Neuroleptikas bmrkninger Undersøgelse af 159 patienter med UKU's bivirkningsskala

One hundred and fifty-nine psychiatric inpatients treated with neuroleptic drugs were evaluated by means of the UKU side effect rating scale. The main side effects were asthenia (20.8%), hypokinesia (35%), rigidity (16.8%), tremor (18.6%), dyskinesia (16.5%), akathisia (25.2%), orthostatic dizziness (21.8%), and hyper-/hypo-salivation (25%/20%), Galactorrhoea was seen in 10% and sexual disturbances in 5-9%. Twenty-five per cent of the patients felt that the side effects had a moderate to severe influence on their daily living, whereas 54% felt no such influence at all. It is concluded that side effects detract substantially from the beneficial effects of neuroleptics and that systematic use of a side effect rating scale may contribute to an increased awareness of neuroleptic side effects and to attempts at lowering the dose     

Receptorændringer i rottehjerne efter kronisk behandling med Buspirone

As consulting psychiatrist for students the author interviewed 95 20- to 25-year-old students consulting her from different institutions of higher education in Stockholm. In the group typical problems of adolescence were found; 68% had difficulties in their heterosexual adjustment, and 67% had problems connected with liberation from parents. The author draws attention to the possibility of including developmental aspects in diagnoses of young people, using DSM-III. The concept of prolonged adolescence is discussed.     

Behandling av äldre människor med icke-sederande psykofarmaka

Huvudsyftet med denna artikel är att diskutera lämpligheten av den konventionella behandlingen av ångest och orostillstånd hos äldre människor med sederande psykofarmaka samt efterlysa forskning rörande medel som förbättrar kognitiva funktioner och höjer vakenhetsgraden hos äldre.     

Ambulant intensiv miljø- og psykoterapi af unge skizofrene patienter: En beskrivelse af behandlingscentret Nordhuset,Helsingør

Orientering Nordhuset er en ambulant behandlingsenhed under psykiatrisk afdeling R, Centralsygehuset i Hillerød.

Behandlingen i Nordhuset påbegyndtes I 1983 udfra ønsket om at give yngre kroniske patienter et relevant ambulant behandlingstilbud som alternativ ti1 døgnindlaeggelse. Personalenormeringen er: 1 sygeplejerske, 1 1/2 ergoterapeut, 1 fysioteråpeut, 1 socialridgiver, 1 psykolog, 2 læger og 1 1/2 sekretaer.     

Indledende forsøg med behandling med et nyt psykofarmakon Truxal

Kirsten Pauss, Torhild Leira Haugsgjerd, Bjørn Urdal: Vansker og vekst hos barn og ungdom 164 sider, Universitetsforlaget Oslo 1980

Leif J. Braaten: Studenters emosjonelle problemer 225 sider, Universitetsforlaget Oslo 1980     

Om domstolsprøvelse af sindssyge personers administrative frihedsberøvelse

Denna artikel av tidskriftens svenske lokal-redaktör, docent Jan Wålinder (bilden) är en bearbetning av ett föredrag hållet vid Medicinska Riksstämmans symposium om anorexia nervosa i november 1973.     

Foreløbige erfaringer med lobotomia frontalis

Objective: To study the correlation of personality traits measured by the Temperament and Character Inventory (TCI) with the prognosis of major depressive disorder in patients treated with either fluoxetine or short-term psychodynamic psychotherapy in a randomized comparative study. Method: 35 patients with DSM IV-defined major depressive disorder of mild or moderate severity were randomized to receive either short-term psychodynamic psychotherapy or fluoxetine treatment for 16 weeks. Prior to beginning of the therapy, patients were assessed with TCI. The Hamilton Depression Rating Scale (HDRS) was used as the outcome measure completed at the baseline and follow-up at 4 months. Results: In the combined group (n=35), Harm Avoidance was associated with the severity of the depression measured by the HDRS at the baseline (P=0.01) and baseline Self-Directedness with the HDRS at 4 months follow-up (P=0.03). In the fluoxetine treatment group, Reward Dependence (P=0.03), Self-Directedness (P=0.01) and Cooperativeness (P=0.02) at the baseline associated with HDRS at 4 months follow-up. No statistically significant associations between personality traits and depression scores at the follow-up were found in the patients treated with psychotherapy. Conclusion: In this whole cohort of depressive patients, baseline high Self-Directedness predicted higher depression scores after 4 months of treatment. In the fluoxetine treatment group, subjects with high baseline Reward Dependence, Self-Directedness or Cooperativeness were likely more severely depressed at the 4 months follow-up. We suggest that associations between personality traits and remaining depressive symptoms after 4 months treatment with fluoxetine could be caused by the potential differences in the placebo effect.     

Tilrettelaeggelse af medicamentelle behandlingsforsøg ved psykoser

Lett J. Braaten: Psykoterapeutisk leering i grupper. Universitetsforlaget 1974, Oslo. 192 sider. Pris: N.kr. 59,—.

Bogen, B. &; H. S. Sundby (red) (1976): Helsestasjonen — alltid i støpeskjeen.

Erfaringer fra en storkommune. Universitetsforlaget, Oslo-Bergen -Tromsø.     

Foreløbig klinisk vurdering af N 750 SA i behandling af depressive tilstande

Av författama till vidstående artikel är Anse Leroy (bilden till vänster) 1. reservelcege vid Set. Hans Hospital och Jonna Ryberg, tidigare också 1, reservelcege vid Set. Hans Hospital sedan februari 1972 overlage vid Sundbygård.     

Anorexia nervosa: Kliniske eksempler på forskellige typer af behandlingsforløb

Seventy-eight patients with severe alcohol abstinence symptoms were given 20 mg diazepam intramuscularly twice with an interval of 12–24 h, and a further 28 received only one injection. The patients were informed that this was the only pharmacologic treatment given for abstinence. By random allocation 52 patients were given conventional Valium® (solvent, alcohol, propylene glycol, water) and 54 patients Diazemuls® (solvent, o/w emulsion of the Intralipid type). The severity of abstinence symptoms was estimated at admission. Only three epileptic seizures occurred during the treatment period. Most patients had improved enough to be discharged within a week. Diazemuls has previously been shown to cause minimal thrombophlebitis and pain reactions compared with conventional diazepam solutions for injection when given intravenously. Much less is known about reactions at the site of injection when diazepam is given intramuscularly. With both preparations there were virtually no spontaneous reports of pain and also rather few on query. Oral anxiolytic drugs were strictly limited.