弱视复发原因分析

目的:探讨弱视复发的相关因素。方法:对173例(298眼)临床基本治愈的弱视患儿进行3年以上的随访观察。标准经散瞳验光后矫正视力下降至<0.9者定为弱视复发。结果:本组弱视复发率为29.53%,旁中心凹注视性弱视复发率高于中心凹注视性弱视。弱视程度越重,复发率越高。并显示屈光参差性和斜视性弱视复发率明显高于屈光不正性弱视。结论:弱视复发与弱视的注视性质、程度及类型有关。     

弱视复发因素分析

目的 :探讨影响弱视复发的因素。方法 :对 15 0例 2 72眼基本治愈的弱视患者进行了 3年以上的随访观察 ,经散瞳验光后证实视力下降至≤ 0 .9时为弱视复发眼。结果 :本组弱视复发率为 2 9.4 1% ,弱视程度越重 ,复发率高 ,旁中心注视弱视复发率高于中心注视性弱视 ,屈光参差性 ,斜视性弱视复发率高于屈光性弱视复发率。结论 :弱视眼视力恢复到正常 ,双眼正位后 ,不可立即摘除眼镜 ,要逐步减低屈光度 ,易复发的弱视进行重点监视。     

弱视复发因素分析

目的　探讨弱视复发影响及远期疗效的因素。方法　对 2 4 2例 (4 36眼 )基本治愈的弱视患者进行 3年以上的随访。经散瞳验光后证明视力下降至 0 .9时为弱视复发眼。结果　本组弱视复发率为 2 9.82 % ,屈光参差性弱视和斜视性弱视复发率明显高于屈光不正性弱视复发率。弱视程度     

综合疗法治疗儿童弱视245例疗效分析

目的：探讨综合疗法治疗儿童弱视的疗效,方法：选用综合疗法治疗儿童弱视245例,440眼。结果：治愈高,轻度83．87％,中度59．08％,重度29．55％,中心注视型78．26％,非中心注视型42．86％,屈光不正性71．47％,屈光参差性50．00％,斜视性26．00％,形觉剥夺性及先生性弱视治愈率0。总治愈率61．14％,结论：弱视的疗效与弱视的程度,类型,注视性质及年龄有关,弱视程度越轻效果越好,尤以屈光不正性疗效最好,中心注视型者优于非中心注视型者,在弱视治疗的同时应重视对较小患儿家长的宣教工作。     

综合疗法治疗儿童弱视184眼疗效分析

目的：探讨综合疗法治疗儿童弱视的疗效。方法：对136例184眼弱视患者进行综合治疗。结果：总治愈率69．57％，轻度92．31％，中度80．39％，，重度23．25％；中心注视型84．48％，旁中心注视型44．42％；屈光不正性77．78％，屈光参差性65．79％，斜视性弱视25．00％。结论：弱视疗效与年龄、弱视程度、注视性质、弱视类型有关。综合疗法优于单一疗法。     

儿童弱视复发的原因及治疗措施

目的：探讨儿童弱视复发的原因及治疗措施。方法：对基本治愈的278例（391眼）弱视行3年以上的随访观察。经散瞳验光后证实视力下降至≤0.9时为弱视复发眼。结果：复发率为30.91%。轻、中、重度弱视组复发率分别为9.21%、45.7%、84.93%,差异均有统计学意义（P〈0.05）;旁中心注视弱视的复发率明显高于中心注视的弱视眼,差异有统计学意义（P〈0.01）。不同年龄组的复发率比较,差异无统计学意义（P〉0.05）。结论：弱视复发因注视性质和弱视程度不同而异,对于易复发的弱视类型应进行重点监测并长期系统治疗。     

儿童弱视的屈光状态分析

目的：分析儿童弱视的屈光状态及其与弱视程度的关系。方法：对161例263眼在睫状肌麻痹状态下的验光结果，按屈光不正类型、屈光度，屈光参差、注视性质、弱视程度进行记录，应用统计学进行屈光状态及其与弱视程度进行分析。结果：263眼弱视中，轻度屈光不正占25．8％、中度占43．35％、高度占30．8％。屈光不正类型以远视性最高，占82．89％，其次混合散光占13．31％，近视性占3．8％，弱视程度与屈光度、屈光参差程度相一致，与注视性质有关。结论：儿童弱视以中度屈光不正最多，屈光不正类型以远视性为主。弱视程度与屈光度、屈光参差程度呈正相关，与注视性质有关。     

影响小儿弱视治疗效果相关因素的探讨

目的：了解影响小儿弱视治疗效果的相关因素。方法：对45例（70）眼弱视患者进行疗效观察，矫正视力提高至0．9或以上者为基本治愈眼。结果：本组70眼中，基本治愈43眼，基本治愈率61．4％。弱视的类型、程度及注视性质均影响弱视的治疗效果；屈光不正性弱视疗效最好，斜视性弱视疗效最差；弱视程度越重疗效越差，中心凹注视患者治疗效果优于旁中心注视患者。结论：弱视的治疗效果因弱视的类型、程度及注视性质的不同而异。     

传统遮盖法治疗儿童弱视135眼远期效果观察

用传统遮盖法治疗儿童弱视７６例１３５眼。总治愈（治愈＋基本治愈）１１０眼（８１．５％）。轻度弱视治愈２７例（１００％）,中度７８例（８１．３％）,重度５例（４１．７％）。中心注视者１０４例（８３．９％）,旁中心注视者６例（５４．５％）。斜视性弱视２２例（９５．７％）,屈光参差性２９例（８５．３％）,屈光不正性５４例（７８．３％）,斜视并屈光参差性５例（５５．６％）。弱视的治疗效果与弱视的程度及注视性质关系密切,即弱视程度越轻、效果越好;中心注视者疗效明显高于旁中心注视者。传统遮盖法仍为治疗儿童弱视行之有效、简便易行的疗法。     

远视性屈光参差程度与弱视深度关系的研究

研究了６８例１２岁以下的远视性屈光参差弱视及合并屈光参差的斜视性弱视,以探讨屈光参差程度与弱视深度的关系及屈光参差性弱视发病的机制及临床意义。远视性中心注视组屈光参差性弱视中,弱视深度与屈光参差程度存在正相关关系,弱视深度与引起弱视时的屈光参差程度、发生年龄及其他因素有关,屈光参差程度的增加为伴随现象。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.