厚皮指症

报告1例厚皮指症。患者男,19岁。双手近端指间关节梭形肿胀伴皮肤增厚、粗糙1年,无疼痛,双手指活动不受影响。手部X线检查示双手示指、中指、无名指和小指的近端指间关节周围软组织肿胀。组织病理学检查示表皮角化过度,棘层肥厚,真皮胶原纤维增多,排列不规则,真皮网状层成纤维细胞轻度增生。免疫组化染色结果示真皮网状层轻度增生的梭形成纤维细胞表达波形蛋白(vimentin)。其临床表现及组织病理学检查符合厚皮指症的诊断。     

Pachydermodactyly: A Case Report

Pachydermodactyly is an uncommon variant of digital fibromatosis that has previously been related to knuckle pads. It is a benign condition that needs no investigation for an underlying systemic disease. We present a new case of pachydermodactyly and comment on the available literature.     

Pachydermodactyly associated with extensive computer gaming: A report of three cases

Pachydermodactyly is an uncommon, progressive, nontender thickening of the fingers with prominent involvement of the proximal interphalangeal joints. Pachydermodactyly mimics inflammatory arthritis but plain film radiography is normal in this condition. Pachydermodactyly has been previously described in workers performing manual labor. Mechanical stimulation has been identified as a predisposing factor in the majority of cases. We present three cases in adolescent males arising in association with excessive computer gaming.     

Pachydermodactyly in Two Young Girls

Abstract: Pachydermodactyly is a benign, superficial fibromatosis frequently observed in young males. We describe the condition in two young girls affected by Ehlers-Danlos syndrome (EDS) and tuberous sclerosis, respectively. We hypothesized that in the patient with tuberous sclerosis, pachydermodactyly is a clinical manifestation of the associated systemic disease, whereas obsessive-compulsive behavior is probably the main cause in the girl with EDS.     

A Case of Pachydermodactyly

Pachydermodactyly (PDD) is a rare, benign form of digital fibromatosis and this is characterized by asymptomatic soft tissue swelling that affects the lateral aspects of the proximal interphalangeal (PIP) joints of the fingers. Although the etiology of PDD is unknown, the possibility of repetitive minor trauma by habitual or compulsive habits of interlacing the fingers or rubbing of the fingers has been suggested as a cause by several authors. We experienced a 14-year-old boy who was diagnosed as having PDD by the clinical manifestations and this was supported by a radiological study and the routine laboratory tests. He also had the habit of repetitively manipulating his hands when feeling emotional distress. PDD sometimes can be misdiagnosed as a rheumatic condition. Although an unusual disorder, PDD should be considered in the differential diagnosis of patients who present with digital bulbous swelling.     

厚皮指症1例

患者女,22岁。左手无名指近端指间关节肿胀伴两侧皮肤增厚半年。左手X线示:左手无名指近端关节肿胀,骨质无破坏,关节无异常。皮损组织病理示:表皮角化过度,棘层增厚,真皮胶原纤维增多,排列不规则。诊断:厚皮指症。     

Pachydermodactyly: Report of a case

We report a case of pachydermodactyly, a rare entity characterized by acquired diffuse swelling of the lop and sides of the fingers.     

骨膜增生厚皮症2例

2例男性患者均有不同程度的头面部皮肤增厚、褶折及沟纹加深 ,回状颅皮 ,皮脂溢出 ,指趾变粗呈杵状 ,多汗 ;X线检查示四肢长骨骨膜增生 ,骨皮质增厚 ;组织病理示真皮内胶原纤维增生 ,粘蛋白沉积。     

Two Cases of Eosinophilic Fasciitis

Eosinophic fasciitis (EF) is an uncommon connective tissue disease characterized by scleroderma-like cutaneous changes, peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate (ESR). Typical histopathologic findings include chronic inflammatory infiltration affecting the deep fascia with lymphocytes, histiocytes, and occasionally eosinophils. We report two cases of EF, the first of which is a 36-year-old man with a tender brownish induration on both forearms, for 2 months. Histopathologic examination showed fibrotic fascia with a mixed inflammatory cell infiltration. The second case is a 52-year-old woman with a symmetrical painful swelling and skin induration on both forearms, for 4 months. A deep biopsy demonstrated chronic inflammatory cell infiltration and hyaline degeneration in the fascia. Increased signal intensity in the fascia and tendon sheath was shown on magnetic resonance imaging. In laboratory examination, mild eosinophilia was found in both cases. Both patients had a history of physical activity (weight training and excessive housework, respectively) and showed marked improvement with high doses of oral prednisolone for several months.     

隆突性皮肤纤维肉瘤2例

报告2例隆突性皮肤纤维肉瘤。例1男,37岁,左侧肩部红色斑块20年;例2女,64岁,左侧腹股沟包块7年。皮损组织病理均示真皮全层大量的梭形肿瘤细胞,排列成席纹状或漩涡状,部分肿瘤细胞核大、深染,部分核分裂。均诊断为:隆突性皮肤纤维肉瘤。     

胎传梅毒2例

<正> 例1女,30天,顺产。因鼻塞、气急、咳嗽、发热20余天来就诊。生后1周出现鼻塞、流涕、口唇干裂,唇周红斑、痂皮,渐加重,咳嗽、发热,T37.5℃。外院诊断“上呼吸道感染”,给予“止咳糖浆、先锋霉素”治疗3天,症状稍缓解,体温降至正常。2周后面部皮疹加重,后背、臀、肛周、四肢出现红斑及小红丘疹,尤以口周、颈前、臀部皮疹为重,并出现水疱,在当地给予“炉甘石洗剂、扑尔敏”等药物治疗无效,遂来我科就诊。体检:     

寻常狼疮2例

患者为 2 0岁、62岁男性 ,皮损位于右侧面颈部 ,呈逐渐扩大的红褐色斑片 ,无明显自觉症状 10余年。结核菌素试验均为强阳性 ,未发现其它活动性结核病灶 ,组织病理检查呈典型结核改变。予异烟肼、利福平和乙胺丁醇短程三联药物治疗 ,效果满意。     

正圆形糠疹2例

例1女,39岁。躯干、双下肢起浅褐色斑片30余年;例2女,18岁。腰腹部淡褐色斑片11年。皮疹呈圆形、椭圆形钱币至鹅蛋大小的褐色、浅褐色斑片,界线清楚,表面粗糙,有细小鱼鳞病样皱纹。皮损真菌镜检(-)。组织病理符合正圆形糠疹。     

青斑状血管炎2例

报告2例青斑状血管炎。例1男,35岁。双足踝、足背瘀斑、坏死性丘疹,形成血疱、溃疡、伴疼痛。例2女,25岁。双足踝、足背瘀斑,坏死性丘疹、血疱,伴疼痛。2例双小腿均有毛细血管扩张性环状紫癜样皮损。结核抗体(+),结核菌素试验(4+)。组织病理示表皮轻度坏死,棘层增生、水肿,真皮内血管增生、扩张、充血,管周可见灶状淋巴细胞为主的炎性细胞浸润,部分血管管壁见纤维素样物质沉积。     

胎传梅毒2例

例 1,女 ,45天。生后 1月余双上下肢、手足见类圆形红斑及暗红斑 ,部分红斑上有少许脱屑 ,以双手足为甚 ,伴发热。WBC 12 .5× 10 9/L。TPHA(+ ) ,RPR 1∶3 2阳性 ,其母TPHA(+ ) ,RPR 1∶16阳性。例 2 ,男 ,7天。生后 2h出现双手足脱屑性、浸润性铜红色斑 ,见脓疱 ,渐蔓延至周身 ,伴发热 ,活动受限。一般状态欠佳 ,四肢呈软瘫状。WBC14 .0× 10 9/L ,RPR 1∶16阳性 ,TPHA(+ )。其父、母均TPHA(+ ) ,RPR 1∶16阳性。诊断 :胎传梅毒。予青霉素治疗     

发疹型汗管瘤2例

汗管瘤是一种汗腺的良性肿瘤,皮损需与很多丘疹性疾病相鉴别。本文报告2例女性患者,组织病理符合发疹型汗管瘤。     

先天性角化不良2例

先天性角化不良是一种罕见的多系统疾病，主要累及中胚层和外胚层，约80％以上的患者发生骨髓衰竭，并于早期死亡。报告2例患者，1例为22岁男孩，另1例为16岁女孩，均具有网状色素沉着伴毛细血管扩张及皮肤萎缩、甲营养不良、黏膜白斑等典型临床表现。男性患者伴有血液系统异常。     

Marshall-White综合征2例

例1男,26岁,四肢间断皮疹8年;例2女,16岁,左上肢、双下肢皮疹15年,逐渐加重。皮疹为大理石样,肢端下垂后明显。