An extrapulmonary manifestation of lymphangioleiomyomatosis: A rare case report

Lymphangioleiomyomatosis (LAM) is a rare and fatal disease which occurs almost exclusively in young women. The disease often affects lungs and most of the patients die from respiratory failure. It is often initially misdiagnosed as asthma or chronic obstructive pulmonary disease. The most common presentations of pulmonary LAM (P-LAM) include dyspnea and coughing. Chylothorax and spontaneous pneumothorax may be seen in advanced cases. Although rare, it may present with extrapulmonary LAM (E-LAM). Renal angiomyolipomas and abdominal lymphadenopathies (LAPs) are common in E-LAM cases. Pelvic retroperitoneal masses are very rare and often require exploratory laparotomy. Herein, we report a 36-year-old female case of a rare extrapulmonary manifestation of LAM who was treated with abdominal and thoracic surgery, radiotherapy and finally sirolimus.     

Lead-related gout. A case report

Gout secondary to lead-induced nephropathy is a long-term complication of occupational lead exposure. We report a case of this now-rare condition. The patient was a 63-year-old man who had been a miner from 1950 to 1970. Thirty years after cessation of his exposure to lead, he experienced onset of inflammatory symmetric polyarthritis with joint deformities. Hyperuricemia, moderately severe renal failure, and tubular acidosis were found, indicating gouty polyarthritis. Blood lead levels were high, establishing that the cause was lead poisoning. EDTA chelation therapy was effective. Lead poisoning is frequently under-recognized because the clinical manifestations are often minimal and the diagnosis difficult to establish. We suggest that lead bound to bone may result in continued exposure to lead after cessation of industrial or environmental exposure. Chelating agents are valuable for the diagnosis and can ensure a full recovery.     

Acute acalculous cholecystitis as a rare manifestation of chronic mesenteric ischemia. A case report

IntroductionSymptomatic chronic mesenteric ischemia (CMI) is an uncommon condition that usually presents with intestinal angina, sitophobia and unintentional weight loss. Acute acalculous cholecystitis (AAC) has very rarely been described in the settings of CMI.Presentation of caseWe describe a case of a 73 year old man that developed an AAC as a complication of CMI. The patient underwent a simultaneous cholecystectomy and open aortic revascularization which was successful. At 24 months of follow-up the patient is clinically well and regained weight.DiscussionIschemia has been considered an important etiology for the development of AAC. In the settings of CMI, an AAC might develop has a herald sign of progression to acute mesenteric ischemia and infarction, as the cystic artery is a terminal artery with no collateral network. Performing the aortic revascularization simultaneously with the cholecystectomy might prevent this possible fatal outcome.ConclusionThis case reinforces aortic and visceral occlusive disease as a possible risk factor for the development of AAC, and discusses the treatment controversies when managing both conditions simultaneously.     

Retroperitoneal paraganglioma presenting with pancytopenia: A rare case with rare manifestation

IntroductionParagangliomas are tumors that arise from extraadrenal chromaffin cells and most of them are asymptomatic presenting with painless mass. Retroperitoneal paragangliomas are mostly benign with good prognosis; however, they can present with abdominal pain, palpable mass, or hypertensive episodes. Surgical resection is still the main treatment and necessary for histological assessment.Case reportA 41 year old female patient presented with 6 months of loss of appetite, weight loss, weakness and breathlessness on exertion.. The patient’s initial blood examination showed marked anemia, reduced leukocyte count with neutropenia and lymphopenia and a marked reduction in the platelet count. The patient was admitted for evaluation of her pancytopenia. Magnetic resonance imaging revealed a 8 × 7 × 8 cm sized mass closed to the pancreatic tail invading splenic hilum. A large mass was identified retroperitoneally, closed to the tail of pancreas with a splenic hilum invasion. Total mass resection and splenectomy was performed.DiscussionComplete surgical excision is the treatment of choice for extra-adrenal paragangliomas as well as for recurrent or metastatic neoplasms. Reactive thrombocytosis is a common cause of thrombocytosis. Splenectomy was found to be one of the main causes of extreme reactive thrombocytosis. Reactive thrombocytosis is a predictable finding after splenectomy and management of the thrombocytosis and prevention of complications should be initiated.     

Parosteal osteosarcoma of the distal ulna. A rare tumour at a rare location: a case report

We report a case of a histologically well differentiated, grade I, parosteal osteosarcoma of the distal ulna. The tumour's radiological and histological features are described, and the patient's course after wide en-bloc resection is detailed. Parosteal osteosarcoma is a rare low-grade malignant neoplasm. It belongs to the group of the osteosarcomas originating from the surface of the bone, representing a distinct tumour entity within this group, with defined histological and radiological features. We describe the radiological and histological characteristics of parosteal osteosarcoma and, based upon these features, present its classification. The differential diagnosis, including parosteal osteoma, myositis ossificans and osteochondroma, is also discussed. Finally, therapy and prognosis are outlined in accordance with the current literature. Wide en-bloc resection represents the mainstay of therapy offering an excellent prognosis with a 5-year survival rate of more than 90%. Incomplete resection, on the other hand, increases the risk of recurrence and dedifferentiation of the tumour. Dedifferentiation induces tumour spread and is associated with a poor prognosis equivalent to conventional osteosarcoma.     

Osteolipoma of the ankle: A rare case report

Osteolipoma are uncommon benign soft tissue tumors, deriving from fat cells metaplasia. We report a case of 47-year-old female with a progressively enlarging, painless mass over the anteromedial aspect of left ankle, explorations showed a calcified masse and histopathologic diagnosis was in favor of osteolipoma, which was resected surgically without any recurrence after 2 years follow up. This tumor can affect different regions of the body but ankle location is very rare and must be distinguished from other diagnosis essentially sarcoma.     

A rare intramuscular hemangioma — case report

Intramuscular hemangiomas are rare, slow growing, angiomatous tumors, generally asymptomatic, and rarely presenting with complications. We report a rare case of a Hemangioma of the Flexor Digitorum Superficialis in a 13-year-old boy, present since birth and with extensive involvement, necessitating excision of the muscle. The patient is presently doing well, barring minimal weakness in finger flexion.     

Case report. Initial manifestation of gout after carpal tunnel release.

A carpal tunnel release was performed on a patient with recurrent carpal tunnel syndrome and asymptomatic hyperuricaemia with no prior history of gouty arthritis. Intraoperatively, the patient was found to have tenosynovitis without crystals or tophaceous deposits in the carpal tunnel. Postoperatively, the patient developed an acutely inflamed hand, which responded dramatically to anti-gout medications. We report this patient as an initial attack of gout after a carpal tunnel release.     

Ovarian haemangioma: A rare case report

INTRODUCTIONHaemangioma of ovary is a rare tumour.PRESENTATION OF CASEWe report an ovarian haemangioma which presented as an acute abdomen due to an adnexal mass.DISCUSSIONWe report an ovarian haemangioma which presented as an acute abdomen due to an adnexal mass. Haemangiomas have been reported in other organs but ovarian haemangioma is a rare tumor, usually asymptomatic and presenting as an incidental finding. Large lesions tend to present clinically with pain. A few cases have been described in the literature.CONCLUSIONConsidering their rare occurrence such tumors are a diagnostic challenge.     

Septic arthritis of the knee caused by antibiotic-resistant Acinetobacter baumannii in a gout patient: a rare case report

Over recent years, the incidence of infection caused by antibiotic-resistant Acinetobacter baumannii (a conditional pathogenic bacterium) has showed an increasing trend in such hospital departments as ICUs. Infections caused by antibiotic-resistant A. baumannii have drawn much attention from the medical professionals because it is difficult to manage such infections, and because the mortality related to such infections is high. To date, no cure of gouty arthritis and septic arthritis meanwhile complicated by antibiotic-resistant A. baumannii infection has been reported. We cured such a patient of intractable knee infection caused by A. baumannii resistant to all conventional antibiotics including imipenem by taking comprehensive measures including surgery, and infection did not recur during the 14-month follow-up.