非甾体抗炎新药舒林酸的抗炎,镇痛和解热作用

舒林酸有明显的抗炎，镇痛、解热作用。灌胃给药使巴豆油致小鼠耳廓肿胀、角叉菜胶致大鼠足碱肿胀抑制２５％的半数有数量分别为３６±ｓ６和１４±５ｍｇ／ｋｇ，２０和４０ｍｇ／（ｋｇ．ｄ）或连续５ｄ对棉球肉芽肿和佐剂性关节炎也有显抑制作用，镇痛试验：小鼠热板法醋酸扭体法测得ＥＤ５０分别为４６±１９５２±１１ｍｇ／ｋｇ；命名酵母致热大鼠降低１℃的ＥＤ５０为６．２±２．５ｍｇ／ｋｇ；使大鼠试验群５０％致胃内血     

几种非甾体抗炎药的不良反应

本文对二氟尼柳、吲哚美辛、托美汀、布洛芬、萘普生、非诺洛芬、甲灭酸、氟灭酸、甲氯灭酸、吡罗昔康等非甾体抗炎药的不良反应作一综述,以期对我国非甾体抗炎药的开发有所裨益。     

八角麻的抗炎、镇痛、解热作用

口服八角麻酒提取物,对大鼠角叉菜胶性足肿胀和棉球肉芽肿有明显的抗炎作用,LD50为1290±238g/kg;角叉菜胶性足肿胀的ED50为111.4±42.1g/kg。小鼠醋酸扭体法的ED50为47.1±16.9g/kg,并与大鼠k~+透入测痛法等实验结果均有镇痛作用。以DNP为致热剂的大鼠发热试验,有较强的解热作用,但对大鼠正常体温没有明显影响。     

安儿宁颗粒解热抗炎镇痛作用

目的 研究安儿宁颗粒的解热、抗炎及镇痛作用. 方法 运用干酵母致大鼠发热模型,观察安儿宁颗粒解热作用;通过安儿宁颗粒对小鼠腹腔毛细血管通透性的影响观察其抗炎作用;采用醋酸致小鼠扭体模型,研究安儿宁颗粒的镇痛作用. 结果 与模型组比较,安儿宁颗粒中、高剂量组给药2 h后显著抑制干酵母导致的体温升高(P<0.01),其解热作用可持续至给药后4 h,但安儿宁颗粒的解热作用未见明显的剂量依赖关系. 对照组腹腔液伊文兰含量为(2.7±0.5) μg.mL^-1,模型组为(10.4±2.2) μg.mL^-1,安儿宁颗粒低、中、高剂量组分别为(7.3±3.0),(7.4±1.7),(5.2±1.3) μg.mL^-1. 在15 min内,对照组小鼠扭体(33.8±13.4)次,安儿宁颗粒低、中、高剂量组分别为(28.0±13.1),(20.5±5.0),(18.2±7.9)次. 结论 安儿宁颗粒具有解热、抗炎及镇痛作用.     

新癀片抗炎镇痛作用机制的蛋白组学研究

目的分析新癀片抗炎镇痛作用机制,通过蛋白组学方法寻找其作用的蛋白靶点。方法大鼠随机分成对照组、模型组、吲哚美辛(2 mg/kg)组以及新癀片23.8、47.5、95.0 mg/kg组。给药组均ig给药10 m L/kg,对照组及模型组ig给予同体积去离子水。1次/d,连续3 d。于末次给药后30 min,除对照组外,在大鼠右后足垫部sc 1%角叉菜胶0.05 m L/只致炎。在致炎前和致炎后1、2 h,记录大鼠抬足潜伏期。剖杀大鼠取肝脏,肝组织蛋白经提取、双向电泳、染色和图谱分析,确定差异表达蛋白,进行蛋白质质谱分析。结果与模型组比较,新癀片23.8、47.5、95 mg/kg组差异表达蛋白个数依次为67、71、94,其中上调个数为10、11、33,下调个数为57、60、61;新癀片95 mg/kg组与吲哚美辛(2 mg/kg)组比较,差异表达蛋白89个,其中上调27个,下调62个。共鉴定出11个差异蛋白质。与模型组比较,新癀片组均可以抑制Shank3、ANXA5、TPI、PSMA2表达,增强PAH、LZTS1表达。结论新癀片可调节的蛋白明显增多,能够抑制多种相关炎症因子和肿瘤因子,增强抗炎因子及抑癌因子的表达,为新癀片"增效"作用机制提供重要理论依据。     

吲哚美辛锌的抗炎,镇痛及胃刺激性研究

动物实验表明，吲哚美辛锌对大鼠由角叉菜胶诱发的足跖肿胀急性炎症、大鼠棉球肉芽肿慢性炎症、大鼠佐剂关节炎及腹腔注射０．７％醋酸诱发的小鼠急性渗出性炎症，都有明显的抑制作用。吲哚美辛锌在小鼠热板试验中有明显的镇痛作用，其抗炎、镇痛作用与吲哚美辛均无显著差异。胃刺激性实验表明，吲哚美辛锌对胃刺激性比吲哚美辛小。     

白前的镇痛、抗炎和抗血栓形成作用

目的 :研究白前的镇痛、抗炎和抗血栓形成作用。方法 :采用常规的炎症和疼痛模型以及电刺激麻醉动物颈动脉的体内血栓形成模型。结果 :给小鼠ig(口服灌胃 )白前醇提物5g/kg 和15g/kg,能显著延长热痛刺激甩尾反应的潜伏期 ,减少由乙酸引起的扭体反应的次数 ,抑制二甲苯引起的耳肿、角叉菜胶引起的足跖肿胀。此外 ,它还能显著延长大鼠体内血栓形成时间和凝血时间。结论 :白前具有镇痛、抗炎和抗血栓形成作用     

一种红蜂胶提取物治银屑病、消炎及镇痛作用(英文)

AIM: To study the antipsoriatic, anti-inflammatory, and analgesic effects of ethanolic extract of red propolis. METHODS and RESULTS: This extract induced the formation of granular layer in the mouse tail test used as a model of psoriasis. Propolis 50 mg·kg-1 ig showed anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in croton oil-induced edema in mice at a dose of 25 % (2.5μL), and in the peritoneal capillary permeability test in mice at a dose of 10 mg·kg-1. The extract (25 mg·kg-1 ig) showed analgesic effect in the model of acetic acid-induced writhings, whereas 40 mg·kg-1 was effective in the hot plate test in mice. CONCLUSION- Anti-inflammatory, analgesic, and antipsoriatic properties of Cuban red propolis were evident.     

重连口服液解热镇痛抗炎免疫作用的实验研究

目的研究重连口服液的解热、镇痛、抗炎、免疫调节作用。方法采用内毒素致大鼠发热法,观察重连口服液的解热作用;小鼠扭体法,观察重连口服液的镇痛作用;小鼠腹腔毛细血管通透性增高法,观察重连口服液的抗炎作用;环磷酰胺致小鼠免疫低下法,观察重连口服液的免疫调节作用。结果重连口服液对内毒素引起的大鼠体温升高、醋酸所致小鼠扭体次数、H＋致小鼠腹腔毛细血管通透性升高有明显的抑制作用;对环磷酰胺致小鼠免疫功能低下有明显的促进作用。结论重连口服液具有明显的解热、镇痛、抗炎、免疫调节作用。     

Double-blind clinical evaluation of a new anti-inflammatory drug,protacine, versus indomethacin

Summary

A double-blind clinical trial was carried out in 69 rheumatic in-patients to compare the eficacy and tolerance of a new, non-steroidal anti-inflammatory agent, protacine, with that of indomethacin. Patients received either 150?mg protacine or 50?mg indomethacin 3-times daily for 21 days, The time course of symptoms was recorded by semiquantitativr scoring, as were side-effects. Uropepsinogen excretion, occult blood in faeces and stundard physiological parameters were also monitored. Protacine globally decreased symptom scores by 58.5 % and indomethacin by 24.3 %(p < 0.001). The computed time to reduce symptom scores by 50% was 17.2 days with protacine as compared to 39.2 clays with indomethacin (p<0.001). Physiological parameters did not change, except white blood cells which decreased after protacine (each subject however, remaining well within the physiological range) and erythrocyte sedimentation rate, which decreased in both groups. Uropepsinogen ewretion increased 6.v 70 % after protacine, and threefold after indomethacin (p < 0.001). Occult blood search was positive in 1 patient receiving protacine, while 2 who were already positive before receiving protacine became negative during the treatment. Four patients taking indomethacin were journal to be positive, 1 showing melaena. The one who was already positive before treatment showed increasing severity of occult bleeding during indomethacin administration. Frequency and severity of side-effects were significantly less with protacine (p =0.004). In conclusion, protacine showed analgesic and anti-inflammatory actions significantly more potent and rapid than those of indomethacin, with significantly fewer and less severe side-effects.     

解热镇痛抗炎药说课设计案例

说课是教师针对具体的课程,系统地分析教材,阐述自己的教学设计思路、方法及理论依据,进行同行之间交流的教研活动。本文以解热镇痛抗炎药为例,从教材、教学目标、教学方法、教学过程和教学评价几个方面陈述本章说课的设计方案。通过对说课的探讨,达到优化教学过程、提高教学效果的目的。     

消炎退热颗粒清热解毒作用研究

目的：观察中成药消炎退热颗粒（DPZG）对家兔发热模型、小鼠急性耳廓肿胀模型、小鼠内毒素血症模型的作用,探讨其清热解毒的作用和机理。方法：采用脂多糖（lipopolysaccharides,LPS）耳缘静脉注射建立家兔发热模型,评价其解热作用;采用二甲苯致小鼠急性耳廓肿胀模型评价其抗炎作用;建立小鼠内毒素血症模型,观察DPZG对于D-氨基半乳糖（ACTD）敏化小鼠LPS致死攻击的影响,评价其抗内毒素的作用;以Elisa法检测DPZG对内毒素血症模型小鼠血清中TNF-α、IL-1β等炎症因子水平的影响,Western blot法检测小鼠肝、脾、肾组织中膜突蛋白（moesin）以及磷酸化P38 MAPK表达。结果：与模型组比较,DPZG对家兔体温升高有显著抑制作用,与阿司匹林趋同;可显著降低二甲苯致小鼠急性耳廓肿胀程度;可显著升高内毒素血症模型小鼠存活率;显著降低小鼠血清中TNF-α、IL-1β水平和小鼠肝脾肾组织内p-P38MAPK和膜突蛋白（moesin）的表达,效果明显优于中成药对照药蒲地蓝消炎口服液（PBKH）。结论：消炎退热颗粒有显著清热解毒作用,主要作用方式是解热、抗炎、抗内毒素,且效果明显优于PBKH。其作用机制可能与抑制IL-1β、TNF-α、Moesin以及p-P38 MAPK的表达有关。     

三叶青提取物抗炎、镇痛及解热作用的实验研究

目的:探讨三叶青提取物(ERT)的抗炎、镇痛及解热作用,并验证其相关功效.方法:以小鼠腹腔毛细血管通透法、小鼠耳肿胀法及大鼠足肿胀法观察其抗炎作用;以小鼠扭体法、热板法观察其镇痛作用;以干酵母致热法及2,4-二硝基苯酚致热法观察其解热作用.结果:三叶青提取物能明显抑制小鼠腹腔毛细血管炎性渗出,抑制二甲苯所致小鼠耳廓肿胀及10%蛋清致大鼠足跖肿胀;减少醋酸致小鼠扭体次数,提高热板法小鼠痛阈值;并降低干酵母和2,4-二硝基苯酚致大鼠发热模型的体温.结论:三叶青提取物具有较好的抗炎、镇痛及解热作用,与其相关的中医临床功效及主治相符.     

赖氨匹林的解热、镇痛和抗炎作用

目的：应用大鼠及小鼠研究赖氨匹林的抗炎、镇痛及解热作用。方法：用大鼠足跖肿胀研究抗炎作用，用小鼠醋酸扭体法及热板法测定镇痛作用，用鲜酵母法测定解热作用。结果：赖氨匹林对大鼠足跖肿胀有明显抑制作用，最大抑制率为８０％（Ｐ＜０．０１）。小鼠醋酸扭体法测得镇痛ＥＤ５０＝７２±２３ｍｇ／ｋｇ，对鲜酵母致大鼠体温升高有明显抑制作用。小鼠半数致胃溃疡剂量ＵＤ５０＝０．１８±０．０６ｍｍｏｌ／ｋｇ，是阿司匹林的２．４倍。结论：赖氨匹林具有和阿司匹林相当的解热、镇痛和抗炎作用，而对胃肠道的毒副作用比阿司匹林小。     

柴菊口服液的抗病毒抑菌和抗炎解热作用

目的:考察柴菊口服液抗病毒抑菌和抗炎解热作用。方法:采用细胞病变抑制法、琼脂稀释法、小鼠流感病毒感染法来研究柴菊口服液对常见呼吸道病毒和细菌的抑制作用;采用小鼠耳廓肿胀法、小鼠腹腔致炎法和细菌内毒素致家兔发热法研究柴菊口服液的抗炎解热作用。结果:柴菊口服液对流感病毒甲3型(A3)、副流感病毒1型(HVJ)、呼吸道合胞病毒(RSV)、单纯疱疹病毒1和2型(HSV-1,HSV-2)以及所试6种细菌56株菌株均有不同程度的抑制作用,其中对副流感病毒和金葡菌的抑制作用较强。高、中、低剂量(19.2,9.6,4.8 g生药.kg-1)柴菊口服液能不同程度降低流感病毒感染小鼠的肺指数(P<0.01或0.05),增加感染小鼠的体重(P<0.05),减少感染小鼠的死亡率(P<0.05),延长感染小鼠的存活时间(P<0.01或0.05);高中剂量柴菊口服液能显著抑制二甲苯引起的小鼠耳廓炎性肿胀(P<0.05);高、中、低剂量柴菊口服液能够明显降低醋酸引起的小鼠腹腔毛细血管通透性(P<0.01或0.05);高剂量(19.2 g生药.kg-1)柴菊口服液对细菌内毒素引起的家兔体温升高有较好的解热作用(P<0.05)。结论:柴菊口服液具有较明显的抗病毒抑菌和抗炎解热功效。     

Toxicological aspects of feprazone,a new nonsteroidal anti-inflammatory drug

The subacute and chronic toxicities of oral feprazone were studied in rats and beagle dogs. Administration of more than 150 mg/kg/day of feprazone to rats for 1 month induced retardation of growth and liver enlargement. In addition, treatment with 600 mg/kg/day of feprazone caused death, gastrointestinal ulcers, decreased hemoglobin concentration, and leucocytosis. Treatment of rats with 540 mg/kg/day of feprazone for 6 months had similar effects to those described above except that it did not cause death or gastrointestinal ulcers. Toxic nephropathy, nontoxic goiter, hepatomegaly, and increase of ovarian weight were observed in rats given more than 60 or 180 mg/kg/day of feprazone for 6 months. Injection of 1080 mg/kg/day of feprazone into dogs, caused one of six animals to become moribund on Day 18 and one to die on Day 7. The dogs surviving after administration of 360 and 1080 mg/kg/day of feprazone for 1 month showed anemia, leucocytosis, and elevations of phenolsulfonphthalein retention and serum alkaline phosphatase (ALP) activity. Similar effects were observed in dogs surviving after treatment with 150 or 375 mg/kg/day of feprazone for 12 months; in addition, increased ALP activity was observed even at a dose of 60 mg/kg/day. Liver enlargement was observed in dogs treated with all doses of feprazone for 1 or 12 months, and cytoplasmic inclusion bodies were observed in liver cells of dogs given more than 120 mg/kg/day of feprazone for 1 month.     

非甾体类抗炎药抗阿尔采末病作用的研究进展

神经炎症过程可能是阿尔采末病(AD)的重要发病原因之一。AD的流行病学研究显示,长期服用非甾体类抗炎药(NSAIDs)可减低AD的发病率;实验研究还发现,NSAIDs的作用除了调节COX机制外,还可能涉及一些非COX机制。