乳化剂后加法制备O/W型乳膏基质及质量考察

目的 探讨乳化荆后加法对O／W型乳膏基质质量的影响。方法 用乳化剂分相加入法和乳化剂后加法分别制备O／W型乳膏基质．并对稳定性和释放度进行评价。结果 乳化剂后加法所制得的乳滴粒径小，分散均匀，质量稳定，释放度高。结论 本法可在生产中推广应用。     

不同乳化剂对酮康唑乳膏含量测定影响的研究

OBJECTIVE To observe the influence of the stability and ketoconazole with different emulsifier in its cream.METHODS Ultraviolet spectrophotometry was used according to Chinese Pharmacopoeia 2005.The wavelength of detection was 244 nm. RESULTS The content     

聚氧乙烯在口服控释制剂中的应用

简要介绍了聚氧乙烯的理化性质，综述了近年来聚氧乙烯在口服渗透泵片(OPT)、结肠靶向制剂、部分互相渗透聚合物网络(Semi—IPN)等口服控释制剂中的应用，并与羟丙基甲基纤维素(HPMC)在控释制剂中的应用进行了比较，最后探讨了聚氧乙烯的相对分子质量和药物溶解度对控释制剂释放动力学的影响。     

乳化剂的添加方法对水包油型乳膏基质质量的影响

目的探讨O／W型乳膏基质的乳化剂添加方法对其质量的影响。方法用3种乳化方法制备乳膏基质，对稳定性和释放性进行评价。结果后加乳化剂法所制得的乳膏质量最好。结论本法可推广应用。     

聚氧乙烯硬脂酯酯在霜剂中的应用

简要介绍聚氧乙烯（40）硬脂酸酯的应用现状，重点介绍在霜剂中的应用。实验表明，用S－40配制的霜剂，基质稳定，膏体晶亮、细腻。     

3种乳化法对水包油型乳膏基质质量的影响

目的探讨O/W型乳膏基质的乳化剂添加方法对其质量的影响。方法用3种乳化方法制备乳膏基质,对稳定性和释放性进行评价。结果后加乳化剂法所制得的乳膏质量最好。结论后加乳化剂法是一种值得推广的乳膏的乳化方法。     

新型水溶性基质——聚氧乙烯硬脂酸酯试用于部分栓剂的初步研究

聚氧乙烯硬脂酸酯(S—40)是我国新研制成功的半合成水溶性基质。过去国内多采用脂肪性基质。为了解新基质性能,经多次试验,制成十七种药物栓剂。经过多项测试后,认为此半合成水溶性基质可在部分阴道栓剂与肛门栓剂中使用.     

比较法在药用高分子材料学教学中的应用

药用高分子材料学是现代药剂学的主要基础专业,根据药用高分子材料学的教学内容与结构特点,介绍比较法在药用高分子材料学教学中的应用。在教学过程中,科学合理地运用比较法进行教学可充分调动学生学习的积极性,有利于学生综合素质的提高。     

恩纳乳膏在小儿静脉穿刺术中的应用

目的:研究恩纳乳膏(EMLA)用于小儿静脉穿刺术的临床价值及应用方法.方法:选择120例需行静脉穿刺术患儿,随机平均分为4组.分别于术前穿刺局部涂抹乳白色安慰剂(对照组,Ⅰ组),实验组涂抹不同剂量EMLA,0.2 g·cm-2(Ⅱ组),0.1 g·cm-2(Ⅲ组)和 0.1 g·cm-2(Ⅳ组),面积10 cm-2.各组患儿入治疗室分别于局麻后不同时间2,0.5,1,2 h后行静脉穿刺术.记录患儿痛觉表情评分、哭闹、肢体抵抗、穿刺次数、局部并发症及不良反应.结果:4组患儿穿刺术基本成功,局麻组患儿痛觉表情评分分别为(2.6±1.9),(1.5±1.5)和(1.3±1.6),显著低于对照组(6.9±3.0),P＜0.01.患儿哭闹、肢体抵抗结果与痛觉表情评分分析结果相符.结论:EMLA局麻用于小儿静脉穿刺术安全有效,具有一定的临床应用价值.     

An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation

A reverse phase high performance liquid chromatographic method for quantitation of perillyl alcohol in a topical cream pharmaceutical formulation was developed. Previously reported methods for analyzing drugs in lipid formulations are relatively complex and time consuming, with extraction, purification and derivatization involved. Through a simple dilution of the cream formulation in isopropyl alcohol, the present assay method enables the direct injection of the samples, on an Alltima C18 5 mu, 150 mm x 2.1 mm, narrow bore column (Alltech Associates, Deerfield, IL). The method includes an isocratic run with acetonitrile-water (40:60, v/v) at 0.35 mL/min for 12 min, followed by a gradient wash with isopropyl alcohol for 20 min, to ensure that all formulation excipients are eluted. Ultraviolet detection was performed at 210 nm with a retention time for perillyl alcohol of 7 min. The high sensitivity assay utilizes a small (5 microL) injection volume for the accurate and precise analysis of perillyl alcohol from a complex cream formulation.     

药学信息在药学科研中的应用

目的：介绍药学科研各环节中药学信息的应用，从而提高科研工作的效率与水平。方法：结合药学科研实际工作，介绍科研过程中药学信息的应用情况。结果：无论是在药学科研的选题与方案设计过程中，还是在药学科研方案的实施与总结过程中，药学科研人员都应快速、准确、全面地获取各种相关药学信息。结论：药学信息与药学科研工作息息相关。     

复方利多卡因软膏作为无菌耦合剂在超声定位中的应用

目的:评价复方利多卡因软膏作为无菌耦合剂在超声定位下穿刺中的应用可行性.方法:拟行超声定位下麻醉穿刺的患者60例,ASA分级Ⅰ级或Ⅱ级,年龄18～76岁,体重41～75kg,采用随机数字表法,分为两组(n=60):对照组(C组)和复方利多卡因软膏组(L组).实验组使用复方利多卡因软膏作为耦合剂,对照组使用聚维酮碘溶液作为耦合剂.观察两组超声声像图的清晰程度.结果:与C组比较,L组的超声声像图效果较为理想(P＜0.05).结论:复方利多卡因软膏可作为无菌耦合剂在超声定位中使用.     

Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: A phase II trial

Summary Paclitaxel (Taxol) is formulated in 50% Cremophor EL (CrEL)/absolute ethanol for clinical use. In order to reduce vehicle-related side effects, Genetaxyl was developed to have paclitaxel formulated in a solution containing lesser amounts of CrEL and ethanol plus 2 other solvents. The purpose of the study was to evaluate the efficacy and safety of Genetaxyl as first-line therapy to treat breast cancer patients. Patients with newly diagnosed stage III (N = 8) or IV (N = 10), or recurrent (N = 11) breast cancer received single-agent Genetaxyl at 175 mg/m² administered in a 3-h infusion every 3 weeks for 3–6 cycles. A total of 148 cycles were delivered to 29 patients. The overall response rate was 41.4% (95% confidence interval, 23.4 to 59.2%), and that of patients with metastatic disease (N = 20) was 30%. Median survival for all patients was 32.4 months and 24.3 months for patients having metastatic disease. The toxicity profile seems favorable, especially regarding myelosuppression and myalgia/arthralgia. No severe hypersensitivity reaction occurred. These phase II trial results demonstrate that a 60% reduction of CrEL by Genetaxyls formulation does not affect the activity of paclitaxel and could allow for better control of several CrEL-related toxicities.Taxol is a trademark of Bristol-Myers Squibb Company     

Application of mid-IR spectroscopy for the characterization of pharmaceutical systems

In this article, the use of mid-IR in pharmaceutical settings is reviewed. An overview of mid-IR instrumentation and sampling techniques is provided. Subsequently, different pharmaceutical applications of the technique are described, including structure elucidation and identification, characterization of crystalline (polymorphs, hydrates, salts and co-crystals) and amorphous forms, as well as quantitative and remote sensing applications. Finally, an overview of current trends in FTIR-based imaging applications is provided, with special attention paid to currently emerging FTIR-AFM coupled techniques which have high spatial resolution.     

Application of pharmaceutical profiling assays for optimization of drug-like properties

Pharmaceutical profiling assays provide an early assessment of drug-like properties, such as solubility, permeability, metabolism, stability and drug-drug interactions. This information can be used to alert project teams to potential property issues, predict and diagnose in vivo assay results, guide structure-property relationships, provide insight into structure modification, and help drug discovery teams to make informed decisions. Successful drugs can be developed when biological activities of interest and pharmaceutical properties are optimized in parallel.