308nm准分子激光联合胡椒碱治疗白癜风疗效观察

目的评价308nm准分子激光联合胡椒碱对白癜风的临床疗效和安全性。方法将入选的87例白癜风患者按就诊顺序随机分为2组,共80例患者完成试验观察,治疗组予308nm准分子激光局部照射每周2次,联合胡椒碱酊局部外用2次/d治疗,对照组予308nm准分子激光局部照射每周2次,联合8-甲氧基补骨脂素(8-MOP)溶液局部外用2次/d治疗。治疗时间为4周一疗程,治疗3个疗程,比较2组患者在白癜风皮损复色上的差异。结果治疗组的显效率90%,对照组为77.5%。2组显效率差异有统计学意义(P0.05),治疗中未出现严重的不良反应。结论 308nm准分子激光联合胡椒碱对于治疗白癜风有明显的效果,且无明显不良反应,对白癜风的治疗是一个很好的选择。     

308nm准分子激光治疗白癜风进展

由氯化氙准分子激光器发出的308nm准分子激光,具有选择性作用于病变皮损、方便、高效、不良反应小的特点,近来在白癜风治疗中取得了显著效果,并为较多的患者所接受,本文简单综述该激光在白癜风治疗中的应用进展。     

308nm准分子激光治疗白癜风临床分析

目的 观察308nm准分子激光治疗白癜风的效果.方法 统计接受308nm准分子激光一个疗程治疗后的门诊300例白癜风患者的1 051处皮损,逐个对治疗后皮损的色素恢复情况进行统计,并分部位、分级、分年龄段进行分析和评价.结果 1 051处皮损,色素恢复情况:0级18处,Ⅰ级134处,Ⅱ级317处,Ⅲ级431处,Ⅳ级151处;显效率为55.4％;总有效率为85.5％.按部位:显效率排序为面、颈部,胸腹部、背部,上肢、下肢,手、足部;总有效率排序为面部、颈部、胸腹部、背部,上肢,下肢,手、足部.按皮损分级:显效率、总有效率排序为Ⅰ级,Ⅱ级,Ⅲ级,Ⅳ级.按年龄段:显效率、总有效率排序为青少年,中青年,中老年.结论 308nm准分子光治疗仪治疗白癜风疗效好、不良反应少.疗效与部位、皮损分级程度、年龄有关.     

308nm准分子激光治疗儿童白癜风疗效观察

目的评价308nm准分子激光治疗儿童白癜风的疗效及安全性。方法采用自身对照的方法,用Xt-rac颠峰准分子激光系统治疗85例稳定期儿童白癜风患者(年龄≤12岁)的自身对称或相邻皮损,每周治疗1～3次,共30次,每隔10天及治疗结束3天后评价疗效。结果治疗的皮损痊愈12例,显效45例,好转21例,无效7例,显效率为67.1%,有效率为91.8%;未治疗的皮损仍为色素脱失斑。面颈部疗效优于躯干四肢,躯干四肢优于肢端,面颈部非节段型优于节段型。结论308nm准分子激光治疗稳定期儿童白癜风疗效高、副作用少,其疗效与皮损部位有关。     

308 nm准分子激光治疗白癜风临床疗效观察

目的：观察308nm氯化氙准分子激光治疗白癜风的临床疗效及不良反应。方法：采用Xtrac颠峰准分子激光系统对77例白癜风患者不同部位共292处皮损进行治疗,每周1～2次。并观察疗效,达到3级色素恢复后对相关因素进行分析。结果：经治疗面颈部皮损起效最快,其次为躯干部、四肢,褶皱部最慢;年龄〈18岁患者皮损起效快于年龄〉18岁患者;不同性别、疾病分期、病程、皮肤类型患者的起效快慢差异无统计学意义。结论：308nm准分子激光治疗白癜风疗效好,不良反应少,其疗效与年龄、皮损部位有关。     

308 nm准分子激光治疗白癜风疗效与影响因素分析

目的:评价308 nm准分子激光治疗白癜风的疗效及其影响因素。方法:采用308 nm准分子激光系统治疗103例白癜风患者171处皮损,每周治疗1～2次,共12～50次,治疗结束后评价疗效。结果:皮损的总显效率为59.06%,有效率为83.04%。疗效影响因素分析显示不同部位、年龄、病程以及皮损大小对治疗效果有显著影响。结论:308 nm准分子激光治疗白癜风疗效高、副作用少。     

308nm准分子激光治疗稳定期白癜风疗效观察

目的 308nm准分子激光治疗稳定期白癜风的疗效.方法 采用Xtrac巅峰准分子激光系统治疗,选择498例稳定期白癜风患者皮损1 697片,每周2次,治疗次数10～30次.结果 治疗的皮损痊愈为549片,显效552片,好转403片,无效193片.有效率为64.88%.头面、颈部优于躯干、四肢,躯干、四肢优于肢端.儿童疗效比成人疗效好.痛程越短疗效越好.结论 308准分子激光治疗稳定期白癜风疗效较好,不良反应少.     

308 nm准分子激光联合他克莫司软膏治疗白癜风的临床疗效Meta分析

目的:系统评价308 nm准分子激光联合他克莫司软膏对比窄谱中波紫外线(NB-UVB)联合他克莫司软膏治疗白癜风的临床疗效。方法:计算机检索中文科技期刊数据库(VIP)、中国知网(CNKI)、万方数据库,百度学术、谷歌学术等搜索引擎,搜索308nm准分子激光联合他克莫司软膏、NB-UVB联合他克莫司软膏治疗白癜风的随机对照试验(RCT),按制定的纳入及排除标准进行文献筛选、数据提取,采用Revman 5.3软件分析统计,以有效率作为疗效指标进行分析,计算比值比(OR)及95%可信区间(CI)。结果:纳入14篇RCT,共计2223例患者。亚组间OR值比较结果显示:308 nm准分子激光联合他克莫司软膏对比单用他克莫司软膏治疗白癜风的有效率OR值[OR=7.53,95%CI(4.52,12.53)]大于NB-UVB联合他克莫司软膏对比单用他克莫司软膏治疗白癜风的OR值[OR=3.48,95%CI(2.81,4.30)],差异有统计学意义(P<0.05)。结论:308nm准分子激光联合他克莫司软膏治疗白癜风的临床疗效优于NB-UVB联合他克莫司软膏。     

308nm准分子激光联合吡美莫司软膏治疗白癜风临床观察

目的评价308nm准分子激光联合吡美莫司软膏治疗白癜风的疗效和安全性。方法将150例白癜风患者随机分成3组。治疗组50例,308nm准分子激光(2次/周)联合吡美莫司软膏(2次/d)治疗,疗程12周。对照1组50例,单纯予308nm准分子激光治疗,用法同上。对照2组50例,单纯予吡美莫司软膏治疗,用法同上。结果治疗组有效率88.00%,对照1组为70.00%,对照2组为42.00%。治疗组和对照1组及对照2组比较,有效率差异有统计学意义(P<0.05)。治疗组皮损位于面颈部、躯干和四肢者疗效优于对照组(P<0.05),3组肢端皮损疗效差异无统计学意义(P>0.05)。患者均未出现严重不良反应。结论 308nm准分子激光联合吡美莫司软膏治疗位于面颈部、躯干和四肢的白癜风起效快,疗效好,不良反应少。     

308nm准分子光治疗白癜风疗效评价

目的：评价308nm准分子紫外光治疗白癜风的临床疗效。方法：31例进展期和34例稳定期白癜风患者皮损行308nm准分子紫外光治疗,共照射30次。结果：进展期和稳定期白癜风患者总有效率分别为62．14％、73．52％,无显著性差异（P〉0．05）。头面部及躯干部效果较好,肢端效果最差。结论：308nm准分子紫外光治疗白癜风安全有效,其疗效与皮损部位相关,与进展期或稳定期无关。     

308nm准分子激光治疗白癜风概述

白癜风治疗方法较多,308 nm准分子激光凭借起效快、疗效高及副作用小等优势而迅速应用于临床。其治疗白癜风的作用机制不清,可能通过诱导皮损处浸润的淋巴细胞凋亡而取得疗效。联合外用他克莫司软膏或吡美莫司乳膏治疗白癜风效果比单独应用308 nm准分子激光更为显著。     

CO2点阵激光联合308 nm准分子激光治疗白癜风疗效和安全性meta分析

目的：评价CO₂点阵激光联合308 nm准分子激光治疗白癜风的临床疗效和安全性。方法：通过检索Cochrane Library、PubMed、Embase、万方、中国知网、维普数据库,收集CO₂点阵激光与308 nm准分子激光联合治疗白癜风相关的文献,运用软件（Revman 5.3）进行Meta分析。结果：13篇临床随机对照实验被纳入,其中1014处皮损给予CO₂点阵激光与308 nm准分子激光联合治疗,1005处皮损给予308 nm准分子激光单独治疗。结果显示：联合疗法总有效率和显效率优于单用308 nm准分子激光;两组不良反应发生率无明显差异。结论： CO₂点阵激光+308 nm准分子激光联合治疗白癜风的疗效优于单独使用308 nm准分子激光,且两种疗法的不良反应没有明显差异。     

Compound glycyrrhizin tablets combined with the 308 nm excimer laser in the treatment of vitiligo: A systematic review and meta-analysis

Background

Although the 308 nm excimer laser is commonly used to cure vitiligo, its clinical efficacy is limited. Experts have found that the efficacy of compound glycyrrhizin tablets combined with the 308 nm excimer laser in the treatment of vitiligo is significantly enhanced, but the specific research methods and clinical data must be clarified.

Objective

To determine the clinical efficacy of compound glycyrrhizin tablets combined with the 308 nm excimer laser in the treatment of vitiligo.

Methods

Until August 2022, studies were searched in PubMed, the Cochrane Library, the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, the Chinese Scientific Journal Database, and the Wan Fang Database. We also searched for clinical RCTs involving compound glycyrrhizin tablets combined with the 308 nm excimer laser for the treatment of vitiligo. The meta-analysis was conducted in accordance with the Cochrane Handbook's recommendations. Two reviewers regulated the study selection, data extraction, and assessment of bias risk, and consulted a third reviewer as necessary. For the meta-analysis, Review Manager 5.4 was utilized.

Results

Finally, 9 articles and 1052 patients were included. A systematic review compared the efficacy of compound glycyrrhizin tablets combined with the 308 nm excimer laser to that of the 308 nm excimer laser alone: OR = 3.33, p < 0.00001, 95% confidence interval [2.25, 4.92].

Conclusion

In the treatment of vitiligo, compound glycyrrhizin tablets combined with the 308 nm excimer laser are more effective than the 308 nm excimer laser alone, and there are no serious adverse reactions. It is a safe and efficient way of treatment.     

308nm准分子光联合吡美莫司乳膏治疗白癜风疗效观察

目的：评价308 nm准分子光联合吡美莫司乳膏治疗白癜风的疗效和安全性.方法：将150例白癜风患者随机分为3组.治疗组50例,采用308 nm准分子光联合1%吡美莫司乳膏治疗.对照1组50例,采用NB-UVB联合1%吡美莫司乳膏治疗.对照2组50例,单纯外用1%吡美莫司乳膏治疗.3组均连续治疗12～24周,进行临床疗效和不良反应评价.结果：治疗组有效率为92.0%,对照1组为74.0%,对照2组为50.0%.3组患者均未出现严重不良反应.结论：308 nm准分子光联合吡美莫司乳膏治疗白癜风疗效确切,安全性好.     

他克莫司软膏联合308 nm准分子激光治疗白癜风临床疗效观察

目的：评价0．1％和0．03％他克莫司软膏联合308nm准分子激光治疗对紫外线治疗抵抗的白癜风皮损的疗效与安全性。方法：采用随机、自身对照的临床试验，每例患者选取紫外线治疗抵抗区域的皮损，随机选取躯体一侧皮损为治疗侧，采用他克莫司软膏联合308nm准分子激光治疗；另一侧为对照侧，仅用308nm准分子激光治疗。2个月后进行疗效判定。结果：联合治疗组有效率为89．0％，对照组为71．6％，两组间疗效比较差异有统计学意义（P〈0．05）。结论：他克莫司软膏联合308nm准分子激光治疗白癜风起效快，疗效好。     

308‐nm excimer lamp vs. 308‐nm excimer laser for treating vitiligo: a randomized study

Background The 308‐nm excimer laser and 308‐nm excimer lamp have both been shown to be effective in treating vitiligo but a direct comparison has never been performed. Objectives To test the equivalence of these two devices for treating nonsegmental vitiligo. Patients and methods A randomized monocentric study was undertaken. One lesion was treated with the 308‐nm excimer laser and its counterpart with the 308‐nm excimer lamp. Lesions were treated twice weekly with the same dose on both sides for a total of 24 sessions. The evaluation was done by two independent physicians blinded to the treatment on direct light and ultraviolet light photos. Results Twenty patients were included: 17 completed the study and 104 lesions were treated. The two treatments showed similar results in terms of efficacy for a repigmentation of at least 50% (P = 0·006). The lamp induced more erythema than the laser. Conclusions The 308‐nm excimer lamp and laser showed a similar efficacy in treating vitiligo. For the same fluence, the lamp induced more erythema suggesting photobiological differences between the two devices.     

他克莫司软膏联合308 nm准分子激光治疗小儿面部白癜风的疗效观察

目的 观察他克莫司软膏联合308 nm准分子激光治疗小儿面部白癜风的临床疗效。方法 将98例(269处)面部白癜风患儿,以各所医院为独立单元,按就诊时间顺序分组,对照组49例(131处皮损)单纯使用308 nm准分子激光治疗仪治疗,每周2次;治疗组49例(138处皮损)在使用准分子激光治疗仪治疗基础上加外用他克莫司软膏,每天2次。治疗3个月后对两组患儿的疗效和不良反应进行评价。结果 治疗组有效率为92.03%,不良反应率为6.52%;对照组有效率为79.39%,不良反应率为6.11%,两组有效率比较,差异有统计学意义(χ²=8.85,P<0.01),不良反应率比较差异无统计学意义(χ²=0.02,P>0.05)。结论 他克莫司软膏联合308 nm准分子激光治疗小儿面部白癜风疗效确定、安全无痛,容易被小儿及家长接受,值得进一步推广。