共查询到20条相似文献,搜索用时 31 毫秒
1.
mputer Enginee 《中国现代医药杂志》2006,(11)
椎-基动脉供血不足(vertebrobasifarinsufficiency,V BI)是指椎-基动脉由于各种原因引起的形态、机能的异常,产生相应灌流区供血不足,引起眩晕、头晕、复视、共济失调、偏瘫、视力及视野改变等临床症状,而眩晕、头晕为其主要症状。我们采用盐酸倍司汀联用参麦注射液治疗椎-基动 相似文献
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Immunogenicity is a frequent adverse event observed with biological agents' therapy. Challenges of management in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis treated with golimumab, an anti-TNF-alpha blocker, include limited generation of antibodies like anti-nuclear, anti-golimumab, and anti-double stranded DNA antibodies. We conducted here a meta-analysis study in order to evaluate and compare the newly generated antibody levels after golimumab therapy. The examination of original clinical trials revealed that their levels were neither higher nor significant. Moreover, no evident associations between the induced-antibodies and lupus-like syndromes and/or infusion site reaction were reported. The reduced patients cohort and the absence of systematic newly generated antibodies follow-up might be implicated in the difficulty to evaluate their risk in delaying diseases therapy, and/or predicting for their worse prognosis. Hence, further studies are required to ascertain the real impact of the induced antibodies after golimumab's therapy. 相似文献
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《Journal of pharmaceutical and biomedical analysis》1996,14(3):233-246
Biological macromolecules are complex systems and in order to understand their inner workings we need information from many sources. In this review we present some of the underlying principles for current methods of choice for structural and dynamical studies of biological macromolecules. Interplay between these disciplines—X-ray diffraction, nuclear magnetic resonance spectroscopy and theoretical calculations—has been extremely fruitful and our knowledge in this area of bioscience is rapidly increasing due to this cross-fertilization. While structural aspects of proteins are increasingly well studied and understood we do however still need to put more emphasis on their dynamical properties. 相似文献
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《中国药理学与毒理学杂志》2006,(3)
S21Possibleinvolvementofhereditaryfactors intheriskmodulationofarseniasisintwoethnic clansexposedtoindoorcombustionofhigharse niccoal LINGuo Fang1,DUHui2,CHENJi Gang3,LU Hong Chao2,GUOWei Chao1,ZHANGXin Jiang4,SHENJian Hua1(1.ShanghaiInstituteforBiologicalSciences,Institute ofPlantPhysiologyandEcology,ChineseAcademyof Sciences,Shanghai200032,China;2.Prefecture CenterforDiseasePreventionandControl,Guiyang562400,China;3.MunicipalCenterforDiseasePre ventionandControl,Shang… 相似文献
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《中国药理学与毒理学杂志》2006,(3)
W31ICHS8Guideline:immunotoxicitystud iesforhumanpharmaceuticals JSAWADA(NationalInstituteofHealthSciences,Tokyo,Japan)Toxicitytotheimmunesystemencompassessup pressionorenhancementoftheimmuneresponse.Sup pressionoftheimmuneresponsecanleadtodecreased hostresistancetoinfectiousagentsortumorcells.En hancingtheimmuneresponsecanexaggerateautoim munediseasesorhypersensitivity.Therfore,evaluationofpotentialadverseeffectsofhumanpharmaceuticals ontheimmunesystemshouldbeincorporatedinto standardd… 相似文献
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《Acta pharmacologica Sinica》1998,(Z1)
Onceaclinicaltrialiscompleted,itmustbepublishedinorderforotherstoknowofitsresults.Primarysource,perreviewedmedicaljournalsar... 相似文献
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《中国药理学与毒理学杂志》2006,(3)
W1:ToxicogenomicsandProteomics W11Differentialgeneexpressionprofilesofacuteandchronicinjuryandrecoveryinratliv ersteatosis fibrosis/cirrhosismodel HeekyoungCHUNG(KST)W12SNPsinCYP450s:apreliminaryphar macogenomicstudyinaChinesepopulation WENSi Yuan1,CHENKun2,XULi1,LIJian2,WANGRui2,WANGSheng Qi1(1.BeijingInstituteofRadiationMedicine,2.Beijing301GeneralHospital,Beijing100039,China)Pharmacogenomicswasestablishedonthefactthat certaingeneticpolymorphismsmaycausesignificantly di… 相似文献
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Acid–base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton–Robinson’s buffer at 25 °C. Acidity constant of loratadine was found to be pKa 5.25 and those of desloratadine pKa1 4.41 and pKa2 9.97. The values of intrinsic solubilities of loratadine and desloratadine were 8.65 × 10−6 M and 3.82 × 10−4 M, respectively. Based on the pKa values and intrinsic solubilities, solubility curves of these two drugs as a function of pH were calculated. The effects of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micelle concentration (cmc) on acid–base properties of loratadine and desloratadine, as well as on intrinsic solubility of loratadine were also examined. The results revealed a shift of pKa values in micellar media comparing to the values obtained in water. These shifts (ΔpKa) ranged from −2.24 to +1.24. 相似文献
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Fitting Sylvia McRae MaryPeace Hauser Kurt F. 《Journal of neuroimmune pharmacology》2020,15(4):584-627
Journal of Neuroimmune Pharmacology - With the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus... 相似文献
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Evidence suggests that in-utero exposure to environmental chemicals, such as persistent organic pollutants (POPs), heavy metals, and radionuclides, that might bioaccumulate in the mother may increase a newborn's risk of adverse developmental, neurological, and immunologic effects. Chemical contamination of bodies of water and strong ocean currents worldwide can drive these chemicals from lower latitudes to Arctic waters where they accumulate in common traditional subsistence foods. In response to concerns of the people from Alaska of the effects of bio-accumulated chemicals on their children, the Maternal Organics Monitoring Study(MOMS) was developed. The objective of the study was to assess the risks and benefits associated with the population's subsistence diet. Data analysis of biological samples at the CDC's NCEH laboratory and maternal questionnaires is ongoing. Results will be provided to Alaska Native communities to help support public health actions and inform future interventions and research. 相似文献
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Oumar Ouchar Mahamat Marie Kempf Manon Lounnas Abelsalam Tidjani Mallorie Hide Julio A. Benavides Christian Carrière Anne-Laure Bañuls Hélène Jean-Pierre Abdoul-Salam Ouedraogo Yann Dumont Sylvain Godreuil 《International journal of antimicrobial agents》2021,57(1):106203
Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) are widespread. Here we used the ‘One Health’ approach to determine knowledge gaps on ESBL-E and CPE in West and Central Africa. We searched all articles on ESBL-E and CPE in these African regions published in PubMed, African Journals Online and Google Scholar from 2000 onwards. Among the 1201 articles retrieved, we selected 165 studies (West Africa, 118; Central Africa, 47) with data from 22 of the 26 West and Central Africa countries. Regarding the settings, 136 articles focused only on humans (carriage and/or infection), 6 articles on humans and animals, 13 on animals, 1 on humans and the environment, 8 on the environment and 1 on humans, animals and environments. ESBL-E prevalence ranged from 11–72% in humans and 7–79% in aquatic environments (wastewater). In animals, ESBL-E prevalence hugely varied: 0% in cattle, 11–36% in chickens, 20% in rats, 21–71% in pigs and 32–75% in dogs. The blaCTX-M-15 gene was the predominant ESBL-encoding gene and was associated with plasmids of incompatibility groups F, H, K, Y, N, I1 and R. CPE were studied only in humans. Class B metallo-β-lactamases (NDM) and class D oxacillinases (OXA-48 and OXA-181) were the most common carbapenemases. Our results show major knowledge gaps, particularly on ESBL and CPE in animals and the environment, that might limit antimicrobial resistance management in these regions. The results also emphasise the urgent need to improve active surveillance programmes in each country and to support antimicrobial stewardship. 相似文献
15.
Huperzine-A and ginkgolides inhibit nitric oxide production from rat and human astrocytoma and block its neurotoxicity 总被引:1,自引:0,他引:1
《Acta pharmacologica Sinica》1999,(5)
While the complex reasons causing Alzheimer's disease (AD) remain unclear, pre-inflammatory cytokines, complement proteins, activated glia, and nitric oxide (NO) are proposed playing important roles in AD.Using cultured rat C6 and human BT325 astrocytoma cell lines as model of astrocytes, and human neuroblastoma SK-N-SH cell line as target cell in the potential neurotoxicity,the effects of lipopolysaccharide(LPS) and proinflammatory cytokines on NO production from cultured astrocytes, the effects of NO on the proliferation and apoptosis of 相似文献
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Ethopharmacological studies on the behavior of socially housed rats and squirrel monkeys were conducted to explore the role of the benzodiazepine GABAA-coupled ionophore receptor complex in aggressive and social interactions. Benzodiazepine receptor (BZR) antagonists, ZK 93426 (1–10 mg/kg) and flumazenil (3–10 mg/kg), the partial agonist, ZK 91296 (1–10 mg/kg) and the partial inverse agonists RO 15-4513 (0.3–10 mg/kg), were administered to (1) squirrel monkeys prior to 1 h focal observations within established social groups or to (2) resident male rats before confrontations with a naive male intruder in their home cage for 5 min. Aggression was modified in a similar manner in both species, although squirrel monkeys were more sensitive to BZR challenges. Specifically, resident male rats showed dose dependent reductions in attack bites directed at intruder males that were significant at the highest dose of ZK 93426 (10 mg/kg). In squirrel monkeys, ZK 93426 (3 and 10 mg/kg) reduced aggressive grasps, threats and displays, as well as reducing the duration of being the target of aggression from untreated group members (1–10 mg/kg). The BZR partial agonist, ZK 91296 and the antagonist, flumazenil produced few effects on social behavior, low and high intensity aggression and motor activity in both species. Flumazenil (10–30 mg/kg) and ZK 91296 (10 mg/kg), but not ZK 93426, produced significant increases in foraging and feeding behaviors in squirrel monkeys. The hyperphagic effects of ZK 91296 and flumazenil, that are typical of BZR agonists compounds, were not observed in rats. Similarly, the inverse agonist-like reductions in social interactions produced by ZK 93426 (3–10 mg/kg) were observed only in squirrel monkeys. The partial inverse agonist Ro 15-4513 reduced aggression in rats, but low doses (1 mg/kg) produced tremors or seizures in 80% of the monkeys tested. Decreases in aggressive and social behaviors are often interpreted to reflect anxiogenic drug properties, whereas increased feeding has been associated with anxiolytic actions. The concurrent emergence of these apparent opposites suggests independent actions on social and alimentary functions. 相似文献
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《Xenobiotica; the fate of foreign compounds in biological systems》2013,43(9):995-1005
1. The toxicokinetics of [3H]-α-solanine after oral (p.o.) and intravenous (i.v.) administration in rat and hamster were studied, in order to decide which is the most appropriate model in risk assessment studies. The i.v. Dose was 54 βg/kg; the oral dose was 170 βg/kg.2. After i.v. Administration, the toxicokinetics of total radioactivity in blood were comparable in rat and hamster. However, the clearance of total radioactivity from plasma was more effective in rat than in hamster. The half-lives of distribution and of the terminal phase of unchanged α-solanine were not different between rat and hamster, whereas the systemic and metabolic clearance were, respectively, about 1.6 and 2.7 times higher in rat than in hamster. The clearance of unchanged α-solanine is more effective than of total radioactivity.3. After p.o. Administration in rat and hamster, the mean bioavailability of total radioactivity is about 29 and 57%, respectively. The bioavailability of unchanged α-solanine is only 1.6 and 3.2%, respectively, when compared with i.v. administration.4. T1/2el of α-solanine after p.o. Administration was in rats a factor of four and in hamsters a factor of two shorter than after i.v. Administration. A strong retention of radioactivity was seen in the hamsters after p.o. Administration; only 40% of the dose was excreted within 7 days versus 90% in rat.5. Based on these and toxicological data from literature, it was decided that the hamster is a more appropriate model in (sub) chronic toxicity studies with α-solanine than the rat. 相似文献
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β-blockers are a class of antihypertensive drugs that are used for the management of cardiac arrhythmias, cardioprotection after myocardial infarction (heart attack) and hypertension. They have revolutionized the medical management of angina pectoris and are recommended as first-line agents by national and international guidelines. Although β-blockers are still the cornerstone for the treatment of heart failure, some of the drugs in this category are prohibited in several sports requiring vehicle control and bodily movements as they reduce heart rate and tremors, and improve performance. As a result, urine analysis of β-blockers is mandatory in doping control and toxicological screening. The determination of plasma levels of β-blockers helps to ensure noncompliance in patients with persistent hypertonia to confirm the diagnosis of β-blocker poisoning and for therapeutic drug monitoring. This review provides a comprehensive account of various analytical methods developed for detection and quantitation of β-blockers in plasma and urine. 相似文献
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Aims: Previous studies suggested that Salvianolic acid B (SalB) has strong protective effect against cerebral ischemia. Recently, Sal B has been reported to enhance angiogenesis in vitro. Based on the information above, in this study we are interested in the effect of SalB on neurogenesis and angiogenesis. Methods:In vitro study, we used embryonic mouse (El6) primary cortical neural cultures. Neuron was recognized by anti-MAP2 with immunocytochemistry. Neurogenesis was tested with BrdU incorporation by ELSA method. SalB( 10 -6 -10 -8M) or vehicle was added to the culture medium 24 hrs before BrdU addition. In vivo, middle cerebral artery occlusion (MCAO) rats were used as focal cerebral ischemia model. 相似文献
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Shrestha SP Thompson JA Wempe MF Gu M Agarwal R Agarwal C 《Pharmaceutical research》2012,29(3):856-865