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Angelika A. Schlarb Friederike Lollies Merle Claßen 《Somnologie - Schlafforschung und Schlafmedizin》2016,20(3):199-211
Introduction
Cortisol release is often associated with physiological arousal or perceived stress. Findings in adults as well as in older children and adolescents show that cortisol is also connected to sleep. Furthermore, it is assumed that high-quality sleep is a predictor of regular cortisol release throughout the day.Objective
This review summarizes the current literature on how sleep and cortisol levels are associated in early childhood.Methods
In order to identify studies on sleep and cortisol in young children, a structured literature search was performed in the PsychINFO, PsycARTICLES, PSYNDEX, and Google Scholar databases.Results
A total of 14 studies could be included this review. According to the results of the reviewed publications, daily cortisol release patterns develop within the first 6 months of life. In addition, young children display a cortisol awakening response (CAR) and cortisol levels are influenced by taking naps during the day as well as by the quality of nighttime sleep.Conclusion
After reviewing the recent findings in the literature concerning children from birth up to the age of 5 years, it can be assumed that sleep patterns and sleep are associated with cortisol secretion in early childhood. This finding could be included in the creation and further development of interventional sleep training programs.3.
Hepatitis C and urticaria: cause and effect? 总被引:2,自引:0,他引:2
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The establishment of central tolerance in the thymus is critical for avoiding deleterious autoimmune diseases. Autoimmune regulator (AIRE), the causative gene in autoimmune polyendocrine syndrome type-1 (APS-1), is crucial for the establishment of self-tolerance in the thymus by promoting promiscuous expression of a wide array of tissue-restricted self-antigens. This step is critical for elimination of high-affinity self-reactive T cells from the immunological repertoire, and for the induction of a specific subset of Foxp3+ T-regulatory (Treg) cells. In this review, we discuss the most recent advances in our understanding of how AIRE operates on molecular and cellular levels, as well as of how its loss of function results in breakdown of self-tolerance mechanisms characterized by a broad and heterogeneous repertoire of autoimmune phenotypes. 相似文献
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Anthony M Dart 《中国病理生理杂志》2000,16(10)
Introduction Thearterialcirculationistraditionallymodeledintwowaysneitherofwhichaloneisabletofullyaccountforitsproperties.Inthewell knowntwoelementwindkesselmodelthecirculationisviewedintermsofparal lelcapacitanceandresistancecomponents .Theresistancet… 相似文献
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《中国生物医学工程学报(英文版)》1993,(2)
Aug.17 ams,00一10,00,10,30一12,00At Room No.1(213)CO一CHAIRMAN Prof.Jos A.E,SPaan Prof.Tao ZulaiTITLEABSTRACT PAGESFlow and regurgitation in meehanieal heart valves:visualization,numberies and exPerimentation 5 .Einav,et al.·······················································································……106Vaseular endothelial eell resPonses to wall shear stress Akira Kamlya,et al… 相似文献
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BAO Jia li HU Qiao hong LANG Wen quan GAO Jian qing WU Ping .Clinical Engineering Institute Zhejiang University Hangzhou China .Pharmaceutics Institute Zhejiang University Hangzhou China 《中国生物医学工程学报(英文版)》2000,(2)
INTRODUCTIONWiththedevelopmentofmedicinetechnique,peoplehavebeenrealizedthatoralorinjectionlimitsmanypharmaceuticalsbybiotechnologyfromwidelyusing.Be-causealmostthesedrugsconsistofproteinsorpolypeptideseasydegraded.Trans-dermaldrugdelivery(TDD)providesano… 相似文献
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Victor K. Lai Christina R. Frey Allan M. Kerandi Spencer P. Lake Robert T. Tranquillo Victor H. Barocas 《Acta biomaterialia》2012,8(11):4031-4042
Collagen and fibrin are important extracellular matrix (ECM) components in the body, providing structural integrity to various tissues. These biopolymers are also common scaffolds used in tissue engineering. This study investigated how co-gelation of collagen and fibrin affected the properties of each individual protein network. Collagen–fibrin co-gels were cast and subsequently digested using either plasmin or collagenase; the microstructure and mechanical behavior of the resulting networks were then compared with the respective pure collagen or fibrin gels of the same protein concentration. The morphologies of the collagen networks were further analyzed via three-dimensional network reconstruction from confocal image z-stacks. Both collagen and fibrin exhibited a decrease in mean fiber diameter when formed in co-gels compared with the pure gels. This microstructural change was accompanied by an increased failure strain and decreased tangent modulus for both collagen and fibrin following selective digestion of the co-gels. In addition, analysis of the reconstructed collagen networks indicated the presence of very long fibers and the clustering of fibrils, resulting in very high connectivities for collagen networks formed in co-gels. 相似文献
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Daniela Amital Calanit Herskovitz Leah Fostick Alysa Silberman Yariv Doron Joseph Zohar Alek Itsekson Matityahu Zolti Alan Rubinow Howard Amital 《Clinical reviews in allergy & immunology》2010,38(2-3):107-115
The aim of the study was to assess the clinical similarities and common features of fibromyalgia syndrome (FM) and premenstrual dysphoric syndrome (PMDD). Thirty young patients who met the diagnostic criteria for PMDD were included in the study and compared to 26 women belonging to the medical staff of a general psychiatry department. All enrollees were interviewed and examined by a skilled physician. They completed the following nine survey items: demographic information, clinical health assessment questionnaire, fibromyalgia impact questionnaire, sleep and fatigue questionnaires, Sheehan disability scales, SF-36 assessment for quality of life, visual analog scale for pain, Mini International Neuropsychiatric Interview (MINI) questionnaire (assessment of coexistent psychiatric conditions), and the premenstrual severity scale. Additionally, each individual underwent a physical examination measuring the classical tender points and was asked to describe the distribution and continuum of her pain or tenderness. The PMDD group scored significantly higher in the measures pain and tenderness as well as in severity of premenstrual symptoms compared to the control group. Five patients in the PMDD group and none in the control group had FM. Quality of life measured by the SF-36 was higher in the control group than in the PMDD group and correlated with the degree of tenderness reported. Psychiatric comorbidity was significantly more common in the PMDD group, affecting 16 of the 30 PMDD patients compared to only three of the 26 control patients. In this study, patients with PMDD were found to have higher levels of tenderness, higher psychiatric comorbidity, greater level of physical disabilities, and a lower quality of life. These parameters were highly correlated with a lower pain threshold. 相似文献
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Thomas D O��Brien Neil D Reeves Vasilios Baltzopoulos David A Jones Constantinos N Maganaris 《Journal of anatomy》2010,216(5):631-642
Muscle performance is closely related to the architecture and dimensions of the muscle–tendon unit and the effect of maturation on these architectural characteristics in humans is currently unknown. This study determined whether there are differences in musculo‐tendinous architecture between adults and children of both sexes. Fascicle length and pennation angle were measured from ultrasound images at three sites along the length of the vastus intermedius, vastus lateralis, vastis medialis and rectus femoris muscles. Muscle volume and muscle–tendon length were measured from magnetic resonance images. Muscle physiological cross‐sectional area (PCSA) was calculated as the ratio of muscle volume to optimum fascicle length. Fascicle length was greater in the adult groups than in children (P < 0.05) but pennation angle did not differ between groups (P > 0.05). The ratios between fascicle and muscle length and between fascicle and tendon length were not different (P > 0.05) between adults and children for any quadriceps muscle. Quadriceps volume and PCSA of each muscle were greater in adults than children (P < 0.01) but the relative proportion of each head to the total quadriceps volume was similar in all groups. However, the difference in PCSA between adults and children (men ~ 104% greater than boys, women ~ 57% greater than girls) was greater (P < 0.05) than the difference in fascicle length (men ~ 37% greater than boys, women ~ 10% greater than girls). It is concluded that the fascicle, muscle and tendon lengthen proportionally during maturation, thus the muscle–tendon stiffness and excursion range are likely to be similar in children and adults but the relatively greater increase in PCSA than fascicle length indicates that adult muscles are better designed for force production than children’s muscles. 相似文献
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Introduction The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist
in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common
to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-β). TGF-β and
Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis.
Discussions The immune suppressive functions of TGF-β and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent
studies revealed the positive roles for TGF-β and Treg cells in shaping the immune system and the inflammatory responses.
In this paper, we will discuss the role of these mechanisms in the control of immunity and autoimmunity and the mechanisms
that underlie how these molecules control these responses. 相似文献
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Dahlbäck B 《Seminars in immunopathology》2012,34(1):1-3
The integrity of our bodies is under constant threat by external forces. Blood coagulation and inflammatory pathways are important,
highly efficient defence systems that support health and well-being in both normal and challenged conditions. Being potentially
dangerous for the own organism, they are kept under strict control by anticoagulant and anti-inflammatory mechanisms. Coagulation
and inflammatory pathways are closely integrated by extensive crosstalk and tend to function in concert. They comprise a large
number of cellular and molecular actors, which interact in extremely complex manners. A basic principle governing these interactions
is the mutual activation of the pathways. Thus, the activation of coagulation leads to concomitant activation of inflammatory
pathways, mirrored by the initiation of coagulation by inflammatory pathways. Efficient anticoagulant systems not only keep
coagulation reactions under strict control but also exert control on inflammatory reactions. During inflammation, these anticoagulant/anti-inflammatory
systems are repressed allowing full activation of coagulation and inflammation. Dysregulation of the delicate balance between
these systems contributes to the pathogenesis of many diseases. 相似文献
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《Seminars in immunology》2014,26(2):114-126
Bone marrow-derived natural killer (NK) cells constitute the major subset of cytotoxic lymphocytes in peripheral blood. They provide innate defense against intracellular infection or malignancy and contribute to immune homeostasis. Large numbers of NK cells are also present in tissues, including the liver and uterus, where they can mediate immunosurveillance but also play important roles in tissue remodeling and vascularization. Here, we review the pathways involved in NK cell lineage commitment and differentiation, discussing relationships to other lymphocyte populations and highlighting genetic determinants. Characterizing NK cells from distinct tissues and during infections have revealed subset specializations, reflecting inherent cellular plasticity. In this context, we discuss how different environmental and inflammatory stimuli may shape NK cells. Particular emphasis is placed on genes identified as being critical for NK cell development, differentiation, and function from studies of model organisms or associations with disease. Such studies are also revealing important cellular redundancies. Here, we provide a view of the genetic framework constraining NK cell development and function, pinpointing molecules required for these processes but also underscoring plasticity and redundancy that may underlie robust immunological function. With this view, built in redundancy may highlight the importance of NK cells to immunity. 相似文献
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F. Majewski B.
ztürk Gabriele Gillessen-Kaesbach 《American journal of medical genetics. Part A》1996,63(1):74-79
We report on a male infant with internal hydrocephalus, absence of corpus callosum, papillomas and lobulation of the tongue, notches of the alveolar ridges, short ribs, dysplastic pelvis, hypospadias, short limbs with bowed long tubular bones and postaxial polydactyly of hands, and preaxial polydactyly in one foot. Radiologically this case shares manifestations with Jeune syndrome; the tongue lobulation and the preaxial polydactyly are similar to findings in Mohr syndrome, or short-rib polydactyly syndrome (SRPS), type Majewski. In addition, a female newborn presented with manifestations of Jeune and Ivemark syndromes. One explanation for this overlap may be compound heterozygosity for these syndromes. © 1996 Wiley-Liss, Inc. 相似文献
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