CT引导下经皮穿刺活检对纵隔占位病变的诊断价值

目的评价CT引导下经皮穿刺活检术在纵隔占位病变中的应用价值和安全性。方法采用弹簧式自动活检枪,在CT精确定位下对纵隔内占位病变行经皮穿刺活检,所获标本送病理组织学检查,并对穿刺准确性、病理确诊率和并发症发生情况进行分析。结果本组33例病灶穿刺成功率100%,病理确诊率85%,无一例发生并发症。结论CT引导下经皮穿刺活检术是一项操作方便,定位精确,穿刺准确率和病理确诊率高,安全可靠的介入放射诊断技术,对纵隔占位病变的定性诊断很有价值,值得临床推广应用。     

直径3cm以下肺孤立性病灶的CT引导下经皮肺穿刺活检

目的:评价直径3cm以下肺孤立性病灶的CT引导下经皮肺穿刺活检的价值。方法:68例直径3cm以下肺孤立性病灶在CT引导下,采用抽吸式活检针,选择最佳穿刺层面及穿刺点获取标本。结果:本组病例共行84次穿刺活检,获得细胞学涂片检查者68例,获得组织学检查59例。总的诊断准确度为89.7%,其中细胞学和组织学标本诊断准确度分别为662%(45/68)和81.4%(48/59)。阳性预告值和阴性预告值分别为100%(51/51)和58.8%(10/17)。并发症:气胸16例(23.5%),出血5例(7.4%),咯血4例(5.9%)。结论:CT引导下经皮肺穿刺活检是一种创伤小而实用的定性诊断方法,对直径3cm以下肺孤立性病灶的诊断具有较高的临床应用价值。     

320例胸部病变CT引导经皮穿刺活检总结

目的：评价CT引导经皮胸部穿刺术的诊断价值和并发症。材料和方法：收集资料完整的320例CT引导胸部穿刺活检病例作回顾性分析。肺部病变267例,纵隔病变30例,胸壁和胸膜病变23例。统计敏感性、特异性、准确性和并发症,并分析其影响因素。结果：191例穿刺确诊为恶性肿瘤。穿刺未发现癌细胞者129例,后经手术和随访证实其中属特征性阴性结果者58例,非特征性阴性结果46例,假阴性25例。未见假阳性,阳性预测值为100％（191／191）,敏感性为88．4％（191／216）,特异性为80．6％（104／129）,准确性为92．2％（295／320）,假阴性率为19．4％（25／129）。29例发生气胸,占9．1％（29／320）,但仅1．6％（5／320）需要引流处理。肺出血12例,咯血12例,纵隔血肿8例,均为少量,不需处理。结论：CT引导经皮胸部穿刺是敏感性高和安全的定性诊断方法,降低假阴性是进一步提高准确性的关键。     

艾滋病并发症中CT引导下经皮肺穿刺活检术的应用

目的：探讨CT引导下经皮穿刺活检术在艾滋病肺部病变中的应用、诊断价值及其暴露防护。方法：回顾性分析16例经皮肺穿刺活检的相关资料,男10例,女6例,平均年龄28.7岁;其中单个病灶7例,多发块影或结节影5例,大片实变影4例,合并纵隔淋巴结肿大4例,合并胸水3例。结果：所有病例均穿刺成功,16例患者行18例次穿刺,12例病例获得诊断,其中肺结核6例,真菌感染3例,细菌感染3例,诊断符合率66.7%;不能明确诊断4例。术后并发症：病灶周围出血5例,少量气胸3例。无医护人员暴露感染。结论：CT引导下经皮肺穿刺活检较为安全,有利于患者早期诊断,操作应严格预防暴露感染。     

Factors affecting diagnostic accuracy of CT-guided coaxial cutting needle lung biopsy: retrospective analysis of 631 procedures

PURPOSE: To analyze variables affecting diagnostic accuracy of computed tomography (CT)-guided percutaneous coaxial cutting needle biopsy of lung lesions. MATERIALS AND METHODS: A retrospective analysis of factors affecting diagnostic accuracy of CT-guided percutaneous coaxial cutting needle lung biopsy was performed in 631 consecutive procedures with confirmed final diagnoses. Benign and malignant needle biopsy results were cross-examined with correct and incorrect final outcomes to determine diagnostic accuracy. Factors affecting diagnostic accuracy were determined by multivariate logistic regression analysis of variables thought to affect diagnostic accuracy. A P value less than 0.05 was interpreted as statistically significant. RESULTS: The overall diagnostic accuracy of CT-guided percutaneous coaxial cutting needle biopsy of lung lesions was 95% (95% CI: 92.7%-96.2%). Sensitivity was 93%, specificity 98%, negative predictive value 6%, positive predictive value 99%, false-positive rate 0.7%, and false-negative rate 15%. The factors affecting diagnostic accuracy were final diagnoses (benign, 86%; malignant, 99%; chi(2) test, P < 0.001) and lesion size (lesions <1.5 cm, 84%; lesions 1.5-5.0 cm, 96%; lesions >5 cm, 93%; chi(2) test, P = 0.06). CONCLUSION: Benign lung lesions, lung lesions smaller than 1.5 cm (which pose technical difficulty), and lung lesions larger than 5 cm (which are associated with a higher necrosis rate) affect diagnostic accuracy of CT-guided percutaneous coaxial cutting needle biopsy of lung lesions.     

CT导引下胸部病变穿刺活检的临床分析

目的：评价CT导引下穿刺活检在胸部病变诊断中的价值。方法：有手术病理或临床随诊的胸部病变CT穿刺活检223例，其中125例133次活检为传统CT导引下活检，其余98例105次CT穿刺活检应用激光导引装置。结果：223例胸部病变中212例有临床诊断结果，CT穿刺活检诊断正确率为82．1％（174／212），对恶性病变的敏感率86．2％（131／152），特异性100％、对良性病变明确诊断率为71．7％（43／60）。并发症包括13．0％（31／238）发生气胸，1．3％（3／238）需要放胸腔引流管，5．0％（1／238）发生肺实质少量出血，0．8％（2／238）出现少量咳血。激光导引下CT穿刺活检诊断正确率为88．4％（84／95），明显高于传统CT导引下活检76．9％（90／117）的诊断正确率，两者在气胸发生率、每次活检平均胸膜穿刺次数方面无统计学差异。结论：CT导引下胸部病变穿刺活检是一种安全、准确、有效的诊断及鉴别诊断方法。激光导引装置在胸部CT穿刺活检中有较高的应用价值，尤其对于小病灶和中心性病变。与传统CT导引下活检相比激光导引下CT活检可提高诊断证确率、缩短活检时间。     

孤立性肺结节的CT引导下经皮肺穿刺活检

目的　探讨CT引导下经皮肺穿刺活检术对孤立性肺结节的诊断价值。方法　回顾性分析于 1993 -0 3～ 2 0 0 1-0 3期间行CT引导下经皮肺穿刺活检并经手术病理、临床治疗或随访观察证实的资料完整的 61例孤立性肺结节病灶。采用美国Cook公司的抽吸式活检针和套管式自动活检枪 ,选择最佳穿刺层面及穿刺点获取标本。结果　 61例孤立性肺结节病灶中经手术病理、临床治疗或随访观察证实为恶性肿瘤者 47例 (原发性支气管肺癌 43例 ,转移癌 4例 ) ,良性病变者 14例。而CT引导下经皮肺穿刺活检诊断为恶性肿瘤者 43例 ,良性病变者 9例。并发症 :气胸 12例 (19.8% ) ,出血 5例 (8.2 % ) ,咯血 4例 (6.6% )。结论　孤立性肺结节的CT引导下经皮肺穿刺活检是一种创伤小而实用的定性诊断方法 ,具有较高的临床应用价值     

CT导向下经皮针刺活检前纵隔肿瘤

目的　探讨经皮针刺活检前纵隔肿瘤的影响穿刺准确性的因素。资料与方法　回顾性分析 80例前纵隔肿瘤CT导向下经皮针刺活检术。结果　 (1)病理学明确诊断 6 7例 ,不能确定诊断 13例 ;(2 )细针抽吸、切割针活检穿刺敏感性分别为 75 %、90 .5 % ;(3) 16例小病灶穿刺敏感性为 6 8.8% ,6 4例大病灶穿刺敏感性为 87.5 % ;(4)胸腺类肿瘤、淋巴结转移性癌活检准确性均为 92 % ,淋巴瘤活检准确性仅为 6 5 % ,与前两组比较有统计学意义(P <0 .0 5 ) ;(5 )穿刺并发症发生率为 7.5 %。结论　切割针活检阳性率高于细针活检 ,活检阳性率大病灶高于小病灶 ,胸腺类肿瘤、淋巴结转移性癌活检阳性率显著高于淋巴瘤 ;CT导向下经皮针刺活检术是前纵隔肿瘤安全、有价值的诊断方法。     

CT引导下经皮肺穿刺切割活检的价值及安全性

目的：评价CT引导下经皮肺穿刺活检对肺部疑难疾病的诊断价值及安全性。方法：回顾性分析有手术病理、临床或影像随访结果的CT引导下经皮肺穿刺活检105例,其中97例为肺部局限性病灶（A组）,8例肺部弥漫性病灶（B组）。结果：2组共有101例穿刺物结果与手术病理、临床或影像学随访结果相符：穿刺诊断正确率96．2％。A组穿刺诊断正确率（99．0％）高于B组（62．5％）（P〈0．01）。A组肺癌占79．4％（77／97;B组肺癌占60．0％（3／5）;二组差异无统计学意义（P〉0．05）。两组合计发生气胸24例;出血34例,其中咯血18例。结论：cT引导下经皮肺穿刺切割活检穿刺诊断正确率高,是肺内疑难病变定性诊断的理想方法;使用18G穿刺针,可减少穿刺次数、降低出血的发生。     

CT-guided transthoracic needle biopsy using an ipsilateral dependent position

OBJECTIVE: We postulated that the pneumothorax rate of transthoracic needle biopsy might improve with an ipsilateral dependent position of the affected side. We tried to determine the feasibility, effectiveness, and safety of CT-guided biopsy with the patient in this position. SUBJECTS AND METHODS: CT-guided needle biopsy with the patient in an ipsilateral dependent position was performed in 23 patients with 17 lung lesions (15 posterior and two anterior) and six mediastinal lesions. Fine-needle aspiration was used in all patients, and core biopsy was also used in six patients. The technical difficulty of the procedure was classified into three grades compared with a routine transthoracic needle biopsy as follows: grade I, no more difficult; grade II, somewhat more difficult; and grade III, much more difficult. RESULTS: Adequate samples were obtained in 22 (96%) of 23 patients. A small asymptomatic pneumothorax occurred in two patients (8.7%). Difficulty was rated grades I, II, and III in 18 (78%), two (9%), and three (13%) procedures, respectively. Four of the five grades II and III procedures were biopsies of anterior lesions. Traversing the pleura was avoided in three of six mediastinal masses. CONCLUSION: Transthoracic needle biopsy of selected lung and mediastinal lesions using an ipsilateral dependent position is feasible, effective, and safe. The role of this technique for reducing the rate of pneumothorax as a result of the biopsy requires further investigation.     

CT导向经胸穿刺活检108例报告

CT导向经胸穿刺活检108例;纵隔,肺门36例,周围肺野66例,胸膜6例。经手术证实和临床随访,恶性肿瘤的穿刺活检正确率为96％、良性肿瘤为54.5％、非肿瘤性病变为36.4％。4例并发症:2例气胸、2例轻微出血。无空气栓塞及肿瘤扩张。本文讨论了CT导向与电视监视,超声导向的比较,认为CT导向对深部小病灶以及组织结构重叠部位病灶比电视监视、超声导向为好。另外也分析了穿刺针与并发症的关系以及产生并发症的其它因素。并且评价了CT导向穿刺活检在临床诊断的作用。     

64排螺旋CT在肺结节病变经皮穿刺活检中的临床应用研究

目的 探讨64排螺旋CT在肺结节病变经皮穿刺活检中的临床应用价值.方法 有手术病理或临床、影像学随访结果的肺结节病变CT导向下穿刺活检126例,其中经64排螺旋CT导向下穿刺活检61例,普通CT导向下穿刺活检65例.比较64排螺旋CT导向下和普通CT导向下肺结节病变穿刺活检在诊断正确率和并发症发生率等方面的差异.统计学处理采用t检验、x2检验等.结果 64排螺旋CT导向下肺结节穿刺活检诊断正确率91.8％(56/61)显著高于普通CT导向下的诊断正确率78.5％(51/65),差异有统计学意义(x2=3.89,P＜0.05).64排螺旋CT导向下肺结节穿刺活检的并发症发生率18.0％(11/61)显著低于普通CT导向下的并发症发生率35.4％(23/65),差异有统计学意义(x2=6.57,P＜0.05).结论 64排螺旋CT导向下经皮肺结节穿刺活检优于普通CT,有重要临床应用价值.     

CT透视引导下的纵隔小病灶穿刺活检的临床价值

目的探讨CT引导下纵隔小病灶穿刺活检技术及诊断价值。方法42例纵隔小病灶(小于3cm)在CT引导下采用自动切割式活检针穿刺活检。结果42例纵隔肿块穿刺活检病灶取材成功率97.65(41/42)。纵隔肿块穿刺活检的诊断准确率92.3%(39/42),对于恶性病变诊断准确率96.3%(26/ 27),良性病变为86.7%(13/15)。并发气胸2例(4.8%),纵隔少量出血1例(2.3%)。结论CT引导下穿刺活检是安全、有效的诊断手段,对于纵隔病变诊断的准确率高,CT引导下纵隔小病灶穿刺活检对纵隔病变的诊断和治疗具有重要意义。     

CT导引下的纵隔病变穿刺活检

目的探讨CT导引纵隔病变穿刺活检技术及其临床意义。方法35例纵隔病变在CT导引下行穿刺活检。结果35例纵隔病变穿刺活检病灶成功率100%。诊断准确率94.2%(33/35),其中恶性病变诊断准确率100%(21/21),良性病变为85.7%(11/14)。并发气胸3例(8.6%),纵隔出血1例(2.9%)。结论CT导引下穿刺活检术对于纵隔病变诊断的正确率高,对纵隔病变的诊治具有很大的帮助。     

CT-guided core-needle biopsy in the diagnosis of mediastinal lymphoma

The advent of radiologic guidance techniques for percutaneous biopsy has changed the approach to the routine diagnosis of mediastinal lymphoma. The aim of the present study was to evaluate the diagnostic accuracy of CT-guided percutaneous core-needle biopsy (PCNB) in the clinical management of patients with mediastinal lymphoma. The results of 49 CT-guided PCNB of mediastinal lymphoma performed under local anesthesia in 42 ambulatory patients were analyzed. A positive diagnosis of lymphoma was obtained in 30 of 42 patients, with an overall success rate of 71.5 %. The technique was equally successful in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma. There were no major complications. Percutaneous CT-guided CNB of mediastinal lymphoma is a quick, safe, accurate, and efficient alternative to open biopsy in the evaluation of mediastinal lymphoma, mainly at presentation. It should become the preferred initial diagnostic procedure for obtaining histologic samples in patients with suspected mediastinal lymphoma. Received: 28 January 1999; Revised: 21 May 1999; Accepted: 15 October 1999     

Transthoracic CT-guided biopsy with multiplanar reconstruction image improves diagnostic accuracy of solitary pulmonary nodules

OBJECTIVE: To evaluate the utility of multiplanar reconstruction (MPR) image for CT-guided biopsy and determine factors of influencing diagnostic accuracy and the pneumothorax rate. MATERIALS AND METHODS: 390 patients with 396 pulmonary nodules underwent transthoracic CT-guided aspiration biopsy (TNAB) and transthoracic CT-guided cutting needle core biopsy (TCNB) as follows: 250 solitary pulmonary nodules (SPNs) underwent conventional CT-guided biopsy (conventional method), 81 underwent CT-fluoroscopic biopsy (CT-fluoroscopic method) and 65 underwent conventional CT-guided biopsy in combination with MPR image (MPR method). Success rate, overall diagnostic accuracy, pneumothorax rate and total procedure time were compared in each method. Factors affecting diagnostic accuracy and pneumothorax rate of CT-guided biopsy were statistically evaluated. RESULTS: Success rates (TNAB: 100.0%, TCNB: 100.0%) and overall diagnostic accuracies (TNAB: 96.9%, TCNB: 97.0%) of MPR were significantly higher than those using the conventional method (TNAB: 87.6 and 82.4%, TCNB: 86.3 and 81.3%) (P < 0.05). Diagnostic accuracy were influenced by biopsy method, lesion size, and needle path length (P < 0.05). Pneumothorax rate was influenced by pathological diagnostic method, lesion size, number of punctures and FEV1.0% (P < 0.05). CONCLUSION: The use of MPR for CT-guided lung biopsy is useful for improving diagnostic accuracy with no significant increase in pneumothorax rate or total procedure time.     

CT导向下经皮纵隔病变自动切割活检准确率分析

目的探讨影响CT导向下经皮纵隔病变自动切割活检(automated cutting needle biopsy,ACNB)准确性的相关影响因素。资料与方法回顾性分析89例采用CT导向下经皮纵隔病变ACNB的患者资料,以最终诊断结果为金标准,计算穿刺活检诊断恶性病变的敏感性、特异性、阳性预测值、阴性预测值及准确性。应用χ2检验分析不同病变部位、大小、良、恶性及穿刺次数等对穿刺活检准确性的影响。结果 89例纵隔病变穿刺活检患者中有80例与最终诊断结果相符,穿刺活检诊断恶性病变的敏感性、特异性、阳性预测值、阴性预测值、准确性及其95%可信区间分别为90.5%(84.4%～96.6%)、86.7%(79.6%～93.8%)、97.1%(93.6%～100%)、65.0%(55.0%～75.0%)、89.9%(83.6%～96.2%)。经统计学分析,经皮纵隔病变ACNB活检准确性与病灶大小、穿刺次数有统计学意义,穿刺层面病灶越大,活检准确性越高;穿刺次数为3次组活检准确性高于<3次组,而与>3次组无明显差异。结论 CT导向下经皮纵隔病变ACNB对纵隔病变定性诊断准确性高且安全,纵隔病变大小及活检次数可影响活检诊断的准确...     

Accuracy of CT-guided transthoracic needle biopsy of lung lesions: Factors affecting diagnostic yield

PURPOSE: This study was performed to analyse the variables affecting the diagnostic accuracy of computed tomography (CT)-guided transthoracic needle biopsy of pulmonary lesions. MATERIALS AND METHODS: A retrospective study of 612 consecutive procedures with confirmed final diagnoses was undertaken. Benign and malignant needle biopsy results were compared with final outcomes to determine diagnostic accuracy. A statistical analysis of factors related to patient characteristics, lung lesions and biopsy technique was performed to determine possible influences on diagnostic yield. A p value less than 0.05 was interpreted as statistically significant. RESULTS: There were 508 (83%) malignant and 104 (17%) benign lesions. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy for a diagnosis of malignancy were 90.2%, 99.0%, 99.8%, 67.3% and 91.7%, respectively. Overall diagnostic accuracy was 83.3%. Variables affecting diagnostic accuracy were the final diagnosis (benign 67%, malignant 92%; p<0.001) and lesion size (lesions<1.5 cm 68%, lesions 1.5-5.0 cm 87%, lesions>5 cm 78%; p<0.05). CONCLUSIONS: In CT-guided transthoracic needle biopsy, the final diagnosis and lesion size affect diagnostic accuracy: benign lung lesions and lesions smaller than 1.5 cm or larger than 5.0 cm in diameter provide lower diagnostic yield.     

CT导引下经皮肺部肿块穿刺活检术的临床应用研究

目的探讨肺部肿块CT导引下经皮穿刺活检术(percutaneouspuncturebiopsy,PPB)的临床应用价值和影响其诊断正确率的相关因素。方法对72例肺部肿块患者进行CT导引下PPB检查,对比PPB结果与临床影像学诊断以及手术病理结论,并进一步分析影响CT导引下PPB诊断正确率的相关因素。结果肺部肿块CT导引下PPB的穿中率为100%,诊断正确率为89.6%(61/72),并发症发生率为11.1%(8/72)。患者年龄,有无肺气肿,肺部肿块的大小、肿块内部组分为影响肺部肿块CT导引下PPB正确率和引起有关并发症的主要因素。结论CT导引下PPB在肺部肿块的诊断和鉴别诊断中具有安全、准确、简便等优点。为提高PPB的正确率和减少并发症的发生,应注意患者、病灶和操作过程中的相关因素。     

经皮肺活检对肺部病变的临床诊断意义

目的 评价经皮肺活检术对原发性肺癌、肺转移性癌以及非恶性肺疾病的诊断价值.方法 回顾性总结近10年来436例经皮肺活检患者的临床资料,其中明确为原发性肺癌患者341例、肺转移性癌62例、非恶性肺疾病33例.统汁分析经皮肺活检术对上述疾病的诊断准确率及灵敏度.结'果原发性肺癌组经皮肺活检阳性321例,诊断准确率为94.7%、灵敏度94.1%;肺转移性癌组阳性32例,诊断准确率58.2%、灵敏度51.6%;非恶性肺疾病组阳性19例,诊断准确率以及灵敏度均为57.6%.436例患者中427例经皮肺活检获得足够病变组织标本,9例活检失败,活检成功率97.9%.全部患者共穿刺474例次,其中74例次出现并发症,发生率15.6%.主要并发症有气胸(63例次,13.3%)和肺内出血(56例次,11.8%).结论 临床上怀疑原发性肺癌的肺部病变,经皮肺活检术诊断准确率高,并发症少且轻微.对于考虑为肺转移性癌以及非恶性肺疾病,该技术尚有待进一步改进.