Perforating marginal ulcers after laparoscopic gastric bypass

Background: Laparoscopic Roux-en-Y gastric bypass (LGB) can be performed with minimal morbidity and mortality. This article describes the first presentation of a known disease entity after LGB: perforating marginal ulcers of the jejunum immediately distal to the gastrojejunal anastomosis. Methods: A chart review of 902 LGB procedures performed by a single surgeon between April 2000 and September 2004 identified eight patients with perforating marginal ulcers. Results: The patients presented an average of 157 days (range, 53–374 days) after LGB. All the patients were treated using laparoscopic primary closure followed by medical therapy. Morbidity, in one patient only, consisted of two abdominal fluid collections requiring separate drainage procedures. There was no mortality. The average follow-up period was 13 months (range, 2–18 months). No patient experienced recurrent ulceration. Conclusions: Although the etiology is unclear, marginal ulcers, a known complication of gastrojejunostomy, may present as perforating ulcers after LGB in a characteristic fashion and can be managed laparoscopically.     

Perforated marginal ulcer after gastric bypass for obesity: a systematic review

Marginal ulcers are a recognized complication of gastric bypass procedures for obesity. Perforated marginal ulcer (PMU) is a life-threatening complication of marginal ulcers. We performed a systematic review to understand the presentation, management, and outcomes of PMUs. PubMed, Google Scholar, and Embase databases were searched to identify all studies on PMUs after gastric bypass procedures. A total of 610 patients were identified from 26 articles. The mean age was 39.8±2.59 years, and females represented most of the cohort (67%). The mean body mass index was 43.2±5.67 kg/m². Most of the patients had undergone a Roux-en-Y gastric bypass (98%). The time gap between the primary bariatric surgery and the diagnosis of PMU was 27.5±8.56 months. The most common presenting symptom was abdominal pain (99.5%) and a computed tomography scan was the diagnostic modality used in 72% of the patients. Only 15% of patients were on prophylactic proton pump inhibitors or H2 blockers at the time of perforation, and 41% of patients were smoking at the time. Twenty-three percent of patients were on nonsteroidal anti-inflammatory drugs. Laparoscopic omental patch repair of the perforation (59%) was the most used technique; 18% of patients underwent open surgery, and 20% were managed non-surgically. Thirty-day mortality was 0.97%; it was 1.21% (n=5) and 0% (n=0) in those who were managed surgically and nonsurgically, respectively. Ulcers recurred in 5% of patients. In conclusion, PMU is a surgical emergency after gastric bypass that can result in significant morbidity and even mortality. This is the first systematic review in scientific literature characterizing this condition.     

Ulcer disease after gastric bypass surgery

BACKGROUND: The mechanism of marginal ulceration after laparoscopic gastric bypass surgery is poorly understood. We reviewed the incidence, presentation, and outcome of ulcer disease in consecutive patients undergoing laparoscopic gastric bypass surgery. METHODS: The outcomes of 201 consecutive laparoscopic gastric bypass surgery procedures were prospectively analyzed for complications. All procedures were performed using a linear stapled anastomosis and absorbable suture. RESULTS: The incidence of marginal ulcer disease was 3.5% (7 patients). One patient, the only smoker, presented with an acute perforation 4 months postoperatively. Three other patients presented with bleeding-all required transfusion. The remaining 3 patients presented with severe pain. At endoscopy, all patients had ulcerations associated with the Roux limb mucosa and were all successfully treated using proton pump inhibitors and sucralfate therapy. Symptoms of marginal ulceration occurred an average of 7.4 months (range 3-14) after surgery. The average follow-up was 19.8 months. No preoperative factors were predictors of ulcer disease, including body mass index, age, gender, or co-morbidities. CONCLUSION: Marginal ulcers using the linear-stapled technique occurred in 3.5% of patients. Three distinct clinical presentations occurred: bleeding, pain, or perforation. No preoperative risk factors were identified that predicted for this complication. Medical management is an effective treatment.     

Multimedia article. Laparoscopic repair of a perforated marginal ulcer 2 years after gastric bypass

The authors present the case of a 43-year-old women who underwent a laparoscopic gastric bypass in 2003 for morbid obesity. They report that 2 years later, she had maintained significant weight loss, but had developed acute abdominal pain, followed by nausea and emesis. In the emergency room, she had diffuse tenderness, tachycardia, and leukocytosis. After initial resuscitation, a computed tomography was performed, which showed free air above the liver and thickened small bowel loops. She was brought emergently to the operating room for laparoscopy. At surgery, turbid fluid and inflamed small bowel loops were seen. A perforated marginal ulcer was discovered in the Roux limb, approximately 2 cm distal to the gastrojejunal anastomosis. The perforation was oversewn primarily and patched with omentum. The repair was tested by intraoperative endoscopy. A gastrostomy tube also was placed within the gastric remnant for enteral access. The patient did extremely well postoperatively, and had an uneventful postoperative course. She was discharged on postoperative day 4. The gastrostomy tube was removed at 1 month, and at this writing, she remains well since surgery. An upper endoscopy at 2 months was completely normal, and the Helicobacter pylori test results were negative. The gastric pouch had not significantly enlarged since initial surgery, as indicated by both endoscopy and barium study. Marginal ulcer is reported to be 0.6% to 16% after laparoscopic gastric bypass. Etiologies include gastrogastric fistula, excessively large gastric pouch containing antral mucosa, H. pylori infection, nonsteroidal antiinflammatory use, and smoking. Unfortunately, none of these applied to the reported patient. Because her exact etiology remains unknown, she at this writing continues to receive proton pump inhibitor therapy.     

Management and treatment outcomes of marginal ulcers after Roux-en-Y gastric bypass at a single high volume bariatric center

BackgroundMarginal ulceration (MU) is one of the most common complications after Roux-en-Y gastric bypass (RYGB). However, the rate of MU varies from 1% to 16% of RYGB patients and predisposing factors remain unclear. The aim of this study is to describe frequency, management, and outcomes of treatment in patients with MU after laparoscopic RYGB.MethodsBetween January 2004 and December 2012, a total of 2,535 patients underwent laparoscopic RYGB at our institution. Patients were routinely placed on proton pump inhibitors (PPI) for 90 days after the procedure. A total of 59 (2.3%) patients presented with MU. A retrospective review of a prospectively collected database was performed for all patients.ResultsPatients with MU presented with abdominal pain (n = 35), nausea/vomiting (n = 9), anemia (n = 5), hematemesis (n = 5), and dysphagia (n = 5) as chief complaints. Diagnosis was made at a mean period of 15.2±17.4 months (range, 1–64) after the laparoscopic RYGB. Of these patients, 26 (44.1%) required reoperations including 12 (20.3%) with perforated ulcers. Urgent operation was required in 14 (23.7%) patients due to perforation or active bleeding, and elective operation was performed in 10 (16.9%) patients for chronic and refractory MU or gastrogastric fistula. One (1.7%) patient developed recurrent MU after the revision and had another revision of the anastomosis. One (1.7%) patient underwent reversal of gastric bypass after the revision due to malnutrition and recurrent ulcers. All patients did well at a mean follow up of 28.9±21.7 months (range, 1–78 mo).ConclusionDespite the use of routine PPI, the incidence of MU was not insignificant. A significant portion of patients required surgical treatment. Perforations can be effectively managed by oversewing of the ulcer.     

腹腔镜胃旁路术的并发症及其防治

腹腔镜Roux-en-Y胃旁路手术（LRYGB）治疗病态肥胖,因其疗效快捷、持久而成为减重外科的“金标准”术式。然而,由于其手术操作复杂和学习曲线较长,故具有潜在风险。LRYGB术后并发症分为早期和晚期两类,并发症如果发现不及时或处理不当,可导致严重的后果,甚至死亡。因此,预防和及早诊断LRYGB术后出现的并发症,并及时有效地进行处理,对LRYGB的健康开展具有重要意义。     

Laparoscopic suture closure of perforated peptic ulcer

Background: Laparoscopic vs open suture in the surgical treatment of perforated peptic ulcer were compared in a retrospective study. Methods: The outcome of 10 patients having the laparoscopic procedure was compared with the outcome of 17 patients treated with suture via laparotomy during the same time period. Results: The mortality rate and the complication rate were comparable. The laparoscopic procedure was more time consuming; hospital stay did not differ. Conclusions: The results indicate that surgery for perforated peptic ulcer can be performed with the laparoscopic technique with an outcome comparable to open surgery. No obvious advantages to the patient were noted with the laparoscopic method.This study has been presented as an abstract at the EAES meeting in Madrid, September 1994     

Laparoscopic gastric bypass after failed open horizontal stapled gastroplasty

The number of people in the population who have undergone an operative procedure for morbid obesity is likely to rise steadily as the awareness and popularity of bariatric surgery continues to develop. As this number increases, the number of patients with long-term failures and complications from these procedures will also rise. Although previous operations, particularly open procedures, normally deter surgeons from choosing a laparoscopic approach, the evolving technical skill of laparoscopic surgeons should allow for the reconsideration of these inhibitions. In this case, we present of laparoscopic Roux-en-Y gastric bypass on a 48-year-old woman who had undergone horizontal gastric stapling 20 years prior to presentation.     

Laparoscopic approach to open gastric bypass

BACKGROUND: Gastric bypass is a successful tool in the treatment of morbid obesity. In recent years, laparoscopic Roux-en-Y gastric bypass has gained popularity. However, open bypass is sometimes more suitable for patients who are "superobese." Laparoscopic instrumentation can be used during an open gastric bypass to facilitate dissection, formation of the gastric pouch, and creation of the gastrojejunostomy. METHODS: We describe the use of laparoscopic ultrasonic coagulating shears for dissection during open gastric bypass. Additionally, laparoscopic gastrointestinal anastomosis and end-to-end anastomosis staplers are used for creating bowel anastomoses. CONCLUSIONS: Laparoscopic instrumentation can be useful in the setting of open procedures. Their long handles and jaw design make them ideal for working in the depths of a superobese abdomen.     

Laparoscopic repair/peritoneal toilet of perforated duodenal ulcer

Summary Laparoscopic techniques have been refined to the point where exposure, haemostasis and tissue approximation by suture approach those obtained at open access surgery. We report a patient with acute perforation of an ulcer in the first part of the duodenum who was successfully treated by laparoscopic oversewing and omental patching. The clinical indications for contemplating use of laparoscopic surgery for acute ulcer perforation, techniques employed and the areas for potential improvement of instruments, needles and sutures are discussed.     

腹腔镜与开腹胃十二指肠溃疡穿孔修补术的对比研究

目的:比较腹腔镜与开腹胃十二指肠溃疡穿孔修补术的疗效。方法:回顾分析我院确诊为胃十二指肠溃疡穿孔52例患者的临床资料,其中28例行腹腔镜胃十二指肠溃疡穿孔修补术(腹腔镜组),24例行开腹胃十二指肠溃疡穿孔修补术(开腹组),比较两组手术时间、术中出血量、并发症发生率、术后肠道功能恢复时间、术后体温及住院时间。结果:腹腔镜组与开腹组手术时间分别为(78.75±25.178)min和(97.50±26.029)m in(P<0.05),术中出血量分别为(43.21±12.488)ml和(77.50±21.518)m l(P<0.001),并发症分别为3例和8例(P<0.05),术后体温>38℃分别为5例、11例,术后肠蠕动恢复时间分别为(2.33±0.816)d和(3.75±1.035)d(P<0.001),术后住院分别为(6.83±1.169)h和(10.00±1.309)h(P<0.001)。结论:胃十二指肠溃疡穿孔患者行腹腔镜手术与开腹手术一样安全,且具有创伤小、康复快、住院时间短等优点。     

Perforated pyloric ulcer 13 years after Roux-en-Y gastric bypass: A case report

Introduction and importanceBariatric or metabolic surgery is an emerging surgical specialty. With the increase of obesity and affiliated complications, the Roux-en-Y gastric bypass became a well-established procedure worldwide.Case presentationWe present the case of a 46-year-old female patient who presented herself in the emergency department with diffuse abdominal pain, 13 years after a laparoscopic Roux-en-Y gastric bypass. The CT scan found suspicions of an internal hernia. The diagnostic laparoscopy showed a perforated pyloric ulcer of the gastric remnant as well as an internal hernia without any signs of incarceration. The ulcer was repaired by laparoscopic suture and the mesenteric defect at the enteroenterostomy was closed. The testing for H. pylori by different means showed a negative (stool) and a positive (serology) result.Clinical discussionThe loss of connection of the gastric remnant to the oesophagus poses challenges in the diagnostic process: in regard to the perforated ulcer, free air, the most common sign, is absent, and testing of H. pylori presents limited options.ConclusionBariatric patients remain patients with special considerations even long after undergoing these surgeries because of the drastic change in their anatomy and metabolism. Furthermore, due to the aforementioned reasons, diagnostic by clinical findings and imaging can be difficult and these patients should undergo a diagnostic laparoscopy and multimodal testing for H. pylori.     

Laparoscopic suture repair of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension: first case report.

BACKGROUND: Open digestive surgery in cirrhotic patients is associated with high morbidity and mortality. Laparoscopy in this setting has the potential to reduce postoperative complications. Laparoscopic treatment of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension is herein described. METHODS: A 75-year-old woman affected by cirrhosis of the liver (Child class C) and chronic gastric ulcer presented with acute abdominal pain. The diagnosis of perforation was made with plain films of the abdomen and computed tomography. Diagnostic laparoscopy showed intense peritonitis due to a perforated ulcer of the anterior gastric wall, 2 cm proximal to the pylorus. Suture closure and placement of an omental patch were performed laparoscopically. RESULTS: Postoperative recovery was complicated by a minor leak of the gastric suture, managed by total parenteral nutrition. Closure of the gastric wound was demonstrated by Gastrografin studies on the 10th postoperative day. The patient was discharged on the 16th postoperative day. At 3-months follow-up, the patient is alive and free of gastric disease.     

Laparoscopic Roux-en-Y gastric bypass for morbid obesity.

Surgery is currently the only effective treatment for morbid obesity. The two most commonly accepted operations are the Roux-en-Y gastric bypass and vertical banded gastroplasty. Although multiple authors have reported on a laparoscopic approach to gastric banding, the Roux-en-Y gastric bypass is a complex operation to be replicated using laparoscopic techniques. In this article, we describe our technique of the Roux-en-Y gastric bypass using a laparoscopic approach in four cases.     

Marginal ulceration after laparoscopic gastric bypass: an analysis of predisposing factors in 260 patients

Background Marginal ulceration after Roux-en-Y gastric bypass (RYGB) is diagnosed in 1% to 16% of patients. The factors predisposing patients to marginal ulceration are still unclear. Methods A total of 260 patients who underwent laparoscopic RYGB were retrospectively reviewed. Data regarding demographics, comorbidities, body mass index (BMI), Helicobacter pylori infection, gastrojejunal (GJ) anastomotic leaks, postoperative bleeding, operative time, type of suture material, and marginal ulcer formation were collected. Fisher’s exact test was used for statistical analysis of discrete variables, and Student’s t-test was used for continuous variables. Statistical significance was set at an alpha of 0.05. Results The overall marginal ulceration rate was 7%. Demographic data (age, gender distribution, BMI) did not differ significantly between patients who experienced marginal ulceration and those who did not (p > 0.05). Similarly, technical factors (choice of permanent or absorbable suture for the GJ anastomosis, attending as primary surgeon, robotic GJ, operative time, postoperative hematocrit drop) were not statistically different between the two groups (p > 0.05). Finally, the prevalence of comorbidities (diabetes, hypertension, obstructive sleep apnea, musculoskeletal complaints, dyslipidemia, gastroesophageal reflux disease [GERD] and peptic ulcer disease [PUD]) did not differ significantly between the two groups (p > 0.05). However, preoperative H. pylori infection, although adequately treated, was twice as common among the patients who had marginal ulceration (32%) as among those who did not (12%) (p = 0.02). All the patients who experienced marginal ulcers had complete resolution of symptoms with proton pump inhibitors and sucralfate. No reoperations were required for marginal ulceration. Conclusion Helicobacter pylori may potentiate marginal ulcer formation. The authors hypothesize that H. pylori damages the mucosal barrier in a way that persists postoperatively, which may precipitate marginal ulceration even when the organism has been medically eradicated. Submitted for oral/poster presentation at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), April 2007     

Laparoscopic transgastric access to the common bile duct after Roux-en-Y gastric bypass

Introduction  Rapid weight loss after Roux-en-Y gastric bypass (RYGBP) often is associated with gallstones formation, which can lead to cholecystitis and/or choledocholithiasis. Difficult access to the biliary tract is one of the disadvantages after RYGBP. We report a useful technique of laparoscopic transgastric access to the gastric remnant for an endoscopic retrograde cholangiopancreatography (ERCP). Case report  A 40-year-old woman with a BMI of 48 kg/m², was submitted to a laparoscopic RYGBP in December 2003. At that time the abdominal ultrasound was negative for gallbladder lithiasis. In April 2007, she was admitted for upper right side abdominal pain, vomiting episodes, fever, and jaundice; the BMI at the time was 24 kg/m². Hepatic ultrasound showed lithiasis of the common bile duct with intra- and extrahepatic bile duct dilation, as well as gallbladder lithiasis. The patient was taken to the operating room for laparoscopic evaluation. A pursestring suture was performed on the greater curvature of the gastric remnant. After the opening of the stomach, an 18-mm trocar was inserted into the lumen and the endoscope was directly passed through the port into the duodenum. An ERCP was performed under fluoroscopic guidance, and as a result of sphincterotomy the stone was retrieved. After removing the endoscope, the gastrotomy was closed by tying the pursestring. Cholecystectomy was performed as well. Results  The procedure lasted 98 min. Liver function tests returned normal on postoperative day 2, and the patient was discharged on postoperative day 4. After 9 months, the patient was well and asymptomatic. Conclusions  Patients previously submitted to RYGBP and presenting choledocholithiasis can benefit from an ERCP through the gastric remnant. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users. This paper has been awarded as one of the six best original EAES Video Award Session at the 16th International EAES Congress, Stockholm (Sweden), June 11–14, 2008.     

Laparoscopic repair of perforated peptic ulcer: a meta-analysis

Background Laparoscopic repair of perforated peptic ulcer has been gaining popularity in recent years, but few data exist to support the superiority of the laparoscopic approach over open repair. The objective of the current study was to compare the safety and efficacy of open and laparoscopic repair of perforated peptic ulcer in an evidence-based approach using meta-analytical techniques.Methods A search of electronic databases, including MEDLINE and EMBASE, was conducted to identify relevant articles published between January 1990 and December 2002. Only studies in the English language comparing the outcomes of laparoscopic and open repair of perforated peptic ulcer were recruited. All reports were critically appraised with respect to their methodology and outcome. Data from all included studies were extracted using standardized data extraction forms developed a priori. Both qualitative and quantitative statistical analyses were performed. The effect size of outcome parameters was estimated by odds ratio where feasible and appropriate.Results A total of 13 publications comprising 658 patients met the inclusion criteria. The overall success rate of laparoscopic repair was 84.7% (n = 249). Postoperative pain was lower after laparoscopic repair than after open repair, supported by a significant reduction in postoperative analgesic requirement after laparoscopic repair. Meta-analyses demonstrated a significant reduction in the wound infection rate after laparoscopic repair, as compared with open repair, but a significantly higher reoperation rate was observed after laparoscopic repair.Conclusions Evidence suggests that laparoscopic repair of perforated peptic ulcer confers superior short-term benefits in terms of postoperative pain and wound morbidity. This approach is as safe and effective as open repair. Laparoscopic Graham–Steele patch repair of perforated duodenal or justapyloric ulcer is beneficial for patients without Boeys risk factors.