中孕期子宫动脉及髂内动脉彩色多普勒超声预测不良妊娠结局的价值

目的 应用彩色多普勒超声观测中孕期子宫动脉及髂内动脉血流频谱的变化，分析其预测不良妊娠结局的价值。方法 收集我院中孕期子宫动脉血流频谱出现舒张早期切迹的孕妇46例（切迹组）和子宫动脉舒张早期无切迹的正常孕妇51例（对照组），应用彩色多普勒超声获得子宫动脉及髂内动脉的收缩期与舒张期峰值血流速度比值（S/D）、搏动指数（PI）、阻力指数（RI），以及髂内动脉峰值血流加速时间（IIA-AT）、内径及血流量，比较两组上述参数的差异，分析子宫动脉及髂内动脉血流参数对不良妊娠结局的检出率。结果 与对照组比较，切迹组子宫动脉S/D、PI、RI和髂内动脉S/D均升高，IIA-AT延长，差异均有统计学意义（均P<0.05）。切迹组发生不良妊娠结局9例；对照组发生不良妊娠结局1例。子宫动脉舒张早期切迹联合IIA-AT、髂内动脉S/D对不良妊娠结局的检出率（50.0%）高于子宫动脉舒张早期切迹单独应用（19.6%），尤其对子痫前期的检出价值更高（40.0%vs. 10.9%），差异均有统计学意义（均P<0.05）。结论 中孕期子宫动脉舒张早期切迹联合髂内动脉血流频谱参数可以预测不良妊娠结局的发生...     

孕中期子宫动脉血流多普勒超声检查与子痫前期妊娠结局及新生儿预后的相关研究

目的探讨彩色多普勒超声对孕中期孕妇双侧子宫动脉血流参数值、双侧子宫动脉舒张早期切迹的监测在子痫前期进展中的作用,并分析其与妊娠结局及新生儿预后的关系。方法回顾性分析行孕期产前检查并分娩的89例子痫前期患者,分为轻度子痫前期组(A组),重度子痫前期组(B组),同时选择100例同期无任何妊娠合并症的单胎孕妇作为对照组(C组)。比较3组孕患在孕20~26周行四维超声检查时其子宫动脉血流参数情况,测量子宫动脉的搏动指数(PI)、阻力指数(RI),记录舒张早期切迹数目,分析这些参数预测妊娠结局与新生儿预后的价值。结果 B组新生儿预后较其他2组显著较差(P0.05),子宫动脉PI、RI值显著高于A组及C组(P0.05)。子痫前期组舒张早期切迹发生率显著高于对照组(P0.05)。结论孕中期双侧子宫动脉血流参数值及舒张早期切迹可用于预测子痫前期特别是重度子痫前期的发生。     

子宫动脉血流检测在预测妊娠合并糖尿病围产儿结局中的价值

目的 探讨子宫动脉血流检测在预测妊娠合并糖尿病围产儿结局中的价值.方法 选择妊娠合并糖尿病孕妇58 例,随机选择同期分娩的正常孕妇60 例为对照组,进行子宫动脉血流指数S/D 值、阻力指数(RI),搏动指数(PI)的测定.比较两组数据,并随访围产儿结局.结果 在妊娠合并糖尿病组中S/D 值、PI、RI 分别高于对照组,但差异无统计学意义(均P ＞0.05).病例组低体重儿PI、RI 明显高于正常儿(P ＜0.05).巨大儿RI、PI 低于正常儿(P ＜0.05).病例组其他预后不良PI、RI 高于正常儿(P ＜0.05).结论 在妊娠合并糖尿病孕妇中进行子宫动脉血流监测,对围产儿结局的预测存在一定局限.     

孕11～13~(+6)周子宫动脉超声多普勒血流参数与子痫间前期相关性的研究

目的 :探讨孕11~13+6周时,采用超声多普勒监测孕妇子宫动脉血流以评估超声检测对预测子痫间前期的可行性。方法:选择1 500例在我院行正规产前检查的单胎妊娠孕妇,于孕11~13+6周时采用超声多普勒检测双侧子宫动脉血流,并记录双侧子宫动脉血流搏动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、有无舒张早期切迹等。随访所有研究对象的妊娠过程及母胎结局等情况。结果:11 500例孕妇中11例于中孕期终止妊娠,72例发生妊娠期高血压疾病,214例发生其他不良妊娠结局,另1 203例正常妊娠(正常组)。2将72例发生妊娠期高血压疾病的孕妇分为早发型子痫间前期(16例)、迟发型子痫间前期(26例)、妊娠期高血压(30例)3组,各组的子宫动脉血流PI和RI值均高于正常组(P     

初产妇子宫动脉频谱多普勒超声表现与妊娠期高血压疾病的关系及对妊娠结局的影响

目的探讨初产妇子宫动脉血流阻力指数(RI)、舒张早期切迹与妊娠期高血压疾病的关系及对妊娠结局的影响。方法选择妊娠20周初产妇632例,测量双侧子宫动脉RI,计算其均值,并观察舒张早期切迹;其中483例RI≤0.58为RI正常组1,149例RI>0.58于妊娠26周再次测量,75例RI≤0.58为RI正常组2,49例RI>0.58为RI异常组。结果 RI正常组1和RI正常组2高血压疾病的发生率差异无统计学意义,故将两组合并为RI正常组。RI异常组的高血压疾病发生率和不良妊娠结局的发生率高于RI正常组。妊娠26周时,有舒张早期切迹的产妇妊娠期高血压疾病及子痫前期、子痫的发生率分别是66.7%、13.3%,高于无切迹者(P<0.05)。结论初产妇子宫动脉RI增高是早期发现妊娠期高血压的一项较敏感指标。     

应用彩色多普勒超声检测子宫动脉对子痫前期的预测价值

[目的]探讨彩色多普勒超声检测孕妇子宫动脉的血流动力学变化对子痫前期的预测价值.[方法]选择在本院建卡产检并分娩的孕妇共90例,根据妊娠经过及妊娠结局分为妊娠高血压组、子痫前期组及对照组,所有孕妇均在孕22～24周接受彩色多普勒超声检查,比较三组孕妇子宫动脉收缩期峰值流速与舒张末期血流速度的比值(S/D)、平均搏动指数(PI)及阻力指数(RI)及有无舒张早期“V”行切迹波出现.[结果]妊娠高血压组、子痫前期组孕妇双侧子宫动脉的S/D、PI、RI值均较对照组高(P＜0.05);且子宫动脉S/D、PI、RI值显著高于妊娠高血压组(P＜0.05).对照组孕妇两侧子宫动脉血流频谱显示无一例出现舒张压早期“V”形切迹;妊娠高血压组两侧子宫动脉同时出现舒张期“V”形切迹18例,单独左侧出现10例,单独右侧出现2例;子痫前期组两侧子宫动脉同时出现舒张期“V”形切迹21例,单独左侧出现7例,单独右侧出现2例.[结论]彩色多普勒超声检测孕妇子宫动脉血流动力学变化对子痫前期可早期预测,为临床子痫前期的早期诊断及治疗提供有价值的依据.     

子宫动脉血流异常频谱与晚发型子痫前期患者围产期结局的相关性研究

[目的]探讨晚发型子痫前期患者子宫动脉血流异常频谱对围产期结局的影响.[方法]观察136例晚发型子痫前期患者子宫动脉血流彩色多普勒频谱,根据子宫动脉阻力指数（RI）和是否存在舒张早期切迹进行分组,对比各组之间围产期不良结局发生率.[结果]频谱正常组52例（RI〈0.61,无舒张早期切迹）、异常频谱1组49例（RI≥0.61,无舒张早期切迹）和异常频谱2组35例（RI≥0.61,或存在舒张早期切迹）.子宫动脉RI≥0.61或存在舒张早期切迹是早产、死胎、新生儿低出生体重和小于胎龄儿、出生5 min时Apgar评分小于7分和缺血缺氧性脑病等围产期不良结局的危险因数.[结论]对晚发型子痫前期患者常规进行子宫动脉血流频谱测定有助于预测围产期不良结局.     

早孕前、后子宫动脉血流与妊娠结局的相关性研究

目的通过对育龄期正常及复发性流产(RSA)妇女备孕前1个月及孕后10周内子宫动脉血流(UtA)动力学系统相关指标的观察,了解月经周期的黄体期及孕10周内UtA动力学特点及其对妊娠结局的影响。方法将既往无不良妊娠史的育龄期妇女250例及既往有3次及以上自然流产的史妇女168例纳入研究,采用阴道超声于排卵后及孕10周内监测研究对象双侧子宫动脉血流动力学参数,测量参数包括搏动指数(PI)、阻力指数(RI)、收缩期峰值流速/舒张末期流速(S/D);记录各组的PI、RI、S/D值,统计分析各组子宫动脉PI、RI、S/D值的差异,比较妊娠丢失率的不同。结果孕前后或孕后子宫动脉血流异常者与正常者相比较,妊娠丢失率有统计学差异(P<0.05)。孕前后或孕后子宫动脉血流值异常未治疗者与治疗后孕10周内恢复正常者比较,PI、RI、S/D及妊娠丢失率均有统计学差异(P<0.05)。RSA患者孕前异常血流经治疗后,孕后子宫动脉血流异常率降低、异常血流治疗恢复率升高,与孕前未纠正者相比较,有统计学差异(P<0.05)。结论孕早期子宫动脉血流参数与妊娠结局有相关性。异常血流早期纠正,能显著改善妊娠结局。RSA患者孕前子宫动脉血流参数影响妊娠结局。     

唐氏血清学指标与子宫动脉血流的相关性及其对不良妊娠结局的预测价值

目的探讨唐氏血清学指标与子宫动脉血流情况的相关性及对不良妊娠结局的预测价值。方法选取建档进行规范化产检的孕妇400例,唐氏血清学筛查指标异常的200例孕妇为实验组,其中神经管缺陷筛查(NTD)高风险者88例,NTD低风险组者112例。唐氏血清学指标正常的200例孕妇为对照组。实验组及对照组孕妇均测量其子宫动脉血流情况(PI、RI、S/D),并记录不良妊娠结局的发生情况,分析唐氏血清学指标与子宫动脉血流情况的相关性及对不良妊娠结局的预测价值。结果实验组中NTD高风险、低风险孕妇及对照组孕妇PI、RI、S/D值比较,差异有统计学意义(P0.05)。实验组中NTD高风险、低风险孕妇及对照组孕妇不良妊娠结局发生率分别为17.05%(15/88)、8.93%(10/112)、2.00%(4/200),实验组与对照组比较,差异有统计学意义(P0.05)。结论唐氏血清学筛查指标与子宫动脉血流相关,唐氏筛查风险越高,子宫动脉血流阻力越大,不良妊娠结局的发生率也越高。应给予唐氏血清学筛查指标异常的孕妇早期干预以改善子宫动脉血流,降低不良妊娠结局发生率。     

超声子宫动脉血流参数与妊娠期高血压综合征孕妇妊娠结局的关系分析

目的 探讨超声子宫动脉血流参数与妊娠期高血压综合征(妊高症)孕妇妊娠结局的关系。方法 从2018年1月至2021年1月在河南宏力医院建档的妊娠晚期孕妇中,选择80例确诊有妊高症的孕妇作为研究组,另选取30例健康孕妇作为对照组,统计并比较两组妊娠前(37～40周)最后一次产检时彩色多普勒超声检查中子宫动脉血流阻力指数(RI)、子宫动脉血流搏动指数(PI)和子宫动脉收缩-舒张流速比值(S/D)水平。另对研究组孕妇随访至分娩,根据妊娠结局分为良好组和不良组,收集并比较良好组与不良组产妇的临床资料,包括年龄、体质指数(BMI)、舒张压(DBP)和收缩压(SBP)水平、超声子宫动脉血流参数(RI、PI、S/D)水平、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血清纤维蛋白原(FIB)、血肌酐(Cr)、尿素氮(BUN)水平、24 h尿蛋白(Pro)量,多胎妊娠史、糖尿病史、高血压史、肾炎史、家族史。采用Logistic回归分析法明确超声子宫动脉血流参数与妊高症孕妇妊娠结局的关系。结果 与对照组比较,研究组孕妇子宫RI、PI、S/D水平均偏高(P<0.0...     

Uterine and umbilical artery flow velocity waveform analysis in pregnancies complicated by chronic hypertension or preeclampsia

Using continuous wave Doppler ultrasound, we studied the umbilical and uterine flow velocity waveforms in 68 pregnant women who had chronic hypertension and/or preeclampsia. The systolic-diastolic (S/D) ratio was considered an expression of vascular resistance peripheral to the point of insonation. Abnormal umbilical artery S/D ratio (greater than 95th percentile) alone or with abnormal uterine artery S/D ratio was associated with poor pregnancy outcome as judged by incidence of intrauterine growth retardation (IUGR), cesarean section rate, birth weight, perinatal morbidity and mortality, and prematurity. In patients with preeclampsia and abnormal Doppler values, pregnancy outcome was poor, whereas in those with normal Doppler values, pregnancy outcome approached normal. The same relationship was also found in patients with chronic hypertension. The sensitivity and specificity for the prediction of IUGR by the umbilical artery S/D ratio alone was 71% and 93%, respectively. The uterine artery S/D ratio alone yielded a 66% sensitivity and 64% specificity, and when both tests were taken into account, the sensitivity increased to 75% and the specificity to 100%. Abnormal umbilical and uterine artery S/D ratios were associated with 100% IUGR and 25% perinatal mortality. We conclude that in pregnant women with hypertensive disorders there is a significant difference in pregnancy outcome between those with normal and those with abnormal Doppler values. Umbilical artery S/D ratio alone is a better predictor of IUGR and poor pregnancy outcome than the uterine artery S/D ratio.     

Perinatal outcome in pregnancies with a positive serum screening for Down's syndrome due to elevated levels of free beta-human chorionic gonadotropin.

OBJECTIVE: To evaluate the potential clinical use of maternal serum free beta-human chorionic gonadotropin (beta-hCG) and uterine artery Doppler investigation to screen for placenta-related adverse outcome in pregnancies at positive risk for Down's syndrome at 15-18 weeks. DESIGN: A cohort of 329 consecutive pregnant women with a singleton viable pregnancy and a positive risk for Down's syndrome was retrospectively investigated. This group was obtained from an unselected population of 3952 women attending the same hospital over a 2-year period. Using the results of this first analysis, we selected a group of 26 women with unexplained high levels of free beta-hCG and followed them prospectively with monthly ultrasound and uterine artery Doppler examinations. RESULTS: In the retrospective cohort, risk ratios stratified for maternal serum beta-hCG multiple of the median (MoM) values indicated that the highest incidence of adverse pregnancy outcome was in those women with values of > or = 5.0. In the prospective study, pregnancy outcome was complicated by uteroplacental disorders in eight cases. Analysis of the Doppler investigation indicated that, in women with a very high level of hCG, an abnormally high uterine artery pulsatility index (PI) had lower sensitivity and negative predictive value than early diastolic notch, whereas the specificity and positive predictive value were higher for a high uterine artery PI. CONCLUSIONS: These findings suggest an association between a high level of maternal serum beta-hCG at 15-18 weeks, the presence of an early diastolic notch in the uterine artery flow velocity waveform and adverse pregnancy outcome due to abnormal development of the uteroplacental circulation. Young women with an unexplained high beta-hCG level would benefit, apart from detailed sonography of the fetus and/or karyotyping, from uterine Doppler investigation and counselling about the follow-up and management of placenta-related pregnancy disorders.     

高危妊娠子宫动脉血流动力学变化及对妊娠结局的影响

目的 探讨高危妊娠子宫动脉的血流动力学及与妊娠结局的关系。方法 高危妊娠组62例，正常妊娠组32例。经彩色多普勒检测两组双例子宫动脉的阻力并与妊娠结局相比较。结果 高危妊娠组子宫动脉的收缩期峰值速度／舒张期血流速度值显著高于正常妊娠组；高危妊娠组子宫动脉舒张早期切迹的出现率显著高于正常妊娠组；高危妊娠组的妊娠结局较差。结论 子宫动脉的彩色多普勒血流动力学检测对研究妊娠病理生理及对高危妊娠围产儿结局的监测具有很大的实用价值。     

First-trimester uterine artery blood flow and birth weight.

OBJECTIVES: To determine reference values for first-trimester uterine artery resistance index (RI) in healthy pregnant women with uncomplicated pregnancies and to investigate the relationship between uterine artery Doppler indices and birth weight. METHODS: This was a cross-sectional study of 265 consecutive pregnant women attending routine ultrasound examination at 11-14 weeks' gestation. Both uterine arteries were identified using color Doppler ultrasound and the RI was measured. The presence or absence of an early diastolic notch was also noted. Pregnancy outcomes were obtained from the delivery suite database and birth weight was expressed as Z-scores. RESULTS: The 5(th), 50(th) and 95(th) centiles for uterine artery RI between 11 and 14 weeks' gestation were 0.53, 0.71 and 0.85, respectively. Complete pregnancy outcome data were available for 246 fetuses. There was a significant negative correlation between birth-weight Z-scores and first-trimester uterine artery mean RI (r = - 0.219, P = 0.001). The difference in birth weight between fetuses with absent and those with bilateral diastolic notches was also significant (P < 0.001). Multiple regression analysis demonstrated that both mean RI (standardized regression coefficient = - 0.14, P = 0.039) and uterine artery notching (standardized regression coefficient = - 0.17, P = 0.017) contributed independently towards the prediction of birth-weight Z-score. CONCLUSIONS: A significant negative correlation exists between birth weight and first-trimester uterine artery Doppler parameters, a reliable and non-invasive method of examining uteroplacental perfusion. The value of first-trimester uterine artery Doppler as a prognostic screening tool, either in isolation or in conjunction with maternal biochemistry, remains to be determined.     

Platelet changes and subsequent development of pre-eclampsia and fetal growth restriction in women with abnormal uterine artery Doppler screening.

OBJECTIVES: To investigate whether, in women with abnormal uterine artery Doppler, platelet volume and function will identify a subgroup of women at increased risk of pre-eclampsia and intrauterine growth restriction and whether in-vitro platelet aggregation precedes the onset of clinical disease. DESIGN: Platelet number, volume and aggregation induced by collagen or adenosine 5'-diphosphate were evaluated in 16 non-pregnant controls, 29 pregnant women with normal uterine artery Doppler and 31 pregnant women with abnormal Doppler, hence at risk of pre-eclampsia and intrauterine growth restriction at 23 weeks. Outcome of pregnancy was recorded in each case. RESULTS: Twelve women in the group with abnormal uterine artery Doppler subsequently developed pre-eclampsia and/or intrauterine growth restriction. All women with normal uterine artery Doppler had a normal pregnancy outcome. No differences in platelet count or in vitro platelet aggregation induced by collagen were observed between the groups. Mean platelet volume was greater in those with abnormal Doppler who had intrauterine growth restriction or normal pregnancy outcome compared with normal Doppler (10.3 and 10.3 vs. 9.4 fL, P = 0.004 and P = 0.01, respectively). Aggregation induced by adenosine diphosphate was higher in women with abnormal Doppler who developed pre-eclampsia or intrauterine growth restriction compared with those with normal outcomes (66.5 and 66.5 vs. 21%, P = 0.02, P = 0.03, respectively). CONCLUSIONS: Women with abnormal uterine artery Doppler at 23 weeks show alterations in mean platelet volume and platelet function that relate to subsequent adverse outcome.     

Comparison of color Doppler uterine artery indices in a population at high risk for adverse outcome at 24 weeks' gestation.

OBJECTIVE: To compare uterine artery Doppler velocity and impedance indices in the presence and absence of uterine artery waveform notches, in the prediction of adverse pregnancy outcome in high-risk women. METHODS: One hundred and fifty-seven women identified at Doppler screening as being at 'high risk' underwent a further uterine artery Doppler assessment at 24 weeks' gestation. Pulsatility and resistance indices and minimum, time averaged and time averaged maximum velocities were measured, and the presence of bilateral notches noted. Adverse outcomes were pre-eclampsia, birth weight less than the tenth centile, placental abruption and intrauterine death. The best cut-off for each parameter was assessed by univariate logistic regression, and the comparative performance of the screening parameters was assessed using kappa values. RESULTS: The best performing index in the presence of bilateral notches was mean resistance index, for a cut-off of 0.67, giving a kappa value of 0.65. Mean pulsatility index and lowest pulsatility index performed similarly well, both with kappa values of 0.58. All velocity indices apart from lowest minimum velocity had kappa values of < 0.4. When indices were analyzed, irrespective of notch status, mean resistance and mean pulsatility indices performed similarly, with kappa values of 0.49 and 0.46, respectively; mean minimum velocity had a kappa value of 0.4. CONCLUSIONS: In a high-risk population, uterine artery Doppler mean resistance indices perform better than do velocity indices in the prediction of adverse pregnancy outcome, irrespective of notch status.     

子宫动脉超声多普勒血流监测在妊娠期高血压疾病晚期中的应用

目的 探讨子宫动脉超声多普勒血流监测在妊娠期高血压疾病晚期中的应用价值.方法 超声检测68例妊娠期高血压疾病和47例正常妊娠孕妇(对照组)的子宫动脉血流动力学参数:收缩-舒张流速比(S/D)、阻力指数、搏动指数,比较两组子宫动脉各血流参数及妊娠结局的差异;同时将妊娠期高血压疾病阻力指数正常组与异常组的妊娠结局进行比较....     

Doppler examination of uteroplacental circulation in early pregnancy: Can it predict adverse outcome?

PURPOSE: To determine whether spectral Doppler measurements obtained from bilateral uterine, arcuate, radial, and spiral arteries in early gestation correlate with adverse pregnancy outcome. METHODS: One hundred five pregnant women underwent transvaginal Doppler sonographic examination of uteroplacental circulation at 6-12 weeks' gestation. Resistance index (RI) and pulsatility index (PI) of bilateral uterine, arcuate, radial, and spiral arteries were measured. Diameters of gestational sac (GS) and yolk sac, crown-rump length (CRL), GS-CRL difference, and GS/CRL ratio were also recorded. Correlation was made with pregnancy outcome. RESULTS: Sixteen women developed adverse pregnancy outcome. In these women, right uterine artery PI and RI were significantly higher than in women with normal obstetrical outcome. Spiral artery PI and RI values were also higher, but the difference was not statistically significant. GS-CRL difference, GS/CRL ratio, and yolk sac diameters were significantly lower in this group. CONCLUSION: Transvaginal Doppler examination can detect hemodynamic changes in uteroplacental circulation associated with subsequent adverse pregnancy outcome.     

Doppler velocimetry discordancy of the uterine arteries in pregnancies complicated by diabetes.

The aim of this study was to examine the association between uterine artery Doppler velocimetry discordance and perinatal outcome, specifically in pregnancies complicated by diabetes. We evaluated 265 women with singleton pregnancies complicated by diabetes who underwent Doppler ultrasonographic examinations of the right and left uterine arteries within 1 week before delivery. The absolute difference between the right and left uterine arteries was computed after measuring the uterine artery systolic-diastolic ratio. Adverse outcome was defined as still-birth, intrauterine growth restriction, delivery before 37 weeks' gestation, or cesarean delivery for fetal risk. The discordance between right and left uterine artery systolic-diastolic ratios ranged from 0 to 2.3, with a mean of 0.39 +/- 0.36 and a median of 0.30. The discordance was significantly larger in the 63 pregnancies with adverse outcome than in those with good outcome (0.48 versus 0.36, P = 0.018). Among the women with large uterine artery S/D ratio differences (> or = 0.60), a cesarean delivery for fetal risk was three times more likely (21.5% versus 7.5%, P = 0.002). In diabetic women with chronic hypertension (n = 36), the discordance was significantly larger than in the 201 normotensive women (0.54 versus 0.35, P = 0.001); yet for this subgroup uterine artery S/D ratio discordance was not predictive of adverse outcome. In conclusion, although considerable overlap in discordance exists between the good and adverse outcome groups, the uterine artery S/D ratio discordance added prognostic information on perinatal outcome for normotensive women with diabetes. The predictive value is independent of White's classification, third trimester glycemic control, sex of the infant, and umbilical artery Doppler waveform data.     

彩色多普勒超声检测子宫动脉及脐动脉在晚发型宫内生长受限中的价值

目的：彩色多普勒超声检测母体子宫动脉和胎儿脐动脉在晚发型宫内生长受限的血流动力学价值及预测不良围产儿结局。 方法：分析晚发型宫内生长受限的孕妇169例和58例同期分娩正常孕妇,于妊娠期产前超声多普勒分别检测子宫动脉和脐动脉的搏动指数(PI),比较各组动脉血流异常及妊娠结局不良发生率。 结果：晚发型FGR孕妇中胎儿宫内窘迫所致急诊剖宫产、早产、新生儿1min Apgar评分评分、转入NICU、子宫动脉血流异常及脐动脉血流异常例数发生率分别为48.5%、39.6%、31.4%、35.5%、31.4%和21.9%,均高于对照组(P <0.05);在晚发型宫内生长受限孕妇中妊娠结局不良发生率,D组(子宫动脉和脐动脉血流均异常)明显高于A组(子宫动脉和脐动脉血流均正常),而除了胎儿宫内窘迫所致急诊剖宫产外,B组(子宫动脉异常,脐动脉正常)妊娠结局不良发生率高于C组(子宫动脉正常,脐动脉异常)。 结论：超声多普勒检测检测晚发型胎儿生长受限孕妇的子宫动脉和脐动脉的血流动力学,是了解围产儿预后的有效监护手段,在晚发型胎儿生长受限孕妇中,子宫动脉和脐动脉均异常,提示妊娠合并症增加和围产儿结局不良。