Toll样受体与慢性乙型肝炎的研究进展

Toll-like receptors (TLRs)are the major pattern recognization receptors of natural immune response. In recent years, studies have shown that HBV inhibits the expression of TLRs to escape from host's immune clearance in some way, then resulting in the persistent infection and chronicity of HBV. On the other hand, binding with their corresponding ligands, TLRs provide a protective immunity for our bodies and play a critical role in anti-HBV infection, through inducing the expression of anti-viral cytokine IFN-α/β, TNF-α, etc. The recent advances about TLRs and chronic hepatitis B are reviewed in this article.     

Role of Toll-like receptor 4 in intestinal ischemia-reperfusion and the interventional role of ω-3 polyunsaturated fatty acids

Toll-like receptors is a super-family of pathogen recognition-receptors discovered in recent years.During the process of ischemia-reperfusion, the Toll-like receptor 4 (TLR4) combines with lipopolysaccharide and many endogenous ligands such as high mobility group protein B1, heparan sulfate, and fibrinogen. Through the myeloid differentiation protein 88 -dependent and -independent signaling pathways, the products induce the release of inflammatory cytokine-mediated inflammatory response, leading to injuries. ω-3 polyunsaturated fatty acids, by inhibiting the signal pathway activation and target gene expression of TLR4, can influence the function of many immune cells and regulate the body's inflammatory response and immune function. This article reviews the function of TLR4 during ischemia-reperfusion injury and the possible interventional role of ω-3 polyunsaturated fatty acids.     

Hantavirus infection and β3 integrin

β3 integrin is one of a large family in cell-surface adhesion receptors, which can mediate cell-cell,cell-extracellular matrix interactions, and plays a key role in many virus infections. In this paper, the biological functions of the β3 integrin family are reviewed and the role in hantavirus infection is delineated.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.     

The assodation between HLA-Ⅱ and chrome hepatitis B virus infection

Human leukocyte antigen (HLA) is the most complex and polymorphism genetic system, whose function involves all aspects of the immunity in human. Many researches have shown that HLA gene polymorphism are associated with HBV clearance, HBV persistent infection, the progress of the disease prognosis, HBsAg response after the vaccine and interferon. In this article, the study on the relevance of chronic HBV infection and HLA- Ⅱ is focused on.