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1.
Rationale
Previous research suggests that the vesicular monoamine transporter-2 (VMAT2) is a novel target for the treatment of methamphetamine (METH) abuse. 相似文献2.
Rationale
Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. 相似文献3.
Holm R Kall MA Frølund S Nielsen AL Jensen A Broberg ML Nielsen CU 《Pharmaceutical research》2012,29(4):1134-1142
Purpose
To investigate the rectal absorption of vigabatrin in rats, based on the hypothesis that PAT1 (Slc36a1) is involved. 相似文献4.
Purpose
To investigate the mechanisms of clearance of AMG 386, an investigational recombinant peptide-Fc fusion protein (peptibody) that blocks tumor angiogenesis by neutralizing the interaction between angiopoietin-1 and -2 and the Tie2 receptor. 相似文献5.
Edvardas Danila Rolandas Zablockis Jolita Norkūnienė Edvardas Žurauskas 《Central European Journal of Medicine》2011,6(3):356-362
Introduction
Organizing pneumonia (OP) is a rare disorder which may be associated with various clinical contexts and radiological patterns. 相似文献6.
Mingming Zhao Min Su Xia Lin Yanfei Luo Haibing He Cuifang Cai Xing Tang 《Pharmaceutical research》2010,27(8):1687-1702
Purpose
The purpose of this study was to carry out a detailed evaluation of an intravenous lipid emulsion for docetaxel (DLE) without Tween 80 before clinical administration. 相似文献7.
Milada Sirova Tomas Mrkvan Tomas Etrych Petr Chytil Pavel Rossmann Marketa Ibrahimova Lubomir Kovar Karel Ulbrich Blanka Rihova 《Pharmaceutical research》2010,27(1):200-208
Purpose
In vivo efficacy and safety of HPMA-based copolymers armed with doxorubicin via a spacer containing pH-sensitive linkage that can be prepared within a broad range of attached drug contents (1) was tested in murine tumor models. 相似文献8.
Zhang Y Brown K Siebenaler K Determan A Dohmeier D Hansen K 《Pharmaceutical research》2012,29(1):170-177
Purpose
To demonstrate rapid (~1 min) lidocaine delivery using 3M’s solid microstructured transdermal system (sMTS) for prolonged, local analgesic action. 相似文献9.
Rationale
Repeated administrations of the D2/D3 agonist quinpirole (QNP) to rats elicit an antieconomical pattern of drinking called “contrafreeloading” (CFL), a putative model of compulsive-like behavior. 相似文献10.
Mendelson JE Coyle JR Lopez JC Baggott MJ Flower K Everhart ET Munro TA Galloway GP Cohen BM 《Psychopharmacology》2011,214(4):933-939
Rationale
Salvinorin A (SA) is a highly selective kappa opioid receptor agonist and the putative psychoactive compound in Salvia divinorum (SD), an increasingly abused hallucinogenic plant. 相似文献11.
Rationale
Several lines of evidence support a role for the endogenous opioid system in mediating behaviors associated with drug dependence. Specifically, recent findings suggest that the kappa-opioid receptor (KOR) may play a role in aspects of nicotine dependence, which contribute to relapse and continued tobacco smoking. 相似文献12.
Rationale
Most individuals can accurately assess the risks and rewards associated with choice alternatives and decide accordingly; however, drug users often display maladaptive decision-making, such that choices are biased toward excessively risky options. 相似文献13.
Introduction
In double-blind randomized placebo-controlled trials (RCT) of therapeutic interventions, the effects of the treatment may provide feedback that undermines blinding and consequently distorts measures of the effectiveness of the intervention. 相似文献14.
Stella Chaviaras Plato Mak David Ralph Lalitha Krishnan Jillian H. Broadbear 《Psychopharmacology》2010,210(1):35-43
Rationale
The distribution of oxytocin receptors in limbic regions, as well as evidence that exogenous oxytocin modulates affect and fear processing, suggests that this neuropeptide may have a role to play in the treatment of mood disorders. 相似文献15.
Mary F. Morrison Paulette Ceesay Ira Gantz Keith D. Kaufman Christopher R. Lines 《Psychopharmacology》2010,209(3):245-253
Rationale
It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. 相似文献16.
Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive,methamphetamine‐using men who have sex with men
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Adam W. Carrico Violeta J. Rodriguez Deborah L. Jones Mahendra Kumar 《Human psychopharmacology》2018,33(1)
Objective
This study examined if methamphetamine use alone (METH + HIV?) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic‐pituitary‐adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine‐using, HIV‐negative comparison group (METH‐HIV?).Methods
Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV? and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH‐HIV? men.Results
There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = ?0.19, p < .05). Compared to METH‐HIV? men, METH + HIV+ MSM displayed 10% higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine‐using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH‐HIV? men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors.Conclusions
Further research is needed to characterize the bio‐behavioral pathways that explain dysregulated HPA axis functioning in HIV‐positive, methamphetamine‐using MSM. 相似文献17.
Rationale
Spontaneous (novel) object recognition (SOR) is one of the most widely used rodent behavioural tests. The opportunity for rapid data collection has made SOR a popular choice in studies that explore cognitive impairment in rodent models of schizophrenia, and that test the efficacy of drugs intended to reverse these deficits. 相似文献18.
Purpose
This work probed the topical delivery and skin-staining properties of a novel co-drug, naproxyl-dithranol (Nap-DTH), which comprises anti-inflammatory (naproxen) and anti-proliferative (dithranol) moieties. 相似文献19.
Background
Little is known about how rapid electrocortical responses (event-related potentials; ERPs) to affective pictures are modulated by benzodiazepine agonists. The present study investigated effects of oxazepam (20 mg p.o.) on behavioral measures and ERPs associated with affective picture processing during perception and recognition memory retrieval. 相似文献20.