Study Program

Book review in this article:
TEXTBOOK OF DERMATOLOGY . Arthur Rook, D. S, Wilkinson and F. J. G. Ebling     

Book Review

Book reviewed in this article:
Text of dermatology , 4th edition, Eds. A. Rook, D. S. Wilkinson, F. J. G. Ebling, R. H. Champion and J. L. Burton.     

BOOK REVIEWS

Book reviews in this article:
Textbook of Dermatology . Edited by A. Rook, D. S. Wilkinson and F. J. G. Ebling.
A Colour Atlas of Pathogenic Fungi . Dorothea Frey. Ronald J. Oidfield and Ronald C. Bridger.
Dermabrasion and Chemical Peeling in the Treatment of Certain Cosmetic Defects and Diseases of the Skin. By James W. Burks.
Your Skin: Its Problems and Care . By S. A. Zacarian.     

Book Review

Books reviewed in this article:
Rook/Wilkinson/Ebling Textbook of Dermatology . 5th edn. E dited by R.H.C hampion , J.L.B urton and F.J.G.E bling .
Cutaneous Surgical Anatomy of the Head and Neck . E.A.B reishch and H.T.G reenway .
Writing Successfully in Science . M aeve O'C onnor .     

BOOK REVIEW

Book Reviewed in this article:
Rook's Textbook of Dermatology. Edited by RH Champion, JL Burton & FJG Ebling     

Erythema gyratum repens,a stage in the resolution of pityriasis rubra pilaris?

Erythema gyratum repens (EGR) is a rare and distinctive eruption which is widely regarded as a marker of internal malignancy (Rook, Wilkinson & Ebling, 1979). We report two cases of pityriasis rubra pilaris which presented in the classical form, but developed EGR during the resolving stage of the condition. Malignancy was not detected in cither case, despite extensive investigation.     

Livedo reticularis and neurological lesions

Two patients with extensive livedo reticularis have developed multiple severe neurological lesions over a 6-year period. The possible pathogenesis is discussed. The presence of livedo reticularis has been described in conjunction with many diseases (Rook, Wilkinson & Ebling, 1979). A rare association between this condition and neurological syndromes has also been reported (Sneddon, 1965; Quimby & Perry, 1980). We report two cases which add further support to this association.     

Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex

Androgenetic alopecia in the female occurs much more frequently than is generally believed. The condition is still considered infrequent, for it differs, in its clinical picture and in the sequence of events leading to it, from common baldness in men. To facilitate an early diagnosis (desirable in view of the therapeutic possibilities by means of antiandrogens) a classification of the stages of the common form (female type) of androgenetic alopecia in women is presented. The exceptionally observed male type of androgenetic alopecia can be classified according to Hamilton or to the modification of this classification proposed by Ebling & Rook.     

Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under 26 years old

BACKGROUND: Finasteride is a 5alpha-reductase inhibitor that has proved to be an effective treatment for men with androgenetic alopecia. OBJECTIVES: To investigate the hormonal influence of finasteride 1 mg daily on hormonal levels and hair growth in men of different ages and with different degrees of alopecia according to the Hamilton-Norwood scale. METHODS: Two hundred and seventy men aged 14-58 years with male androgenetic alopecia III-VI Hamilton-Norwood score (II-III Ebling score) were treated with finasteride 1 mg daily. Steroid hormone (free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone-sulphate, delta4-androstenedione, 17-hydroxyprogesterone), prostate-specific antigen (PSA) and sebum levels, and trichogram changes were determined at baseline, and at 6 and 12 months of treatment. RESULTS: According to significant hormonal statistical analysis, the patients were divided by age (up to or over 26 years). In the group of patients26 years. No variations in sebum levels were observed. CONCLUSIONS: High levels of 5alpha-dihydrotestosterone in patients相似文献   

Fragrances Contact hypersensitivity to ylang-ylang oil

Book reviewed in this article:
Frosch P J, Dooms-Goosens A, Lachapelle J M, Rycroft R J G & Scheper R J. (eds): Current topics in contact dermatitis.     

Book Reviews

Book reviewed in this article:
Pediatric Secrets . Richard A. Polin and Mark F. Ditmar, editors
Smooth as a Baby's Bottom—A Dermatologist's Complete Guide to Your Child's Skin Care . Gary Gewirtzman
Models in Dermatology . H. I. Maibach and N. J. Lowe, editors
Skin Tumors: Experimental and Clinical Aspects. Carcinogenests: A Comprehensive Survey, Vol. 11. . Claudio J. Conti, Thomas J. Slaga, and Andres J. P. Klein-Szanto, editors     

Book Reviews

Books reviewed in this article:
The Scientific Basis of Dermatology—a Physiological Approach. Edited by A.J.T hody and P.S.F riedman
The Biochemistry of Disease, Volume 12. Connective Tissue Disease. Edited by J.U itto and A.J.P erejda
Progress in Lipid Research Vol. 25-Essentially Fatty Acids, Prostaglandins and Leukotrienes. Edited by R.T.H olman
Dermatological Thermography. G. stuttgen and U. flesch
Vascular Birthmarks: Pathogenesis and Management. Edited by T.J.R yan and G.W.C herry
Food Allergy and Intolerance. Edited by J.B rostoff and S.J.C hallacombe
Clinics in Immunology and Allergy; Vol. 6 No. 3: AIDS and HIV Infection. Edited by A.J.P inching
Textbook of Dermatology. Edited by A.J.R ook , D.S.W ilkinson , F.J.G.E bling , R.H.C hampion and J.L.B urton
Advances in Dermatology Vol. 2. Edited by J.P.C allen , M.V.D ahl , L.E.G oltz , J.E.R asmussen and S.J.S tegman
Sexually Transmitted Diseases. Edited by Y.M.Felman
Connective Tissue Diseases, 3rd Edition. Graham R.V.Hughes
Atlas of Cutaneous Surgery. N.A.S wanson     

Topical aminolaevulinic acid‐based photodynamic therapy as a treatment option for psoriasis? Results of a randomized,observer‐blinded study

BACKGROUND: Topical aminolaevulinic acid-based photodynamic therapy (ALA-PDT) has recently been tried in small open studies for several inflammatory dermatoses including psoriasis. OBJECTIVES: The purpose of this randomized, within patient comparison study was to investigate whether topical ALA-based PDT using a range of light doses can induce a satisfactory response in localized psoriasis. PATIENTS AND METHODS: Twenty-nine patients with chronic plaque type psoriasis were enrolled in the study. After keratolytic pretreatment three psoriatic plaques in each patient were randomly allocated to PDT with 1% ALA and a light dose of 5 J cm(-2), 10 J cm(-2) or 20 J cm(-2), respectively. Treatment was performed twice weekly until complete clearance or for a maximum of 12 irradiations. As a measure of clinical response the psoriasis severity index (PSI) of the three target plaques was assessed separately by an observer blinded to the treatment at baseline, before each PDT treatment and 3-4 days after the last irradiation. RESULTS: Eight patients withdrew prematurely from the study. Keratolytic pretreatment alone reduced the baseline PSI in all three dose groups by about 25%. Subsequent PDT with 20 J cm(-2) resulted in a final reduction of PSI by 59%, PDT with the lower doses of 10 J cm(-2) and 5 J cm(-2) decreased the baseline PSI by 46% and 49%, respectively. The difference in clinical efficacy between 20 J cm(-2) and 10 J cm(-2) or 5 J cm(-2) was statistically significant (P = 0.003; P = 0.02), whereas no difference was found between 10 J cm(-2) and 5 J cm(-2) (P = 0.4). All patients reported some degree of PDT-induced stinging or burning during irradiation. CONCLUSIONS: The unsatisfactory clinical response and frequent occurrence of pain during and after irradiation renders topical ALA-based PDT an inadequate treatment option for psoriasis.     

Book Review

Book reviewed in this article:
AIDS and the mouth. Diagnosis and management of oral lesions. D. Greenspan, J. Greenspan, J. J. Pindborg and Morten Schiodt.     

Scalp Dermatoscopic Findings in Androgenetic Alopecia and Their Relations with Disease Severity

Background

Clinicians are searching for new methods to diagnose and predict the course of androgenetic alopecia noninvasively.

Objective

Our aim is to evaluate trichoscopic findings and their relations with disease severity in androgenetic alopecia.

Methods

The videodermatoscopic findings of 143 female and 63 male patients with androgenetic alopecia were compared with each other, with those of healthy subjects (n=100), and with those of patients with other nonscarring alopecias (n=208). Mann-Whitney U-test, χ² analyses, and logistic regression analysis were used for statistical analysis.

Results

No statistically significant relation was found between trichoscopic findings and severity in male androgenetic alopecia (MAGA) on the basis of the modified Hamilton Norwood scale (among 7 degrees); however, multihair follicular unit and perifollicular pigmentation were related to low severity whereas white dots, honeycomb pattern pigmentation, and brown dots were related to high severity. On the other hand, according to the Ludwig classification, arborizing red lines were related to low severity and brown dots were related to high severity, whereas there was no difference in stages between the Ebling and Olsen classifications in female androgenetic alopecia (FAGA). In the characteristic trichoscopic findings in this study, perifollicular pigmentation was found as a normal feature of the scalp, whereas multihair follicular unit and honeycomb pigment pattern, which were previously considered as normal features, were observed to be related to androgenetic alopecia.

Conclusion

No relation was found between MAGA severity and trichoscopic findings, as well as between FAGA severity according to different disease severity classifications and trichoscopic findings.     

Book Reviews

Book review in this article:
COMMON PROBLEMS IN DERMATOLOGY . Kenneth E. Greer.
DERMATOLOGICAL SIGNS OF INTERNAL DISEASE . J. P. Callen, J. Jorizzo, K. E. Greer, N. Penneys, W. Piette, J. J. Zone.
SURGICAL ANATOMY OF THE SKIN . Stuart J. Salache, Gerald Bernstein, Mickey Senkarik.
ESSAYS ON LEPROSY . Terence J. Ryan, A. Colin McDougall, Editors.     

Book Reviews

Books reviewed in this article:
Oral Cancer and Precancer. J.J. Pindborg
Differential Diagnosis in Dermatopathology. A. B. Ackerman, J. Niven and J. M. Grant-Kels
Biology of Skin Cancer (excluding Melanomas). Eds. O. D. Laerum and O. H. Iversen     

Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A

BACKGROUND: Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. OBJECTIVES: To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). METHODS: Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0.33 mg L-1, 0.1 mg L-1 and 0.033 mg L-1 at 2-week intervals. Geometric UVA dose series increasing by a factor of radical2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. RESULTS: For the highest TMP concentration of 0.33 mg L-1, the median MPD72 h was 0.14 J cm-2 (95% confidence interval (CI), 0.10-0.14 J cm-2). For the diluted TMP bath concentration of 0.1 mg L-1, the median MPD72 h increased to 0.29 J cm-2 (95% CI, 0.2-0.41 J cm-2) and for 0.033 mg L-1 to 0.81 J cm-2 (95% CI, 0.57-1.15 J cm-2), respectively. Thus, diluting the labelled concentration of 0.33 mg L-1 1 : 10 increased the median MPD72 h 5.6-fold. CONCLUSIONS: With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials.     

Book Reviews

Books reviewed in this article:
Cutaneous Medicine and Surgery - An Integrated Program in Dermatology . Edited by K.A.A rndt , P.E. L eboit , J.K.R obinson
Pocket Guide to Cutaneous Medicine and Surgery . Edited by J.S.D over
Cutaneous Medicine and Surgery: Self Assessment and Review . J.S.D over (Edited in consultation with K.A.A rndt , P.E.L e boit , J.K.R obinson , B.U.W introub )     

紫外线对光化性角化病和正常皮肤p53、基质金属蛋白酶2、9表达的影响

目的 探讨不同剂量紫外线对光化性角化病（AK）与正常皮肤组织中增殖与凋亡、及p53、基质金属蛋白酶（MMP）2和MMP9表达的影响。方法 AK与正常皮肤组织分别分为4个组,对照组（照射剂量为0 J/cm2）、5 J/cm2组、10 J/cm2组、20 J/cm2组。每块组织连续照射4 d,继续培养24 h后取材。TUNEL检测细胞凋亡、Ki-67检测细胞增殖情况,定量PCR及免疫组化法检测p53、MMP2及MMP9表达。 结果 紫外线照射后,与对照组相比,凋亡细胞百分比在正常皮肤组织 10、20 J/cm2组（46.8 ± 2.1,56.7 ± 2.4）增加,在AK 20 J/cm2（43.5 ± 1.5）组增加,正常皮肤组织10、20 J/cm2组比AK同剂量组增加（P < 0.05）;Ki-67阳性细胞百分比在正常皮肤组织20 J/cm2组（3.34 ± 0.76）表达减少（P < 0.05）,在AK中无明显变化（P > 0.05）;p53 mRNA（5 J/cm2：1.106 ± 0.025;10 J/cm2：1.259 ± 0.045;20 J/cm2：1.425 ± 0.053）及蛋白（10 J/cm2：0.1169 ± 0.0032;20 J/cm2：0.1454 ± 0.0047）在正常皮肤组织中表达增加,在AK中,mRNA（10 J/cm2：0.611 ± 0.050;20 J/cm2：0.578 ± 0.070）及蛋白（20 J/cm2：0.0404 ± 0.0027）表达减少（P < 0.05）;正常皮肤组织中MMP2 mRNA及蛋白（10 J/cm2：1.086 ± 0.013,0.0843 ± 0.0024;20 J/cm2：1.417 ± 0.036,0.1236 ± 0.0042）、MMP9 mRNA及蛋白（20 J/cm2：1.395 ± 0.026,0.3065 ± 0.0162）表达增加,AK中MMP2 mRNA及蛋白（20 J/cm2：1.296 ± 0.028,0.0744 ± 0.0032）、MMP9 mRNA及蛋白（10 J/cm2：1.298 ± 0.035,0.0992 ± 0.0053;20 J/cm2：1.286 ± 0.032,0.1010 ± 0.0063）表达增加（P < 0.05）。结论 紫外线促进AK进展可能与其下调p53表达,上调MMP2和MMP9有关。