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1.
Background and purpose Perthes’ disease leads to radiographic changes in both the femoral head and the acetabulum. We investigated the inter-observer agreement and reliability of 4 radiographic measurements assessing the acetabular changes. Patients and methods We included 123 children with unilateral involvement, femoral head necrosis of more than 50%, and age at diagnosis of 6 years or older. Radiographs were taken at onset, and 1 year and 5 years after diagnosis. Sharp’s angle, acetabular depth-width ratio (ADR), lateral acetabular inclination (LAI), and acetabular retroversion (ischial spine sign, ISS) were measured by 3 observers. Before measuring, 2 of the observers had a consensus meeting. Results We found good agreement and moderate to excellent reliability for Sharp’s angle for all observers (intra-class correlation coefficient (ICC) > 0.80 with consensus, ICC = 0.46–0.57 without consensus). There was good agreement and substantial reliability for ADR between the observers who had had a consensus meeting (ICC = 0.62–0.89). Low levels of agreement and poor reliability were found for observers who had not had a consensus meeting. LAI showed fair agreement throughout the course of the disease (kappa = 0.28–0.52). The agreement between observations for ISS ranged from fair to good (kappa = 0.20–0.76). Interpretation Sharp’s angle showed the highest reliability and agreement throughout the course of the disease. ADR was only reliable and showed good agreement between the observers when landmarks were clarified before measuring the radiographs. Thus, we recommend both parameters in clinical practice, provided a consensus is established for ADR. The observations for LAI had only fair agreement and ISS showed inconclusive agreement in our study. Thus, LAI and ISS can hardly be recommended in clinical practice.Perthes’ disease leads to typical radiographic changes of the femoral head. Several authors have described simultaneous changes of the acetabular anatomy, such as hypertrophy, bicompartmental development, retroversion, and dysplastic changes ( Yngve and Roberts 1985, Joseph 1989, Ezoe et al. 2006).Most measurements describing the radiographic changes of the acetabulum on anteroposterior (AP) pelvic radiographs have been validated in children with hip dysplasia. As the hip pathology and the morphological changes in Perthes’ disease are different from those in hip dysplasia, we wanted to assess inter-observer reliability and agreement of 4 commonly used acetabular measurements at the different stages of skeletal maturity in Perthes’ disease. 相似文献
2.
Background and purpose — The incidence of Perthes’ disease as reported in the literature varies widely between and within countries. The etiology of the disease is still unknown. Both environmental and genetic factors have been suggested to play a part in either causing the disease or increasing the susceptibility of an individual. We determined the incidence of Perthes’ disease in Sweden and investigated possible relationships to parental socioeconomic status, ethnicity, marital status, mothers’ age when giving birth, parity, number of siblings, and smoking habits. Patients and methods — Six Swedish population-based registers were used, together covering all children born in Sweden from 1973 through 1993. Results — The incidence of Perthes’ disease in Sweden was 9.3 per 100,000 subjects. The ratio between boys and girls was 3.1:1. The educational level of the father and the mother of a child with Perthes’ disease was lower than in the controls. The incidence was lower when the fathers were in the highest income bracket (above the 90th percentile). A higher proportion of parents of Nordic lineage had children with Perthes’ disease than parental pairs with one or both who were not of such lineage. Interpretation — This study confirms that there is an association between the incidence of Perthes’ disease and the socioeconomic status of the parents. 相似文献
3.
There is controversy as to whether operative treatment in Legg-Calvé-Perthes (LCP) disease improves the outcome obtained by conservative treatment. This article describes a paired study of mature patients, diagnosed with LCP disease before the age of 8 years, to compare the radiological results after conservative or surgical management. Patients were paired with strict matching of gender, body mass index, age at onset, disease stage at the first visit, necrotic area, and radiological at-risk signs. Each pair was assessed by comparing the values of five radiological measurements. Fourteen pairs (28 hips) fitted the criteria. The only radiological measure which showed a statistically better result in the surgical group was femoral head sphericity as measured by Mose's method. However, there was no difference between the two groups for Stulberg class. Our study supports the hypothesis that for hips affected with LCP disease under the age of 8 years, surgery does not improve the outcome. 相似文献
4.
Cross-sectional epidemiologic scoliosis screening was carried out to determine the current prevalence of scoliosis in the
Korean population and to compare with the results of previous studies. Between 2000 and 2008, 1,134,890 schoolchildren underwent
scoliosis screening. The children were divided into two age groups, 10–12-year-olds (elementary school) and 13–14-year-olds
(middle school), to calculate age- and sex-specific prevalence rates. Children with a scoliometer reading ≥5° were referred
for radiograms. Two surgeons independently measured curve types, magnitudes, and Risser scores (inter-observer r = 0.964, intra-observer r = 0.978). Yearly and overall prevalence rates of scoliosis were calculated. There were 584,554 boys and 550,336 girls in
the sample, with a male to female ratio of 1.1:1. There were 77,910 (6.2%) children (26,824 boys and 51,086 girls) with scoliometer
readings >5°, and 37,339 of them had positive results with Cobb angles ≥10° (positive predictive value, 46.4%). The overall
scoliosis prevalence rate was 3.26%; girls had a higher prevalence (4.65%) than boys (1.97%). Prevalence rates increased progressively
from 1.66 to 6.17% between 2000 and 2008, with the exception of 2002. According to age and gender, 10–12-year-old girls had
the highest scoliosis prevalence rates (5.57%), followed by 13–14-year-old girls (3.90%), 10–12-year-old boys (2.37%), and
13–14-year-old boys (1.42%). In girls and boys, prevalence rates dropped by 64.53 and 60.65% among 10–12-year-olds and 13–14-year-olds,
respectively ( P = 0.00). The proportion of 10°–19° curves was 95.25 and 84.45% in boys and girls, respectively; and the proportion of 20°–29°
curves was 3.91 and 11.28%, which was a significant difference ( P = 0.00). Thoracic curves were the most common (47.59%) followed by thoracolumbar/lumbar (40.10%), double (9.09%), and double
thoracic (3.22%) curves. A comparison of the curve patterns revealed significant differences between genders ( P = 0.00). We present this report as a guide for studying the prevalence of idiopathic scoliosis in a large population, and
the increasing trend in the prevalence of idiopathic scoliosis emphasizes the need for awareness. 相似文献
5.
IntroductionWhile autologous skin grafting has been the standard for coverage of full-thickness areas, several options for deep-partial-thickness defects exist. With regard to economising donor sites, we compared a copolymer based on dl-lactid acid (Suprathel ®) as temporary wound dressing with autologous skin, and analysed time to healing and scar quality in matched areas of deep-partial-thickness burn. MethodsWe recruited 18 patients with a median age of 45 years (range: 25–83 years), for this prospective, non-blinded controlled non-inferiority study, suffering from deep-partial-thickness burns from November 2009 to July 2010. After early tangential excision, matched deep-partial-thickness areas were covered with 1:1.5 meshed autologous skin grafts and the copolymer for direct intra-individual comparison. Scars were evaluated by means of the Vancouver Scar Scale (VSS), the Patient and Observer Scar Assessment Scale (POSAS) and suction cutometry (MPA 580, Courage and Khazaka Electronic GmbH, Cologne, Germany) on days 30 and 90, postoperatively. ResultsFifteen days after surgery, complete wound closure was present in 44.4% (8/18) of all areas covered with copolymer and 88.9% (16/18) in the split-thickness skin graft (STSG) area ( p = 0.008). Evaluation of the total VSS, POSAS and cutometry satisfied the criterion of non-inferiority for Suprathel ® on day 30. Ninety days after surgery, only the Observer Scar Scale showed that Suprathel is non-inferior to STSG, albeit the mean total VSS and Patient Scar Scale were better in Suprathel ® areas. ConclusionSuprathel ® represents a solid, reliable epidermal skin substitute with longer healing times in comparison to skin grafts but comparable results concerning early scar formation. Suprathel ® can serve as a tool in treatment portfolio for adult patients suffering from deep dermal burns. Especially in patients with extensive burns, Suprathel ® can be used to cover the deep dermal burn wounds to save STSGs and its donor sites for the coverage of full-thickness burned areas. 相似文献
6.
Background Although the prognosis of Perthes’ disease at skeletal maturity is considered favorable, little is known about the long-term
results after middle age. 相似文献
7.
BackgroundThe traditional outcome measured following treatment of Dupuytren’s Disease (DD) has been digital range of motion; specifically the gain in digital extension. The outcomes research movement in the last three decades however has been advocating the measurement of outcomes from the patient’s perspective using Health-Related Quality of Life questionnaires (HRQOL). Although several generic and region-specific HRQOL questionnaires exist, there is no guidance as to which one is the most appropriate for this population. The objective of this study is to evaluate the psychometric properties of three self-reported HRQOL outcome measures in patients with DD. MethodsPatients with DD were enrolled from the practices of three plastic surgeons. Test-retest reliability, concurrent validity and responsiveness of three HRQOL questionnaires were compared in a prospective study design. The HRQOL measures included Health Utilities Index Mark 3 (HUI3), Short Form-36 (SF-36), and the Michigan Hand Questionnaire (MHQ). ResultsAll three measures demonstrated good test-retest reliability (ICC = 0.77–0.85). Concurrent validity was found between the HUI3 pain and dexterity attributes and SF-36 physical summary score. The sensitivity of the MHQ to detect changes in the status of the patient was found to be high (effect size = 1.14) whereas that of the SF-36 was trivial. ConclusionsThe HUI3 and the MHQ seem to be reliable and valid tools to assess the HRQOL in patients with Dupuytren’s Disease. 相似文献
8.
SummaryThis is the first study indicating an association between gradually diminished risk of fractures and years of increased physical activity. Our results could imply great benefits not only for the individual but also for the healthcare burden and cost of society.IntroductionPhysical activity (PA) in childhood is associated with high bone mass and beneficial neuromuscular function. We investigate if increased PA also is associated with fracture risk.MethodsWe registered fractures in 3534 children aged 6 to 8 years at study start for up to 7 years; 1339 with 40 min of moderate PA every school day (intervention) and 2195 with the Swedish standard curriculum of 60 min of PA per school week (controls). In a subsample of 264 children, we measured areal bone mineral density (aBMD; g/cm2) with dual-energy X-ray absorptiometry (femoral neck and total spine) and muscle strength (peak torque for knee extension and flexion; Nm) with computerized dynamometer at baseline and after 7 years. We estimated annual fracture incidence rate ratios (IRR) in the intervention group compared to the control group as well as changes in bone mass and muscle strength. Data is given as mean (95 % CI).ResultsThe IRR of fractures decreased with each year of the PA intervention (r?=??0.79; p?=?0.04). During the seventh year, IRR was almost halved [IRR 0.52 (0.27, 1.01)]. The intervention group had a statistically significant greater gain in total spine aBMD with a mean group difference of 0.03 (0.00, 0.05) g/cm2 and peak flexion torque 180° with a mean group difference of 5.0 (1.5, 8.6) Nm.ConclusionsIncreased PA is associated with decreased fracture risk, probably in part due to beneficial gains in aBMD and muscle strength. 相似文献
10.
Radiographs of 75 children with unilateral disease were studied to quantify the extent of remodeling of the proximal femur and the acetabulum between healing and skeletal maturity in children with Perthes disease. The mean ages at disease onset, healing, and skeletal maturity were 8.3, 11.9, and 15.5 years, respectively. Fifty-seven children were treated surgically by subtrochanteric varus osteotomy with trochanteric epiphyseodesis; the remaining 18 children were treated nonoperatively. Assessment of the Mose's index and Stulberg grading and measurements of the proximal femur and the acetabulum were made at healing and at skeletal maturity. The Stulberg grade and the Mose's index did not change between healing and skeletal maturity in 88% and 95% of children, respectively. In operated children, there was significant improvement of the articulotrochanteric distance, acetabular depth, neck-shaft angle, and Sharp's angle between disease healing and skeletal maturity, but no such changes occurred in children who were not operated on. We conclude that because little change occurs in the shape of the femoral head and congruity of the hip between healing and skeletal maturity, the outcome of treatment based on these 2 variables can be assessed once the disease heals in children with late-onset Perthes disease. 相似文献
11.
BackgroundThe role of vascular endothelial growth factor (VEGF) after ischaemic necrosis of the femoral head in Legg–Calve–Perthes disease (LCPD) has not been adequately studied in humans, especially in Indian population. Therefore, we aimed to evaluate the serum levels of VEGF-A in Indian children with various stages of LCPD and compare them with those of an age- and sex-matched control group of healthy children.MethodsIn this case–control study, we enrolled 42 children (below 14 years age) suffering from LCPD and 21 age- and sex-matched healthy controls. Patients were classified radiographically according to Waldenstrom’s classification. Serum VEGF-A was estimated by sandwich enzyme-linked immunosorbent assay technique. The serum values were compared between the patient group and the control group, as well as between the Waldenstrom subgroups. Results were expressed as means with ranges or median with interquartile range.ResultsThe mean age in the patient as well as the control group was 9 years (range 4–13 years). The median value (interquartile range) of serum VEGF-A was 162.5 pg/ml (673.75 pg/ml) in the patient group and 652 pg/ml (190.5 pg/ml) in the control group (p = 0.013). When compared between lower Waldenstrom stages (initial stage + stage of fragmentation) and higher Waldenstrom stages (re-ossification stage + stage of healing), the mean values of serum VEGF-A were 464.7 pg/ml (range 0–2211 pg/ml) and 301.1 pg/ml (range 0–1910 pg/ml), respectively (p = 0.305).ConclusionsVEGF is under-expressed in Indian children suffering from LCPD. As VEGF acts as a key regulator of endochondral ossification, our finding may open new therapeutic approaches to the disease. Also, serum VEGF may act as a valuable marker for the follow-up of the disease. Our study also provides baseline data about serum VEGF-A levels in Indian cohort of LCPD patients. Future multi-centre studies are warranted with a larger sample size to fully appreciate the patho-physiological changes in VEGF occurring in LCPD. 相似文献
12.
In recent years, newer tools have been developed and used in thyroid surgery. This study compared patients with multinodular goiter undergoing thyroidectomy using the Harmonic FOCUS? with patients undergoing the clamp-and-tie technique. Medical records of 268 patients with multinodular goiter undergoing thyroidectomy from December 2006 to July 2011 in two centers in Italy, the Department of Surgery of Pisa and the General Surgery Unit of Grosseto, were prospectively evaluated. Patients were divided into group A (Harmonic FOCUS? Shear), and group B (clamp-and-tie technique). Patient demographics and specific end points analyzed included age, sex, diagnosis, thyroid gland volume, operative time, complications, need for clips and hemostatic agents, need for suction balloon, postoperative blood loss, and postoperative hospital length of stay. 141 patients were included in group A, and 127 patients were included in group B. The two groups were similar in age, sex ratio, indication for surgery, and thyroid volume. Mean operative time was significantly shorter with the Harmonic FOCUS? Shear (51.8 min) than with the clamp-and-tie technique (70.9 min). The mean postoperative amount obtained from the suction balloon was similar. Vascular clips were needed significantly more frequently in group A (26.2 %) than in group B (12.5 %), whereas the need for hemostatic agents was significantly reduced in group A (4.2 %) compared with group B (14.9 %). The decision to leave a suction drain at the end of the operation occurred significantly more frequently in group B (96 %) than in group A (78 %). Mean postoperative hospital length of stay was 2.02 days in group A compared with 3.1 days in group B, which was significant. No definitive postoperative complications were documented in either group, except a higher rate, but not statistically significant, of permanent hypoparathyroidism in group B versus Group A. Transient laryngeal nerve injury was similar in both groups, whereas transient hypoparathyroidism occurred more frequently in Group B (4.7 %) than in Group A (2.4 %). Harmonic FOCUS device was significantly associated with lower rate of postoperative transient hypocalcemia, decreased operative time, shorter hospitalization, and lesser need for hemostatic agents and postoperative drain balloon. These results might be considered “indirect” money-saving factors, despite the cost of the device, especially in countries where the cost of thyroidectomy is influenced also by the hospital length of stay. 相似文献
13.
Summary
Background. The aim was to asses the clinical profile and urodynamic findings and the outcome of surgery in children with spinal dysraphism.
Method. Twenty five children with spinal dysraphism who were treated at our institute between January 2005 and June 2006 were studied
prospectively. There were 10 with an open spina bifida and 15 closed. The clinical profile of bladder dysfunction was assessed
and urodynamic evaluation done pre-operatively in each child. An ultrasound study of the kidneys was also done to assess for
hydro-uretero-nephrois. All underwent surgery for their primary and associated malformations. Post-operatively, re-evaluation
of bladder dysfunction and urodynamic parameters was performed at 6–8 months.
Results. Before operation there was a history indicating that the bladder was involved in 14 of the 25 children. Six of the 10 cases
with an open spina bifida showed clinical involvement of the bladder as compared to 8 of 15 with a closed pattern. Urodynamic
studies showed evidence of bladder dysfunction in 19 children. Of 10 with a meningomyelocele, there were abnormal urodynamics
in 9 as compared to 10 of 15 with closed dysraphism. Follow up urodynamic studies showed improvement in 9 of 20 children 3
of 7 with a meningomyelocele and 6 of 13 with closed dysraphism.
Conclusion. Children with open spina bifida, as compared to closed dysraphism, tend to have more bladder dysfunction as exemplified on
clinical history and urodynamic assessment. A pre-operative urodynamic study helps to identify severity of bladder dysfunction
which is clinically overt cases and also identifies subtle bladder dysfunction in clinically silent cases. Evaluation after
operation tends to shows better outcome in children with closed dysraphism. The study also identifies deterioration in some
patients with seemingly clinical improvement.
Correspondence: Dr. Raj Kumar, MS, Mch, Professor and Head, Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute
of Medical Sciences, Lucknow 226014, UP, India. 相似文献
14.
Osteochondritis dissecans (OCD) and loose body formation are rare following Perthes' disease. We have reviewed the literature about clinical presentation, treatment and outcome and added a further three cases of the condition. Cases mentioned in the literature were poorly documented. We feel that a thorough documentation should be carried out as soon as the diagnosis is made. Conservative treatment should be given when the disability is moderate. The loose body should only be removed surgically when it is mobile, when it bulges into the joint space or when there are signs of early arthritis. 相似文献
15.
PurposeThe cementless Bicontact® total hip arthroplasty (THA) system (AESCULAP AG, Tuttlingen, Germany) was introduced in 1986/1987 and has been in successful clinical use in an unaltered form up to today. Although good long-term results with the Bicontact® stem have been published, it is questionable whether the implant provides the criteria for a state-of-the-art stem regarding proximal bone stock preservation. The purpose of the study was to monitor the periprosthetic bone mineral density (BMD) in a prospective two-year follow-up dual-energy X-ray absorptiometry (DEXA) study. MethodsAfter power analysis, a consecutive series of 25 patients with unilateral Bicontact® stem implantation was examined clinically and underwent DEXA examinations. Scans of seven regions of interest were taken preoperatively and at one week, six months, and one and two years. ResultsOne patient required stem revision due to a deep infection. The Harris Hip Score increased significantly by 44 points. The most significant bone loss was observed in the calcar region (R7) in the first six months (−19.2 %). It recovered in the following 18 months to −8.5 %. The BMD in the greater trochanter dropped significantly after six months and remained stable at this level. BMD exceeded baseline values in distal regions and even more in the lesser trochanter region after two years. ConclusionsWe conclude that the Bicontact® stem provides adequate proximal bone stock preservation. We observed some signs of stress shielding at the tip of the stem, which is inevitable to some degree in THA with cementless straight stems. However, in this prospective DEXA investigation, we showed that proximal off-loading does not occur after THA with the Bicontact® system. Thus, we believe that this stem is still a state-of-the-art implant. 相似文献
16.
We evaluated the LMA ® Protector TM in 280 ASA physical status 1–3 patients aged 18–75 years by assessing the ease of insertion, insertion time, oropharyngeal leak pressure, ease of gastric tube passage and complications. First-attempt and overall insertion success was 234/280 (84; 95%CI 79–88%) and 274/280 (98; 95–99%). Median (IQR [range]) insertion time was 17 (12–25 [5–44]) s, and manoeuvres to facilitate insertion were required in 56 (50–63)% of patients. Median oropharyngeal leak pressure was 31 (26–36 [14–40]) cmH 2O. Multivariate analysis identified two risk factors for oropharyngeal leak pressure < 25 cmH 2O: male sex (OR 2.44; 1.01–5.91, p = 0.048) and the insertion of a LMA size different to that recommended by weight (OR 1.98; 0.97–4.03, p = 0.06). Gastric tube insertion was possible in 256 out of 274 patients (93%). On fibreoptic view, vocal cords were visible in 86% of patients. During maintenance, 14 patients (5%) required airway manipulation. There were no episodes of regurgitation or aspiration. Blood staining on LMA removal was present in 70 out of 280 patients (25%). Use of the LMA Protector appears safe and is associated with a high success rate, provision of a highly effective seal and low rates of clinical complications. These attributes would suggest considerable potential for use during anaesthesia. 相似文献
17.
Amyand’s hernia is a very rare condition with a presence of a vermiform appendix in an inguinal hernia sac. It is estimated
to be found in approximately 1% of adult inguinal hernia. In this study, we report a retrospective analysis of 30 patients
aged between 19 days and 8 years with an Amyand’s hernia operated in our institution from 1998 to 2009, and we reviewed the
literature on the topic. Hernia repair without an appendectomy was performed in patients with normal appendix. Emergency appendectomy
through herniotomy was performed in cases of inflamed and perforated appendices. 相似文献
18.
PurposeLegg−Calvé−Perthes disease (LCPD) is uncommon in girls. The presentation of LCPD in female patients has been reported as later in onset and associated with certain high-impact activities. Our aim is to characterize the presentation of female LCPD at a large center, with particular attention to the clinical and radiographic features of late-onset disease (>ten years of age). We perceived an increasing burden of late-onset disease with adult-like radiographic features. MethodsAll patients presenting to a single large urban children’s hospital from 1990−2014 with a diagnosis of LCPD were reviewed. Demographic, clinical, and radiographic data for all female patients were examined and compared to historical norms. ResultsFour-hundred and fifty-one patients presented with LCPD in the study period, of which 82 (18.2 %) were female. The average age at presentation was 6.58 years in girls, which is similar to the classically reported mean age. Fourteen patients participated in high-impact repetitive activities or those with deep flexion and abduction, although few were late presenters. There were four female patients who presented for initial diagnosis >ten years of age. ConclusionsThere was a paucity of late-onset LCPD in girls in the study population, and the females with LCPD had a very similar age and character to their presentation as did males. Although their presentation is infrequent, three of four older females with LCPD were engaged in high-level physical activity, and their disease may be attributed to high-impact, repetitive athletics. Level of evidenceCase series, Level IV. 相似文献
19.
Background This study aimed to assess the feasibility, safety, and immediate postoperative outcome of laparoscopically assisted ileocolic
resection for Crohn’s disease.
Methods Data were collected retrospectively from a database of 50 consecutive patients with Crohn’s disease who underwent ileocolic
resection between 1997 and 2007. The mean age of the patients was 40 years (range, 20–74 years), and 21 of the patients were
men. Of the 50 patients, 18 had a history of abdominal surgery. The mean time from diagnosis to operation was 6.4 years (range,
1–31 years). The indications for surgery included subobstruction (48%), failure of medical treatment (20%), and internal fistulas
(32%).
Results The mean operating time was 150 min (range, 80–360 min), and the blood loss was 130 ml (0–400 ml). Only 1 of the 50 patients
underwent conversion to laparotomy. Return of bowel movement occurred at a mean of 3 days (range, 1–7 days). The median hospital
stay was 8 days (range, 5–130 days). There was no 30-day mortality. The minor complication rate was 20%. The complications
included wound infection, pneumonia, urinary infection, postoperative bleeding, prolonged ileus, and fever of unknown origin.
Major complications occurred for four patients, with three patients experiencing an anastomotic leak and one patient a leak
after fistulectomy.
Conclusions The laparoscopically assisted approach to ileocolic Crohn’s disease seems to be feasible and safe, with acceptable immediate
postoperative outcomes. 相似文献
20.
BackgroundThe objective of this study was to compare the effectiveness of FloSeal® matrix hemostatic agent with hemostatic surgical procedures and Tabotamp® in thyroid surgery.MethodsOne hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5?×?5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations.ResultsMean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p?=?0.02) and vs. Tabotamp (122 min, p?=?0.0003). Also, wound drain removal occurred earlier with FloSeal (p?=?0.006 vs. surgical; p?=?0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p?=?0.02 vs. surgical; p?=?0.002 vs. Tabotamp).ConclusionsFloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery. 相似文献
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