血清循环免疫复合物中胆固醇含量与缺血性心脑血管疾病关系的研究

目的：了解血清循环免疫复合物（CIC－C）中胆固醇（TC）含量与缺血性心、脑血管疾病发病中的意义和作用。方法：测定冠心病（CHD）、急性心肌梗死（AMI）、脑梗死（CI）、糖尿病（DM）患者及健康人（30例）血清CIC－C含量,并将其与相关指标进行对比分析。结果：各患者组CIC－C含量、血脂TC、甘油三酯（TG）及心肌酶（肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶和α－羧丁酸脱氢酶）水平均显著高于健康人组（P＜0．05或P＜0．01）。CHD、AMI、CI患者CIC－C含量与TC呈正相关（P均＜0．05）,且其异常率高于TC、TG。结论：CIC－C含量升高与缺血性心、脑血管疾病的发生密切相关,且有较高的诊断价值。     

Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease

Initially discovered as a potent T cell proliferation factor, IL-2 was soon used for cancer immunotherapy, especially for metastatic melanoma and renal cell carcinoma; however, the severe side effects of IL-2 therapy, plus the negative role of IL-2 in maintaining of CD4⁺ CD25⁺ T regulatory cells (Tregs), has somewhat dampened enthusiasm for using IL-2 in immunotherapy. This opinion article discusses the possibility of combining IL-2 with certain anti-IL-2 antibodies for reducing the dose of IL-2 needed and preferentially stimulating effector T cells, but not Tregs, an approach that might provide an improved strategy for anticancer immunotherapy. Alternatively, complexes of IL-2 with other anti-IL-2 antibodies can selectively stimulate Tregs and could, therefore, be useful for treating autoimmune diseases.