原发性胃肠道恶性淋巴瘤23例诊治体会

原发性胃肠道淋巴瘤(PGIL)术前确诊率低,现对我院1982～1996年23例经手术治疗的PGIL患者的临床资料进行回顾性分析.     

原发性胃肠道恶性淋巴瘤的诊断与治疗

胃肠道是结外型淋巴瘤的好发部位,早期症状缺乏特异性,术前诊断较困难,临床误诊率高,其疗效和预后与胃肠道其他恶性肿瘤不同.我院1995～2001年共收治38例胃肠道恶性淋巴瘤患者,所有患者均经手术及病理证实,现分析报告如下.     

胃肠道原发性恶性淋巴瘤ll例临床分析

胃肠道原发性恶性淋巴瘤临床少见,约占胃肠道恶性肿瘤的1％～4％,我们自1990年1月至2002年6月共收治11例,现报告如下。 临床资料 1.一般资料:本组11例,男7例,女4例,年龄25～52岁,     

胃肠道原发性恶性淋巴瘤11例临床分析

胃肠道原发性恶性淋巴瘤临床少见,约占胃肠道恶性淋巴瘤的1%-4%,我们自1990年1月至2002年6月共收治11例,现报告如下.     

原发性胃肠道恶性淋巴瘤的诊治体会

目的探讨原发性胃肠道恶性淋巴瘤的临床特征、诊断和治疗。方法对广东省普宁市人民医院1999年1月～2009年12月普外科所收治22例原发性胃肠道恶性淋巴瘤患者临床资料进行回顾性分析。结果本组22例中,男性13例,女性9例,所有患者均经手术或内窥镜病理活检证实为恶性淋巴瘤,病理均为非霍奇金淋巴瘤（NHL）。病灶位于胃14例,肠道8例。给予手术、放疗、化疗等综合治疗。本组随访19例,3年生存率52.6%（10/19）,5年生存率26.3%（5/19）。结论原发性胃肠道恶性淋巴瘤发病率低,临床表现复杂,易漏诊、误诊,应早期诊断,合理治疗。治疗以手术、化疗、放疗综合治疗效果良好。     

原发性胃肠道恶性淋巴瘤64例临床分析

目的探讨原发性胃肠道恶性淋巴瘤的发病、诊断、治疗.方法对64例经病理证实的原发性胃肠道恶性淋巴瘤的临床资料并结合相关文献进行回顾性分析.结果本病占同期胃肠恶性肿瘤的2.7%,64例患者平均年龄39.5岁.好发部位顺序为回盲部及回肠(54.69%)、胃(21.875%)、结肠(14.06%)、直肠(9.375%).主要临床表现是腹胀、腹痛、腹部包块、腹泻、血便.病理类型本组64例中,非何杰金氏淋巴瘤58例,其中B细胞型52例,T细胞型6例;何杰金氏淋巴瘤6例.本病早期极易误诊为其它消化道疾病,误诊率为67%.结论原发性胃肠道恶性淋巴瘤的诊断应综合临床表现、影像学及内镜检查结果,以提高诊断符合率.治疗以手术加化疗、放疗疗效最佳.     

16例胃肠道原发性恶性淋巴瘤误诊及免疫分型分析

１６例胃肠道原发性恶性淋巴瘤误诊及免疫分型分析皖南医学院病解教研室（２４１０００）何家玉安徽当涂县医院病理科（２４３１００）梅静王婷婷成磊安徽广德县医院病理科（２４２２００）陈韶秀胃肠道是结外性淋巴瘤最常累及部位。近年来由于免疫学的进展，相继提出粘膜...     

原发性肠道恶性淋巴瘤12例临床分析

原发性胃肠道恶性淋巴瘤发生率占消化道恶性肿瘤１％～４５［１］,易误诊为消化系其他疾病。１９９４～１９９９年我科共收治原发性肠道恶性淋巴瘤１２例,均经病理确诊,现总结分析如下。１临床资料１．１一般资料：本组１２例,男８例,女４例,年龄２０～６３岁,平均４２．５岁。初发症状至首次入院时间为１０ｄ至６个月,多为１～２个月。肿瘤部位：空肠１例．回肠２例,回盲部３例,结肠３例,直肠３例。非何杰金氏淋巴瘤１１例,何杰金氏淋巴瘤１例。１．２临床表现：腹痛８例（６６．７％）,消化道出血１０例（８３．３％）,腹胀…     

肾脏原发性恶性淋巴瘤2例

例 1 　 女 ,74岁。 3年前曾患肾盂肾炎。间发性寒战、高热伴体重下降 4个月 ,B超显示右肾实质性占位性病变 ,于 1 998年 6月入院。否认有肉眼血尿史。体检 :重病容 ,心肺正常 ,双肾未触及。右肾区有叩击痛。实验室检查 :血沉 1 40 mm/1 h,血常规血红蛋白 9.0 g/L ,白细胞 1 1 .8× 1 0 9/L,中性 0 .2 6;尿常规白细胞 1× 1 0 9/L,红细胞 0 .5× 1 0 12 /L,蛋白0 .2 5g/L。尿找肿瘤细胞阴性。静脉肾盂造影示右肾中下极向外膨隆、肾盂肾盏受压移位不明显 ,CT增强显示 ( CT值 46Hu)右肾中下极实质内有 5cm× 5cm× 4cm低密度实性占位性病…     

阴茎原发性恶性淋巴瘤1例

患者 ,5 9岁。因发现阴茎进行性增大肿物 3个月余入院。体检 :全身浅表淋巴结无肿大。阴茎腹侧近阴囊处可扪及一 3 .0 cm× 2 .5 cm× 1 .0 cm的质硬肿物 ,局部皮肤无潮红、破溃及发热 ,表面凹凸不平 ,压痛明显 ,与阴茎海绵体和尿道海绵体粘连 ,分界不清 ,不能推动。实验室检查 :血常规白细胞 5 .6× 1 0 9/L,中性分叶核 0 .6 3 ,淋巴细胞 0 .3 7。血沉 5 3mm/h。血清碱性磷酸酶 4u/L。胸部正侧位 X线片未见纵隔淋巴结肿大。 B超 :肝、脾未见异常 ,腹主动脉、髂血管旁淋巴结未见肿大。膀胱镜检查膀胱、尿道内未见肿物。局麻下行肿物穿刺活…     

Primary Gastrointestinal Tract Lymphomas

Aim: To evaluate the prognostic factors and treatment modalities affecting survival in patients with primary gastrointestinal tract lymphoma.

Material and Methods: Gastrointestinal tract lymphoma patients were retrospectively studied. Age and sex of patients, location and histopathological grade of tumour, stage of disease, extent of surgical resection and chemotherapy were evaluated as prognostic factors. Effects of clinicopathological and treatment associated factors on disease-free and overall survival were calculated in univariate and multivariate analyses.

Results: On univariate analysis, disease stage (p = 0.002), extent of surgical resection (p = 0.003) and chemotherapy (p = 0.001) were found to be significantly affecting overall survival and none of the studied factors were found to be related with disease-free survival. Multivariate analysis revealed that grade of the tumour (p = 0.042) and chemotherapy (p = 0.028) significantly affected disease-free survival and disease stage (p = 0.013) and chemotherapy (p = 0.0003) were independent prognostic factors for overall survival. In addition, surgery and chemotherapy in combination, significantly increased overall survival compared to surgery or chemotherapy only.

Conclusion: Early stage patients have a better survival and it could be prolonged if surgery with no residual disease is performed; adjuvant chemotherapy provides an additional benefit.     

原发性胃肠道淋巴瘤的诊断与治疗

目的探讨原发性胃肠道淋巴瘤的诊治经验。方法回顾性分析12例原发性胃肠道淋巴瘤,均行剖腹探查,其中行根治性切除7例,姑息性手术3例,肿块活检术2例。结果胃淋巴瘤5例,肠淋巴瘤7例。病理分类:弥漫性非何杰金氏淋巴瘤9例,粘膜相关性淋巴瘤2例,高度恶性淋巴瘤1例。Ann Arbor临床分期:ⅡE期3例,ⅢE期7例,ⅣE期2例。平均随访18(6~72)月,6例存活,死亡6例。结论内镜和消化道造影是淋巴瘤主要诊断手段,手术切除为主的综合治疗为最佳治疗方案。     

Primary Cutaneous B-Cell Lymphomas

B-cell lymphomas occurring in the skin often tend to be of systemic origin with secondary cutaneous involvement. Primary cutaneous B-cell lymphomas tend to be indolent disorders, with the exception of primary cutaneous diffuse large B-cell lymphoma–leg type (PCDLBCL-LT). In indolent conditions, the distinction between cutaneous lymphoma and cutaneous lymphoid hyperplasia can be difficult. Integration of all available information, including the clinical setting, is crucial to arriving at the appropriate diagnosis. In this review, we cover the diagnostic approaches to primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and PCDLBCL-LT, and discuss their differential diagnosis.     

胃肠道间质瘤的诊断与治疗

目的:总结胃肠道间质瘤的诊断与治疗方法。方法:回顾性分析93例胃肠道间质瘤临床资料。结果:临床表现主要为腹痛、腹胀,上腹部不适,以CT、MRI为主要影像学检查。全部行手术治疗,免疫组化示CD117及CD34阳性率达95.7%和62.4%,术后1、3、5年生存率分别为94.2%、85.2%和78.2%。结论:胃肠道间质瘤无特异性临床表现,治疗以手术切除为主;对于无法手术切除者,伊马替尼治疗具有一定效果。     

胃肠手术后肺部并发症228例临床分析

目的探讨胃肠手术患者术后发生肺部并发症的易患因素. 方法回顾性分析228例胃肠手术后肺部并发症患者(并发症组)的有关临床资料,以同期774例胃肠手术后无肺部并发症作为对照(对照组). 结果并发症组患者平均年龄、有吸烟史和基础心肺疾病者所占的比例、血清尿素氮和肌酐水平、术中出血和输血量、术中气管插管时间、术后留置胃管和机械通气时间均显著高于对照组;并发症组血清白蛋白水平显著低于对照组. 结论高龄、有吸烟史和基础心肺疾病、血清白蛋白水平低于正常、术中出血量多、气管插管时间长、术后留置胃管及机械通气时间长的胃肠手术患者易发生肺部并发症.     

胃肠道间质瘤的临床分析

目的探讨胃肠道间质瘤的临床诊断与治疗。方法回顾性分析95例胃肠道恶性间质瘤病人的临床资料。结果发生于胃、小肠、结直肠、肠系膜、大网膜的病例分别为65、25、2、2、1例；肿瘤直径1～10cm；其中恶性者47例，良性者48例；行根治性切除62例，行切除术31例，2例广泛转移者行肝结节活检。17例术后发生伤口感染，免疫组化指标：CD117、CD34、CK、EMA、S-100及Desmin阳性率分别为89．5％、86．3％、5．3％、0、9．5％及8．4％。随访80例，2例胃间质瘤广泛转移者分别于术后4月、6月死亡，17例术后5～25月死于其他疾病，余者均无瘤生存，5年生存率43．7％。结论提高对胃肠道间质瘤的认识，强化术中病理学检查及免疫组化检查，确定良恶性及恶性程度，采取合理规范的手术方式，对预后及防止复发有一定意义。     

Management of Primary Gastrointestinal Non-Hodgkin Lymphomas: a Population-Based Survival Analysis

Introduction

Primary gastrointestinal non-Hodgkin lymphomas (PGINHL) are a heterogeneous group of rare GI malignancies with limited data to guide management. This study describes management of PGINHL in a population-based registry and aims to determine the association between receipt of surgery and long-term survival.

Methods

All adults diagnosed with PGINHL over 27 years in the Surveillance, Epidemiology, and End Results were identified (excluding mucosa-associated lymphoid tissue lymphomas). Demographic and clinical characteristics were assessed. Survival was compared using the log-rank method. Cox hazard modeling was used to determine independent prognostic factors.

Results

We identified 16,129 patients. The majority were of gastric origin and had diffuse large B cell histology. Surgery was performed in 46.9 % of patients, not recommended in 41.8 % and recommended but not performed in 10.1 %. Overall 1-year and 5-year survival rates were 65.6 and 35.6 %, respectively. Patients undergoing surgery had a 5-year survival of 43.6 % compared to 34.8 % for whom surgery was recommended but not performed (p?<?.0001), (receipt of chemotherapy not available). Female gender, gastric location, follicular or mantle cell histology, and radiation therapy were associated with improved survival.

Conclusions

Nearly 50 % of PGINHL patients underwent surgery. Surgery was not associated with improved survival. More prospective, case-matched studies are needed to guide management.

     

原发性阴茎恶性淋巴瘤1例报告(附文献24例复习)

目的:探讨原发性阴茎恶性淋巴瘤的早期诊断与治疗。方法:根据1例罕见的原发性阴茎恶性淋巴瘤临床诊治经过,结合文献,对其临床特点、鉴别诊断及治疗方法进行分析。并对病理标本的免疫组化酶标特点在临床诊断中的价值进行分析。结果:手术治疗阴茎、睾丸和阴囊病变,术后予化疗。本例免疫酶标提示CD56+,颗粒酶B、穿孔素阳性;CD3(+/-),表面CD3阴性,胞质CD3ε阳性。结论:阴茎原发性恶性淋巴瘤可行手术、局部放疗、全身化疗的综合治疗方法,深部活检及免疫组化检查是最主要的诊断方法。     

胃肠间质瘤的临床诊治

目的 探讨胃肠间质瘤的临床诊断和治疗方法。方法 回顾分析我院近期收治的7例胃肠间质瘤患者的临床资料。结果 本组7例患者中胃部肿瘤3例，小肠肿瘤3例，直肠肿瘤1例。良性1例，潜在恶性2例，恶性4例。根治性切除5例，姑息性切除2例。免疫组化示CDll7、CDM、Vimentin多为弥漫阳性，SMA、S-100多为阴性。结论 胃肠间质瘤术前不易确诊，根治性外科切除是最有效的治疗方法。     

Cutaneous Lymphomas with Cytotoxic Phenotype

Primary cutaneous cytotoxic lymphomas are T-cell or natural killer–cell lymphomas that express 1 or more cytotoxic markers. These neoplasms constitute a spectrum of diseases. In this review, an overview of clinical, morphologic, and phenotypical features of each subtype is provided. Differential diagnosis is discussed with attention to scenarios in which diagnostic difficulties are most frequently encountered.