The epidemiology of chronic venous insufficiency and varicose veins

Chronic venous disease is a common condition presenting to physicians in Western Europe and the United States. This article provides a comprehensive review of the published literature in the English language, from 1942 to the present, and focuses on the prevalence of chronic venous insufficiency and varicose veins, as well as the involved risk factors. Prevalence estimates vary widely by geographic location, with the highest reported rates in Western countries. Reports of prevalence of chronic venous insufficiency vary from < 1% to 40% in females and from < 1% to 17% in males. Prevalence estimates for varicose veins are higher, <1% to 73% in females and 2% to 56% in males. The reported ranges in prevalence estimations presumably reflect differences in the population distribution of risk factors, accuracy in application of diagnostic criteria, and the quality and availability of medical diagnostic and treatment resources. Established risk factors include older age, female gender, pregnancy, family history of venous disease, obesity, and occupations associated with orthostasis. Yet, there are several factors that are not well documented, such as diet, physical activity and exogenous hormone use, which may be important in the development of chronic venous disease and its clinical manifestations.     

The epidemiology of varicose veins. A survey in western Jerusalem.

The prevalence and correlates of varicose veins were investigated in a community survey in a neighbourhood of western Jerusalem in 1969-71. The prevalence was 10% among men and 29% among women aged 15 and over; it rose with age in each sex. In both sexes, significant associations were found with standing at work and with region of birth. Among women, varicose veins were associated with weight, the wearing of corsets, and having ever been pregnant. Among men, there was an association with inguinal hernia. The findings support the aetiological role of prolonged standing and raised intra-abdominal pressure. Varicose veins were relatively uncommon among North African-born men and women aged 45 and over. This finding, which was not accounted for by the other observed associations, is consistent with the possible aetiological role of experiences before immigration, such as behavioural patterns laid down in early life.     

Lifestyle factors and the risk of varicose veins: Edinburgh Vein Study

The objective of this study was to determine the inter-relationships between a range of lifestyle factors and risk of varicose veins to identify which factors may be implicated in the etiology. An age-stratified random sample of 1566 subjects (699 men and 867 women) aged 18 to 64 years was selected from 12 general practices throughout Edinburgh. A detailed self-administered questionnaire was completed, and a comprehensive physical examination determined the presence and severity of varicose veins. The slightly higher age-adjusted prevalence of varicose veins in men than in women (39.7% versus 32.2%) was not explained by adjustment for an extensive range of lifestyle risk factors (male odds ratio [OR] 2.11, 95% confidence interval [CI] 1.51-2.96). In both sexes, increasing height showed a significant relationship with varicose veins (male OR 1.50, 95% CI 1.18-1.93 and female OR 1.26, 95% CI 1.01-1.58). Among women, body mass index was associated with an increased risk of varicose veins (OR 1.26, 95% CI 1.02-1.54). The current study casts doubt as to whether varicose veins occur predominantly in women. In addition, no consistent relationship with any lifestyle factor was shown. Self-reported evidence suggested a familial susceptibility, thereby warranting future genetic studies.     

Radiological assessment of varicose veins.

Most patients with straightforward varicose veins only require a careful clinical examination combined with Doppler ultrasound scanning. When varicose veins are secondary to past deep venous thrombosis, recur after treatment or are associated with congenital anomalies, radiology is useful for diagnosis and management.     

Women with pelvic complaints and atypical varicose veins, varicose veins of the vulva and insufficiency of the pelvic veins; treatment with embolisation

In three women, aged 34, 52 and 30 years, respectively, who suffered from chronic pelvic symptoms such as a heavy feeling and abdominal pain, atypical varicose veins were observed on the medial side of the upper thighs together with varicose veins of the vulva; these are indicators of insufficiency of the pelvic veins. The symptoms were reduced following embolisation of the insufficient pelvic veins. These symptoms are also known as the pelvic congestive syndrome. The exact correlation between insufficiency of the pelvic veins and the complaints mentioned above has not yet been determined, but it seems that in most patients the symptoms diminish or disappear following embolisation of the insufficient pelvic veins. When patients complain of chronic pelvic pain of unknown aetiology, one should look for atypical varices and vulval varices and consider pelvic-vein insufficiency as a possible cause.     

Physical examination--tourniquet tests for varicose veins

Physical examination of patients with varicose veins is time-consuming and subjective. Nowadays, it is frequently replaced by hand-held Doppler examination and duplex scanning. Adequate studies investigating the value of physical examination for varicose veins are lacking. It is unclear whether the tourniquet tests of Trendelenburg and Perthes are more accurate than other physical tests, such as the cough test or tap test. In selected patients, who are not obese, have clearly visible varicose veins and have not been treated before, physical examination seems accurate, especially for assessment of the long saphenous vein. When physical examination is inconclusive, as often is the case with recurrent varicose veins, suspected short saphenous vein or perforator incompetence, or adipose legs, additional Doppler or duplex testing is required for an accurate diagnosis.     

Standing at work and varicose veins

OBJECTIVES: This study attempts to determine whether or not prolonged standing at work involves an excess risk for the occurrence of varicose veins. METHODS: A cohort of 1.6 million 20-to-59-year-old Danes gainfully employed in 1991 were followed for 3 years according to first hospitalization due to varicose veins of the lower extremities. The exposure data came from a representative sample of the baseline population. Altogether 5940 people were interviewed about occupational exposure and confounding factors. RESULTS: For men working mostly in a standing position, the risk ratio for varicose veins was 1.85 [95% confidence interval (95% CI) 1.33-2.36] in a comparison with all other men. The corresponding risk ratio for women was 2.63 (95% CI 2.25-3.02). The results were adjusted for age, social group, and smoking. CONCLUSIONS: Working in a standing position is associated with subsequent hospitalization due to varicose veins for both men and women.