电针内关、神门穴对海洛因依赖者稽延性戒断症状疗效观察

目的观察和分析针刺不同穴位对海洛因依赖者稽延性戒断症状的干预效果,为科研、临床筛选针刺治疗海洛因依赖稽延性症状的特异穴位提供临床依据。方法将60例男性海洛因依赖者随机分为对照组、针刺1组、针刺2组,采用稽延性戒断症状评分量表和汉密尔顿焦虑量表观察各组患者治疗前、治疗过程中及治疗3星期后的变化。结果针刺1组、针刺2组在控制稽延性戒断症状上与对照组相比有统计学差异（P〈0.01,P〈0.05）;但针刺1组、针刺2组之间比较差异没有统计学意义（P〉0.05）。结论 针刺可有效缓解海洛因依赖者稽延期戒断症状和精神焦虑症状;治疗海洛因依赖者稽延期诸症时,内关穴与神门穴具有同样显著疗效,并且神门穴对于心神的异常具有更快更好的显效趋势。     

电针夹脊穴干预海洛因依赖者稽延性戒断症状的临床观察

目的:研究电针夹脊穴对海洛因依赖者稽延性戒断症状的干预效应.方法:将120例海洛因依赖者随机分为4组:针刺1组(夹脊穴、肾俞)、针刺2组(四肢穴)、模拟组和对照组,采用稽延性戒断症状评分量表、汉密尔顿焦虑量表(HAMA)和抑郁自评量表积分(SDS)观察治疗前、治疗4、8、10周的变化.结果:在治疗4、8、10周,针刺1组、针刺2组的稽延性戒断症状和HAMA、SDS与对照组相比差异均有非常显著性意义(P＜0.01).结论:电针可明显改善稽延性戒断症状,减轻焦虑和抑郁情绪.电针夹脊穴明显优于四肢穴位.     

针刺夹脊穴对海洛因依赖者稽延性戒断症状疗效观察

目的观察和分析针刺T5夹脊穴对海洛因戒断者稽延性戒断症状的干预效果,为临床筛选针刺治疗海洛因依赖稽延性症状的特异穴位。方法将40例脱毒治疗后男性海洛因依赖者随机分为对照组（不予治疗）、针剌组（T6夹脊穴）,治疗4星期,每星期3次。采用稽延性戒断症状评分量表观察患者治疗前及治疗4星期后的变化。结果在改善稽延性戒断症状方面,针刺组明显优于对照组（P〈0．01）。结论针刺T。夹脊穴可改善海洛因依赖者的稽延性戒断症状。     

针刺治疗海洛因依赖者稽延期睡眠障碍疗效观察

目的观察和分析针刺对海洛因依赖者稽延期气阴两虚型睡眠障碍者的干预效果。方法将60例气阴两虚型睡眠障碍的海洛因依赖者随机分为治疗组（神门、内关、足三里、三阴交、胸”夹脊穴、肾俞穴）和对照组（不予任何药物及针剌干预）,治疗3星期,观察治疗前后稽延性戒断症状评分量表中三条有关睡眠障碍项目的积分变化以及稽延期中医四诊量表中符合证型标准的兼症数量变化。结果治疗组在稽延性戒断症状评分量表中有关睡眠障碍的三项积分和总分与对照组相比差异均具有统计学意义（P〈0．05,P〈0．01）。治疗组稽延期中医四诊量表中兼症数量与对照组相比差异具有统计学意义（P〈 0．05,P〈0．01）。结论针刺可改善海洛因依赖者的稽延期气阴两虚型睡眠障碍。针刺对稽延期气阴两虚型睡眠障碍者的伴随症状也有较明显的缓解作用。     

辨证治疗海洛因依赖稽延性戒断症状96例临床观察

目的:观察辨证治疗海洛因依赖稽延性戒断症状的疗效。方法:以清解余毒、扶助正气、调畅气血之中药为基本方剂,辨证治疗海洛因依赖稽延性戒断症状96例,并与纳屈酮对照组作对比研究。结果:治疗组整体疗效与对照组相当,两组临床躯体依赖性评估量表(CINA)评分比较无明显差异(P>0.05),但治疗组汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、睡眠指数(S)、疼痛体验等指标的改善情况明显优于对照组(P<0.01)。结论:辨证治疗海洛因依赖稽延性戒断症状疗效确切,无明显毒副作用,值得临床应用。     

穴位埋线对海洛因依赖者稽延性戒断症状的临床研究

目的：观察穴位埋线对海洛因依赖者稽延性戒断症状的临床疗效。方法：选取宁夏回族自治区某强制隔离戒毒所的稽延期海洛因依赖者30名,随机分成对照组(CG)和穴位埋线组(TG),每组各15例。对照组予通过强制隔离戒毒所日常基本管教项目进行干预,在此基础上穴位埋线组每2周进行穴位埋线治疗1次。采用高通量16SrDNA测序技术检测两组之间的差异肠道微生物群落结构,采用海洛因稽延性戒断症状评定量表评价对照组与穴位埋线组干预前后躯体症状、情绪症状、渴求症状和睡眠障碍的变化。结果：治疗2个月后,穴位埋线组海洛因稽延性戒断症状评分低于对照组,差异具有统计学意义(P<0.01)。与治疗前比较,两组治疗后chao、sobs指数降低,差异具有统计学意义(P<0.05),治疗后穴位埋线组OTU数目和simpson指数高于治疗前穴位埋线组和治疗后对照组。治疗后与对照组比较,穴位埋线组放线菌门,差异具有统计学意义(P<0.05)和变形菌门(P<0.01)相对丰度增加。与治疗前比较,治疗后穴位埋线组瘤胃球菌相对丰度增加,差异具有统计学意义(P<0.05);与治疗后对照组比较,穴位埋线组双歧...     

海洛因依赖者稽延性戒断症状的临床调查

目的 通过研究针刺对海洛因依赖者稽延性戒断症状的影响,为临床治疗康复和预防复吸提供临床依据。方法 按随机对照的方法把海洛因依赖者分为海洛因依赖组和正常对照组,分别观察并记录针刺治疗不同治疗时间段两组的稽延性戒断症状、HAMA、SDS评分,并进行统计学分析。结果 稽延性戒断症状随戒断时间的延长可逐渐缓解,在戒断d45时稽延症状积分下降明显。至戒断d75、d90趋于平稳。在戒断d90仍遗留有稽延性戒断症状。对稽延性戒断症状的单项分分析显示：在戒断d15时症状最明显的是睡眠障碍,其次是焦虑情绪和躯体不适。至戒断dg0,睡眠障碍仍比较明显。结论 针刺在一定时间段内可以干预海络因戒断者的稽延性戒断症状,但并不能完全缓解。     

穴位埋线对海洛因依赖大鼠稽延性戒断症状及海马区CCK和C-fos表达的影响

目的:寻找适合的治疗海洛因依赖的方法并阐述穴位埋线法控制海洛因大脑海马区稽延性戒断症状的机制。方法:对大鼠采用剂量递增方法皮下注射海洛因建立大鼠海洛因依赖模型,随机分为模型组、自然戒断组、美沙酮治疗组、针刺治疗组和穴位埋线治疗组,并比较各组大鼠戒断症状和信使核糖核酸(Messenger Ribonucleic Acid,mRNA)和蛋白水平表达的情况。结果:我们发现穴位埋线和针刺都和美沙酮一样能有效控制对海洛因依赖大鼠稽延性戒断症状,各个治疗组大鼠海马区的胆囊收缩素(Cholecystokinin,CCK)和C-fos因子在mRNA和蛋白水平表达量都较模型组偏低,说明治疗后大鼠海马区因海洛因依赖受损大脑功能正在逐步恢复,证明我们的治疗是有效的。结论:穴位埋线能控制大鼠海洛因依赖稽延性戒断症状,同时,可以降低大鼠海马区神经元CCK和C-fos表达水平来修复大脑由于海洛因依赖所受损伤。     

针刺对海洛因精神依赖小鼠稽延性戒断症状作用机制的研究

目的:研究针刺对海洛因精神依赖小鼠核苷酸代谢及大脑和脾脏病理形态的影响,为针刺改善稽延性戒断症状提供理论依据.方法:将经行为学筛选后的昆明种小鼠随机分为空白组、空白针刺组、模型组、针刺组和药物对照组.按剂量逐日递增原则复制海洛因精神依赖小鼠模型,针刺"内关"、"三阴交"及"四神聪"进行治疗,观察黄嘌呤氧化酶(XOD)、腺苷脱氧酶(ADA)活性、及大脑和脾脏的病理形态变化.结果:针刺能降低海洛因精神依赖小鼠脾脏ADA及大脑XOD、ADA活性;针刺可减轻大脑、脾脏的病理损害.结论:针刺改善海洛因精神依赖小鼠的稽延性戒断症状与改善其核苷酸代谢、减轻大脑的病理损害有密切关系.     

穴位电刺激治疗海洛因依赖者稽延性综合征临床研究

目的：探讨穴位电刺激法及多虑平对海洛因依赖者在脱毒期稽延性戒断综合征的疗效观察。方法：在应用戒毒药的同时随机取戒毒药合穴电刺激及口服多虑平40例（治疗组）与单用戒毒药25例（对照组）,进行为期10天的对比观察。结果：治疗组总有效率90．0％,对照组为44．0％（P＜0．01）,两组差异有非常显著性意义。两组治疗前后戒断症状计分比较,治疗组各项分值明显较对照组低。治疗组稽延症状改善明显优于对照组,x^2检验P＜0．01。结论：穴位电刺激和多虑平可有效地改善海洛因依赖者在脱毒期的稽延性戒断综合征的程度。     

针灸对海洛因依赖者睡眠障碍和焦虑情绪的影响

目的:观察针灸对海洛因依赖者睡眠障碍和焦虑情绪的影响.方法:将62例男性海洛因依赖者按随机数字表随机分为2组,针灸组35例,采用针刺百会、内关、神门,艾灸足三里治疗.对照组27例,不接受任何治疗措施.观察8星期后统计疗效.结果:治疗后,两组依赖者焦虑总分及标准分均较治疗前有所下降,但仅针灸组与治疗前有统计学差异(P＜0.05);两组焦虑总分及标准分虽无统计学差异,但针灸组标准分达到常模水平.治疗后,对照组仅入睡所需时间明显改善(P＜0.05),而针灸组睡眠障碍症状均明显改善(P＜0.05),且实际睡眠时间改善程度优于对照组(P＜0.05),PSQJ总分下降到常模水平以下.结论:针灸对海洛因依赖者睡眠障碍、焦虑情绪都具有改善作用.     

Clinical study on acupoint injection plus acupuncture for insomnia due to heart-kidney disharmony

Objective： To observe the clinical efficacy of acupoint injection at Neiguan （PC 6） plus acupuncture in treating insomnia due to heart-kidney disharmony. Methods： A hundred patients with insomnia due to heart-kidney disharmony were randomized into an observation group and a control group. Fifty-three cases in the observation group were intervened by acupoint injection at Neiguan （PC 6） plus acupuncture; while 54 cases in the control group were intervened by acupuncture alone. The Pittsburgh sleep quality index （PSQI） was evaluated before and after intervention, and the therapeutic efficacies of the two groups were compared. Results： Acupoint injection at Neiguan （PC 6） plus acupuncture produced significantly higher efficacies in improving sleep quality, shortening sleep latency, and enhancing sleep efficiency than acupuncture alone （P〈0.05）. Conclusion： The two groups both can improve the condition of insomnia; acupoint injection at Neiguan （PC 6） has significant advantages, manifested by a higher therapeutic efficacy for insomnia due to heart-kidney disharmony, higher safety evaluation, efficiency, and less adverse events, thus proper for clinical application.     

Determination of temperature-time curve of two mild moxibustion methods: Reinforcing and reducing

Objective:To observe the specificity of reinforcing and reducing methods of mild moxibustion and explore its clinical significance.Methods:Thirty healthy students were selected and given reinforcing of mild moxibustion on the left Neiguan(PC 6)and reducing on the right Neiguan(PC 6)respectively.Temperature of the acupoint skin surface and the temperature-time curve were recorded by a digital thermometer.Results:In application of mild moxibustion on Neiguan(PC 6),there was a statistical difference in the temperature-increase section between reinforcing and reducing methods(P<0.01).The temperature-increasing section of the temperature-time curve in the reducing method was obviouslysteeper than that in the reinforcing method.In the period of0.5-3 min during moxibustion,the temperature of Neiguan(PC 6)was remarkably higher in the reducing than in the reinforcing(P<0.01).In the application of the reducing,the time for the temperature of Neiguan(PC 6)to increase to 40℃was remarkably advanced(P<0.05)and the rate of burning pain in the subjects was remarkably higher in the reducing method than in the reinforcing method(P<0.001).Conclusion:In comparison with the reinforcing method,the acupoint temperature increased more quickly in the application of reducing method and can produce obvious hot stimulation in a short period of time.In the application of the reinforcing method,the acupoint temperature increased mildly and could enhance the tolerance of the organism to the high temperature.     

Clinical study on brain-benefiting and collateral-sunblocking needling technique for chronic alcoholic gastritis complicated with depression

Objective

To observe the clinical efficacy of brain-benefiting and collateral-unblocking needling technique for chronic alcoholic gastritis complicated with depression.

Methods

A total of 92 cases with chronic alcoholic gastritis complicated with depression were included in this trial. They were randomly allocated into an observation group (n= 46) and a control group (n= 46) by random number (envelope) method. Patients in the observation group received the brain-benefiting and collateral-unblocking needling technique. Scalp points included Shenting (GV 24), Xinhui (GV 22), Qianding (GV 23), Baihui (GV 20), Chengguang (BL 6), Tongtian (BL 7) and Luoque (BL 8). Body points included Neiguan (PC 6), Zusanli (ST 36), Zhongwan (CV 12), Gongsun (SP 4), Shenmen (HT 7), Daling (PC 7), Qimen (LR 14), Xinshu (BL 15) and Taichong (LR 3). The control group only received the same body acupuncture as the observation group. The treatment was conducted once a day, 30 min for each treatment, and 10 times made up a course of treatment. The efficacy was observed after 3 courses of treatment, and there was a 2-d interval between two courses.

Results

After 3 courses of treatment, the clinical symptoms and gastroscopic features were significantly improved in the observation group than that in the control group. The clinical efficacy, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were significantly better than those in the control group (all P<0.05).

Conclusion

The brain-benefiting and collateral-unblocking needling technique can significantly improve clinical symptoms in patients with chronic alcoholic gastritis complicated with depression and substantially alleviate their gastroscopic features, anxiety and depression.

     

Clinical study on acupuncture and daytime wakefulness in insomnia patients

目的：观察针刺对原发性失眠患者日间觉醒状态的影响。方法：将60例原发性失眠患者随机分为2组,每组30例。治疗组针刺百会、神庭、神门、四神聪、三阴交,对照组口服艾司唑仑,疗程均为30d。对所有病例进行爱泼沃斯思睡量表（Epworth Sleepinss Scale,ESS）及匹茨堡睡眠质量指数量表（Pittsburgh Sleep Quality Index,PSQI）测评。结果：与对照组比较,治疗组患者日间的觉醒程度及睡眠质量提高更快。结论：针刺相对于艾司唑仑治疗原发性失眠具有一定的优势。     

Clinical observation on electroacupuncture for post-stroke flaccid paralysis

Objective:To observe the clinical efficacy of electroacupuncture (EA) in treating post-stroke flaccid paralysis. Methods:Forty patients with post-stroke flaccid paralysis were randomized by the random number table into a treatment group and a control group, 20 cases in each. The treatment group was intervened by acupuncture at Jiquan (HT 1), Tianquan (PC 2), Ququan (LR 8), Yinlingquan (SP 9), and Yongquan (KI 1), and the control group was treated by acupuncture with conventional acupoint selection. Barthel index (BI) was adopted for evaluating the activities of daily living (ADL), and therapeutic efficacy was analyzed. Results:The two groups both had marked increases of BI score after treatment. Compared to the control group after 1 treatment course and 2 treatment courses respectively, the treatment group had significant differences in BI score (P<0.01). The total effective rate was 100.0% in the treatment group versus 90.0% in the control group, and the difference was statistically significant (P<0.01). Conclusion:EA at Jiquan (HT 1), Tianquan (PC 2), Ququan (LR 8), Yinlingquan (SP 9), Yongquan (KI 1) is an effective approach in treating post-stroke flaccid paralysis.     

Effect of electroacupuncture on anxiety and craving in heroin addicts during detoxification

Objective:To observe the effect of electroacupuncture at Jiaji (EX-B 2) points for anxiety and craving in heroin addicts during detoxification. Methods:A total of 60 cases were randomized into an electro-acupuncture group and a control group, 30 in each group. Cases in the electroacupuncture group were treated with electroacupuncture at Jiaji (EX-B 2) points, whereas cases in the control group were treated with Methadone and Doxepin. Then scores were graded using Zung self-rating anxiety score (SAS) and self-made visual analogue scale (VAS). The assessment was conducted once a day to record the adverse reactions. Results:After treatment, the SAS and VAS scores in the electro-acupuncture group were significantly lower than that in the control group (P<0.01). Conclusion:Electroacupuncture at Jiaji (EX-B 2) points can effectively alleviate anxiety and craving intensity in heroin addicts during detoxification.     

Effect of electroacupuncture at Neiguan (PC 6) and Baihui (GV 20) on CHOP and caspase-12 gene expressions in rats after ischemia-reperfusion injury

Objective

To investigate the effects of electroacupuncture (EA) at Neiguan (PC 6) and Baihui (GV 20) by observing the changes of CCAAT/enhancer-binding protein(C/EBP) homologous protein (CHOP) and caspase-12 gene expressions in rats after cerebral ischemia-reperfusion injury (IRI), and explore whether the apoptosis pathway of endoplasmic reticulum stress (ERS) is involved in the protective mechanisms of EA.

Methods

Sixty rats were randomly assigned to five groups (12 in each group): a normal control group (group A), a sham-operation group (group B), an operation group (group C), an Edaravone group (group D) and an EA group (group E). The cerebral IRI rat model was induced by middle cerebral artery occlusion (MCAO) using intraluminal monofilament. 2,3,5-triphenyl tetrazolium chloride (TTC) staining was adopted in the measurement of cerebral infarction volume. Real-time polymerase chain reaction (RT-PCR) was used to determine the mRNA expressions of CHOP and caspase-12.

Results

Compared with group A and group B, the volume of cerebral infarction and mRNA expressions of CHOP and caspase-12 in group C, group D and group E were increased, with statistical significances (P<0.05 or P<0.01); compared with group C, the volume of cerebral infarction and mRNA expressions of CHOP and caspase-12 in group D and group E were decreased significantly (P<0.05 or P<0.01); there were no significant differences between group D and group E in comparing the above items (P>0.05).

Conclusion

EA at Neiguan (PC 6) and Baihui (GV 20) can effectively suppress the volume of cerebral infarction. Furthermore, the underlying mechanism of EA at Neiguan (PC 6) and Baihui (GV 20) is possibly related to the down-regulation of CHOP and caspase-12 mRNA expressions, so as to decrease cell apoptosis.

     

电针内关和神门穴对脑功能成像不同影响的观察

目的:观察针刺内关和神门对脑功能成像的影响作用.方法:采用功能磁共振成像技术研究电针内关和神门对不同脑区的激活状态.结果:电针刺激内关主要引起额叶的激活,刺激神门主要引起颞叶的激活.结论:针刺刺激不同的穴位,可以激活不同的脑区,电针内关和神门穴激活脑区的功能与智能有关,提示应用内关、神门穴治疗智能障碍有一定的客观性.