射在反映肺通气功能方面的相对特异性.方法用PHE201型体表红外光谱仪,对104名志愿者的太渊、内关、大陵及非穴位对照点的自发红外辐射进行检测,分析其与肺功能的相关性.结果在穴位和非穴对照点共10个检测部位中,有6个检测部位在某些波长的自发红外辐射强度与FEVI和MVV有相关关系,但左太渊穴自发红外辐射与肺功能有相关关系的波长数明显多于其它检测部位(P＜0.001或P＜0.01).结论左太渊穴自发红外辐射比邻近的其它检测部位更能灵敏地反映肺通气功能的变化.     

针刺地机与地机、关元对原发性痛经即刻镇痛效应的比较

目的 比较针刺地机与地机、关元治疗原发性痛经的疗效差异,以探讨针刺治疗原发性痛经常用腧穴的配伍关系。方法 将40例原发性痛经患者随机分为单穴组和双穴组,每组20例。单穴组针刺地机穴,双穴组针刺地机、关元穴,观察针刺前后两组患者视觉模拟评分(VAS)随时间的变化,并比较两组数据的差异。结果 双穴组针刺后各时间点VAS读数与针刺前差值均大于单穴组差值。结论 疼痛时针刺地机及地机、关元均可有效治疗原发性痛经,但针刺地机、关元有优于单刺地机的趋势,针刺地机、关元治疗原发性痛经时可能存在协同作用。     

刮痧疗法疾病谱研究

归纳总结中医刮痧疗法疾病谱,为临床应用发展提供参考依据。采用文献计量学方法,对中国知网、万方医学、维普期刊、中国生物医学文献服务系统中刮痧临床观察类论文报道的病证,按照病证分类进行分析总结,并对成人和儿童分别统计。刮痧疾病谱病证总频次1 258个,共涵盖19类,185个病证。成人疾病18类,其中西医疾病144种,西医症状6种,中医病证22种,共172种。儿童疾病8类,其中西医疾病18种,西医症状2种,中医病证7种,共27种。频次在50次以上疾病为颈椎病、肩周炎和失眠,三者占成人疾病总频次的27.37%。单纯使用刮痧疗法的文献有374篇,刮痧联合其他疗法的文献874篇。刮痧疾病谱范围广,优势病种突出,成人疾病以骨骼肌肉系统、神经系统和呼吸系统疾病为主;儿童疾病以呼吸系统、消化系统和泌尿系统疾病为主。并且无论是单独或联合治疗都得到广泛应用,值得临床推广。     

在全国企事业专利试点工作会议上的讲话(摘要)

在我国加入世贸组织开局之年,国家知识产权局与国家经贸委联合召开全国企事业专利试点单位工作会议,是一件很有意义的事。这是我们推动企事业单位专利工作,大力促进企业技术创新,增强企业竞争能力,应对加入世贸组织挑战采取的一项重要措施。下面,我讲三点意见。