56例残胃癌早期诊治临床分析

目的：探讨残胃癌的早期诊断和治疗手段。方法：分析56例残胃癌患者的临床资料。结果：残胃癌多在胃十二指肠良性疾病行胃大部分切除术10年后发病，毕Ⅱ式癌发生率82．14％（46／56），毕Ⅰ式癌发生率17．86％（10／56），两种手术方式癌变率呈显著性差异（P〈0．01）；胃镜及组织活检是早期诊断的主要方法。残胃癌的治疗首选根治性手术切除。根治性切除40例中患者生存3年以上27例（67．50％），生存5年以上13例（32．5％）。姑息性切除9例生存12-30月，未能手术切除的7例生存2-14个月。结论：对胃十二指肠良性疾病行胃大部分切除术后10年以上患者进行定期胃镜检查及组织活检，是早期诊断的重要手段。根治性手术切除是早期残胃癌首选的治疗方法，综合治疗则是进展期胃癌的最佳手段，能有效提高患者的生存时间和生存质量。     

残胃癌23例临床分析

目的探讨残胃癌的临床特点。方法回顾性分析自1996年9月～2003年7月收治的残胃癌23例临床资料。结果残胃癌多在良性胃十二指肠疾病行胃大部分切除10年后发病,毕Ⅱ式癌发生21例（91％）,毕Ⅰ式癌发生2例（9％）,毕Ⅱ式癌发生率显著高于毕Ⅰ式。残胃癌的治疗首选根治性手术切除,根治性切除16例中,患者生存5年以上6人（38％）,生存3年以上11人（69％）,姑息性切除4例生存1～2年,未能手术切除3例生存1～10月。结论胃良性病变行胃部分切除术后的病人应行严密随访,早期外科根治性手术切除效果较好,晚期也应积极行姑息手术切除,以延长患者生命。     

残胃癌的临床特征及预后研究

目的：探讨残胃癌的临床特点及外科治疗方法。方法：回顾性分析我院1995年4月～2004年9月收治的33例残胃癌的临床资料。结果：残胃癌多在良性胃十二指肠疾病行胃大部分切除10年后发病。毕Ⅱ式术后残胃癌30例（90.90%）,毕Ⅰ式术后残胃癌3例（9.09%）,毕Ⅱ式术后残胃癌的发生率显著高于毕Ⅰ式。残胃癌的治疗首选根治性手术切除,33例患者中生存5年以上6例（18.18%）,生存3年以上10例（30.30%）;6例患者行姑息性切除治疗,生存1～2年;3例患者未能行手术治疗,生存1～10个月。结论：胃良性病变行胃部分切除术后的患者应行严密随访,早期外科根治性手术切除效果较好,晚期也应积极行姑息手术切除,以延长患者生命。     

残胃癌肿21例的外科治疗

残胃癌肿２１例,其中残胃癌１１例,残胃复发癌９例,残胃遗留癌１例。根治性切除１２例,姑息性切除５例,手术切除的１７例,病人生存＞５年以上２例,生存３年以上５例,姑息性切除５例生存８～１６个月,平均１１．３个月。提高残胃癌肿疗效关键在于早期诊断。提高加强对胃大部切除术后病人的随访是早期发现残胃癌肿的有效手段。     

残胃癌与残胃复发癌内镜及临床分析

临床上因胃或十二指肠良性病变行胃大部切除术后 5a以上残胃发生的癌为残胃癌 ,胃癌术后残胃发生的癌为残胃复发癌。我院在 2 3a间经内镜检查残胃患者 2 5 8例 ,发现残胃癌 10例 ,残胃复发癌 2 2例 ,现分析如下。1　临床资料1.1　一般资料　内镜检查因胃或十二指肠良性病变行胃大部切除术后患者 16 0例 ,发现残胃癌 10例 ,发生率 6 .3% ,男 9例 ,女 1例 ,年龄 4 3～ 6 9a ,平均 5 7.3a。因胃溃疡及其并发症行胃次全切除术的患者 5 0例 ,发生残胃癌 7例 ,发生率 14 .0 % ,而因球溃疡及其并发症行手术的患者 90例 ,发生残胃癌 3例 ,发生率3.3%…     

残胃癌11例临床诊疗分析

残胃癌(gastric stump cancer,GSC)是胃十二指肠溃疡行胃大部切除术5年后残胃发生的原发性癌[1],由Balfour于1922年首次提出,由于其早期诊断率低,其根治性手术率和生存率均明显低于原发性胃癌。近年来残胃癌的发生率有日渐增高的趋势。我院2003年5月至2009年4月共诊治11例残胃癌患者,占我院同期收治胃癌总数的1.5%(11/716),现总结如下。1临床资料1.1一般资料11例中男10例,女1例。年龄48~79岁,平均年龄58.6岁。距胃部分切除时间6~37年,平均21.4年,其中间隔>20年者占54.5%(6/11)。胃部分切除原因:胃溃疡或伴穿孔、出血、梗阻7     

残胃癌5例报告(来稿摘登)

本文报告5例残胃癌的诊治。患者原发疾病为胃溃疡2例,十二指肠溃疡3例、均行毕罗Ⅱ式胃大部分切除。病灶位于吻合口者4例,贲门部1例;全部由胃镜检查获得诊断,原手术至残胃癌确诊时间平均24年。本组病例进行残胃次全切除4例和全胃切除1例,术后生存6～18个月。作者认为:残胃癌与原发     

残胃癌及残胃再发癌的临床特征和外科治疗(附27例分析)

目的探讨残胃癌及残胃再发癌的临床特点、诊断和外科治疗。方法回顾性分析2000年2月～2005年6月27例残胃癌及残胃再发癌的病人。结果手术切除率为77.8%,根治切除率为59.1%,根治性手术后1年、3年和5年的生存率分别为75%、50%及37.5%。结论胃良性病行手术治疗时以B-I式为首选;定期胃镜检查残胃癌及残胃再发癌高危人群,早期诊断、早期治疗是提高残胃癌及残胃再发癌预后的关键;根治性手术是治疗残胃癌及残胃再发癌的有效方法。     

92例残胃病变临床分析

本文报告经内镜检查结合活检确诊的胃大部切除术后残胃粘膜病变92例,其中残胃炎89例,残胃癌3例。上腹痛(41%)、黑粪(15.2%)、腹胀(12%)与嗳气(3.3%)为其主要症状。早期残胃癌往往无明显症状,一旦出现症状,多属进展期。本组残胃癌3例均为毕氏Ⅱ式,在手术8年后发生。对胃良性病变行胃大部切除毕氏Ⅱ式术后,尤其是术后5年以上,年龄大于45岁者定期作内镜复查;可能发现早期残胃癌。良性消化性溃疡病人仍以药物治疗为首选,对需要毕氏Ⅱ式手术者应尽可能采用残胃空肠长襻 Roux-en-Y 吻合术,以减少残胃癌的发生。     

残胃癌的临床研究

【目的】总结和分析残胃癌的临床诊治特点。【方法】回顾性分析1997年2月-2000年11月收治的10例残胃癌。【结果】手术切除率为80%,根治切除率60%,5年生存率20%,根治性切除者的2年生存率达83.3%。【结论】胃良性疾病行手术治疗时,应以BillrothⅠ式为首选;定期胃镜检查残胃患者,早期诊断和根治性外科治疗是决定残胃癌预后的关键。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.