Proximal caries detection accuracy using intraoral bitewing radiography, extraoral bitewing radiography and panoramic radiography

Objective

To compare proximal caries detection using intraoral bitewing, extraoral bitewing and panoramic radiography.

Methods

80 extracted human premolar and molar teeth with and without proximal caries were used. Intraoral radiographs were taken with Kodak Insight film (Eastman Kodak Co., Rochester, NY) using the bitewing technique. Extraoral bitewing and panoramic images were obtained using a Planmeca Promax Digital Panoramic X-ray unit (Planmeca Inc., Helsinki, Finland). Images were evaluated by three observers twice. In total, 160 proximal surfaces were assessed. Intra- and interobserver kappa coefficients were calculated. Scores obtained from the three techniques were compared with the histological gold standard using receiver operating characteristic analysis. Az values for each image type, observer and reading were compared using z-tests, with a significance level of α = 0.05.

Results

Kappa coefficients ranged from 0.883 to 0.963 for the intraoral bitewing, from 0.715 to 0.893 for the extraoral bitewing, and from 0.659 to 0.884 for the panoramic radiography. Interobserver agreements for the first and second readings for the intraoral bitewing images were between 0.717 and 0.780, the extraoral bitewing readings were between 0.569 and 0.707, and the panoramic images were between 0.477 and 0.740. The Az values for both readings of all three observers were highest for the intraoral bitewing. Az values for the extraoral bitewing images were higher than those of the panoramic images without statistical significance (p > 0.05).

Conclusion

Intraoral bitewing radiography was superior to extraoral bitewing and panoramic radiography in diagnosing proximal caries of premolar and molar teeth ex vivo. Similar intra- and interobserver coefficients were calculated for extraoral bitewing and panoramic radiography.     

A comparison of conventional intra-oral radiography and computer imaging techniques for the detection of proximal surface dental caries.

The detection of proximal surface caries by the visual interpretation of bitewing radiographs is known to be relatively inaccurate. The present study was designed to examine whether computer image processing could improve the diagnostic accuracy. A computer-aided, software-driven, TV-based system was used to digitize conventional radiographs and digitally process the images using histogram equalization and grey-scale inversion to enhance the images. The computer-enhanced images were compared with conventional intra-oral radiographs for the detection of proximal surface caries using receiver operating characteristic analysis. The results indicate that the digital image processing techniques used did not improve the diagnostic accuracy of dental radiographs. No significant difference in diagnostic accuracy could be detected between the non-enhanced digital images and conventional film-based images for the detection of proximal surface caries.     

Comparing the accuracy of panoramic and intraoral radiography in the diagnosis of proximal caries

OBJECTIVES: The purpose of this study was to compare the diagnostic accuracy of panoramic and intraoral radiographic surveys in the diagnosis of proximal caries according to the different dental regions (maxillary and mandibular incisor, canine, premolar and molar). METHODS: In this study, full mouth series and panoramic radiographs of 79 patients were used. The radiographs were evaluated for proximal caries by three observers. The diagnostic accuracy of radiographic surveys for each dental region was assessed by means of receiver operating characteristic (ROC) curve analysis. RESULTS: Full mouth series was the most efficient method in the diagnosis of caries for incisor and canine teeth. However, full mouth series and combination of panoramic plus bitewings had similar diagnostic accuracy for premolar and molar teeth. CONCLUSIONS: Panoramic survey alone was not sufficient for the diagnosis of proximal caries for the entire dentition. The combination of panoramic plus bitewing plus anterior periapical survey exhibited a diagnostic accuracy for proximal caries that was comparable with full mouth series.     

End-user survey for digital sensor characteristics: a pilot questionnaire study

OBJECTIVE: To survey end-user opinions on dental digital sensor characteristics for the design of a new X-ray imaging sensor. MATERIALS AND METHODS: 100 questionnaires were sent out to dentists and dental radiologists. The questionnaire consisted of six parts related to dental sensors. A: Details about the respondent; B: Prioritization of most important aspects of digital sensors; C: Rating advantages and D: disadvantages of digital sensors; F: Dental features that need to be enhanced by digital sensors; G: End-user comments. RESULTS: Fifty-six questionnaires were returned. Contrast resolution and imaging time were assessed as the most and the least important aspects, respectively. Aspects considered as advantages by approximately 80% of respondents were: optimal contrast resolution, increased specificity, increased discrimination between diseased and healthy tissue, increased sensitivity, lower dose to the patient by more than 20%; as a disadvantage, increased patient dose was given. Dental features considered important by over 80% of the respondents were for intraoral radiographs: the visibility of caries, periapical, periodontal, and bone lesions; for panoramic radiographs: reduction of ghost images, image sharpness and bone. Bone and soft tissues on cephalograms and bone on temporomandibular joint (TMJ) tomograms were mentioned by over 70%. CONCLUSION: The most desired characteristic for a new sensor is contrast resolution. Dose saving is not considered as important unless it is more than 20%. Examination time is not a major issue. Caries, periapical and periodontal, and bone lesions for intraoral radiographs, reduction of ghost images, image sharpness and bone for panoramic radiographs were the most frequently mentioned dental features that should be enhanced by digital sensors.     

Marginal bone in periodontal disease: an evaluation of image quality in panoramic and intra-oral radiography

Five observers assessed the panoramic and full-mouth (14 periapical and four posterior bitewing) radiographs of 20 patients each for the ability to interpret and measure the marginal bone level. The image quality of each site was classified as excellent, acceptable or unacceptable. Depiction errors affecting interpretability and measurability were also noted. In the upper arch, the frequency of uninterpretable and non-measurable sites was almost equal for panoramic and periapical radiography. Image quality was better with periapical radiography in the lower arch. In the posterior regions of both arches, more sites could not be measured from panoramic compared with bitewing radiographs. Due to overlapping the distal surface of the maxillary canine and the mesial surface of the first maxillary premolar could often not be interpreted in either panoramic or periapical radiographs, but infrequently in the bitewings. In the lower arch, the most frequent depiction error was inadequate density in the incisor region of panoramic radiographs. On the basis of these results, we proposed that in clinical practice the panoramic radiograph can be supplemented with individually selected periapicals. In epidemiological studies, the panoramic radiograph should be combined with a premolar bitewing radiograph.     

Evaluation of two imaging techniques: near-infrared transillumination and dental radiographs for the detection of early approximal enamel caries

Objectives

The aim of this paper was to evaluate a transillumination (TI) system using near-infrared (NIR) light and bitewing radiographs for the detection of early approximal enamel caries lesions.

Methods

Mesiodistal sections of teeth (n = 14) were cut with various thicknesses from 1.5 mm to 4.75 mm. Both sides of each section were included, 17 approximal surfaces with natural enamel caries and 11 surfaces considered intact. The approximal surfaces were illuminated by NIR light and X-ray. Captured images were analysed by two calibrated specialists in radiology, and re-analysed after 6 months using stereomicroscope images as a gold standard.

Results

The interexaminer reliability (Kappa test statistic) for the NIR TI technique showed moderate agreement on first (0.55) and second (0.48) evaluation, and low agreement for bitewing radiographs on first (0.26) and second (0.32) evaluation. In terms of accuracy, the sensitivity for the NIR TI system was 0.88 and the specificity was 0.72. For the bitewing radiographs the sensitivity ranged from 0.35 to 0.53 and the specificity ranged from 0.50 to 0.72.

Conclusion

In the same samples and conditions tested, NIR TI images showed reliability and the enamel caries surfaces were better identified than on dental radiographs.     

Clarity and diagnostic quality of digitized conventional intraoral radiographs

OBJECTIVES: To compare digital images of conventional radiographs with the original radiographs for perceived clarity of endodontic files, periapical lesions and carious lesions, and to establish the diagnostic value of the digital images. METHODS: Four groups of ten radiographs were used: standardized bitewings demonstrating carious lesions, periapical radiographs of apical lesions, periapical radiographs showing endodontic files of various sizes at working length, and standardized periapical radiographs with size 08 files at working length. Radiographs were photographed using an Olympus C 2500-L digital camera and a Nikon D1X digital camera and were scanned using a Nikon Supercoolscan 4000 ED film/slide scanner. The digital images were then transferred to a Toshiba Satellite 2210 laptop. Three general dental practitioners compared each conventional radiograph with the three matching digital images. Images were ranked for clarity and were assessed for diagnostic quality. Data were analysed using General Estimating Equations. RESULTS: The clarity and diagnostic quality of the conventional radiographs were superior to the digital images produced by the three techniques (P < 0.001). No significant difference was found between the Nikon D1X and Camedia 2500-L cameras for clarity or diagnostic quality. The scanner was equivalent to the Camedia 2500-L camera for diagnostic quality, but was otherwise inferior to both cameras. CONCLUSIONS: Digitizing conventional radiographs using current high-grade digital cameras or scanners does not produce images of diagnostic quality. Improved resolution of viewing monitors is necessary to fully harness the potential of digital technology.     

Comparing the accuracy of Dutch dentists and dental students in the radiographic diagnosis of dentinal caries.

OBJECTIVES: To compare the diagnostic accuracy of dental students using bitewing radiographs for the diagnosis of dentinal caries with that of general dental practitioners and to establish a bench mark for testing for improvement in diagnostic performance. METHODS: Fourth year dental students (n=259) viewed bitewing radiographs of 105 proximal tooth surfaces. According to a micro-radiography "gold standard" 45 surfaces had dentine caries. The students were asked to diagnose presence and absence of dentine caries from which, under supervision, they calculated their sensitivity (TPR) and false positive rate (FPR). The students binary diagnostic data was compared with the historical data from a random sample of Dutch dentists (n=273). The Summary Receiver Operating Characteristic (SROC) curve method was used to analyse the data. The two groups were tested for differences in (a) diagnostic odds ratio and (b) the area under the SROC curve. RESULTS: The students mean TPR for dentine caries diagnosis was 67.2% (s.d. 11.8%) and the FPR was 8.3% (s.d. 8.4%). The corresponding values for dentists were: TPR 54.0% (s.d. 14.1%) and FPR 3.1% (s.d. 4.5%). Significantly more dentists (85%) than students (72%, P<0.001) had a diagnostic odds ratio > or =21. The area under the SROC curve (Az) was 0.8194 for students and 0.8140 for dentists (P=0.70). CONCLUSIONS: In our study (i) the students had a higher TPR but also a higher FPR than the dental practitioners, (ii) their overall performance (Az) was similar but (iii) for a clinically relevant population the dental practitioners would out-perform the students in diagnostic performance.     

Effects of healthcare policy and education on reading accuracy of bitewing radiographs for interproximal caries

ObjectivesThe aim of this study is to assess the accuracy of bitewing radiograph interpretation of predoctoral students, residents and general dentists who work under different core curriculum of dental education and healthcare policy.MethodsA total of 118 examiners including predoctoral dental students, residents and general dentists from USA and Japan were tasked with evaluating a series of bitewing radiographs and diagnosing interproximal carious lesions. This study was approved by the Harvard Medical School Institutional Review Board (IRB). Participants graded interproximal aspects of those images and categorized the following criteria; “intact”, “enamel caries <1/2 width”, “enamel caries >1/2 width” or “caries into dentin”. The gold-standard was determined by the consensus of two HSDM full-time faculty.ResultsThere was significant difference in the sensitivity for all three caries levels between the two groups but there was no significant difference on specificity. The positive-predictive and negative-predictive values of the USA group for the enamel caries (<1/2 of enamel) were significantly higher than the Japanese group. The average of AUC (ROC) was significantly higher in the USA group (0.885 ± 0.04) than the Japanese group (0.785 ± 0.08, p<0.01).ConclusionTeaching and adopting BW radiographs for diagnosis of interproximal caries is integral for dental providers to accurately and efficiently use them in their practices. It is critical that all dental educators approach policymakers to explain the importance of BW radiographs and promote their efficacy for prevention and early diagnosis of interproximal caries.     

Scanning resolution and the detection of approximal caries.

OBJECTIVE: To determine a proper scanning resolution for digitizing bitewing radiographs in the detection of approximal caries. METHODS: Fifty-two premolars and 48 molars were mounted in blocks and imaged on conventional film (Ektaspeed Plus, Eastman-Kodak, Rochester, NY USA) simulating a bitewing projection. The 15 bitewing radiographs were then scanned with a flatbed scanner at three resolutions 150, 300 and 600 d.p.i. The digitized images were displayed in random order on a high-resolution cathode ray tube monitor. Ten observers assessed the caries status of 200 approximal surfaces. They scored lesion presence on a 5-point confidence scale and depth on a 3-point scale. The observer's scores were compared with the results from a histological examination. Data were analysed using analysis of variance, by calculating signed observer error, absolute observer error and observer confidence. RESULTS: Lesion depth had a significant effect on confidence of lesion recognition. The main effect of resolution and the interaction between resolution and lesion depth were significant. Pair-wise comparison showed a significant difference between resolutions in case of sound surfaces and surfaces with dentinal lesions for absolute error. The confidence increased as the resolution increased but no significant difference was found between 300 and 600 d.p.i. The best score for depth estimation was obtained at the 300 d.p.i. scanning resolution. CONCLUSIONS: When bitewing radiographs are scanned with a flatbed scanner, a resolution of 300 d.p.i. seems the best choice. At this resolution the digital file size is manageable without significant loss of the information necessary for caries diagnosis.     

Irreversible JPEG compression of digital chest radiographs for primary interpretation: assessment of visually lossless threshold

PURPOSE: To determine if digital chest images could be compressed in a primary interpretation context without perceived loss of fidelity (below the visually lossless threshold) at transilluminated film or cathode ray tube (CRT) display. MATERIALS AND METHODS: One hundred forty-four posteroanterior radiographs were obtained with a digital chest radiography system. At both film and CRT display, an identified original image was presented side by side with a replicate, which was either an unaltered image or an image that had been Joint Photographic Experts Group (JPEG) compressed to 10:1, 20:1, or 50:1 and reconstructed. Each of the 10 readers indicated whether the replicate was "indistinguishable from the original" or "degraded" at clinical reading distance and at close inspection. The readers' ability to detect compressed images was examined for patterns; 95% CIs were used for statistical testing. RESULTS: With transilluminated film at clinical reading distance, readers were as likely to rate originals (48 [20%] of 240 readings) as degraded as they were to rate 20:1 replicates (106 [22%] of 480 readings) as degraded, but they frequently identified 50:1 replicates (283 [59%] of 480 readings) as degraded. At close inspection, 20:1 replicates (163 [34%] of 480 readings) were often identified as degraded, but 10:1 replicates (19 [8%] of 240 readings) were not identified as degraded more often than originals (17 [7%] of 240 readings). With CRT display, the results were nearly identical. CONCLUSION: At reading distance for primary interpretation, full-size digital chest radiographs that have been JPEG compressed to 10:1 or 20:1 and reconstructed are visually lossless at film or CRT display. Images compressed to 10:1 remain visually lossless at close inspection.     

Experience of Norwegian general dental practitioners with solid state and storage phosphor detectors.

OBJECTIVES: To evaluate the opinions of Norwegian dental practitioners regarding the use of solid state sensor and storage phosphor (SP) detectors for intra-oral radiography. METHODS: A questionnaire received from 2199 dentists 309 (219 male, 86 female, four unknown) confirmed the use of digital radiography in their practices. RESULTS: Sixty-one per cent of dentists used a SP and 35% a sensor system; four (1.3%) used both. Approximately 50% of dentists had experienced technical problems and 33% had needed repairs. Almost all dentists stored their images on the hard disk (>97%) and 81% made a daily back-up. More sensor than SP users found difficulty with the positioning holder. Two-thirds of dentists reported digital image quality was the same or better than film. More Digora (Soredex, Helsinki, Finland) users reported better image quality than Denoptix (Gendex, Milan, Italy) or Digident (Digident, Nesher, Israel) users. Mean reduction in exposure time was 55% (range 2-90%), although 17 dentists stated that no reduction was achieved. Approximately half of the sensor users also used film and 38% of the SP users. Film was used more often for bitewing examination by the sensor users (27%) than by the SP users (4%). Mean time saved by the sensor users was 36 min/day (range 10-120) and by the SP users 25 min/day (range 5-120). CONCLUSIONS: The majority of dentists felt that digital image quality was the same or better than film and exposure and examination times were reduced. However, technical problems and repairs were common.     

Outcomes of digital X-ray mini-panel examinations for patients having mental retardation and developmental disability

OBJECTIVES: Severely and profoundly mentally retarded and developmentally disabled (MR/DD) patients are unable to communicate disease symptoms, and radiographic examinations are often difficult to perform on non-sedated patients. This clinical trial evaluated the impact on dental treatment planning of radiographic mini-panels for MR/DD patients. METHODS: With Institutional Review Board approval and informed consent of the legal guardian of each patient, a digital series of six periapical radiographs was achieved without sedation on 72 MR/DD inpatients (the survey was attempted on 74 patients). RESULTS: The average number of teeth included in each mini-panel was 20.4 compared with 22.2 teeth found clinically and 22.7 teeth determined combining both clinical and radiographic findings. Individual mini-panel images were judged technically excellent in 65% of cases, diagnostically satisfactory in 26% of cases and suboptimal in 9%. The radiographic panels were judged to affect treatment planning for more than 60% of the patients included in the trial. In 32% the detected condition was one or more periapical radiolucency. Several radiographic findings indicated potentially painful conditions that perhaps explained patient actions previously attributed to behavioural problems. Potential sources of dental pain and sepsis were treated by endodontic therapy or dental extractions on a case-by-case basis with or without general anesthesia. The trial also demonstrated a need that has translated into increased state allocations for dental treatment of MR/DD patients resident in the Commonwealth of Kentucky. CONCLUSIONS: Dental inspections of MR/DD patients are incomplete if radiographs are excluded. Whilst the mini-panel approach could be considered incomplete, it is better than no radiographs at all. 91% of images were excellent to satisfactory in diagnostic quality and a majority of patients' treatments were modified because of the radiographic information.     

Film tomography compared with film and digital bitewing radiography for proximal caries detection

OBJECTIVES: The purpose of this study was to evaluate the efficiency of conventional tomography for proximal caries detection compared with conventional bitewing and digital intraoral radiography. METHODS: In this study, 48 extracted human posterior permanent teeth were used. Conventional bitewing radiographs, digital intraoral radiographs and conventional tomograms were obtained of the teeth. The presence or absence of caries was scored according to a five-point scale by two oral and maxillofacial radiologists. True caries depth was determined by histological examination. The diagnostic accuracy of each radiographic system was assessed by means of receiver operating characteristic (ROC) curve analysis. The mean of areas under the ROC curve (A(z)) was analysed by pairwise comparison of ROC curve. The interobserver agreement was evaluated using a t-test. RESULTS: The statistical analysis of A(z) scores has shown no significant difference for three imaging modalities (P>0.05). There was no statistically significant difference between interobserver agreement (P>0.05). CONCLUSIONS: This study has demonstrated that the diagnostic accuracy of conventional tomograms is comparable to that of conventional bitewing and digital intraoral radiographs for proximal caries detection.     

Digital camera resolution and proximal caries detection

OBJECTIVES: To evaluate the diagnostic accuracy of proximal caries detection from digitized film images captured by a digital camera at different resolution settings. METHODS: Twenty-five periapical radiographs of 50 premolar and 25 molar teeth were photographed using a digital camera, Sony Cyber-shot, DSC-S75 at three different resolution settings: 640 x 480, 1280 x 960 and 1600 x 1200. Seventy-five digital images were transferred to a computer, saved and opened using ACDSee software. In addition, a PowerPoint slide was made from each digital image. Five observers scored three groups of images (the films, the displayed 1:1 digital images on the ACDSee software, and the PowerPoint slides) for the existence of proximal caries using a 5-point confidence scale, and the depth of caries on a 4-point scale. Ground sections of the teeth were used as the gold standard. Az values under the receiver operating characteristic (ROC) curve of each group of images and at different resolutions were compared using the Friedman and Wilcoxon signed rank tests. Mean different values between the lesions' depth interpreted by the observers and that of the gold standard were analysed. RESULTS: Films showed the highest Az values. Only the 1280 x 960 images on the ACDSee software showed no significant difference of the Az value from the films (P=0.28). The digital images from three resolution settings on the PowerPoint slides showed no significant differences, either among each other or between them and the films. For caries depth, the 1280 x 960 images showed lower values of mean difference in enamel lesions compared with the other two resolution groups. CONCLUSIONS: This study showed that in order to digitize conventional films, it was not necessary to use the highest camera resolution setting to achieve high diagnostic accuracy for proximal caries detection. The 1280 x 960 resolution setting of the digital camera demonstrated comparable diagnostic accuracy with film and was adequate for digitizing radiographs for caries detection.     

Machine Classification of Dental Images with Visual Search

RATIONALE AND OBJECTIVES: The authors performed this study to assess the performance of a computer-based classification system that uses gaze locations of observers to define the subspace for machine learning. MATERIALS AND METHODS: Thirty-two dental radiographs were classified by an expert viewer into four categories of disease of the periapical region: no disease (normal tooth), mild disease (widened periodontal ligament space), moderate disease (destruction of the lamina dura), and severe disease (resorption of bone in the periapical area). There were eight images in each category. Six observers independently viewed the images while their eye gaze position was recorded. They then classified the images into one of the four categories. A sample of image space was used as input to a machine learning routine to develop a machine classifier. Sample space was determined with three techniques: visual gaze, random selection, and constrained random selection. K analyses were used to compare classification accuracies with the three sampling techniques. RESULTS: With use of the expert classification as a standard of reference, observers classified images with 57% accuracy, and the machine classified images with 84% accuracy by using the same gaze-selected features and image space. Results of kappa analyses revealed mean values of 0.78 for gaze-selected sampling, 0.69 for random sampling, 0.68 for constrained random selection, and 0.44 for observers. The use of sample space selected with the visual gaze technique was superior to that selected with both random-selection techniques and by the observers. CONCLUSION: Machine classification of dental images improves the accuracy of individual observers using gaze-selected image space.     

Diagnostic image quality of hand-held and wall-mounted X-ray devices in bitewing radiography: a non-inferiority clinical trial

Objectives:The present clinical trial was intended to clarify whether subjective assessments of diagnostic X-ray image quality achieved via hand-held (HH) Nomad Pro 2 (KaVo Kerr, Brea, CA, USA) X-ray device is non-inferior that of the wall-mounted (WM) KaVo Focus (KaVo Dental, Bieberich, Germany).Methods:A prospective, cross-over, and in vivo non-inferiority clinical trial was conducted to compare these two diagnostic modalities. Based on sampling calculations, 205 patients were selected for study, generating 410 paired bitewing radiographs in randomized sequence. The films were assessed independently, engaging three observers blinded to modality for random, side-by-side-comparisons. Diagnostic image quality was rated as follows: no preference, HH preference, or WM preference. Observer judgements were combined accordingly to reach a majority.Results:Collective observer ratings indicated no preference for diagnostic image quality in 63.9% of cases, with WM preference at 16.6% and HH preference at 19.5%. The difference in HH and WM preferences (19.5%–16.6% = 2.9%) was within the expected 95% confidence interval. Majority agreement was reached in 82.7%.Conclusions:Subjectively assessed diagnostic image quality in bitewing radiographs acquired by HH and WM devices did not differ significantly. The hand-held device is thus non-inferior to the WM in this regard. Our data set of paired bitewing radiographs may subsequently aid in future research.     

Effect of dose reduction in digital dental panoramic radiography on image quality.

OBJECTIVES: To investigate the effect of dose reduction in digital panoramic radiography on subjective image quality and diagnostic performance. METHODS: Two digital panoramic radiographs were obtained with the Orthophos DS(Sirona, Bensheim, Germany) of patients (n=100) receiving dental care. The first image was taken at the standard exposure setting. For the second image the tube current was reduced by between 48 and 53%, 63 and 69%, 75 and 80% and 80 and 81% respectively. Ten observers rated both images for 21 specific anatomical details and 30 pathological findings. RESULTS: All radiographs taken at reduced mA levels had a significantly inferior score (P<0.01) for anatomical details. There was no difference in the scores for pathological findings. CONCLUSION: Radiographs obtained at reduced mA had inferior subjective image quality, but there was no difference in diagnostic performance. Thus, a reduction in tube current of approximately 50% is recommended. In certain circumstances such as follow-up radiographic examinations, a reduction of up to 65% should be considered.     

Intra-oral storage phosphor and conventional radiography in the assessment of alveolar bone structures

OBJECTIVES: To compare storage phosphor (SP) with conventional film radiography for accuracy of linear measurements of the marginal alveolar bone and visibility of anatomical structures. METHODS: Linear measurements were made in paired SP and conventional images of dried human mandibles with a metal pin fixed 10 mm below the alveolar crest. One observer measured the distance from the alveolar crest to the reference point on the radiographs. The difference between the measured and the true distance was calculated. Two observers rated the visibility of bony structures (periodontal ligament space, periapical bone tissue, alveolar crest) in 51 paired digital and conventional images of 21 patients on a 3-point scale. Overall agreement and Kappa index were calculated. RESULTS: Accuracy of linear measurements was higher in digital radiography (mean difference 0.17 mm) than in conventional radiography (mean difference 0.59 mm). Overall, the two observers rated visibility higher in conventional radiographs. The Kappa indices for the periodontal ligament space and periapical bone indicated fair to almost perfect agreement (kappa = 0.38 and 0.5; kappa = 0.39 and 0.84) while for the alveolar crest there was only poor or moderate agreement (kappa = 0.2 and 0.5). CONCLUSIONS: The small differences in linear measurements indicate that the Digora system is suitable for clinical assessment of periodontal and peri-implant bone loss. The visibility of dental structures depends as much on the individual features assessed, as the radiographic system.     

Measurement of endometrial thickness at US in multicenter drug trials: value of central quality assurance reading

PURPOSE: To assess the value of central quality assurance (QA) reading of transvaginal ultrasonographic (US) images obtained to measure endometrial thickness and to assess image quality. MATERIALS AND METHODS: Results of 2,000 US examinations performed in 1,000 subjects during one of two multicenter drug trials were evaluated. Endometrial thickness was measured at the study site; images were then sent to the QA center, where an experienced sonologist evaluated endometrial thickness and image quality. RESULTS: In 360 (18%) of the 2,000 examinations, image quality was insufficient for central QA reading. Repeat examinations were requested, and suggestions for improvement in technique were provided. In 349 (97%) of the 360 examinations, repeat US images were of acceptable quality. In 99 (5%) of the 1,989 examinations in which endometrial thickness was measured, central measurement of thickness differed by more than 2 mm from that of the site. In a group (n = 300) that was followed up for 1 year, requests for repeat US examinations decreased from 24% at baseline to 11% at 1 year. CONCLUSION: Central QA reading provides a consistent evaluation of endometrial thickness on US images obtained in multicenter drug trials and helps to ensure the acquisition of high-quality transvaginal US images. It further leads to demonstrable improvement in site performance.