Treatment of palmoplantar lichen nitidus with acitretin

We report a patient with lichen nitidus of the palms of the hands and the toes, whose skin lesions responded to treatment with acitretin.     

系统性红斑狼疮合并扁平苔藓1例

报告１例系统性红斑狼疮伴发扁平苔藓。患者女,２８岁,面部蝶形红斑３个月,躯干、四肢紫红斑丘疹伴脱屑１个月,伴关节疼痛。血清抗核抗体及抗Ｓｍ抗体均阳性。手背皮损组织病理检查符合扁平苔藓。     

Coexisting lichen planus and subacute cutaneous lupus erythematosus

We report a patient who presented with annular erythematous skin lesions and generalized lichenoid papules. The clinical picture as well as histopathology, immunofluorescence and laboratory findings indicated coexistence of subacute cutaneous lupus erythematosus (SCLE) and extensive generalized lichen planus (LP). Clinically and historically, SCLE-like lesions appeared to progress into LP-like lesions, supporting the concept of a common autoimmune pathophysiology in these disorders. Treatment with cyclosporin A (2.5 mg/kg body weight) resulted in a significant remission of the inflammatory skin lesions.     

Hypertrophic lichen planus – successful treatment with acitretin

Lichen planus classifies into different subtypes according to morphology and location. Hypertrophic LP (HLP) manifests a great challenge due to persistent itching, the risk to develop into squamous cell carcinoma and therapeutic resistance. We report two clinical cases exemplary for the successful treatment of dramatic‐resistant HLP with acitretin.     

An unusual variant of lupus erythematosus or lichen planus

Four patients with a similar eruption of distinct livid plaques are presented. Clinically, the lesions were difficult to diagnose as either lichen planus or lupus erythematosus. However, histological studies with standard and immunofluorescence staining methods were more consistent with lichen planus. In contrast, certain laboratory findings and the clinical course were suggestive of lupus erythematosus.     

Blaschkoid lichen planus occurring in childhood systemic lupus erythematosus

Lupus erythematosus-lichen planus (LE-LP) overlap syndrome represents a rare disorder with clinical and histopathological features of both lichen planus and lupus erythematosus presenting in the same lesions. However, lichen planus and lupus erythematosus can also coexist in the same patient. Blaschkoid lichen planus in the setting of concurrent childhood-onset systemic lupus erythematosus has not been previously described.     

A case of lupus erythematosus/lichen planus overlap syndrome

A case of lupus erythematosus/lichen planus overlap syndrome (LE/LP overlap syndrome) was reported. A 53-year-old woman developed violaceous erythema around the nostrils and the upper lips and atrophic scaly erythema on the cheeks and neck. Histopathological studies revealed that the patient had distinct discoid lupus erythematosus (DLE), LP, and a lesion with combined features of DLE and LP. Direct immunofluorescent (DIF) studies of the mixed lesion revealed both prominent immunoglobulin (Ig)G deposits in a granular pattern at the basement membrane zone (BMZ) and IgM deposits in the clusters of cytoid bodies; the former are more typical of LE and the latter more of LP. DIF features in combination were unique for LE/LP overlap syndrome. The patient was satisfactorily treated with topical tacrolimus. While reports support the effectiveness of tacrolimus in either LE or LP, this is the first case of LE/LP overlap syndrome treated with topical tacrolimus.     

红斑狼疮／扁平苔藓重叠综合征一例

临床资料患者,男,66岁。主因双耳郭、手背及足跟部紫红色斑片、反复破溃伴疼痛10年余,于2012年1月13日就诊。     

A comparative immunohistochemical study of lichen planus and discoid lupus erythematosus

A comparative immunohistochemical study was performed on skin biopsies from 10 patients with lichen planus and 10 patients with discoid lupus erythematosus (DLE). A panel of antibodies against T lymphocytes (UCHL-1, OPD-4, CD8, CD45), B lymphocytes (L-26), granulocytes (Leu-M1), activation markers (Ki-1, LN-3), macrophages, fibroblasts and dendritic cells (FXIIIa, S-100, Mac-387, K.P-1, vimentin), endothelial cells (CD34), and epithelial cells (epithelial membrane antigen) was employed using a peroxidase-anti-peroxidase technique. The recently released CD8 antiserum required microwave antigen retrieval of formalin-fixed, paraffin-embedded tissue to label lymphocytes. The results showed many similarities in the lymphocyte subsets and macrophages between lichen planus and discoid lupus erythematosus. The most important differences between the two conditions were statistically significant increases in the number of S-100⁺ cells in the epidermis and dermis, FXIIIa⁺ cells in the dermis and CD34⁺ vessels within the inflammatory infiltrate in lichen planus.     

Keratin and involucrin expression in discoid lupus erythematosus and lichen planus

Received: 23 April 1996     

口腔和掌跖扁平苔藓一例

正临床资料患者,女,67岁。主因口腔黏膜丘疹及斑块5个月余,掌跖部紫红色斑丘疹3个月,于2015年4月13日就诊。5个月前,无明显诱因患者左侧口腔颊黏膜出现数个黄豆大小淡红色丘疹,3个月前皮损蔓延至右颊黏膜,并由淡红色丘疹转为灰白色斑块,同时双掌跖部也出现紫红色斑疹和丘疹,伴轻度瘙痒。1个月前曾于外院诊断为口腔黏膜白斑,口服羟基氯喹1个月(具体剂量不详),皮损未见消退,