A clinical study on compound da huang (radix et Rhizoma rhei) preparations for improvement of senile persons' memory ability.

By comparison of the effects of the Compound Tong Jiang Oral Liquid with Da Huang added (TJ [symbol: see text]) and Qi Yin Oral Liquid (QY [symbol: see text]) without Da Huang on senile persons' memory ability, it is discovered that the effects of TJ on shortening the interval between defecations and the duration of defecation, and on improving senile persons' memory ability are significantly better than that of QY (P < 0.05). In addition, TJ can also decrease the serum content of lipid peroxidase and increase the superoxide dismutase activity in red blood cells (RBC). Thus, it is demonstrated that Dahuang and its agents possess the action of anti-senility and can improve mentality.     

Effects of San Qi on Gastric Secretion and Protective Factors of Gastric Mucosa in the Rat with Precancerous Lesion of Stomach

In the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste, effects of San Qi ([symbol: see text] Radix Notoginseng) on gastric secretion and protective factors of stomach were investigated. The results indicated that gastric secretion, gastric mucosal blood flow (GMBF) and aminohexose content lowered significantly, and malondialdehyde (MDA) increased significantly (P < 0.01) in the model group as compared with the normal group; after treatment with San Qi Powder for 12 weeks, both gastric secresion and GMBF increased, and MDA content decreased as compared with the negative control group (P < 0.01), with no significant increase of aminohexose content. It is suggested that San Qi ([symbol: see text] Radix Notoginseng) may improve gastric secretion, and that increase of GMBF and antagonism against the lesion of oxygen free radicals are possibly one of its mechanisms.     

An experimental study on drugs for improving blood circulation and removing blood stasis in treating mild chronic hepatic damage.

Large and small doses of drugs for improving blood circulation and removing blood stasis were used in model rats to treat mild chronic hepatic damage induced by carbon tetrachloride (CCl4). The results show that large dose of Dang Gui ([symbol: see text] Radix Angelicae Sinensis) and Dan Shen ([symbol: see text] Radix Salviae Miltiorrhizae) (drugs for regulating blood flow) and small dose of Yu Jin ([symbol: see text] Radix Curcumae) and Niu Xi ([symbol: see text] Radix Achyranthis Bidentatae) (drugs for activating blood flow) can significantly elevate the activity of SOD (P < 0.05) and/or lower the T/K ratio, markedly reduce the MDA content (P < 0.05 or P < 0.01) and significantly decrease the activities of ALT and AST (P < 0.05 or P < 0.01), demonstrating that these drugs are effective in combating oxygen free radicals (OFR) in chronic liver damage. On the contrary, large dose of Tu Bie Chong ([symbol: see text] Eupolyphaga seu Steleophaga) and E Zhu ([symbol: see text] Rhizoma Curcumae) (drugs for removing blood stasis) tend to increase the ALT and AST (P < 0.05) activities. The results suggest that the synergism of elevation of the SOD activity and reduction of T/K ratio contributes to the action of drugs for improving blood circulation and removing blood stasis in combating the liver damage induced by CCl4.     

Effects of Huang Qi Wu Wu Decoction on Plasma Proteins in 70 Cases of Chronic Pulmonary Heart Disease

Simple immune agar diffusion test was used to assay the contents of 12 plasma proteins in 70 cases ofchronic pulmonary heart disease treated by Huang Qi Wu Wu Decoction(黄芪五物汤),with theother 70 cases who were not given Huang Qi Wu Wu Decoction as the control group.The totalclinical effective rate in the treatment group was 90.0%,while that in the control group was 75.7%,with a statistically significant difference between the two groups(P<0.05).In the treatment group,thelevels of prealbumin,transferrin and fibronectin elevated obviously after treatment,and the contentsof C-reactive protein,ceruloplasmin,haptoglobin,α_1-antitrypsin and oh-acid glycoprotein decreasedmarkedly(P<0.01).In the control group,only the levels of ceruloplasmin and C-reactive proteindecreased significantly(P<0.05).It is shown that Huang Qi Wu Wu Decoction may enhance thetherapeutic effects for pulmonary heart disease,regulate the metabolism of plasma proteins,andimprove the life quality of the patients.     

A clinical investigation on 30 cases of senile benign renal arteriolosclerosis treated by huang qi gu jing yin.

Huang Qi Gu Jing Yin (HQGJY[symbol: see text]decoction of Astragalus root for Strengthening the Essence) was used in a controlled clinical trial for treatment of senile benign renal arteriolosclerosis. In the therapeutic group (n = 30), cure, marked effect and no effect were obtained respectively in 18 (60%), 9 (30%) and 3 (10%) cases with the total effective rate being 90%; the corresponding figures in the control group (n = 30) were 10 (33.3%), 9 (30%) and 11 (36.7%) with the total effective rate being 63.3%. The significant difference (P < 0.01) between the two groups demonstrated that HQGJY is an effective agent for treatment of the disease.     

黄芪、水蛭、地龙不同配伍治疗缺血性中风实验研究

提出气虚血瘀络阻为缺血性中风的基本病机,而益气活血通络则为基本治法。通过黄芪水蛭地龙、黄芪水蛭、黄芪地龙、水蛭地龙四个配伍组比较,以观察其对急性脑缺血大鼠血浆一氧化氮(NO)、丙二醛(MDA)、血小板聚集性及大鼠在体血栓形成时间的影响。结果表明,黄芪水蛭地龙配伍组在以上诸方面的作用明显优于其他组。     

Treatment of the Localized Neurodermatitis by Plum-blossom Needle Tapping and with the Modified Yangxue Dingfeng Tang——A Clinical Observation of 47 Cases

Since 1993, the authors have successfully treated 47 cases of the localized neurodermatitis by plum-blossom needle tapping and with the modified Yangxue Dingfeng Tang, with quite good therapeutic results reported as follows. Clinical Data The 141 patients…     

黄芪治疗新生儿缺血缺氧性脑病有效性和安全性的Meta分析

目的：系统评价黄芪治疗新生儿缺血缺氧性脑病（HIE）的疗效和安全性。方法计算机检索Cochrane图书馆、PubMed、Cochrane对照试验数据库、EMBASE中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、中国科技期刊全文数据库（VIP）、万方数据库,全面收集黄芪治疗HIE的随机对照试验（RCT）,根据Cochrane协作网系统评价的方法进行评价。结果共纳入13项研究（1031名患者）,其中11项研究为空白对照,2项为阳性对照。无随访12个月后病死率或致残率的研究报道,仅1项研究比较了黄芪组和空白对照组在治疗期末降低HIE病死率的疗效,Meta分析结果显示,两组差异无统计学意义〔RR=0.33,95%CI（0.04,3.07）, P=0.33〕。7项研究（n=597）评价了黄芪组和空白对照组治疗HIE的有效率,Meta分析结果显示,两组差异有统计学意义〔RR=1.22,95%CI（1.07,1.39）,I2=48%,P=0.33〕。3项研究（n=163）比较了黄芪组和空白对照组在改善第7天（NBNA）分值的疗效,Meta分析结果显示,两组差异有统计学意义〔MD=5.37,95%CI（1.46,9.27）,I2=89%,P=0.007〕。2项研究（n=111）比较了黄芪组和空白对照组在改善第10天NBNA分值的疗效,Meta分析结果显示,两组差异有统计学意义〔MD=2.03,95%CI（1.37,2.69）,I2=0,P＜0.00001〕。未见严重不良反应报道。结论基于当前的研究证据,因研究质量及研究样本的局限性,尚不足以推荐黄芪在治疗新生儿HIE中的应用,其长期疗效和安全性尚需远期高质量的研究证实。     

Clinical observation of Chinese drugs in prevention of neonatal hyperbilirubinemia.

Observation of the preventive and curative effects of Herba Artemisiae Scopariae [symbol: see text], Fructus Gardeniae [symbol: see text], Radix Scutellariae [symbol: see text] and Radix et Rhizoma Rhei Preparata [symbol: see text] in 30 cases of neonatal hyperbilirubinemia showed that both the peak value of serum total bilirubin and the incidence of hyperbilirubinemia were obviously lower than that in the control group.     

A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis.

The rate of detection of helicobacterium pylori (HP) in chronic atrophic gastritis (CAG) is 67%, HP being a slightly aerobic Gram-negative bacterium. Some drugs of traditional Chinese medicine (TCM) for clearing away heat and for removing blood stasis have significant effect on inhibition of HP. The drugs in both the recipe for nourishing yin, clearing away heat and invigorating blood circulation and the recipe for clearing away heat and invigorating blood circulation have inhibitory action on HP in vitro. All patients with CAG have symptoms of damp-heat and blood stasis. Radix et Rhizoma Rhei and Rhizoma Coptidis Decoction for Purging Stomach-Fire ([symbol: see text]) as the basic recipe and "Huo Wei" ([symbol: see text]) No. 2 recipe as the supplementary have good inhibitory effect on HP in inhibition tests. The results show several forms of the medicine all resulted in significant good therapeutic effect.     

One hundred and seven middle-aged and senile cases of coronary heart disease with ventricular premature beat treated by qing xin an shen fang.

The therapeutic principle of clearing away the heart-heat to induce tranquilization was adopted in 107 middle-aged and senile patients with ventricular premature beat of coronary heart disease on the basis of pathogenic features of phlegm, heat, blood stasis and deficiency in this condition. Qing Xin An Shen Fang ([symbol: see text] a formula for clearing away the heart-heat to induce tranquilization) was used in the treatment group and compared with mexiletine and Fu Fang Dan Shen Tablets ([symbol: see text] Compound Salvia Tablets) used in the control group. The results turned to be that the markedly effective rate was 85.1% and the total effective rate 96.3% in the treated group, better than that in the control group, with the former having a good antihypertensive and antihyperlipemic effect and an effect of improving microcirculation and clinical symptoms.     

黄芪三七水蛭益母草对缺血性中风急性期脑水肿作用的实验研究

气虚血瘀是缺血性中风急性期脑水肿的病理基础 ,瘀水互结、阻络壅窍是其关键病机。通过观察黄芪、三七、水蛭、益母草配伍对急性脑缺血大鼠脑含水量、毛细血管通透性、血液黏度、血小板聚集性、MDA含量、SOD活性以及对大脑组织结构学的影响 ,认为益气活血利水为其主要治法。     

放射自显影技术研究老年大鼠不同脑区M胆碱受体的变化

目的： 观察自然衰老大鼠不同脑区Ｍ 胆碱受体包括Ｍ１ 亚型受体的变化。方法： 采用放射自显影技术显示大鼠脑Ｍ 受体,并用图像分析仪进行灰度分析,以反映Ｍ 受体在不同脑区的相对定量分布。结果： 所得脑切片自显影灰度层次清晰,主要分布在大脑皮质,海马,纹状体等部位,非特异结合灰度很低,图像分析仪分别给出不同脑区的平均灰度值,老年鼠皮质,海马,纹状体部位的灰度显著低于青年鼠,Ｍ 受体分别降低２４８７ ％ ,１４１２ ％ ,１２７６ ％ （ Ｐ＜ ００５） ,Ｍ１ 亚型受体分别降低１５７８ ％ ,８６９ ％ ,１２３６ ％ （ Ｐ＜ ００１） 。结论： 以上３ 个重要脑区Ｍ 胆碱受体密度的改变可能是脑衰老的一个重要机制     

TCM Treatment of Bronchial Asthma

Xuan Fei Ding Chuan Wan(宣肺定喘丸 pills for facilitating the flow of the lung-qi to relieve asthma)and Xiao Chuan Gu Ben Wan (哮喘固本丸 pills for treating asthma by consolidating the origin)wereused for treatment of bronchial asthma.The cure rate in the treated group(n=600)was 81.33%,significantly higher(P<0.01)than that in the control group(n=164,with a cure rate of 9.76%).     

黄芪改善髓鞘蛋白抑制成年鼠皮层神经元活力的研究

目的:MMP(髓鞘膜蛋白)减低新生神经元的活力的现象可以被黄芪纠正.然而,新生神经元与成年神经元具有不同的生理特性.因此,研究黄芪能否改善成年神经元的活力有重要意义.方法:用MTT(四甲基偶氮唑盐)实验检测体外培养的,并用MMP,NGF,Radix Astragali,NGF MMP,Radix Astragali MMP处理的各组成年大鼠脑皮层神经元的细胞活力.结果:MMP组的细胞活力明显低于对照组(未加任何药物组),而黄芪、NGF、NGF MMP以及黄芪 MMP组之间,神经元的活力无显著性差异.结论:黄芪可以改善MMP减低的成年皮层神经元的活力.     

牡蛎肉与黄芪防治去卵巢大鼠脑衰老协同作用的研究

目的观察牡蛎肉与黄芪防治去卵巢大鼠脑衰老的协同作用。方法采用4月龄的雌性大鼠行双侧卵巢摘除术后,分别给予牡蛎肉、黄芪和牡蛎肉加黄芪水提液灌胃3个月,测定大鼠脑组织生化指标和形态计量学。结果牡芪水提液组大鼠较牡蛎肉和黄芪水提液组的超氧化物歧化酶活性增强而丙二醛含量下降,纹状皮质分子层厚度增加,分子层厚度和皮层总厚度的比值下降,海马CA_1区单位面积大锥体细胞数增多。结论黄芪能够增强牡蛎肉水提液延缓去卵巢大鼠脑衰老的作用。