三苯双脒肠溶片治疗肠道线虫感染的效果观察

目的：观察三苯双脒（Tribendimidine)肠溶片对钩虫、蛔虫、鞭虫和蛲虫感染的驱虫效果。方法：对单纯钩虫、蛔虫、鞭虫、蛲虫感染或混合感染者共424例进行分组，观察成人服用单剂三苯双脒400mg治疗钩虫感染，300mg治疗蛔虫感染，400mg连服3d治疗鞭虫感染，14岁以下儿童顿服三苯双脒200mg治疗蛲虫感染，及同等剂量的对照药物阿苯达唑（蛔虫感染400mg)的驱虫效果及不良反应。结果：三苯双脒和阿苯达唑治疗钩虫感染虫卵阴转率分别为87．93％（51／58）和66．03％（35／53）；蛔虫感染的阴转率分别为98．30％（58／59）和97．87％（46／47）；鞭虫感染的阴转率分别为33．33％（25／75）和56．09％（23／41）；儿童蛲虫感染的阴转率分别为77．58％（45／58）和93．93％（31／33）。结论：三苯双脒治疗钩虫、蛔虫感染有显著疗效，治疗鞭虫和蛲虫感染有疗效，但虫卵阴转率较低。该药还有服用简便、不良反应少而轻等优点。     

三苯双脒治疗钩虫感染效果

目的了解三苯双脒治疗钩虫感染的效果。方法以横断面调查中发现的钩虫感染者为研究对象,随机分成实验组和对照组,分别给予三苯双脒和阿苯达唑治疗,观察两组钩虫感染转阴率及不良反应情况。结果共调查47例钩虫感染者,实验组23例,对照组24例。三苯双脒和阿苯达唑治疗钩虫感染转阴率分别为95.65%和95.83%,不良反应率分别为8.70%和8.33%,差异均无统计学意义（P均〉0.05）。结论三苯双脒治疗钩虫感染的疗效与阿苯达唑相仿。     

三苯双脒肠溶片治疗肠道线虫感染的效果观察

目的 观察三苯双脒（Tribendimidine)肠溶片对钩虫、蛔虫和蛲虫感染的驱虫效果和可能发生的不良反应。方法 对2岁以上单纯钩虫、蛔虫、蛲虫感染或混合感染者251例随机分组，比较成人服用单剂三苯双脒400mg或阿苯达唑400mg治疗钩虫感染和蛲虫感染，三苯双脒300mg或阿苯达唑400mg治疗蛔虫感染的驱虫效果及不良反应。结果 三苯双脒、阿苯达唑对蛔虫感染的虫卵阴转率分别为98．0％（49／50）和100．0％；对钩虫感染的虫卵阴转率分别为92．0％（46／50）和74．0％（37／50）；对蛲虫感染的虫卵阴转率分别为7／10和9／10。三苯双脒的不良反应发生率低而轻，对血象、肝肾功能和心电图无明显影响。结论 三苯双脒400mg治疗美洲钩虫和十二指肠钩虫感染有显著疗效，300mg组与阿苯达唑400mg组治疗蛔虫感染的效果相当，对蛲虫感染也有效，并且有排虫快，服药简便、不良反应少而轻等优点。     

新药三苯双脒肠溶片治疗肠道线虫感染的效果观察

目的 观察三苯双脒肠溶片对钩虫、蛔虫、鞭虫和蛲虫感染的驱虫效果和可能发生的不良反应。方法 广东、江苏2省4县流行区的单纯钩虫、蛔虫、鞭虫、蛲虫感染者共629例,按统一的临床试验方案,随机双盲治疗522例,开放治疗107例。对钩虫感染者同时作虫卵计数、钩蚴培养及虫种鉴定。以阿苯达唑为对照药物,观察驱虫效果和不良反应。结果 三苯双脒400mg和阿苯达唑400mg顿服,钩虫感染者的虫卵阴转率分别为89.5%(85/95)和70.6%(60/85)(P<0.01),其中对美洲钩虫感染者的虫卵阴转率分别为94·9%(37/39)和76.5%(26/34)(P<0.05);三苯双脒300mg和阿苯达唑400mg顿服,对蛔虫感染者的虫卵阴转率分别为97.4%(114/117)和98.9%(91/92)(P>0.05);三苯双脒400mg×3d和阿苯达唑400mg×3d对鞭虫感染者的虫卵阴转率分别为33.3%(25/75)和56.1%(23/41)(P<0.05);三苯双脒或阿苯达唑200mg顿服对儿童蛲虫感染者的虫卵阴转率分别为74.1%(60/81)和93.0%(40/43)(P<0.05)。治疗过程中未发现明显不良反应。结论 三苯双脒肠溶片治疗钩虫、蛔虫等感染,疗效显著,服用方便,不良反应少而轻微。尤其对美洲钩虫感染的疗效优于阿苯达唑。     

新药三苯双脒治疗肠道线虫感染的临床观察

三苯双脒（Ｔｒｉｂｅｎｄｉｍｉｄｉｎｅ）是我国研制的一类驱肠道寄生虫新药,１９８７年已经报道实验研究结果［１］。对美洲钩虫、犬钩虫、日本巴西圆线虫、鼠蛲虫均有驱虫作用。经卫生部药政管理局批准,中山医科大学卫生部临床药理基地作Ⅰ期临床研究,中山医大抗寄生虫药物临床试验专业组牵头,委托我们作Ⅱ期临床观察,现将结果报告如下。１　内容和方法１．１　治疗对象　选择江苏省肠道线虫感染较严重的泰兴市农村,对１８～６５岁农民进行粪便筛查,采用改良加藤氏法（Ｋａｔｏ－Ｋａｔｚ）作定性定量检查,凡钩虫卵计数（ＥＰＧ…     

三苯双脒对钩虫超微结构的影响

应用透射电镜观察了用三七双脒在人体驱出的十二指肠钩虫和美洲钩虫的超微结构变化，结果显示三苯双脒400mg顿服对两种钩虫的体壁，肠管及卵巢的细胞膜，细胞核及多种细胞器均有明显的破坏作用。其中以对卵巢的破坏作用最为严重。     

三苯双脒肠溶片治疗肠道线虫感染的效果观察

目的观察三苯双脒 (Tribendimidine)肠溶片对钩虫、蛔虫、鞭虫和蛲虫感染的驱虫效果。方法对单纯钩虫、蛔虫、鞭虫、蛲虫感染或混合感染者共 42 4例进行分组 ,观察成人服用单剂三苯双脒 40 0 mg治疗钩虫感染 ,3 0 0 mg治疗蛔虫感染 ,40 0 mg连服 3 d治疗鞭虫感染 ,1 4岁以下儿童顿服三苯双脒 2 0 0 mg治疗蛲虫感染 ,及同等剂量的对照药物阿苯达唑 (蛔虫感染 40 0 mg)的驱虫效果及不良反应。结果三苯双脒和阿苯达唑治疗钩虫感染虫卵阴转率分别为 87.93 % (5 1 /5 8)和 66.0 3 % (3 5 /5 3 ) ;蛔虫感染的阴转率分别为 98.3 0 % (5 8/5 9)和97.87% (4 6/4 7) ;鞭虫感染的阴转率分别为 3 3 .3 3 % (2 5 /75 )和 5 6.0 9% (2 3 /4 1 ) ;儿童蛲虫感染的阴转率分别为 77.5 8% (4 5 /5 8)和 93 .93 % (3 1 /3 3 )。结论　三苯双脒治疗钩虫、蛔虫感染有显著疗效 ,治疗鞭虫和蛲虫感染有疗效 ,但虫卵阴转率较低。该药还有服用简便、不良反应少而轻等优点     

三苯双脒治疗肠道线虫感染的临床研究

目的观察三苯双醚治疗人体肠道线虫感染的临床效果及其副作用。方法180例2岁以上钩虫、蛔虫、蛲虫和鞭虫单独或混合感染者分组分别用三苯双醚和阿苯达唑治疗。成人及14岁以下儿童的钩虫和蛲虫感染者分别给三苯双醚40mg和200mg,蛔虫感染者给三苯双醚300mg,鞭虫感染者每天400mg三苯双醚,连续3天。各感染对照组均给予阿苯达唑400mg。同时观察三苯双醚及阿苯达唑的临床治疗的副作用。结果三苯双醚和阿苯达唑对钩虫感染的治愈率分别为73.9%(17/25)and50.0%(9/18)。两药物对蛔虫感染的治愈率分别为85.7%(18/21)and90%(10/11)。两药对蛲虫感染的治愈率分别为84.9%(28/33)and100.0%(18/18)。三苯双醚的临床副作用轻微,对外周血象,肝、肾功能及心电图没有显著的影响。结论三苯双醚对钩虫、蛔虫和蛲虫感染有显著的疗效,对鞭虫作用较差。     

三苯双脒肠溶片治疗肠道线虫感染的临床观察

目的评价三苯双脒肠溶片治疗肠道线虫感染者的安全性和疗效。方法在海南省屯昌县进行开放临床试验,受治者用改良加藤法（Kato-Katz）粪检确诊为钩虫、蛔虫感染,钩虫与蛔虫混合感染或合并鞭虫感染等,共收治785例。4～14岁儿童感染者顿服三苯双脒200mg;〉14岁蛔虫感染者顿服三苯双脒300mg,钩虫和蛔虫混合感染及钩虫或蛔虫合并其他肠道蠕虫感染顿服三苯双脒400mg,观察不良反应,并于治疗后3～4周用相同方法粪检,评价治疗效果。结果总体钩虫感染治愈率及有效率分别为86．57％（606／700）和98．86％（692／700）;蛔虫感染治愈率及有效率分别为82．84％（111／134）和98．51％（132／134）;儿童钩虫感染治愈率及有效率分别为86．16％（249／289）和98．62％（285／289）;儿童蛔虫感染治愈率及有效率分别为81．75％（103／126）和99．21％（125／126）。三苯双脒的不良反应轻微且短暂,不良反应出现率为2．42％（19／785）,主要表现为头晕、恶心和呕吐,对血、尿常规、肝肾功能和心电图无明显影响,儿童未见不良反应。结论三苯双脒治疗钩虫、蛔虫感染者的疗效显著,不良反应率低。     

三苯双脒抗肠道蠕虫感染的进一步临床观察和实验研究的新进展

Tribendimidine is a new broad-spectrum anthelmintic agent developed in China. After tri-bendimidine enteric-coated tablet was approved by the Chinese State Food and Drug Administration in 2004, a phase Ⅳ clinical trial was carried out during 2006-2007. Through the treatment of the larger sample of patients with intestinal helminthiasis and various ages, including children, the efficacy of tribendimidine enteric-coated tablet against Ascaris lumbricoides infection and hookworm infection was further confirmed, when the drug was administered orally to the adults and children patients at a single dose of 400 rag and 200 mg, respectively, Tri-bendimidine was also showed promising efficacy against Enterobius vermicularis infection in children, In recent years, the results from the laboratory study and clinical trial indicate that tribendimidine exhibits promising effect against several species of trematodes, including Clonorchis sinensis, Opistorchis viverrini, Echinoswma ca-proni, Strongyloides spp. and Taenia spp.. This paper summarizes the new progress on tribendimidine re-search.     

Ectopic Enterobius vermicularis

Enterobius vermicularis (the pinworm) commonly infests the lumen of the intestine but on rare occasions has been found in the wall or in the tissues outside the gastrointestinal tract. Three such patients have been encountered in whom Enterobius vermicularis was found in the wall of the colon, in the retrocaecal tissues, and on the peritoneum. The pathological lesions and their relationship to the clinical features are discussed. A brief review of the literature is given. It is concluded that Enterobius vermicularis can only penetrate the wall of the gastrointestinal tract if this is diseased. Once in the tissues the worms can cause an inflammatory reaction simulating carcinoma and Crohn's disease, and, by perforation of the intestine, cause a generalized peritonitis.     

金湖县低年龄儿童蛲虫感染情况和防治效果

目的了解低年龄儿童蛲虫感染状况,探讨防治对策.方法采用透明胶纸肛试法,在肛门周围粘贴检查蛲虫卵,采取以驱虫服药为主、健康教育为辅的措施进行综合防治.结果低年龄儿童蛲虫感染率在1.49%～16.42%之间,总感染率为8.40%;男性感染率为7.21%,女性感染率为9.79%;年龄分布以8～岁年龄组感染率最高,为16.32%,7～岁年龄组感染率最低,为7.44%.集体驱虫服药半年后复查蛲虫感染率从12.60%降至1.38%,阳性者服驱虫药后,蛲虫感染率从7.03%降至2.27%.结论金湖县低年龄儿童蛲虫感染得到了有效控制,但仍高于其他肠道线虫的感染,应继续采取驱虫服药加健康教育的防治手段,降低并遏制蛲虫感染的反弹.     

青岛地区儿童蛲虫感染调查与分析

蛲虫病是小儿常见的肠道寄生虫病 ,感染率高达 40 %～70 %。为了解青岛市儿童蛲虫病感染情况 ,2 0 0 3年 3月至2 0 0 4年 2月在青岛市儿童医院检查蛲虫病的 5～ 12岁 2 3 70人进行了调查 ,报告如下。1　对象与方法1 1　对象　 2 0 0 3年 3月～ 2 0 0 4年 2月 ,在青岛市儿童医院检查蛲虫病的 5～ 12岁儿童共 2 3 70人为本次调查对象。1 2　方法　清晨起床 ,采用透明胶纸肛拭子法采样。镜检蛲虫卵。2　结果2 1　市区与郊区感染情况　本次共调查 2 3 70人 ,阳性率为3 0 0 % (712 /2 3 70 )。其中 ,市区调查 1184人 ,阳性率2 0 9% (2 48/1184…     

Enterobius vermicularis infection among population of General Mansilla, Argentina

AIM: To evaluate the relationships between the personal,sociocultural, and environmental characteristics, and the presence or absence of symptoms with the detection of Enterobius vermicularis ( E. vermicularis) in a population sample in our region (General Mansilla, Province of Buenos Aires, Argentina), by individual and familiar analyses.METHODS: E. vermicularis was diagnosed in 309 people from 70 family units residing in the urban area and the rural area of the city of General Mansilla. Each of them was surveyed so as to register personal, environmental and sociocultural data. Questions about the presence or absence of anal itch, abdominal pain and sleeping disorder were also asked. Significant associations were determined by square chi tests. Logistic regression models were adjusted by using a backward conditional stepwise method to determine the presence of this parasite in the individuals and in the families.RESULTS: The parasites were found in 29.12% (90/309) of the individuals, with a frequency of 14.28% (20/140) among the heads of the families and of 41.42% (70/169) among the children. The only variables showing a significant association were affiliation, where the risk category was “being the son/daughter of“, and the symptoms were abdominal pain, sleeping disorder, and anal itch. Families with a member infected with parasite were considered Positive Families (PF) and they were 40/70 (57.14%), only 5% (2/40) of the PF had 100% of their members infected with the parasite. The logistic regression models applied showed that the risk categories were mainly affiliation (son/daughter) and housing (satisfactory) among others.CONCLUSION: The presence of E. vermiculariswas proved in one third of the studied population. The frequency of families with all their members infected with the parasite was very low. Most of the studied personal, sociocultural,and environmental variables did not rum out to be significantly associated with the presence of the parasite. An association with the category of “son/daughter“ and housing classified as “satisfactory“ was determined. The latter may be due to the fact that the people living in that category of housing have hygienic practices at home that favour the distribution of the eggs in the environment. The presence of the analysed symptoms was associated with the presence of the parasite,thus strengthening the need of periodical control of the population showing at least one of these symptoms.     

苦连栓剂的研制及蛲虫感染驱治效果观察

本文报告了中药苦连栓剂的研制及驱治蛲虫的效果。     

浙江省儿童蛲虫病十年防治效果分析

蛲虫病妨碍儿童的生长,影响儿童的健康,是较为严重的公共卫生问题之一。1989～1990年,浙江省开展了人体寄生虫虫种分布调查,在全省28县106点55 291人中,共查见26种人体寄生虫,总感染率为80.17％,其中蛲虫感染率为24.14％(3 045/12 616),其后,结合社会经济发展,开展了以每年进行1～2次集体化疗为主的综合性防治措施,为了解蛲虫在化疗驱虫防治后的感染状况,间隔10年后,特于1999～2000年进行此次调查。