肿胀性红斑狼疮1例

患者男 ,3 0岁 ,面部、上胸背及双手背水肿性红斑 5 0天。实验室检查免疫学指标均正常 ,皮损组织病理检查示 :表皮未见明显异常 ,真皮血管周围少量慢性炎性细胞浸润 ;阿新蓝染色示真皮胶原纤维间有粘蛋白沉积 ,诊断为肿胀性红斑狼疮。     

肿胀性红斑狼疮1例

患者女,33岁。面部出现肿胀性红斑3个月,发病前有牙龈肿痛。面部皮损组织病理检查示真皮浅层淋巴细胞浸润,网状层胶原束间有大量黏蛋白沉积。查抗核抗体、抗双链DNA、抗Sm、抗Ro/SSA、抗La/SSB抗体均为阴性。光敏试验显示皮肤对UVA和UVB有异常反应。诊断为肿胀性红斑狼疮。经外用17-α丁酸氢化可的松、硅油炉甘石霜(硅炉霜),口服泼尼松1mg/(kg·d)和羟氯喹8mg/(kg·d)治疗,皮损得到控制。     

肿胀性红斑狼疮1例

肿胀性红斑狼疮（lupus erythemrlsus lumidus）临床上较少见，现将我们所见1例报道如下。     

肿胀性红斑狼疮

患者女,41岁。因左面部肿胀半年,于2002年11月入我院治疗。半年前患者无明显诱因于左上眼睑内侧出现一小指甲盖大红斑,伴肿胀,1周后肿胀蔓延至左面上半部及右眼眶周,自觉左眼眶上部轻度疼痛,皮损经日晒后加重。曾在外院诊断为慢性丹毒,给予青霉素静脉滴注,无明显疗效。自发病以来,睡眠较差,两便正常。否认面部有外伤史。体格检查:一般情况好,系统检查无异常。皮肤科检查:左侧面部见一手掌大红色斑块,累及左侧眼睑、颧部及左颊上部,边界欠清,呈暗红色,表面光滑(图1A),斑块质地略硬,无压痛。右侧眼睑及右侧颧部可见类似皮损,边界较清,有浸润…     

肿胀性红斑狼疮一例

肿胀性红斑狼疮（lupuserythematasustumidus,LET）是慢性皮肤型红斑狼疮（CCLE）的一个亚型,1930年由Gougerot和Burnier首先报道[1,2]。近年来LET引起了国内外专家的关注。我科于2002年收治1例,现报道如下。患者男,48岁。因颜面、躯干、上肢近端伸侧红斑1年,加重1个月于2002年4月30日入院。该患者于2001年7月经常在户外游泳,日晒后颜面起小片红斑、丘疹,呈肿胀浸润性鲜红色斑,触之较硬,不伴鳞屑及毛囊角化过度,有时瘙痒。部分皮损未经治疗数周后可自动消退,消退后无皮肤萎缩及瘢痕,无色素减退。有时可在同一部位再发,病情…     

肿胀性红斑狼疮一例

患者女,54岁。因右侧眼睑面颊红斑肿胀反复1年,于2011年6月就诊。1年前患者无明显诱因,右侧面颊部出现暗红色水肿性斑片,因皮疹无自觉症状,未予重视,未行诊治。之后红斑范同逐渐扩大,渐累及右侧眼睑,表现为右侧上下眼睑肿胀。就诊前1个月右侧眼睑肿胀逐渐加重,睁眼网难,视力未受明显影响。患者在当地医院诊断为皮炎,予以抗过敏药物等（具体不详）治疗后未见明显好转．红斑肿胀不断加重,     

肿胀性红斑狼疮四例

目的 探讨肿胀性红斑狼疮的临床与病理特点,提高对本病的认识.方法 对2008-2010年确诊的4例肿胀性红斑狼疮的临床资料进行总结.结果 4例均具有肿胀性红斑狼疮的表现,在面部曝光部位发生肿胀性红斑,有光敏并日晒后加重.红斑狼疮免疫学指标多为阴性.组织病理检查:真皮网状层黏蛋白沉积,阿新蓝染色阳性.4例均应用羟氯喹200 mg,每日2次口服治疗.用药6个月至1年,有明显疗效,正在随访中.结论 肿胀性红斑狼疮是慢性皮肤型红斑狼疮的一个亚型,提高对肿胀性红斑狼疮的认识,有助于减少误诊,及时治疗.     

10例肿胀性红斑狼疮临床及病理分析

回顾性分析2012-2016年确诊的10例肿胀性红斑狼疮患者的临床资料,10例患者均为多发性皮损,累及面、颈、胸背部和上肢,表现为红色荨麻疹样丘疹或斑块,表面光滑,其中6例有光敏感。组织病理:真皮浅层及深层血管周围以淋巴细胞为主的浸润,胶原束间可见黏蛋白沉积,7例有轻度表皮改变。     

肿胀性红斑狼疮1例

肿胀性红斑狼疮是1930年首先由Gougerol和Bumier报道的一种少见的皮肤型红斑狼疮的亚型，现将笔者所见1例报道如下。     

肿胀性红斑狼疮1例

报道1例肿胀性红斑狼疮(LET).患者女,36岁,藏族,面部反复出现不对称肿胀性红斑伴痒痛6年.皮肤科查体:双侧眼睑不对称性肿胀,其上可见紫红色不规则斑片,境界欠清,压之不褪色,无鳞屑、瘢痕及萎缩.实验室检查:抗核抗体等自身抗体均阴性.皮肤组织病理检查:表皮轻度角化过度,有毛囊角栓形成,棘层萎缩变薄,基底细胞伴空泡变,...     

肿胀性红斑狼疮1例

患者男，36岁。因面部、双上肢和背部反复起水肿性红班2年。实验室检查免疫学指标均正常，皮损直接免疫荧光检查阴性。组织病理检查示真皮浅层和深层血管周围以及附属器周围有淋巴细胞、组织细胞浸润。阿新蓝染色在真皮胶原纤维束间有大量黏蛋白沉积。     

Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus

Background  Lupus erythematosus tumidus (LET) is a rare disease which was first described in 1909 but has not always been considered as a separate entity of cutaneous lupus erythematosus (CLE) in the international literature.
Objectives  To compare characteristic features of different subtypes of CLE and to analyse whether LET can be distinguished as a separate entity in the classification system of the disease.
Methods  The study involved 44 patients with CLE, including 24 patients with LET, 12 with discoid lupus erythematosus (DLE) and eight with subacute CLE (SCLE), from two centres in Germany. A core set questionnaire and an SPSS database were designed to enable a consistent statistical analysis.
Results  Location of skin lesions did not differ significantly between the CLE subtypes; however, the activity score was significantly lower in LET than in DLE ( P  <   0·01), and the damage score was significantly lower in LET than in SCLE ( P  <   0·01) and DLE ( P  <   0·01). Photosensitivity and antinuclear antibodies were confirmed to be different in LET compared with SCLE and DLE but without statistical significance. Moreover, histological analysis of skin biopsy specimens showed that abundant mucin deposition is significantly more present in LET compared with SCLE ( P  <   0·01) and DLE ( P  <   0·01) while prominent interface dermatitis and alteration of hair follicles were absent in LET.
Conclusions  Several significant differences were found between LET and other subtypes of CLE with regard to clinical, histological and laboratory parameters. These data strongly indicate that LET should be defined as a separate entity in the classification of CLE.     

肿胀性红斑狼疮的研究进展

肿胀性红斑狼疮为皮肤型红斑狼疮的亚型之一,其临床特征为紫红色斑,单个或多发斑块,表面光滑,边界清楚,不形成瘢痕,无糜烂、萎缩、鳞屑、毛囊角栓等表皮的改变,且具有显著光敏性,好发于日光暴露部位.组织病理学特点为血管及附属器周围淋巴细胞浸润,真皮网状层黏蛋白沉积,无明显表皮受累,直接免疫荧光检测为阴性.氯喹和羟氯喹治疗有效.     

新生儿红斑狼疮三例并文献复习

报道3例新生儿红斑狼疮并对相关文献进行复习。3例患儿皮损表现为红斑、丘疹,以面部为主,第2例患儿母亲有干燥综合症6年,第1例及第3例患儿母亲无结缔组织病史。患儿及其母亲抗核抗体、抗Ro/SSA抗体、抗La/SSB 抗体、抗Ro-52抗体均阳性。3例心电图检查均未见心脏传导阻滞,2例患儿伴肝损伤。均予泼尼松及对症治疗后病情好转。     

Eyelid discoid lupus erythematosus and contact dermatitis: a case report

We report a patient with discoid lupus erythematosus (DLE) and associated allergic contact dermatitis (ACD) in the eyelids. In women, ACD caused by nail varnish is frequent and often seen in the eyelids. ACD caused by drugs (e.g. neomycin) is also frequent in this region. However, DLE with periorbital presentation without evidence of systemic or other cutaneous involvement is rare.