Thenar metastasis from lung cancer

We report an unusual occurrence of skin metastasis to the thenar eminence. Skin metastasis reflects the progression of the primary malignancy. Biopsy should be performed from the skin lesions, even those located at uncommon sites, for patients who have a history of uncontrolled lung cancer.     

肺癌眼脉络膜转移的临床分析

目的探讨肺癌眼脉络膜转移的临床特点、诊断和治疗。方法采用回顾性研究的方法,对收治的21例肺癌眼脉络膜转移的临床资料进行总结、分析。结果 21例中,以肺部为首发症状的7例,以眼部为首发症状的14例;肺部病变位于左肺12例,右肺9例;中心型8例,周围型13例。眼部病变位于单眼20例,双眼1例,共22只眼受累,左眼13例,右眼9例;病变位置在后极14例,近视乳头5例,脉络膜周边3例。病理类型:肺腺癌13例,小细胞肺癌4例,鳞癌3例,大细胞肺癌1例。18例并发眼以外器官的转移。随访19例,中位生存期12.0月,1年生存率44.7%,2年生存率6.5%。结论肺癌眼脉络膜转移应对其重视及完善检查,使其尽早确诊。恰当的治疗可延长患者的生存期、缓解症状及提高生活质量。     

Intracranial hemorrhage due to cerebral metastasis of lung cancer - a case report

Lung cancer often metastasizes to brain. However, hemorrhage of the metastatic lesions is uncommon. We report a case of a 68-year old man with lung cancer who underwent right upper lobectomy of the lung and presented in 15 months with a cerebral hemorrhage from a metastatic lesion of the brain.     

肺癌脑膜转移11例临床分析

目的:探讨肺癌合并脑膜转移的临床表现、诊断、治疗和预后。方法:回顾分析11例肺癌脑膜转移患者的临床资料。结果:11例腺癌患者均有头痛、呕吐等神经系统症状,影像学表现为脑膜强化、脑室扩张及脑转移。9例患者颅内压升高,11例患者脑脊液均发现肿瘤细胞。9例患者接受了综合治疗,包括全身化疗、靶向治疗、鞘内化疗、脑室腹腔分流术、全脑放疗。中位生存期3个月。结论:脑膜转移是晚期肺癌并发症之一,根据临床表现、影像学及脑脊液检查可明确诊断。给予鞘内化疗、靶向治疗等综合治疗可减轻症状、延长生存。     

Penile metastasis from lung cancer.

A case of metastatic tumor of the penis from lung cancer is reported. The patient, who had received a right pneumonectomy 17 months previously for a squamous cell carcinoma of the lung, complained of urinary retention and painful erection of the penis. He underwent an emergency suprapubic cystostomy. Twenty days after the procedure, he died of disseminated lung carcinoma. The autopsy demonstrated massive metastasis to the penis from squamous cell carcinoma of the lung. Penile metastasis from lung cancer is a very rare condition and only 14 cases of this secondary carcinoma have been reported.     

A case of small intestinal hemorrhage secondary to metastatic lung cancer in the elderly

Gastrointestinal metastasis from primary lung cancer is rare.In the present study,we report the case of a 78-year-old male who was admitted to the emergency department with acute bleeding of the digestive tract.During evaluation,he was found to have lung adenocarcinoma metastasis in the small bowel leading to hemorrhage.A jejunum wedge resection was carried out and bleeding was controlled.However,2 months after the operation,the patient thed from severe pulmonary infection.We also review the published literature of primary lung cancer with gastrointestinal metastasis.     

Hand-assisted laparoscopic adrenalectomy to a solitary adrenal metastasis from lung cancer

A 75-year-old man with right chest pain was diagnosed with primary lung cancer in the right apical portion, and was treated with chemoradiotherapy because of a synchronous left adrenal tumor of 1.6 cm. Since the adrenal tumor did not increase in size for three months and there were no other relapses, the right upper lobectomy of the lung with the excision of the chest wall was performed. Afterward, an enlargement of the left adrenal tumor was encountered; he was admitted to our hospital for an operation. For the metastatic adrenal tumor from lung cancer, we performed a hand-assisted laparoscopic adrenalectomy. He recovered rapidly and returned to the previous hospital in two weeks after the operation. After the first report in 1992, the laparoscopic adrenalectomy has been established as the curative operation to adrenal benign tumor. The indication is being expanded to the malignancy because of the improvement of operation techniques and advancement of the operation equipments. We conclude that the laparoscopic adrenalectomy for malignant tumor is a safe, curative, and clinically useful surgical technique.     

Management of bone metastasis originating from lung cancer

The preceding molecular target therapies have prolonged the life expectancy of many lung cancer patients, and some lung cancer patients have become long-term survivors. On the other hand, the proportion of patients who suffer from complications with bone metastasis and skeletal-related events(SRE)is increasing. Through management of bone metastasis, the preservation of quality of life and functional independence can be better maintained. Zoledronic acid and denosumab are usable in clinical practice; However, there are many problems in regard to treatments for bone metastasis. Lung cancer patients should be treated with bone metastasis with the coordinating cooperation between orthopedists, radiotherapists and dental surgeons.     

Long-term survival after brain metastasis from lung cancer

A case is reported of prolonged survival after lobectomy for large cell undifferentiated carcinoma of the lung and resection of metastatic carcinoma of the brain. The patient had survived 11 years 5 months after lung resection and 10 years 4 months after excision of brain metastasis. A review of the reports of another 12 patients who survived 5 years or longer after craniotomy, shows that the surgical excision of a single metastatic lesion of the brain with or without postoperative irradiation offers the best hope for prolonged survival.     

An operated case of metastasis to the small intestine from lung cancer

We report a rare case of a 68-year-old man with long-term survival after a surgical treatment of solitary metachronous small intestinal metastasis from lung cancer. He underwent a right upper lobectomy for primary lung adenocarcinoma. Thirty -four months after the operation, a tumor of small bowel was detected by computed tomography. The tumor was resected and diagnosed as a metastasis from lung cancer. Eighteen months after resection of metastasis, a tumor located at mesentery of the jejunum was pointed out. The tumor was resected and also diagnosed as a metastasis from lung cancer. The postoperative course was uneventful, and the patient is still alive without recurrence for 3 years after the last operation. We reviewed of 222 Japanese cases that underwent a resection of small intestinal metastasis from lung cancer. Although the prognosis was extremely poor for those who underwent a resection of the primary lung cancer and who had no remnant metastatic lesion at the time of metastasectomy, they seem to have a longer survival time.     

非小细胞肺癌脑转移治疗进展

非小细胞肺癌(NSCLC)脑转移的治疗方法包括激素、抗惊厥药物治疗、手术、放疗、化疗.近年来分子靶向治疗如表皮生长因子(EGFR)酪氨酸激酶抑制剂(TKI)成为NSCLC脑转移的新的治疗选择.     

Successful management of solitary malar metastasis from lung cancer

A right malar mass developed in a 68-year-old man who had undergone right upper and middle bilobectomy for lung cancer 2 years previously. The mass was diagnosed to be a malar metastasis from lung cancer and was surgically resected because no other metastases were found. The patient is well without signs of recurrence 5 years after resection of the malar mass. This is the first report of a malar metastasis from lung cancer and of successful resection for malar metastasis.     

Diagnosis and treatment of cerebral metastasis from lung cancer

A clinical analysis of 38 patients with cerebral metastasis from lung cancer is reported 17 patients had primary cancer symptoms prior to the increased intracranial pressure 34 patients were examined by cerebral angiography or ventriculography and 4 by CT scan. The incidence of cerebral metastasis with lung as the primary focus ranks first (54.7%). Three pathologic processes of intracranial metastasis: (1) cancer cell thrombosis stage (2) growth reaction stage (3) increased intracranial pressure stage. In this series, 16 patients were given conservative treatment and 22 were operated by craniotomy and resection. The results show that the operation could improve the symptoms and signs and prolong the survival time. The surgical treatment of lesions in the brain is emphasized and the indications are discussed.     

肺癌肾上腺转移30例分析

目的 探讨肺癌肾上腺转移的综合治疗效果。方法 回顾性分析1995年2月-2001年4月间收治的30例肺癌肾上腺转移患者资料，其中小细胞肺癌14例，非小细胞肺癌16例，患者均采用化疗和（或）放疗，18例化疗 放疗综合治疗，12例单纯化疗。结果 全组患者中位生存期8个月，12例单纯化疗者中部分缓解3例，有效率为25.0%；18例化疗 放疗综合治疗者中完全缓解1例，部分缓解7例，有效率为44.4%，有疼痛症状者放疗后疼痛明显缓解。结论 肺癌肾上腺转移的化疗 放疗的综合治疗比单一化疗效果更好。     

肺癌转移进展

肺癌的发病率和死亡率一直居高不下,肺癌患者的预后一直未得到有效提高。原因是因为肺癌是一种非常复杂的肿瘤,而肺癌的转移是肺癌的恶性标志和特征,也是导致治疗失败和患者死亡的主要原因。约30%的患者在诊断时就已有远处转移,50-60%在治疗过程中发生远处转移,80-90%的肺癌患者死亡是由转移引起的。因此,肺癌的转移是一个重大的难题。其中,肺癌脑转移和骨转移是最常见的转移部位,约占总转